LOCUS       NM_012714               2701 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus gastric inhibitory polypeptide receptor (Gipr),
            mRNA.
ACCESSION   NM_012714
VERSION     NM_012714.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2701)
  AUTHORS   Homolak,J., Babic Perhoc,A., Knezovic,A., Osmanovic Barilar,J.,
            Koc,F., Stanton,C., Ross,R.P. and Salkovic-Petrisic,M.
  TITLE     Disbalance of the Duodenal Epithelial Cell Turnover and Apoptosis
            Accompanies Insensitivity of Intestinal Redox Homeostasis to
            Inhibition of the Brain Glucose-Dependent Insulinotropic
            Polypeptide Receptors in a Rat Model of Sporadic Alzheimer's
            Disease
  JOURNAL   Neuroendocrinology 112 (8), 744-762 (2022)
   PUBMED   34607331
  REMARK    GeneRIF: Disbalance of the Duodenal Epithelial Cell Turnover and
            Apoptosis Accompanies Insensitivity of Intestinal Redox Homeostasis
            to Inhibition of the Brain Glucose-Dependent Insulinotropic
            Polypeptide Receptors in a Rat Model of Sporadic Alzheimer's
            Disease.
            Erratum:[Neuroendocrinology. 2023;113(5):577-578. doi:
            10.1159/000528617.. PMID: 37497980]
REFERENCE   2  (bases 1 to 2701)
  AUTHORS   Teng,L., Guan,T., Guo,B., Ma,C., Lin,G., Wu,R., Xu,M., Liu,M. and
            Liu,Y.
  TITLE     GIP-GIPR promotes neurite outgrowth of cortical neurons in Akt
            dependent manner
  JOURNAL   Biochem Biophys Res Commun 534, 121-127 (2021)
   PUBMED   33321289
  REMARK    GeneRIF: GIP-GIPR promotes neurite outgrowth of cortical neurons in
            Akt dependent manner.
REFERENCE   3  (bases 1 to 2701)
  AUTHORS   Berglund,L.M., Lyssenko,V., Ladenvall,C., Kotova,O., Edsfeldt,A.,
            Pilgaard,K., Alkayyali,S., Brons,C., Forsblom,C., Jonsson,A.,
            Zetterqvist,A.V., Nitulescu,M., McDavitt,C.R., Duner,P.,
            Stancakova,A., Kuusisto,J., Ahlqvist,E., Lajer,M., Tarnow,L.,
            Madsbad,S., Rossing,P., Kieffer,T.J., Melander,O.,
            Orho-Melander,M., Nilsson,P., Groop,P.H., Vaag,A., Lindblad,B.,
            Gottsater,A., Laakso,M., Goncalves,I., Groop,L. and Gomez,M.F.
  TITLE     Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin
            Expression in the Vasculature via Endothelin-1 and CREB
  JOURNAL   Diabetes 65 (1), 239-254 (2016)
   PUBMED   26395740
  REMARK    GeneRIF: Gipr is expressed in healthy arteries, predominantly in
            endothelial cells.
REFERENCE   4  (bases 1 to 2701)
  AUTHORS   Privatananupunt,J., Watari,I., Podyma-Inoue,K.A., Kubono,M. and
            Ono,T.
  TITLE     Expression of glucose-dependent insulinotropic polypeptide and its
            receptor in the rat major salivary glands
  JOURNAL   Acta Histochem 116 (4), 545-550 (2014)
   PUBMED   24360021
  REMARK    GeneRIF: glucose-dependent insulinotropic polypeptide and
            Glucose-dependent insulinotropic polypeptide receptors expression
            in the rat major salivary glands, as well as its variation in the
            rat SMG during the growth period
REFERENCE   5  (bases 1 to 2701)
  AUTHORS   Ravn,P., Madhurantakam,C., Kunze,S., Matthews,E., Priest,C.,
            O'Brien,S., Collinson,A., Papworth,M., Fritsch-Fredin,M.,
            Jermutus,L., Benthem,L., Gruetter,M. and Jackson,R.H.
  TITLE     Structural and pharmacological characterization of novel potent and
            selective monoclonal antibody antagonists of glucose-dependent
            insulinotropic polypeptide receptor
  JOURNAL   J Biol Chem 288 (27), 19760-19772 (2013)
   PUBMED   23689510
  REMARK    GeneRIF: Structural and pharmacological characterization of novel
            potent and selective monoclonal antibody antagonists of
            glucose-dependent insulinotropic polypeptide receptor.
REFERENCE   6  (bases 1 to 2701)
  AUTHORS   Tseng,C.C. and Zhang,X.Y.
  TITLE     The cysteine of the cytoplasmic tail of glucose-dependent
            insulinotropic peptide receptor mediates its chronic
            desensitization and down-regulation
  JOURNAL   Mol Cell Endocrinol 139 (1-2), 179-186 (1998)
   PUBMED   9705086
REFERENCE   7  (bases 1 to 2701)
  AUTHORS   Tseng,C.C., Kieffer,T.J., Jarboe,L.A., Usdin,T.B. and Wolfe,M.M.
  TITLE     Postprandial stimulation of insulin release by glucose-dependent
            insulinotropic polypeptide (GIP). Effect of a specific
            glucose-dependent insulinotropic polypeptide receptor antagonist in
            the rat
  JOURNAL   J Clin Invest 98 (11), 2440-2445 (1996)
   PUBMED   8958204
REFERENCE   8  (bases 1 to 2701)
  AUTHORS   Tseng,C.C., Boylan,M.O., Jarboe,L.A., Usdin,T.B. and Wolfe,M.M.
  TITLE     Chronic desensitization of the glucose-dependent insulinotropic
            polypeptide receptor in diabetic rats
  JOURNAL   Am J Physiol 270 (4 Pt 1), E661-E666 (1996)
   PUBMED   8928774
REFERENCE   9  (bases 1 to 2701)
  AUTHORS   Usdin,T.B., Mezey,E., Button,D.C., Brownstein,M.J. and Bonner,T.I.
  TITLE     Gastric inhibitory polypeptide receptor, a member of the
            secretin-vasoactive intestinal peptide receptor family, is widely
            distributed in peripheral organs and the brain
  JOURNAL   Endocrinology 133 (6), 2861-2870 (1993)
   PUBMED   8243312
REFERENCE   10 (bases 1 to 2701)
  AUTHORS   Kato,S., Hirano,A., Llena,J.F., Ito,H. and Yen,S.H.
  TITLE     Ultrastructural identification of neurofibrillary tangles in the
            spinal cords in Guamanian amyotrophic lateral sclerosis and
            parkinsonism-dementia complex on Guam
  JOURNAL   Acta Neuropathol 83 (3), 277-282 (1992)
   PUBMED   1557958
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012714.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L19660.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000001.1  87942427-87942492   c
            67-229              JAXUCZ010000001.1  87941353-87941515   c
            230-329             JAXUCZ010000001.1  87940916-87941015   c
            330-437             JAXUCZ010000001.1  87940305-87940412   c
            438-541             JAXUCZ010000001.1  87939812-87939915   c
            542-645             JAXUCZ010000001.1  87939127-87939230   c
            646-790             JAXUCZ010000001.1  87938813-87938957   c
            791-950             JAXUCZ010000001.1  87936717-87936876   c
            951-1011            JAXUCZ010000001.1  87936445-87936505   c
            1012-1081           JAXUCZ010000001.1  87936076-87936145   c
            1082-1170           JAXUCZ010000001.1  87935859-87935947   c
            1171-1309           JAXUCZ010000001.1  87935635-87935773   c
            1310-1351           JAXUCZ010000001.1  87933884-87933925   c
            1352-1534           JAXUCZ010000001.1  87933624-87933806   c
            1535-2701           JAXUCZ010000001.1  87932318-87933484   c
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2701
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /note="gastric inhibitory polypeptide receptor"
                     /db_xref="GeneID:25024"
                     /db_xref="RGD:2689"
     exon            1..66
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            67..229
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1534
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /note="GIP-R; glucose-dependent insulinotropic polypeptide
                     receptor; gastric inhibitory peptide receptor"
                     /codon_start=1
                     /product="gastric inhibitory polypeptide receptor
                     precursor"
                     /protein_id="NP_036846.1"
                     /db_xref="GeneID:25024"
                     /db_xref="RGD:2689"
                     /translation="MPLRLLLLLLWLWGLSLQRAETDSEGQTTGELYQRWERYGWECQ
                     NTLEATEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWYRQVAAGFVFRQCGS
                     DGQWGSWRDHTQCENPEKNGAFQDQKLILERLQVVYTVGYSLSLATLLLALLILSLFR
                     RLHCTRNYIHMNLFTSFMLRAGAILTRDQLLPPLGPYTGNQTPTLWNQALAACRTAQI
                     LTQYCVGANYTWLLVEGVYLHHLLVVVRRSEKGHFRCYLLLGWGAPALFVIPWVIVRY
                     LYENTQCWERNEVKAIWWIIRTPILITILINFLIFIRILGILVSKLRTRQMRCPDYRL
                     RLARSTLTLMPLLGVHEVVFAPVTEEQAEGSLRFAKLAFEIFLSSFQGFLVSVLYCFI
                     NKEVQSEIRRLRLSLQEQCPRPHLGQAPRAVPLSSAPQEAAIRNALPSGMLHVPGDEV
                     LESYC"
     exon            230..329
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            330..437
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            438..541
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            542..645
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            646..790
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            791..950
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1011
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1081
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1170
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1309
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1351
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1534
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..2701
                     /gene="Gipr"
                     /gene_synonym="Gippr; RATGIPPR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctctct ggcaggcgag gcagggcagc tgtttcagtg gagattgcga gcaggactcg
       61 gtacaggtga gcactgactt gggctgaagc tcaagagttg gttctgcccg gggaccctcc
      121 agcccaactg cctcgagtgg ccagagtctc caatcacctt tcaaggatgc ccctgcggct
      181 gttgcttctg ctgctgtggc tctggggatt gtcactccag agggcggaga cagattctga
      241 ggggcagacg acgggagagc tgtaccagcg ctgggagcgt tacggctggg aatgccaaaa
      301 caccttggag gccacagaac ctccctcagg cctggcctgt aatggttcct tcgatatgta
      361 tgcctgctgg aactacacgg ctgccaacac cactgcccgg gtgtcctgcc cctggtatct
      421 gccctggtac cgccaggtgg ctgcaggctt cgtcttccgc cagtgtggta gtgatggcca
      481 atggggatct tggagagacc acactcaatg tgagaatcca gagaagaatg gggcctttca
      541 ggaccagaag ctgatcttgg agcgcctgca ggtcgtgtat acagtcggct actccctgtc
      601 cctggccact ctgctgctag ccctactcat tttaagtttg ttcaggcggc ttcactgcac
      661 tcgtaattac attcacatga acctgttcac gtctttcatg ctgcgagcag gggccatcct
      721 cacccgagac cagctgctgc ctccactggg tccctacacg ggaaaccaga cccctaccct
      781 gtggaaccag gccctagctg cctgccgcac agcccagatc ttgacccagt actgtgtggg
      841 agccaattac acctggctgc tggtggaggg tgtgtatctg caccatctgc tggtggttgt
      901 gagacgctca gaaaagggcc acttccgctg ctacctgctt cttggctggg gggcccccgc
      961 gcttttcgtc atcccctggg tgatcgtcag gtacctgtac gagaacacgc agtgctggga
     1021 gcgcaacgaa gtcaaagcca tttggtggat cattcgcacc cccatcctaa taaccatctt
     1081 gatcaatttc ctcatcttta tccgcatcct tggcatcctt gtttcaaagc tgaggactcg
     1141 acagatgcgc tgtcccgact accgactaag gctggctcgc tccacgctga cactgatgcc
     1201 cctgctgggt gtccacgagg tggtatttgc tcccgtgacc gaggaacagg ctgaaggctc
     1261 cctgcgcttt gccaaactgg cctttgaaat cttcttaagt tccttccagg gtttcctcgt
     1321 gagtgtgctc tactgcttca tcaacaaaga ggtacagtcg gagatccgcc gtctgcgtct
     1381 cagccttcag gaacagtgtc cacgtccgca cctggggcag gccccccggg cggtgccttt
     1441 gagctctgca ccccaggaag ctgccatccg caatgccttg ccctctggga tgctgcatgt
     1501 gcctggagat gaggtcttgg aaagttactg ctaggacaac cgactgggag gccacttgcg
     1561 aagacatgat gggacatgtt tgggagagtg gagacagctt gaagagttgg aggataagat
     1621 tccaggcaga cggaacagca caggaaaagg tcctgggaac aggaagaatg gagaaagact
     1681 tccatggtcc cactggaaaa agccagggcc tgcagatggg gaaggagtgg gcagggggtg
     1741 cagaaactgg aatttcaccg caggctcact gaagatttta tttttacttt tacgtgtaca
     1801 attgctttgc ctgtgtgtac ggatggatac cacatgcata cagtgtttgc atatgccaga
     1861 ggacagaaga tctctgggac cgaatgcttg tcagccttta tgtagatgaa gtgaacacaa
     1921 ctccatctct ccagtcccac acagatttta gcagcagtgt ctcctgggct gtttccatgg
     1981 ctctctgttc tagggactag gggcagtgag ttgggagccc agtgagagga atgcaggtgg
     2041 ctggaccaga atggaggcca cagagaggtg ggaaggattt gctgaggggt cccaggagag
     2101 ggatcaaagg agacagtcaa gacaaaagga gagcaatcaa aagtcaaaag gctctgtggt
     2161 gtgggaggct ctgcctgtgc caggctgtga gagatgagca gcaggacctg gagctgtagg
     2221 tggtgagagc tggcagccaa gcaagaggat cctgtggtca gtggaggtag ccagatcttc
     2281 ccacctccca gagagggttg gggatgaagc ctcattgtga ctggtccacc tgtggatgga
     2341 tggacacaca gacacacaca cacacacaca cagaggcctc ctttatcagt actgggtgct
     2401 gtgtttcccc agggttccca gaaagatgtg tctcctagct gaccccgcac tcaacacttc
     2461 agggctttgc cttctggagt ggagactcta gtaaattaag cttctttatg gggtgggagg
     2521 ctaggctaga aagggagatg actagggtgt gtgtgaggta gtctgccata gatcaatgag
     2581 gctcatttgg agccatatgt tggcacaaaa aaccatggac accacattgc tactgtaccc
     2641 tcccctaaga taacctttat tgagaactaa gacatatgta caaattaaag ttgtgtgtgt
     2701 g
//
