LOCUS       NM_031814               3565 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Rattus norvegicus GIT ArfGAP 1 (Git1), mRNA.
ACCESSION   NM_031814
VERSION     NM_031814.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3565)
  AUTHORS   Liu,S., Premont,R.T., Park,K.H. and Rockey,D.C.
  TITLE     beta-PIX cooperates with GIT1 to regulate endothelial nitric oxide
            synthase in sinusoidal endothelial cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 323 (5), G511-G522 (2022)
   PUBMED   36044673
  REMARK    GeneRIF: beta-PIX cooperates with GIT1 to regulate endothelial
            nitric oxide synthase in sinusoidal endothelial cells.
REFERENCE   2  (bases 1 to 3565)
  AUTHORS   Song,W., Zhang,T., Yang,N., Zhang,T., Wen,R. and Liu,C.
  TITLE     Inhibition of micro RNA miR-122-5p prevents
            lipopolysaccharide-induced myocardial injury by inhibiting
            oxidative stress, inflammation and apoptosis via targeting GIT1
  JOURNAL   Bioengineered 12 (1), 1902-1915 (2021)
   PUBMED   34002676
  REMARK    GeneRIF: Inhibition of micro RNA miR-122-5p prevents
            lipopolysaccharide-induced myocardial injury by inhibiting
            oxidative stress, inflammation and apoptosis via targeting GIT1.
REFERENCE   3  (bases 1 to 3565)
  AUTHORS   Shin,E.Y., Lee,C.S., Kim,H.B., Park,J.H., Oh,K., Lee,G.W.,
            Cho,E.Y., Kim,H.K. and Kim,E.G.
  TITLE     Kinesin-1-dependent transport of the betaPIX/GIT complex in
            neuronal cells
  JOURNAL   BMB Rep 54 (7), 380-385 (2021)
   PUBMED   34154701
  REMARK    GeneRIF: Kinesin-1-dependent transport of the betaPIX/GIT complex
            in neuronal cells.
REFERENCE   4  (bases 1 to 3565)
  AUTHORS   Luo,Y., Xu,T., Liu,W., Rong,Y., Wang,J., Fan,J., Yin,G. and Cai,W.
  TITLE     Exosomes derived from GIT1-overexpressing bone marrow mesenchymal
            stem cells promote traumatic spinal cord injury recovery in a rat
            model
  JOURNAL   Int J Neurosci 131 (2), 170-182 (2021)
   PUBMED   32223487
  REMARK    GeneRIF: Exosomes derived from GIT1-overexpressing bone marrow
            mesenchymal stem cells promote traumatic spinal cord injury
            recovery in a rat model.
REFERENCE   5  (bases 1 to 3565)
  AUTHORS   Rathor,N., Chung,H.K., Wang,S.R., Qian,M., Turner,D.J., Wang,J.Y.
            and Rao,J.N.
  TITLE     beta-PIX plays an important role in regulation of intestinal
            epithelial restitution by interacting with GIT1 and Rac1 after
            wounding
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 314 (3), G399-G407 (2018)
   PUBMED   29191942
  REMARK    GeneRIF: Induced association of beta-PIX with GIT1 is essential for
            the stimulation of intestinal epithelial restitution by activating
            Rac1, and this signaling pathway is tightly regulated by cellular
            polyamines.
REFERENCE   6  (bases 1 to 3565)
  AUTHORS   Ko,J., Kim,S., Valtschanoff,J.G., Shin,H., Lee,J.R., Sheng,M.,
            Premont,R.T., Weinberg,R.J. and Kim,E.
  TITLE     Interaction between liprin-alpha and GIT1 is required for AMPA
            receptor targeting
  JOURNAL   J Neurosci 23 (5), 1667-1677 (2003)
   PUBMED   12629171
REFERENCE   7  (bases 1 to 3565)
  AUTHORS   Kim,S., Ko,J., Shin,H., Lee,J.R., Lim,C., Han,J.H., Altrock,W.D.,
            Garner,C.C., Gundelfinger,E.D., Premont,R.T., Kaang,B.K. and Kim,E.
  TITLE     The GIT family of proteins forms multimers and associates with the
            presynaptic cytomatrix protein Piccolo
  JOURNAL   J Biol Chem 278 (8), 6291-6300 (2003)
   PUBMED   12473661
REFERENCE   8  (bases 1 to 3565)
  AUTHORS   Nishiya,N., Shirai,T., Suzuki,W. and Nose,K.
  TITLE     Hic-5 interacts with GIT1 with a different binding mode from
            paxillin
  JOURNAL   J Biochem 132 (2), 279-289 (2002)
   PUBMED   12153727
REFERENCE   9  (bases 1 to 3565)
  AUTHORS   Zhao,Z.S., Manser,E., Loo,T.H. and Lim,L.
  TITLE     Coupling of PAK-interacting exchange factor PIX to GIT1 promotes
            focal complex disassembly
  JOURNAL   Mol Cell Biol 20 (17), 6354-6363 (2000)
   PUBMED   10938112
REFERENCE   10 (bases 1 to 3565)
  AUTHORS   Premont,R.T., Claing,A., Vitale,N., Freeman,J.L., Pitcher,J.A.,
            Patton,W.A., Moss,J., Vaughan,M. and Lefkowitz,R.J.
  TITLE     beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled
            receptor kinase-associated ADP ribosylation factor
            GTPase-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14082-14087 (1998)
   PUBMED   9826657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jun 3, 2021 this sequence version replaced NM_031814.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF085693.1, SRR26643293.64358.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000010.1  62840394-62840497
            105-238             JAXUCZ010000010.1  62845713-62845846
            239-351             JAXUCZ010000010.1  62846284-62846396
            352-457             JAXUCZ010000010.1  62846507-62846612
            458-675             JAXUCZ010000010.1  62847082-62847299
            676-770             JAXUCZ010000010.1  62847381-62847475
            771-813             JAXUCZ010000010.1  62847810-62847852
            814-840             JAXUCZ010000010.1  62849431-62849457
            841-889             JAXUCZ010000010.1  62849627-62849675
            890-962             JAXUCZ010000010.1  62849962-62850034
            963-1060            JAXUCZ010000010.1  62850527-62850624
            1061-1172           JAXUCZ010000010.1  62850966-62851077
            1173-1306           JAXUCZ010000010.1  62851191-62851324
            1307-1459           JAXUCZ010000010.1  62851471-62851623
            1460-1690           JAXUCZ010000010.1  62851741-62851971
            1691-1744           JAXUCZ010000010.1  62852045-62852098
            1745-1831           JAXUCZ010000010.1  62852225-62852311
            1832-1905           JAXUCZ010000010.1  62852400-62852473
            1906-2088           JAXUCZ010000010.1  62852599-62852781
            2089-2152           JAXUCZ010000010.1  62852902-62852965
            2153-3565           JAXUCZ010000010.1  62853096-62854508
FEATURES             Location/Qualifiers
     source          1..3565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3565
                     /gene="Git1"
                     /note="GIT ArfGAP 1"
                     /db_xref="GeneID:83709"
                     /db_xref="RGD:69331"
     exon            1..104
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..2365
                     /gene="Git1"
                     /EC_number="3.6.5.2"
                     /function="GTPase-activating protein for ARF family small
                     GTP-binding proteins"
                     /note="CAT1; CAT-1; ARF GAP GIT1; GRK-interacting protein
                     1; cool-associated and tyrosine-phosphorylated protein 1;
                     GRK-interactor 1; G protein-coupled receptor kinase
                     interacting ArfGAP 1; G protein-coupled receptor
                     kinase-associated ADP ribosylation factor
                     GTPase-activating protein (GIT1); G protein-coupled
                     receptor kinase-interactor 1"
                     /codon_start=1
                     /product="ARF GTPase-activating protein GIT1"
                     /protein_id="NP_114002.1"
                     /db_xref="GeneID:83709"
                     /db_xref="RGD:69331"
                     /translation="MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRH
                     ISIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPI
                     KSEFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQAN
                     FFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAER
                     LVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKK
                     LQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATR
                     NQGRQKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSARNQSDLDDQHDY
                     DSVASDEDTDQEPLPSAGATRNNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQ
                     QLMKVNSSLSDELRKLQREIHKLQAENLQLRQPPGPVPVPSLPSERAEHTLMGPGGST
                     HRRDRQAFSMYEPGSALKPFGGAPGDELATRLQPFHSTELEDDAIYSVHVPAGLYRIR
                     KGVSASSVTFTPSSPLLSSSQEGSRHASKLSRHGSGAESDYENTQSGEPLLGLEGKRF
                     LELSKEDELHAELESLDGDPDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVP
                     CSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQ
                     LLTQQVIQCAYDIAKAAKQLVTITTREKKQ"
     exon            105..238
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..351
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..457
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..675
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..770
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..813
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..840
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..889
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..962
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1060
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1172
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1306
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1459
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1690
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1744
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1831
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1905
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2088
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2152
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..3565
                     /gene="Git1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgcgccc cccacgctgg cccagagggc tgcggccgct tcgccgctga ggatgtcccg
       61 gaaggggccg cgagcggagg tgtgtgcgga ctgcagcgcc cctgaccctg gctgggcatc
      121 tatcagcaga ggtgtgctgg tttgtgacga gtgctgcagt gtgcaccgga gcctgggacg
      181 acacatctcc attgtcaaac accttcgcca cagcgcctgg cctcctacgc tgctacagat
      241 ggtgcacacg cttgccagca acggggccaa ctctatctgg gagcattccc tgctggaccc
      301 tgcacaagtg caaagtggcc ggcgcaaagc caacccccaa gacaaagtcc accccatcaa
      361 gtcagagttc atcagggcaa agtaccagat gctggcgttt gtgcacaagc ttccctgccg
      421 tgatgatgat ggggtcaccg ccaaagacct cagcaagcaa ctgcactcga gtgtgcgaac
      481 aggcaacctg gagacctgtc tgcgcctgct ttccctgggt gcccaggcca acttcttcca
      541 cccagaaaag ggcactacac ctctacacgt ggctgccaag gcagggcaga cactgcaggc
      601 tgagctgcta gtagtgtatg gggctgaccc aggctcccct gatgtcaatg gccgcacacc
      661 cattgactat gccaggcagg cggggcacca tgaactggca gaaaggctag ttgagtgcca
      721 gtatgagctc actgaccggt tggccttcta cctctgtgga cggaagcctg atcacaagaa
      781 tgggcattac atcatcccac agatggctga cagatctcgg caaaagtgca tgtctcagag
      841 tttggatctg tctgaattgg ccaaagctgc caagaagaag ctacaagcac tcagcaaccg
      901 gctctttgag gagctcgcca tggatgtgta tgacgaagtg gaccggagag aaaatgatgc
      961 agtgtggcta gctacccaga atcatagcac cctggtgaca gaacgcagtg ctgtgccctt
     1021 cctgccagtc aaccctgaat actcagccac tcggaatcag ggacgacaga aattggctcg
     1081 ttttaatgcc cgagagtttg ccaccttgat catcgacatc ctcagtgagg ccaaacggag
     1141 gcagcagggc aagagtctga gcagccccac agacaacctc gagctgtctg cacggaacca
     1201 aagtgacctg gacgaccagc acgactacga tagtgtggct tctgacgaag acacagacca
     1261 ggagcccttg cccagtgctg gcgccacgcg gaacaatcgt gccaggagca tggactcctc
     1321 agatctgtcg gatggggctg tgacgctgca ggagtacctg gagctgaaga aggctctggc
     1381 tacctccgag gccaaagtgc agcagctcat gaaagtcaac agcagtctga gtgacgagct
     1441 tcggaagctg cagagggaga tccacaaact gcaggcagag aacctgcagc tccggcagcc
     1501 accaggacca gtgcctgtac cctcacttcc cagtgaacgg gcagaacaca cactcatggg
     1561 ccctggtgga agtacccatc gcagggaccg ccaggccttc tctatgtatg agccaggctc
     1621 cgccctgaag ccctttggag gtgcacctgg ggatgagctc gccacacggc tccagccttt
     1681 ccacagcaca gagctggaag atgatgccat ctattcagta catgtccctg ctggccttta
     1741 ccggatccgg aagggggtgt ctgcctcttc tgtgaccttc actccctcct ccccactgct
     1801 gtcaagctcc caagaaggaa gtcgccatgc gagcaagctt tcacgccacg gcagtggcgc
     1861 agagagtgac tatgagaaca cacagagtgg agagcctctg ctgggacttg aagggaagcg
     1921 attcctagag ctgagcaagg aggatgagct gcacgctgag ctggagagct tagatggaga
     1981 cccagacccc gggctcccca gcacagaaga tgtcatccta aagacagagc aggtcaccaa
     2041 gaacattcag gagctattgc gggcagccca ggagttcaaa catgacagct ttgtgccctg
     2101 ttcagaaaag atccatttgg ctgtgactga gatggcctct ctcttcccaa agaggccagc
     2161 cctggagcct gtgcgcagtt cactgcggct gctcaacgcc agcgcctacc ggctgcagag
     2221 tgaatgccgg aagacagtgc ctccagaacc tggcgcccct gtggacttcc agctactgac
     2281 tcagcaggtg atccagtgcg cctatgacat cgccaaggct gccaagcagc tggtcaccat
     2341 caccacccga gagaagaaac agtgaccact ttccctgccc ttacccacac cctgggacct
     2401 cactggccat gggagctggg ccactccaga cactaaccca cccccaacag agccactggc
     2461 acaagtgccc ttagtgccac cattctcctc tggcatccag gtgccctggt gtccacaccc
     2521 ccttaagccc caaggatggg aatgtgaggt gacaggacca tctgtccccc acattccacg
     2581 cccctccctc tgtacatagc atccctgccc tgctgatacg caggagcctc aaggagtccc
     2641 tcccagctct tcacctgcct tccagggccc cctcagcaaa gggtgggaca gggacactcc
     2701 aagtggggca gccccgccta ctgcacccta tccccatgag ccagttcagc cctggggggt
     2761 cgagcagagg caccccctcc tttgtgcatt atctctgggt gtctctgccc cgtagccagc
     2821 agcccccccg ctgctctttc atgacaaatg gcccctgcca gagcacaggc cccaacttgt
     2881 gtgccagggt ccccagcagc aaacactgga acgtctttct ctcccctacc ccttaatttt
     2941 aactttgtgg taactgagtg tccctgcgtt cttacaactg agtgtgtgag cggcagtgcc
     3001 gtgccagaga cctggtccac ctggagctct gaggggcagg ggaaccagag tagtgggacc
     3061 agcattggaa gtcagcttcc ctctacccaa cctgggacgg ggactgtcag ggtcaccagc
     3121 tgtggtccag ttgctacccc tacttgtatc cctatcctat aaacttaaaa ggaaaaccac
     3181 ttccctccat ctctccccat cccctgtggg aagtgtgctg accaggcaga ggacagagca
     3241 cctgcgcctg gggctggctc cccgggtccc caactcagct ggtggctgtg gaactgagcc
     3301 cctctcccta gcctctgcaa ggccagcacc cacatcacta cctgtaccta cagtgaccca
     3361 cccagaaggc ctggggatct ggctgcagct gaaaaagctg gcaaggcact gacagcaccc
     3421 accagctatt cccccaacca ccttcctagc ctgtggtggt gggtagctgt cagaaggtgt
     3481 gtcatgtaca tttgtatcaa aaataaataa gtgaccatgt gccacttctg atgtctagag
     3541 gtcagaggtg gggctcagcc cggta
//
