LOCUS       NM_173153               1467 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus GTPase, IMAP family member 4 (Gimap4), mRNA.
ACCESSION   NM_173153
VERSION     NM_173153.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1467)
  AUTHORS   Schwefel,D., Arasu,B.S., Marino,S.F., Lamprecht,B., Kochert,K.,
            Rosenbaum,E., Eichhorst,J., Wiesner,B., Behlke,J., Rocks,O.,
            Mathas,S. and Daumke,O.
  TITLE     Structural insights into the mechanism of GTPase activation in the
            GIMAP family
  JOURNAL   Structure 21 (4), 550-559 (2013)
   PUBMED   23454188
REFERENCE   2  (bases 1 to 1467)
  AUTHORS   Carter,C., Dion,C., Schnell,S., Coadwell,W.J., Graham,M.,
            Hepburn,L., Morgan,G., Hutchings,A., Pascall,J.C., Jacobs,H.,
            Miller,J.R. and Butcher,G.W.
  TITLE     A natural hypomorphic variant of the apoptosis regulator
            Gimap4/IAN1
  JOURNAL   J Immunol 179 (3), 1784-1795 (2007)
   PUBMED   17641045
  REMARK    GeneRIF: A severe deficiency of Gimap4 expression in the inbred
            Brown Norway (BN) rat links this trait to the Gimap gene cluster on
            rat chromosome 4, the probable cause being an AT dinucleotide
            insertion in the BN Gimap4 allele.
REFERENCE   3  (bases 1 to 1467)
  AUTHORS   Nitta,T., Nasreen,M., Seike,T., Goji,A., Ohigashi,I., Miyazaki,T.,
            Ohta,T., Kanno,M. and Takahama,Y.
  TITLE     IAN family critically regulates survival and development of T
            lymphocytes
  JOURNAL   PLoS Biol 4 (4), e103 (2006)
   PUBMED   16509771
REFERENCE   4  (bases 1 to 1467)
  AUTHORS   Hornum,L., Romer,J. and Markholst,H.
  TITLE     The diabetes-prone BB rat carries a frameshift mutation in Ian4, a
            positional candidate of Iddm1
  JOURNAL   Diabetes 51 (6), 1972-1979 (2002)
   PUBMED   12031988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK479589.1, BC070952.1 and AY070268.1.
            
            On Oct 1, 2005 this sequence version replaced NM_173153.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM285343.1, AY070268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CK479589.1         1-12
            13-1336             BC070952.1         1-1324
            1337-1442           AY070268.1         1318-1423
            1443-1467           BC070952.1         1431-1455
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BB"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1467
                     /gene="Gimap4"
                     /gene_synonym="Ian1"
                     /note="GTPase, IMAP family member 4"
                     /db_xref="GeneID:286938"
                     /db_xref="RGD:628765"
     exon            1..32
                     /gene="Gimap4"
                     /gene_synonym="Ian1"
                     /inference="alignment:Splign:2.1.0"
     exon            33..104
                     /gene="Gimap4"
                     /gene_synonym="Ian1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..979
                     /gene="Gimap4"
                     /gene_synonym="Ian1"
                     /note="immune-associated nucleotide 1; immunity-associated
                     protein 4; immunity-associated nucleotide 1 protein;
                     IAN-1"
                     /codon_start=1
                     /product="GTPase IMAP family member 4"
                     /protein_id="NP_775176.2"
                     /db_xref="GeneID:286938"
                     /db_xref="RGD:628765"
                     /translation="MEAQYSGVGSIPENSRSSHELGIQDQGSPQLRIVLLGKTGAGKS
                     STGNSILGRKAFLSGICAKSITKVCEKGVSIWDGKELVVVDTPGIFDTEVPDADTQKE
                     ITRCVALTSPGPHALLLVIPLGRYTVEEHKATRKLLSMFEKKARRFMILLLTRKDDLE
                     DTDIHEYLETAPEVLQELIYEFRNRYCLFNNKASGAEQEEQKRQLLTLVQSMVRENGG
                     KYFTNKMYESAEGVIQKQTWKKKEFYREELERERARIRREYEAEIQDLRDELERERRR
                     ARMEREFNENELIFAERQQNARREVENTSMIYLN"
     exon            105..1451
                     /gene="Gimap4"
                     /gene_synonym="Ian1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcagagaag gccacaggac ccagattttc agggatctga actacaatgg aagcccagta
       61 cagtggtgtg gggtccatcc cggaaaattc aaggagcagc catgagcttg gaatacaaga
      121 tcaaggaagt ccccaactga gaattgtcct acttggaaaa actggagcag gaaagagttc
      181 aacagggaac agcatccttg gaagaaaagc atttctttct ggcatttgtg caaaatccat
      241 taccaaggtc tgtgagaaag gagtgagcat ctgggatggg aaagagctcg ttgttgtgga
      301 tacacctggc attttcgaca ctgaggtacc agatgctgac acacaaaagg agatcactcg
      361 ctgtgttgct ctgacctctc cagggcctca tgctctgctt ctggtcatcc cactggggcg
      421 ttatactgtg gaagaacaca aggccacacg gaaacttctg agcatgtttg aaaaaaaggc
      481 tagaagattc atgatactct tgctcaccag gaaggatgac ttggaagaca cagatatcca
      541 tgagtactta gagacggctc ctgaagtcct tcaagagttg atctatgagt tccggaatcg
      601 ctactgtttg ttcaataaca aagcatcagg agctgaacag gaagagcaga agaggcagct
      661 gttgacctta gttcagagca tggtgaggga aaatggtgga aaatacttta ctaacaagat
      721 gtatgaaagt gctgagggtg tgattcagaa acaaacctgg aagaagaaag aattttacag
      781 agaggaactg gagagagaga gagcacggat aagacgggag tatgaagcag agattcaaga
      841 tctgagagat gagctggaaa gggaaaggag aagggcacgt atggagaggg agttcaatga
      901 gaacgagctt atctttgcag agagacaaca aaatgctagg agggaagttg agaacacaag
      961 tatgatatac ttgaattaat cataaaagca tgggagattg cttcctttat cttcaaccag
     1021 tttatgagag actagacttc cttgataaca tgccgtacag agctcacacc catgacacac
     1081 ccactccaac agggctttgc cttctaatgg tgccactccc tgggctaagt atatatgcca
     1141 taacaaacac catggccaaa agacaccttg gagaagaaag ggttcatttt tatcttacag
     1201 cttataaccc atcccagagg aacagcaact caaagcagga acctggagac aggaaccgat
     1261 gcagaggcca tggaggagtg ctttacttgc ttggtgccta tgacttgctt agctttttaa
     1321 aacttttttt tttttgtgaa ttttacatca tgcacaccaa tcccaataat ttccctgtcc
     1381 ctccatatcc accctctgct gctgcacctc ccctctaaaa gaaaacaaaa taaaataaga
     1441 ccaaaaaaaa aaaaaaaaaa aaaaaaa
//
