LOCUS       NM_012567               3148 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus gap junction protein, alpha 1 (Gja1), mRNA.
ACCESSION   NM_012567 XM_346604
VERSION     NM_012567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3148)
  AUTHORS   Chen,X., Wang,W., Li,H. and Zhang,X.
  TITLE     Enriched environment alleviates neurological deficits via
            downregulation of Cx43 after experimental stroke
  JOURNAL   Brain Res 1821, 148619 (2023)
   PUBMED   37805009
  REMARK    GeneRIF: Enriched environment alleviates neurological deficits via
            downregulation of Cx43 after experimental stroke.
REFERENCE   2  (bases 1 to 3148)
  AUTHORS   Tang,Y., Chu,Q., Xie,G., Tan,Y., Ye,Z. and Qin,C.
  TITLE     MLKL regulates Cx43 ubiquitinational degradation and mediates
            neuronal necroptosis in ipsilateral thalamus after focal cortical
            infarction
  JOURNAL   Mol Brain 16 (1), 74 (2023)
   PUBMED   37904209
  REMARK    GeneRIF: MLKL regulates Cx43 ubiquitinational degradation and
            mediates neuronal necroptosis in ipsilateral thalamus after focal
            cortical infarction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3148)
  AUTHORS   Darvishmolla,M., Saeedi,N., Tavassoli,Z., Heysieattalab,S.,
            Janahmadi,M. and Hosseinmardi,N.
  TITLE     Maladaptive plasticity induced by morphine is mediated by
            hippocampal astrocytic Connexin-43
  JOURNAL   Life Sci 330, 121969 (2023)
   PUBMED   37541575
  REMARK    GeneRIF: Maladaptive plasticity induced by morphine is mediated by
            hippocampal astrocytic Connexin-43.
REFERENCE   4  (bases 1 to 3148)
  AUTHORS   An,L., Gao,H., Zhong,Y., Liu,Y., Cao,Y., Yi,J., Huang,X., Wen,C.,
            Tong,R., Pan,Z., Yan,X., Liu,M., Wang,S., Wu,H. and Hu,T.
  TITLE     The potential roles of stress-induced phosphoprotein 1 and connexin
            43 in rats with reperfusion arrhythmia
  JOURNAL   Immun Inflamm Dis 11 (10), e852 (2023)
   PUBMED   37904692
  REMARK    GeneRIF: The potential roles of stress-induced phosphoprotein 1 and
            connexin 43 in rats with reperfusion arrhythmia.
REFERENCE   5  (bases 1 to 3148)
  AUTHORS   Zhou,E., Zhou,J., Bi,C. and Zhang,Z.
  TITLE     Cx43 Facilitates Mesenchymal Transition of Endothelial Cells
            Induced by Shear Stress
  JOURNAL   J Vasc Res 60 (4), 204-212 (2023)
   PUBMED   37673049
  REMARK    GeneRIF: Cx43 Facilitates Mesenchymal Transition of Endothelial
            Cells Induced by Shear Stress.
REFERENCE   6  (bases 1 to 3148)
  AUTHORS   Yeager,M. and Gilula,N.B.
  TITLE     Membrane topology and quaternary structure of cardiac gap junction
            ion channels
  JOURNAL   J Mol Biol 223 (4), 929-948 (1992)
   PUBMED   1371548
REFERENCE   7  (bases 1 to 3148)
  AUTHORS   Dupont,E., el Aoumari,A., Fromaget,C., Briand,J.P. and Gros,D.
  TITLE     Affinity purification of a rat-brain junctional protein, connexin
            43
  JOURNAL   Eur J Biochem 200 (1), 263-270 (1991)
   PUBMED   1652440
REFERENCE   8  (bases 1 to 3148)
  AUTHORS   John,S.A. and Revel,J.P.
  TITLE     Connexon integrity is maintained by non-covalent bonds:
            intramolecular disulfide bonds link the extracellular domains in
            rat connexin-43
  JOURNAL   Biochem Biophys Res Commun 178 (3), 1312-1318 (1991)
   PUBMED   1651718
REFERENCE   9  (bases 1 to 3148)
  AUTHORS   Lang,L.M., Beyer,E.C., Schwartz,A.L. and Gitlin,J.D.
  TITLE     Molecular cloning of a rat uterine gap junction protein and
            analysis of gene expression during gestation
  JOURNAL   Am J Physiol 260 (5 Pt 1), E787-E793 (1991)
   PUBMED   1852114
REFERENCE   10 (bases 1 to 3148)
  AUTHORS   Fishman,G.I., Spray,D.C. and Leinwand,L.A.
  TITLE     Molecular characterization and functional expression of the human
            cardiac gap junction channel
  JOURNAL   J Cell Biol 111 (2), 589-598 (1990)
   PUBMED   1696265
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY324140.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_012567.3.
            
            On or before Jan 7, 2005 this sequence version replaced
            XM_346604.1, NM_012567.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY324140.1, EV775150.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3148
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..3148
                     /gene="Gja1"
                     /gene_synonym="Cx43; Cxnk1"
                     /note="gap junction protein, alpha 1"
                     /db_xref="GeneID:24392"
                     /db_xref="RGD:2690"
     exon            1..183
                     /gene="Gja1"
                     /gene_synonym="Cx43; Cxnk1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..3135
                     /gene="Gja1"
                     /gene_synonym="Cx43; Cxnk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1345
                     /gene="Gja1"
                     /gene_synonym="Cx43; Cxnk1"
                     /note="connexin 43; gap junction 43 kDa heart protein; gap
                     junction membrane channel protein alpha 1; connexin k1"
                     /codon_start=1
                     /product="gap junction alpha-1 protein"
                     /protein_id="NP_036699.1"
                     /db_xref="GeneID:24392"
                     /db_xref="RGD:2690"
                     /translation="MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESA
                     WGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRK
                     EEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISIL
                     FKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSL
                     VSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTA
                     PLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQP
                     FDFPDDNQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI"
ORIGIN      
        1 acgaggtatc agcacttttc tttcattggg ggaaaggcgt gaggaaagta ccaaacagca
       61 gcagactttt aaactttaaa cagacaggtc tgagagcctg aactctcatt tttcctttga
      121 cttcagcctc caaggagttc caccaacttt ggcgcgccgg cttcactttc attaagtgaa
      181 agagaggtgc ccagacatgg gtgactggag tgccttgggg aagcttctgg acaaggtcca
      241 agcctactcc accgctggag ggaaggtgtg gctgtcagtg ctcttcatat tcagaatcct
      301 gctcctgggg acagctgttg agtcagcttg gggtgatgaa cagtctgcct ttcgctgtaa
      361 cactcaacaa cctggctgcg aaaacgtctg ctatgacaag tccttcccca tctctcacgt
      421 gcgcttctgg gtccttcaga tcatattcgt gtctgtgccc accctcctgt acttggccca
      481 tgtgttctat gtgatgagga aggaagagaa gctaaacaag aaagaagagg agctcaaagt
      541 ggcccagact gacggggtca acgtggagat gcacctgaag cagattgaaa tcaagaagtt
      601 caagtacggg attgaagagc acggcaaggt gaaaatgagg ggcggcttgc tgagaaccta
      661 catcatcagc atcctcttca agtctgtctt cgaggtggcc ttcctgctca tccagtggta
      721 catctatggg ttcagcttga gcgcggtcta cacctgcaag agagatccct gcccccacca
      781 ggtagactgc ttcctctcac gtcccacgga gaaaaccatc ttcatcatct tcatgctggt
      841 ggtgtccttg gtgtctctcg ctttgaacat cattgagctc ttctacgtct tcttcaaagg
      901 cgttaaggat cgcgtgaagg gaagaagcga tccttaccac gccaccactg gcccactgag
      961 cccatcaaaa gactgcggat ctccaaaata cgcctacttc aatggctgct cctcaccaac
     1021 ggctccactc tcgcctatgt ctcctcctgg gtacaagctg gttactggtg acagaaacaa
     1081 ttcctcgtgc cgcaattaca acaagcaagc tagcgagcaa aactgggcga actacagcgc
     1141 agagcaaaat cgcatggggc aggccggaag caccatctcc aactcgcacg cccagccgtt
     1201 cgatttcccc gacgacaacc agaatgccaa aaaagttgct gctggacatg aactccagcc
     1261 attagccatc gtggaccaac gaccttccag cagagccagc agccgcgcca gcagcaggcc
     1321 tcggcctgat gacctggaga tttaaaccgg cttgagcatc gagctgtcga ttatggagga
     1381 gaaaaaaagg tgcttgcaga acatgcacct agggtgttca ttttcgttcc cgtggagttg
     1441 gtactcaaca acctcagcaa tgaggcatag aaaacaaaga cattacaata cctaggttcc
     1501 ttgggggtgc ttgggatagc tgggcggaac aggtggggat aagggaggta cacattgata
     1561 tttaatgtag aagattcaaa gaacttaaat tctagtaaga gtcgcattgg gtgaacatag
     1621 ataagggctt tctctctctg cccccatccc ccaactgaac cttaagaatg agtctgtgta
     1681 catgaattga gtgagtgata ttttttttta attttgtttt actgagattc tgcgatagct
     1741 ttgagcagaa atctgagtcc tccacatagc gtttccttta tgaaaagaca gattgtccta
     1801 catccccccc ccccaaaaaa aacattccag tgtttaaaaa cttgcatttt gcaggtaagc
     1861 ttccctggtc tacccctctg ggtgtgagtg gaccttgtgt tatttgctag acacgatttt
     1921 cattcttagt atcaatctga agttcagaca aggctcaaag aaaaacgacc gcccatgtag
     1981 ttgcatctca ctgggttctt tgctgaatct gtctcacctt tgtgccttcc aaacatcatc
     2041 ctcgactggt cctcgccctc accaaacggc ttctatcaac atttttaaaa cagtcataac
     2101 gtcattttta gtttagtttt ttttttttct tttgagttag catcagggag gtgagccatg
     2161 ctcaagattt aacaatcgct tctacgtgtg gatgtgcgca tgtgtaagtg tgtgttttgt
     2221 cattattggt acaagcagag gcagtctaga ctcacaaata cagatttgaa tctaatgcac
     2281 agtgttcaaa tttgaacctt cctagtggat ttttgtggtg tgggccaatg cggtgtttac
     2341 attatagaat tcctgccgtg caagtaaagc acagtttttc cctgaaaatt ttttttccag
     2401 gtattccatt atggatactg gttttgttaa ttataatttc tctctctctc tctctctctc
     2461 tctctctctc tctctctctc tctctctttt agaatgtagc agtaatcgcc attactgaaa
     2521 tgaatgattt tctttttttt tgaaatataa tcattgatgc ttgaatgata gagttttagt
     2581 actgtaaacg ggctttagtc attaatgtga gagacttaga tggggattgc ctagagtgga
     2641 ctatcaagtg agcctaaagg aactttgtag taactggtaa tctgattttt tttttgtcct
     2701 acttaactac acataactca gaacttgtat tctgagttta acagtctttt agattgacga
     2761 gcaacttgga tgtttgcact aagactttgt ttgaaacact aaggggcgag ggaggtttca
     2821 acagtgcaca tgtaactaat ttatttgaac tgtatgctaa agacaccagt ttcttcaaat
     2881 gacttttttt aaaaaaaaac aaaaacaaaa ctcatcacag atgattgaaa tgtcgagtta
     2941 tcatgtgttt ccctcttgcg cgtcagctac agaaaagagt ttttgtacaa tgagaaacta
     3001 atgtgtttga cattccacgt taaactgctg tcgtgttcgg cttcgtagca tgtaatgtag
     3061 acctagccca tccattcatg tgctcgggag agtgttcttt atccaataaa gttttaattt
     3121 agtatataat aaaaaaaaaa aaaaaaaa
//
