LOCUS       NM_145680               1359 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript
            variant 2, mRNA.
ACCESSION   NM_145680
VERSION     NM_145680.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1359)
  AUTHORS   Fischer,H.J., Witte,A.K., Walter,L., Grone,H.J., van den Brandt,J.
            and Reichardt,H.M.
  TITLE     Distinct roles of T-cell lymphopenia and the microbial flora for
            gastrointestinal and CNS autoimmunity
  JOURNAL   FASEB J 30 (5), 1724-1732 (2016)
   PUBMED   26740263
  REMARK    GeneRIF: These findings confirm a critical albeit differential role
            of T-cell lymphopenia in the susceptibility to organ-specific
            autoimmune responses.
REFERENCE   2  (bases 1 to 1359)
  AUTHORS   Chen,X.L., Serrano,D., Ghobadi,F., Mayhue,M., Hoebe,K.,
            Ilangumaran,S. and Ramanathan,S.
  TITLE     TCR and IL-7 Signaling Are Altered in the Absence of Functional
            GTPase of the Immune Associated Nucleotide Binding Protein 5
            (GIMAP5)
  JOURNAL   PLoS One 11 (3), e0151837 (2016)
   PUBMED   27023180
  REMARK    GeneRIF: functional Gimap5 is required for optimal signaling
            through TCR and IL-7R in T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1359)
  AUTHORS   Chen,X.L., Serrano,D., Mayhue,M., Wieden,H.J., Stankova,J.,
            Boulay,G., Ilangumaran,S. and Ramanathan,S.
  TITLE     GTPase of the immune-associated nucleotide-binding protein 5
            (GIMAP5) regulates calcium influx in T-lymphocytes by promoting
            mitochondrial calcium accumulation
  JOURNAL   Biochem J 449 (2), 353-364 (2013)
   PUBMED   23098229
  REMARK    GeneRIF: Data indicate that reduced Ca2+ influx in GTPase of the
            immune-associated nucleotide-binding protein 5 (GIMAP5)-deficient
            T-cells is associated with the inability of their mitochondria to
            sequester Ca2+ following capacitative entry.
REFERENCE   4  (bases 1 to 1359)
  AUTHORS   Moralejo,D.H., Fuller,J.M., Rutledge,E.A., Van Yserloo,B.,
            Ettinger,R.A., Jensen,R., Osborne,W., Kwitek,A. and Lernmark,A.
  TITLE     BB rat Gimap gene expression in sorted lymphoid T and B cells
  JOURNAL   Life Sci 89 (19-20), 748-754 (2011)
   PUBMED   21925515
  REMARK    GeneRIF: results suggest that lack of the Gimap5 protein in the
            DR.(lyp/lyp) congenic rat was associated with impaired expression
            of the entire family of Gimap genes and may regulate T cell
            homeostasis in the peripheral lymphoid organs.
REFERENCE   5  (bases 1 to 1359)
  AUTHORS   Moralejo,D.H., Hansen,C.T., Treuting,P., Hessner,M.J., Fuller,J.M.,
            Van Yserloo,B., Jensen,R., Osborne,W., Kwitek,A.E. and Lernmark,A.
  TITLE     Differential effects of leptin receptor mutation on male and female
            BBDR Gimap5-/Gimap5- spontaneously diabetic rats
  JOURNAL   Physiol Genomics 41 (1), 9-20 (2010)
   PUBMED   19996157
  REMARK    GeneRIF: Obesity and type 2 diabetes in the BioBreeding
            diabetes-resistant (BBDR) rat result in islet expansion associated
            with protection from T1D in female but not male
            BBDR(lepr-/lepr-,Gimap5-/Gimap5-) congenic rats.
REFERENCE   6  (bases 1 to 1359)
  AUTHORS   Ramanathan,S., Marandi,L. and Poussier,P.
  TITLE     Evidence for the extrathymic origin of intestinal TCRgammadelta(+)
            T cells in normal rats and for an impairment of this
            differentiation pathway in BB rats
  JOURNAL   J Immunol 168 (5), 2182-2187 (2002)
   PUBMED   11859104
REFERENCE   7  (bases 1 to 1359)
  AUTHORS   Clark,L., Greenbaum,C., Jiang,J., Lernmark,A. and Ochs,H.
  TITLE     The antibody response to bacteriophage is linked to the lymphopenia
            gene in congenic BioBreeding rats
  JOURNAL   FEMS Immunol Med Microbiol 32 (3), 205-209 (2002)
   PUBMED   11934565
REFERENCE   8  (bases 1 to 1359)
  AUTHORS   Moore,J.K., Gold,D.P., Dreskin,S.C., Lernmark,A. and Bellgrau,D.
  TITLE     A diabetogenic gene prevents T cells from receiving costimulatory
            signals
  JOURNAL   Cell Immunol 194 (1), 90-97 (1999)
   PUBMED   10357884
REFERENCE   9  (bases 1 to 1359)
  AUTHORS   Lau,A., Ramanathan,S. and Poussier,P.
  TITLE     Excessive production of nitric oxide by macrophages from DP-BB rats
            is secondary to the T-lymphopenic state of these animals
  JOURNAL   Diabetes 47 (2), 197-205 (1998)
   PUBMED   9519713
REFERENCE   10 (bases 1 to 1359)
  AUTHORS   Bieg,S., Moller,C., Olsson,T. and Lernmark,A.
  TITLE     The lymphopenia (lyp) gene controls the intrathymic cytokine ratio
            in congenic BioBreeding rats
  JOURNAL   Diabetologia 40 (7), 786-792 (1997)
   PUBMED   9243099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY055776.3 and AY550018.1.
            
            On Oct 19, 2005 this sequence version replaced NM_145680.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' coding region, compared to variant 1, that results in the
            use of an upstream start codon. It encodes isoform 2 which has a
            shorter and distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY055776.3, DQ125352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1331              AY055776.3         1-1331
            1332-1359           AY550018.1         1507-1534
FEATURES             Location/Qualifiers
     source          1..1359
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BB/DR"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1359
                     /gene="Gimap5"
                     /gene_synonym="IAN4; Ian4l1; Ian5; lyp"
                     /note="GTPase, IMAP family member 5"
                     /db_xref="GeneID:246774"
                     /db_xref="RGD:628871"
     exon            1..246
                     /gene="Gimap5"
                     /gene_synonym="IAN4; Ian4l1; Ian5; lyp"
                     /inference="alignment:Splign:2.1.0"
     exon            247..295
                     /gene="Gimap5"
                     /gene_synonym="IAN4; Ian4l1; Ian5; lyp"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1179
                     /gene="Gimap5"
                     /gene_synonym="IAN4; Ian4l1; Ian5; lyp"
                     /note="isoform 2 is encoded by transcript variant 2;
                     immunity-associated nucleotide 4-like 1 protein;
                     immunity-associated nucleotide 4 protein; IAN-4; immune
                     associated nucleotide 4 like 1; lymphopenia"
                     /codon_start=1
                     /product="GTPase IMAP family member 5 isoform 2"
                     /protein_id="NP_663713.1"
                     /db_xref="GeneID:246774"
                     /db_xref="RGD:628871"
                     /translation="MEGLQKSTYGTIVEGQETYSVEDSGLLRILLVGKSGCGKSATGN
                     SILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNC
                     YLMCAPGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESL
                     EEFVTHTGNLDLHRLVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFH
                     SNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTS
                     CLDWHIAVSVLLIVLGLTLLITLINMYIGRWK"
     exon            296..1344
                     /gene="Gimap5"
                     /gene_synonym="IAN4; Ian4l1; Ian5; lyp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1325..1330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gimap5"
                     /gene_synonym="IAN4; Ian4l1; Ian5; lyp"
     polyA_site      1344
                     /gene="Gimap5"
                     /gene_synonym="IAN4; Ian4l1; Ian5; lyp"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 tggtcattta ctaaggcagt tctgctgtgt tctggcggat gttcatggcc tctccaccta
       61 cctgaaggga aacagtctgc agggcagtgt gtgttctgtc accatgggtt ttttttcctg
      121 ccttcggact cagggtttac agctctgcga gtagctgctc cgtgacagca tcgctctgca
      181 gtcacaggcc caccgcctgc ctgtaaggaa ccccatctgg gagacgggaa gctgcggtgc
      241 actcagaaga gaatggaagg ccttcagaag agcacatatg gaactatagt tgaaggacaa
      301 gaaacctaca gtgtagaaga ctctggcctc ctgaggatcc tcctggtggg taaatctggc
      361 tgcggaaaaa gtgccacagg gaacagcatt ctccgcagac cagcgttcga gtccaggctc
      421 agaggccagt ctgtgaccag gaccagtcag gcagagatgg gcacatggga gggaaggagc
      481 ttcctagtgg tggacacgcc ccccatcttc gagtcaaaga tccagaacca agacatggac
      541 aaggacattg ggaactgcta cctgatgtgt gccccaggac cccatgtgtt gttgctggtg
      601 acccaactgg gacgctacac agtcgaagat gccatggctg tgaggatggt gaagcagatc
      661 tttggggtag gggtcatgag gtacatgatt gtcctcttca cccacaagga agacctggca
      721 gatgagtcct tggaagagtt tgtgacccac acaggcaacc tcgacctgca cagactggtt
      781 caggagtgtg ggaggaggta ctgtgccttt aataacaagg cttctgggga ggagcagcag
      841 gggcagctgg cagagctcat ggccctggtg agaagactgg aacaggagca tgagggctcc
      901 ttccacagca atgacctctt cgtttatact caggtgttcc ttagaggtgg ctacagtgaa
      961 caccaggagc catacaagtt ctacctgacc aaggtgaggc aggaggtaga gaagcagaag
     1021 agggagctgg aggagcagga gggcagctgg atggctaaaa tgctttgcag agtcacgtcc
     1081 tgcttggact ggcacattgc agtgtctgtt cttcttattg ttcttggtct gacccttctc
     1141 atcactttaa ttaatatgta cattggcagg tggaaatgag tctctttggg tgaatcctgc
     1201 cattatccct gtccaccaaa tttccccatc tccatgttag ggaagctcag tcttcaaata
     1261 atttcactat catttgactc ctgtgcatga gacacagtag aacccttcta aataccgtta
     1321 agtaaataaa atatgaaaga agaaaaaaaa aaaaaaaaa
//
