LOCUS       NM_001005553            3012 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GIT ArfGAP 2 (Git2), mRNA.
ACCESSION   NM_001005553 XM_222231
VERSION     NM_001005553.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3012)
  AUTHORS   Montesinos,M.S., Dong,W., Goff,K., Das,B., Guerrero-Given,D.,
            Schmalzigaug,R., Premont,R.T., Satterfield,R., Kamasawa,N. and
            Young,S.M. Jr.
  TITLE     Presynaptic Deletion of GIT Proteins Results in Increased Synaptic
            Strength at a Mammalian Central Synapse
  JOURNAL   Neuron 88 (5), 918-925 (2015)
   PUBMED   26637799
REFERENCE   2  (bases 1 to 3012)
  AUTHORS   White,J.K., Gerdin,A.K., Karp,N.A., Ryder,E., Buljan,M.,
            Bussell,J.N., Salisbury,J., Clare,S., Ingham,N.J., Podrini,C.,
            Houghton,R., Estabel,J., Bottomley,J.R., Melvin,D.G., Sunter,D.,
            Adams,N.C., Tannahill,D., Logan,D.W., Macarthur,D.G., Flint,J.,
            Mahajan,V.B., Tsang,S.H., Smyth,I., Watt,F.M., Skarnes,W.C.,
            Dougan,G., Adams,D.J., Ramirez-Solis,R., Bradley,A. and Steel,K.P.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     Genome-wide generation and systematic phenotyping of knockout mice
            reveals new roles for many genes
  JOURNAL   Cell 154 (2), 452-464 (2013)
   PUBMED   23870131
REFERENCE   3  (bases 1 to 3012)
  AUTHORS   Chadwick,W., Martin,B., Chapter,M.C., Park,S.S., Wang,L.,
            Daimon,C.M., Brenneman,R. and Maudsley,S.
  TITLE     GIT2 acts as a potential keystone protein in functional
            hypothalamic networks associated with age-related phenotypic
            changes in rats
  JOURNAL   PLoS One 7 (5), e36975 (2012)
   PUBMED   22606319
  REMARK    GeneRIF: potentially identified the G protein-coupled
            receptor/cytoskeletal-associated protein GIT2 as a vital integrator
            and modulator of the normal aging process
REFERENCE   4  (bases 1 to 3012)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 3012)
  AUTHORS   Gavina,M., Za,L., Molteni,R., Pardi,R. and de Curtis,I.
  TITLE     The GIT-PIX complexes regulate the chemotactic response of rat
            basophilic leukaemia cells
  JOURNAL   Biol Cell 102 (4), 231-244 (2010)
   PUBMED   19912111
  REMARK    GeneRIF: Rat basophilic leukaemia RBL-2H3 cells stably transfected
            with the chemoattractant receptor expressed both GIT1-p21-activated
            kinase and GIT2-p21-activated kinase endogenous complexes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3012)
  AUTHORS   Segura,I., Essmann,C.L., Weinges,S. and Acker-Palmer,A.
  TITLE     Grb4 and GIT1 transduce ephrinB reverse signals modulating spine
            morphogenesis and synapse formation
  JOURNAL   Nat Neurosci 10 (3), 301-310 (2007)
   PUBMED   17310244
REFERENCE   7  (bases 1 to 3012)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   8  (bases 1 to 3012)
  AUTHORS   Bagrodia,S., Bailey,D., Lenard,Z., Hart,M., Guan,J.L.,
            Premont,R.T., Taylor,S.J. and Cerione,R.A.
  TITLE     A tyrosine-phosphorylated protein that binds to an important
            regulatory region on the cool family of p21-activated
            kinase-binding proteins
  JOURNAL   J Biol Chem 274 (32), 22393-22400 (1999)
   PUBMED   10428811
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081967.1.
            
            On Oct 8, 2004 this sequence version replaced XM_222231.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3012
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /note="GIT ArfGAP 2"
                     /db_xref="GeneID:304546"
                     /db_xref="RGD:1359708"
     exon            1..142
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2370
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /note="G protein-coupled receptor kinase-interactor 2; G
                     protein-coupled receptor kinase interacting ArfGAP 2; ARF
                     GAP GIT2; GRK-interacting protein 2; cool-interacting
                     tyrosine-phosphorylated protein 2"
                     /codon_start=1
                     /product="ARF GTPase-activating protein GIT2"
                     /protein_id="NP_001005553.1"
                     /db_xref="GeneID:304546"
                     /db_xref="RGD:1359708"
                     /translation="MSKRLRSNDVCADCSGPDPSWASVNRGTLICDECCSVHRSLGRH
                     ISQVRHLKHTPWPPTLLQMVETLYSNGANSIWEHSLLDPASVMSGRRKANPQDKVHPN
                     KAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQAN
                     FFHPEKGSTPLHVASKAGQILQAELLAVYGADPGTHDSSGKTPVDYARQGGHRELAER
                     LVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNH
                     LFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKL
                     ARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSNQHSTESQDNDQPDY
                     DSVASDEDTDVETRASRTNRQKSLDSDLSDGPVTVQEFMEVKHALVASEAKRQQLMKV
                     NNNLSGELRIMQKKLQTLQSENSSLRRQATASACQVQTASDHKDTVSHSSLKRRPSAR
                     GSRPMSMYETGSGQKPYLPMGEANHPEESRTRLQPFPTHIGRSALVTSSSSLPSFPST
                     LSWSRDESTRRASRLEKQNSTPESDYDNTAYDPEPDDTVSGRKGRQRSMLWQGDGPLP
                     DTAEPHAVPSPALPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHAAVTE
                     MAALFPKKPKSDTVRTSLRLLTASAYRLQSECRKALPGDSSLPTDVQLVTQQVIQCAY
                     DIAKAAKQLVTITTKENSS"
     exon            143..276
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..389
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..495
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..582
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..713
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..808
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..854
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..906
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..979
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1077
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1189
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1332
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1482
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1731
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1821
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1904
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2093
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2157
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2985
                     /gene="Git2"
                     /gene_synonym="CAT-2; CAT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgccagc gccgcccggg gacccgttag agcggaagcg cagccgccgc ctctgccgtc
       61 gcggggttcc cggcaggtga ggtgggagcc atgtcgaagc gtctccggag caacgacgtg
      121 tgcgccgact gcagcgggcc tgatccttcc tgggcatcag tgaacagggg gactctcata
      181 tgtgatgagt gctgcagtgt tcatcggagc ctagggcgcc acatctccca agtcaggcat
      241 cttaaacaca caccatggcc tccaaccctg cttcagatgg ttgagacctt gtatagcaat
      301 ggtgctaatt ctatctggga gcattctttg ctggaccctg cttctgttat gagtgggaga
      361 cggaaagcca atccacagga taaagtccac cccaataaag cagaattcat cagagccaag
      421 tatcagatgt tagcatttgt acacagattg ccctgccgtg acgacgacag tgtgactgcc
      481 aaagatctta gtaagcaact ccattcaagt gtgagaacag ggaatcttga gacctgtctg
      541 agactgttgt cgttaggagc ccaagccaac ttcttccatc ctgaaaaagg aagcactcca
      601 ctccacgtcg cctccaaagc aggacagatc ctacaggctg aattgctggc agtgtacgga
      661 gctgacccag gcacacacga ttctagtggg aagactcctg ttgactatgc aaggcaagga
      721 ggacaccgtg agctggccga acgcctcgta gaaatacagt acgagctgac ggacaggctg
      781 gccttctacc tctgcggccg gaaaccagat cataaaaacg gacagcactt tataatccct
      841 cagatggcag acagcagcct ggatttgtct gagttggcaa aagctgccaa gaagaaactt
      901 cagtctctaa gtaatcattt gtttgaagaa cttgccatgg atgtgtacga tgaagttgac
      961 agacgagaga ctgatgcagt ctggcttgcc acgcaaaacc acagcacctt ggtaactgag
     1021 acaaccgtcg ttccctttct tccggtcaac cctgagtact cctcgacacg aaaccagggc
     1081 agacagaaat tagctcggtt taatgcccat gaatttgcta cactggtcat cgacatcctc
     1141 agtgacgcca agaggagaca gcaaggcagt cctctctcca ggtcaaaaga caatgtggaa
     1201 ctcatattga gaacagtcag taaccagcac agcactgaga gccaggacaa tgaccagcca
     1261 gactatgaca gcgtggcctc agatgaagac acagacgtgg agaccagagc aagcaggaca
     1321 aaccggcaga agagcctaga ttcagatttg tcagatggac cagtcactgt gcaggagttt
     1381 atggaggtca aacacgccct agtggcttct gaggccaaga gacagcagct aatgaaggtg
     1441 aataacaacc tgagtggcga gctgagaatt atgcagaaaa agcttcaaac tctacagagt
     1501 gagaactcaa gcctcaggag acaggccaca gccagtgcct gtcaggtcca gactgcctct
     1561 gaccacaaag acactgtgag ccactcctcc ctgaagcgcc ggccatcagc ccggggcagt
     1621 agacccatgt ccatgtatga gactggatca ggccagaaac catacctccc aatgggagaa
     1681 gccaaccacc ctgaagaaag ccggacaaga cttcagccct tccccactca tattgggagg
     1741 agtgcacttg tgacctcctc ttcgtctctg ccttccttcc cctccacact ttcctggtcc
     1801 agggacgaaa gcacccgaag ggcctccagg ttggagaagc agaacagcac cccagagagc
     1861 gattatgaca acactgccta tgaccctgaa ccagatgaca cggtgtcagg ccggaagggg
     1921 cggcagcgga gtatgctctg gcaaggtgat ggcccactgc cagacacagc agagccccac
     1981 gcggtcccca gccccgccct ccccagcaca gaagatgtca tccgcaagac tgaacagatc
     2041 accaaaaaca tccaggagct cctcagagca gcccaggaga acaagcatga cagctacatt
     2101 ccctgctcag agaggataca cgccgctgtg accgagatgg cagccctgtt ccccaaaaaa
     2161 cctaagtctg acacggtgag gacttccctc cgcctactaa cggccagtgc ctaccggctc
     2221 cagtcagagt gcagaaaggc tctcccagga gactcgagct tgcccacgga tgtgcagctg
     2281 gtcacacagc aggtcatcca gtgtgcctat gacattgcca aggccgccaa acagctggtc
     2341 acaatcacca ccaaagagaa cagcagctga gctgcgggtg ccgccctcct gttgtctgga
     2401 aagtccggct gcaatgtaga catgaacttt gcagagtttt acaaaaatgt ttaatgatga
     2461 cttaaaactt tttaagagaa aactcagtat tatttttgca tgttttctaa cagatttttg
     2521 actgtaattt aacccctgcc ttatttgtgc ctgtttgcag cttagttctg tcctgttgga
     2581 ttgtcaccaa gtgcttactt aggtcatgac cccatgtgtt taaaagtaat tgttcagagt
     2641 ttgttacaac tttcccatcc tttaaaatct ctaccaatgc ctaaaactat aattgatatt
     2701 tttagtaaaa cattttcgta agagataaga aaattggatt ttaaaacagc agtagcagca
     2761 gctcttcctt ccaagcattg gcagtgagag agctttccgt cctgggggcc tcagctcggg
     2821 tgtcttcagg tgtgtatgga gagcagggcc tcgccgctcc ccagggacag cgcatctctt
     2881 aggagtgacc aggaactgat ccttttctaa cttttgtatc atgttaagtg ttgtcttatt
     2941 taatattttt atcttgattt tctatctata aagattttac catcaaaaaa aaaaaaaaaa
     3001 aaaaaaaaaa aa
//
