LOCUS       NM_053341               1563 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GIPC PDZ domain containing family, member 1
            (Gipc1), mRNA.
ACCESSION   NM_053341
VERSION     NM_053341.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1563)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   2  (bases 1 to 1563)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1563)
  AUTHORS   Zhang,X., Bedigian,A.V., Wang,W. and Eggert,U.S.
  TITLE     G protein-coupled receptors participate in cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 69 (10), 810-818 (2012)
   PUBMED   22888021
REFERENCE   4  (bases 1 to 1563)
  AUTHORS   Kedlaya,R., Kandala,G., Liu,T.F., Maddodi,N., Devi,S. and
            Setaluri,V.
  TITLE     Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal
            protein trafficking and melanogenesis in human melanocytes
  JOURNAL   Arch Biochem Biophys 508 (2), 227-233 (2011)
   PUBMED   21291857
REFERENCE   5  (bases 1 to 1563)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1563)
  AUTHORS   Blobe,G.C., Liu,X., Fang,S.J., How,T. and Lodish,H.F.
  TITLE     A novel mechanism for regulating transforming growth factor beta
            (TGF-beta) signaling. Functional modulation of type III TGF-beta
            receptor expression through interaction with the PDZ domain
            protein, GIPC
  JOURNAL   J Biol Chem 276 (43), 39608-39617 (2001)
   PUBMED   11546783
REFERENCE   7  (bases 1 to 1563)
  AUTHORS   Lou,X., Yano,H., Lee,F., Chao,M.V. and Farquhar,M.G.
  TITLE     GIPC and GAIP form a complex with TrkA: a putative link between G
            protein and receptor tyrosine kinase pathways
  JOURNAL   Mol Biol Cell 12 (3), 615-627 (2001)
   PUBMED   11251075
REFERENCE   8  (bases 1 to 1563)
  AUTHORS   Cai,H. and Reed,R.R.
  TITLE     Cloning and characterization of neuropilin-1-interacting protein: a
            PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the
            cytoplasmic domain of neuropilin-1
  JOURNAL   J Neurosci 19 (15), 6519-6527 (1999)
   PUBMED   10414980
REFERENCE   9  (bases 1 to 1563)
  AUTHORS   Bunn,R.C., Jensen,M.A. and Reed,B.C.
  TITLE     Protein interactions with the glucose transporter binding protein
            GLUT1CBP that provide a link between GLUT1 and the cytoskeleton
  JOURNAL   Mol Biol Cell 10 (4), 819-832 (1999)
   PUBMED   10198040
REFERENCE   10 (bases 1 to 1563)
  AUTHORS   De Vries,L., Lou,X., Zhao,G., Zheng,B. and Farquhar,M.G.
  TITLE     GIPC, a PDZ domain containing protein, interacts specifically with
            the C terminus of RGS-GAIP
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12340-12345 (1998)
   PUBMED   9770488
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Feb 5, 2021 this sequence version replaced NM_053341.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1913821.1, FQ182912.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               JAXUCZ010000019.1  41383617-41383942   c
            327-512             JAXUCZ010000019.1  41382740-41382925   c
            513-693             JAXUCZ010000019.1  41382465-41382645   c
            694-806             JAXUCZ010000019.1  41381715-41381827   c
            807-888             JAXUCZ010000019.1  41380901-41380982   c
            889-1563            JAXUCZ010000019.1  41380125-41380799   c
FEATURES             Location/Qualifiers
     source          1..1563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1563
                     /gene="Gipc1"
                     /gene_synonym="Gipc; Rgs19; Rgs19ip1"
                     /note="GIPC PDZ domain containing family, member 1"
                     /db_xref="GeneID:83823"
                     /db_xref="RGD:68338"
     exon            1..326
                     /gene="Gipc1"
                     /gene_synonym="Gipc; Rgs19; Rgs19ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1040
                     /gene="Gipc1"
                     /gene_synonym="Gipc; Rgs19; Rgs19ip1"
                     /note="regulator of G-protein signaling 19 interacting
                     protein 1; GLUT1CBP; RGS19-interacting protein 1;
                     RGS-GAIP-interacting protein; GLUT1 C-terminal-binding
                     protein; GAIP C-terminus-interacting protein; RGS-GAIP
                     interacting protein, C-terminus; synectin"
                     /codon_start=1
                     /product="PDZ domain-containing protein GIPC1"
                     /protein_id="NP_445793.1"
                     /db_xref="GeneID:83823"
                     /db_xref="RGD:68338"
                     /translation="MPLGLGRRKKAPPLVENEEAEPSRSGLGVGEPGPLGGSGAGESQ
                     MGLPPPPASLRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPAAEVMFCTL
                     NTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRI
                     KEGSVIDHIQLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAF
                     DMISQRSSGGHPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYM
                     GIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY"
     exon            327..512
                     /gene="Gipc1"
                     /gene_synonym="Gipc; Rgs19; Rgs19ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..693
                     /gene="Gipc1"
                     /gene_synonym="Gipc; Rgs19; Rgs19ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..806
                     /gene="Gipc1"
                     /gene_synonym="Gipc; Rgs19; Rgs19ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..888
                     /gene="Gipc1"
                     /gene_synonym="Gipc; Rgs19; Rgs19ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1563
                     /gene="Gipc1"
                     /gene_synonym="Gipc; Rgs19; Rgs19ip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaggtctc ccggccaagt ccccacttct ggctgctcat gccactggga ctggggcgaa
       61 ggaaaaaagc accacctctg gtggaaaatg aggaggcgga gccaagccgg agtgggctgg
      121 gcgtcgggga gcccgggccc ctgggtggaa gtggagcagg ggaatcccag atgggtttgc
      181 ccccacctcc tgcttccctc cggcctcgcc tcgtgttcca tacccagctg gcccacggca
      241 gccccacggg ccgcatcgag ggcttcacta atgtcaagga gctgtacggc aagatcgctg
      301 aggccttccg actaccggct gctgaggtga tgttctgtac cctcaacacc cataaagtgg
      361 atatggacaa gctgctgggg ggccagatcg ggctggagga cttcatcttt gcccatgtca
      421 aggggcagcg caaagaggtg gaagtattca agtctgagga tgctctgggg ctcaccatca
      481 ccgacaacgg ggccggctat gccttcatta agcgcatcaa ggaaggcagt gtgattgacc
      541 acatccagct catcagcgtg ggtgacatga ttgaagccat caacgggcag agcctgctgg
      601 gctgtcggca ttatgaggtt gccaggctcc tcaaagagct gccccgaggc cgcaccttca
      661 ccctcaaact caccgaacct cggaaggcgt ttgatatgat cagccagcgt tcatcaggtg
      721 gtcaccctgg ctcaggccca caactgggca ctggccgagg gaccctccgg ctccgatccc
      781 ggggccctgc cacagtggag gatctgccgt cagcttttga ggaaaaggcc attgaaaagg
      841 tggatgactt gctagagagc tacatgggga tcagagacac agagctggct gccacgatgg
      901 tggagctggg gaaagacaaa aggaacccag acgaactggc agaagctctg gatgaacggc
      961 tcggtgactt cgcattccca gatgaattcg tctttgatgt ctggggagcc atcggggatg
     1021 ccaaggttgg ccgctactaa gactgggact gaacctggac cttgagataa cctggctttg
     1081 cccagctggg gtttccagaa accacagcca agacctgggc tgacagctta ggctgtaact
     1141 ccgcagcctg gggatggcac aggctgcaag tgccctgtgg tccaggcccc gctccaatca
     1201 gtaccgccac ggtgcccagc ctggttgggg tccccggcca acccctgccg ggttccccac
     1261 ctacctcaat agagtaagcg catggggagg gaccaacaca ctaggcagcc agccacctct
     1321 atccccaaca cttcccacta tcagctggca actgcccctt ctgtccccct ggcctcagct
     1381 ctcttcgggg tcatgacctc cctactttac tttttttgct ttgttttttt caagacaaag
     1441 tcactatgta gctctggctg tcctggaact ccttctgtaa accaggctgg ccttgaactc
     1501 acagagatcc acctgcatct gcattcacag tgctgggaat aaaggtgtgc atcaccactc
     1561 cca
//
