LOCUS       NM_019630                646 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus gastric inhibitory polypeptide (Gip), mRNA.
ACCESSION   NM_019630
VERSION     NM_019630.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 646)
  AUTHORS   Miskelly,M.G., Shcherbina,L., Thoren Fischer,A.H., Abels,M.,
            Lindqvist,A. and Wierup,N.
  TITLE     GK-rats respond to gastric bypass surgery with improved glycemia
            despite unaffected insulin secretion and beta cell mass
  JOURNAL   Peptides 136, 170445 (2021)
   PUBMED   33197511
  REMARK    GeneRIF: GK-rats respond to gastric bypass surgery with improved
            glycemia despite unaffected insulin secretion and beta cell mass.
REFERENCE   2  (bases 1 to 646)
  AUTHORS   Teng,L., Guan,T., Guo,B., Ma,C., Lin,G., Wu,R., Xu,M., Liu,M. and
            Liu,Y.
  TITLE     GIP-GIPR promotes neurite outgrowth of cortical neurons in Akt
            dependent manner
  JOURNAL   Biochem Biophys Res Commun 534, 121-127 (2021)
   PUBMED   33321289
  REMARK    GeneRIF: GIP-GIPR promotes neurite outgrowth of cortical neurons in
            Akt dependent manner.
REFERENCE   3  (bases 1 to 646)
  AUTHORS   Lee,T.M., Chen,W.T. and Chang,N.C.
  TITLE     Sitagliptin decreases ventricular arrhythmias by attenuated
            glucose-dependent insulinotropic polypeptide (GIP)-dependent
            resistin signalling in infarcted rats
  JOURNAL   Biosci Rep 36 (2), e00307 (2016)
   PUBMED   26811539
  REMARK    GeneRIF: Sitagliptin attenuated resistin expression via the
            GIP-dependent pathway, which inhibited sympathetic innervation
            through a signalling pathway involving phosphatidylinositol
            3-kinase (PI3K) and Akt protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 646)
  AUTHORS   Snook,L.A., Nelson,E.M., Dyck,D.J., Wright,D.C. and Holloway,G.P.
  TITLE     Glucose-dependent insulinotropic polypeptide directly induces
            glucose transport in rat skeletal muscle
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 309 (3), R295-R303 (2015)
   PUBMED   26041107
  REMARK    GeneRIF: provide evidence that gastric inhibitory polypeptide
            regulates skeletal muscle glucose transport; however, the exact
            signaling mechanism(s) remain unknown
REFERENCE   5  (bases 1 to 646)
  AUTHORS   De Toro-Martin,J., Fernandez-Millan,E., Lizarraga-Mollinedo,E.,
            Lopez-Oliva,E., Serradas,P., Escriva,F. and Alvarez,C.
  TITLE     Predominant role of GIP in the development of a metabolic
            syndrome-like phenotype in female Wistar rats submitted to forced
            catch-up growth
  JOURNAL   Endocrinology 155 (10), 3769-3780 (2014)
   PUBMED   25032669
  REMARK    GeneRIF: The role of GIP as a critical link between catch-up growth
            and the development of metabolic disturbances.
REFERENCE   6  (bases 1 to 646)
  AUTHORS   Sharma,S.K., Austin,C., Howard,A., Lo,G., Nicholl,C.G. and Legon,S.
  TITLE     Characterization of rat gastric inhibitory peptide cDNA
  JOURNAL   J Mol Endocrinol 9 (3), 265-272 (1992)
   PUBMED   1476614
REFERENCE   7  (bases 1 to 646)
  AUTHORS   Higashimoto,Y., Simchock,J. and Liddle,R.A.
  TITLE     Molecular cloning of rat glucose-dependent insulinotropic peptide
            (GIP)
  JOURNAL   Biochim Biophys Acta 1132 (1), 72-74 (1992)
   PUBMED   1380834
REFERENCE   8  (bases 1 to 646)
  AUTHORS   Ebert,R., Nauck,M. and Creutzfeldt,W.
  TITLE     Effect of exogenous or endogenous gastric inhibitory polypeptide
            (GIP) on plasma triglyceride responses in rats
  JOURNAL   Horm Metab Res 23 (11), 517-521 (1991)
   PUBMED   1816061
REFERENCE   9  (bases 1 to 646)
  AUTHORS   Tappy,L., Chiolero,R., Randin,J.P., Burckhardt,P. and Felber,J.P.
  TITLE     Effects of cholinergic stimulation and antagonism on plasma insulin
            concentration in lean and obese human subjects
  JOURNAL   Horm Metab Res 18 (12), 821-826 (1986)
   PUBMED   3546047
REFERENCE   10 (bases 1 to 646)
  AUTHORS   Ebert,R., Illmer,K. and Creutzfeldt,W.
  TITLE     Release of gastric inhibitory polypeptide (GIP) by intraduodenal
            acidification in rats and humans and abolishment of the incretin
            effect of acid by GIP-antiserum in rats
  JOURNAL   Gastroenterology 76 (3), 515-523 (1979)
   PUBMED   34554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 23, 2023 this sequence version replaced NM_019630.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ201054.1, L08831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093049, SAMN16093050
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000010.1  81465070-81465143
            75-182              JAXUCZ010000010.1  81465847-81465954
            183-329             JAXUCZ010000010.1  81468884-81469030
            330-419             JAXUCZ010000010.1  81471031-81471120
            420-521             JAXUCZ010000010.1  81471744-81471845
            522-646             JAXUCZ010000010.1  81473092-81473216
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..646
                     /gene="Gip"
                     /gene_synonym="Gludins; RATGLUDINS"
                     /note="gastric inhibitory polypeptide"
                     /db_xref="GeneID:25040"
                     /db_xref="RGD:2709"
     exon            1..74
                     /gene="Gip"
                     /gene_synonym="Gludins; RATGLUDINS"
                     /inference="alignment:Splign:2.1.0"
     exon            75..182
                     /gene="Gip"
                     /gene_synonym="Gludins; RATGLUDINS"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..531
                     /gene="Gip"
                     /gene_synonym="Gludins; RATGLUDINS"
                     /note="glucose-dependent insulinotropic polypeptide;
                     Glucose-dependent insulinotropic peptide"
                     /codon_start=1
                     /product="gastric inhibitory polypeptide precursor"
                     /protein_id="NP_062604.1"
                     /db_xref="GeneID:25040"
                     /db_xref="RGD:2709"
                     /translation="MVALKTCSLLLVLLFLAVGLGEKEEVEFRSHAKFAGPRPRGPRY
                     AEGTFISDYSIAMDKIRQQDFVNWLLAQKGKKNDWKHNLTQREARALELAGQSQRNEE
                     KEAQGSSLPKSLSDEDVLRDLLIQELLAWMADQAELCRLRSQ"
     exon            183..329
                     /gene="Gip"
                     /gene_synonym="Gludins; RATGLUDINS"
                     /inference="alignment:Splign:2.1.0"
     exon            330..419
                     /gene="Gip"
                     /gene_synonym="Gludins; RATGLUDINS"
                     /inference="alignment:Splign:2.1.0"
     exon            420..521
                     /gene="Gip"
                     /gene_synonym="Gludins; RATGLUDINS"
                     /inference="alignment:Splign:2.1.0"
     exon            522..646
                     /gene="Gip"
                     /gene_synonym="Gludins; RATGLUDINS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatcctgag aaccaacagg taggaggaag ggacctcatc ctgccctcct ggaagagcta
       61 agaagagctg ttggctcggg gacacaatct aggaagatgg tggctttgaa gacctgctct
      121 ctgctgctgg tgctcctgtt cctggctgtc gggctgggag aaaaagaaga ggttgagttc
      181 cgatcccatg ctaaatttgc tggcccccga ccacgaggcc caaggtatgc agaggggact
      241 ttcatcagtg attacagcat cgccatggac aagatccgcc aacaagactt tgtgaactgg
      301 cttctggccc agaaggggaa gaagaatgac tggaaacaca acctcaccca gagagaggcc
      361 cgggctttgg agctggcagg acaatctcag agaaacgagg agaaagaggc acaggggagc
      421 tctttgccca agagcctcag tgatgaagat gtgctgaggg accttctgat tcaagagcta
      481 ctggcctgga tggcggacca agcagagctc tgtcgactga ggtcccagtg accgacctac
      541 cccggagcag gactggactc tgaccttagc ttgctcagat cctgcttctg ccctggtcca
      601 aagtctctga gagaaccaaa ccaataaagc cttgagctga agtaaa
//
