LOCUS       NM_198743               5667 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus GID complex subunit 8 homolog (Gid8), mRNA.
ACCESSION   NM_198743 XM_215967
VERSION     NM_198743.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5667)
  AUTHORS   Lampert,F., Stafa,D., Goga,A., Soste,M.V., Gilberto,S., Olieric,N.,
            Picotti,P., Stoffel,M. and Peter,M.
  TITLE     The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell
            proliferation and targets the transcription factor Hbp1 for
            degradation
  JOURNAL   Elife 7, e35528 (2018)
   PUBMED   29911972
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5667)
  AUTHORS   Lu,Y., Xie,S., Zhang,W., Zhang,C., Gao,C., Sun,Q., Cai,Y., Xu,Z.,
            Xiao,M., Xu,Y., Huang,X., Wu,X., Liu,W., Wang,F., Kang,Y. and
            Zhou,T.
  TITLE     Twa1/Gid8 is a beta-catenin nuclear retention factor in Wnt
            signaling and colorectal tumorigenesis
  JOURNAL   Cell Res 27 (12), 1422-1440 (2017)
   PUBMED   28829046
REFERENCE   3  (bases 1 to 5667)
  AUTHORS   Francis,O., Baker,G.E., Race,P.R. and Adams,J.C.
  TITLE     Studies of recombinant TWA1 reveal constitutive dimerization
  JOURNAL   Biosci Rep 37 (1) (2017)
   PUBMED   27920276
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5667)
  AUTHORS   Francis,O., Han,F. and Adams,J.C.
  TITLE     Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in
            eukaryotic cells and dominated by homologous components, the
            muskelin/RanBPM/CTLH complex
  JOURNAL   PLoS One 8 (10), e75217 (2013)
   PUBMED   24143168
  REMARK    Erratum:[PLoS One. 2013 Nov 8;8(11):null. PMID: 29161723]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5667)
  AUTHORS   Kobayashi,N., Yang,J., Ueda,A., Suzuki,T., Tomaru,K., Takeno,M.,
            Okuda,K. and Ishigatsubo,Y.
  TITLE     RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat
            proteins ARMC8alpha and ARMC8beta are components of the CTLH
            complex
  JOURNAL   Gene 396 (2), 236-247 (2007)
   PUBMED   17467196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 8, 2020 this sequence version replaced NM_198743.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.5420.1,
                                           SRR26360186.2851776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000003.1  188203571-188203753
            184-313             JAXUCZ010000003.1  188206289-188206418
            314-510             JAXUCZ010000003.1  188207613-188207809
            511-708             JAXUCZ010000003.1  188208427-188208624
            709-5667            JAXUCZ010000003.1  188209366-188214324
FEATURES             Location/Qualifiers
     source          1..5667
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..5667
                     /gene="Gid8"
                     /gene_synonym="Bwk1; TWA1"
                     /note="GID complex subunit 8 homolog"
                     /db_xref="GeneID:296466"
                     /db_xref="RGD:735024"
     exon            1..183
                     /gene="Gid8"
                     /gene_synonym="Bwk1; TWA1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..313
                     /gene="Gid8"
                     /gene_synonym="Bwk1; TWA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..882
                     /gene="Gid8"
                     /gene_synonym="Bwk1; TWA1"
                     /note="two hybrid associated protein 1; BWK-1; Bwk1
                     leukemia-related"
                     /codon_start=1
                     /product="glucose-induced degradation protein 8 homolog"
                     /protein_id="NP_942038.1"
                     /db_xref="GeneID:296466"
                     /db_xref="RGD:735024"
                     /translation="MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKE
                     AAEKFRMESGIEPSVDLETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYF
                     HLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPF
                     GDLLHMMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTD
                     LSKGVIEEPK"
     exon            314..510
                     /gene="Gid8"
                     /gene_synonym="Bwk1; TWA1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..708
                     /gene="Gid8"
                     /gene_synonym="Bwk1; TWA1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..5667
                     /gene="Gid8"
                     /gene_synonym="Bwk1; TWA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggggcag acgccggtgt atctacctcc gcctcgcgcc ccgcccccgc ctccgctgcg
       61 gcctccgcct ccgcctccgc ctcctcctct atctcccgcc gtctctgccg cccctccccg
      121 gccccgggag cggccgcgga gccgccaccc agaccctgtc gcgcgggagg cgggatccgc
      181 acgaaataag tcataatgag ttacgcagaa aagcccgatg aaataaccaa agatgaatgg
      241 atggaaaagc tcaacaactt acatgttcag cgcgcagaca tgaaccgact catcatgaac
      301 tacttagtca cagagggctt taaggaagca gcagagaaat ttcggatgga gtcagggatc
      361 gaaccaagtg tggacctaga aacactcgat gagcgaatca agattcggga gatgattctg
      421 aagggtcaga tccaggaggc tattgccttg atcaacagcc tccacccaga gctcctagac
      481 acaaaccggt atctttactt ccacctgcag caacagcacc tgatcgagct tatccgtcag
      541 cgagagacag aagcagcttt ggagtttgcc cagacgcaac tggcagagca gggtgaggaa
      601 agcagagaat gcctcacaga aatggagcgc acattggcct tgctggcctt cgatagccct
      661 gaggagtcgc cctttggaga cctcctccac atgatgcaga ggcaaaaggt gtggagtgaa
      721 gttaaccagg ctgttctgga ttatgagaat cgagagtcca cacccaagct ggcaaaatta
      781 ctgaaactgc tactttgggc tcagaatgag ctagaccaga agaaagtaaa atatcccaaa
      841 atgacagacc tcagcaaagg tgtgattgag gagcccaagt agagcctgtc cacggagcca
      901 gcactgtcaa tcagcacagg actcctcctc tgtgactggc aggttgtcac tgcagtagag
      961 aacctttccc cctgtacttt tctttggccc cattgtttaa aaggggaaaa tggccttttt
     1021 aaacactggc aaacccgtga tggaagacac cacctctgcc gtgccctgga tcctgagggc
     1081 tgcacacact tcagttgact gtcctcgcgc ttccggatcg ctggttccag aagatgtggt
     1141 ttgccacctg tgctgcactg ctgggagtgt cacctccgct gaaggcctcc cacaggacag
     1201 cacacaagaa gtgctgaagt gctgaatgct tcgacacctg ctagcgtgca ggcaggcagg
     1261 caggcaggca gggtcttatc ttcctaggtc tcaccagact ttcatggttt tccttacccc
     1321 ttcttttttt tctttttctt cctccttttg ttccttcata ggaaagaata tataaatttg
     1381 taaatcttaa ttcaaagata actttggtgt gggtactgag tttggtttgg ttctttgcct
     1441 ttgccttttg gtgtgggctg tgtggctttt gggaggaagg gtgtgtgtgt gaaaggtgag
     1501 gctgtgggtt tgttttctct tttttttttt ttaattttca aaatatattt tgggtgctgt
     1561 atgtgatgag agactcattc atagtggatc aatgaataat ctcttgtagg taattttatt
     1621 tgaaaataaa gatttctttt tacttccagt ataaccacaa tggcttctaa aaaattctca
     1681 tctcacacag cccttgtttt gggtgtcctt tccctggcac agaggcagca ccttaaccca
     1741 tagctgggag actattccca tgtgcctagg gaatgctctg catggtagcc aggcagtctg
     1801 gtgttggtgg gataaccgag tggtctcaag catcacagag ctggatgttc atgctagcca
     1861 gatggaactt gagcttggca aagtcgtttc ttatttcttg tctcagtgtc agcagtgctg
     1921 tgtgtcctgc ttctcaacag ctatttgtta cctgctcagg ggaaggcatt acctgtaggt
     1981 atggtatgct tacgtaggtc agtgctccga gtaatgagtg tgtacatgca ttgtgccggg
     2041 cacagtgtgt ttggttgatt cttggcagtg gtccaggcct gatggggtca gtgctaaagg
     2101 ctagggtggg ggtggagtgc acaggggtac acagacctgc agagccctca gatagttatc
     2161 cctggctgtg aatggtgaag atgtgagtac catcctctgg tggaagttcc tgcctgtcca
     2221 acacgagagc caggagtttg gtactggtac tggctactaa gaaacagtgt ccttagtaac
     2281 tgctgaatta ggattattcc ctgttcttaa gcaatactag catactgact agctgggtca
     2341 gactgggcag ctcaggtacc acagctaacc agctgtctct ctcttgttcc ctacttcagt
     2401 gttgttcatc agtacctgtc tgttctttac ccacaggatt cttttcttgt tgggatggaa
     2461 tgaagtgtct tccagctctc tgcttctccc tctctgcttc taccgcagag ggcagatctt
     2521 aggatcacat tagtgacaga ctcaaggatg gaattgttgc tgtcatgatc ctccactgct
     2581 cttccggtgt gtgagtaagg agtgagcaga cctctcctta ccttctggac aggtggcttt
     2641 caacattctc gtgaaatgta gccttccgtc tgctttaagg ataagaataa ggtagaggag
     2701 tttctggaga gacaggtctt tagttaagaa gaaatgatga acaaccatga agaccagagt
     2761 ccaccatcca cataagtcag acaacccccg caaattcctg taacttcagt tccaaggaat
     2821 atgatgttct ctgtgacctc cacatacaca caggcaggca ggtgcaggta acacacacac
     2881 atgcacgcac acacatgctc acacacaggc tcacagattt ttaaggcaaa ggggaagtat
     2941 taattttcag gtagctaata ggttaaatga gtcagaagtt ggggaggggt atcaataaag
     3001 atacaatgtt tttaaagcac cacatgaagc caggcatggt ggctcctgcc tgttattaca
     3061 gtattcacga ggctgaggaa ggattttcta gtccagccta ggctatgtta taagatcgtt
     3121 tttcttaaac aaaaaggccc cagatagcca gcatatttgt atctttgtgt gtgtgtgtgt
     3181 gtgtgtgtgt gtgtgtgtgt gtatgtatgt gtgtgtatgt atgtgtatga tcacttgtag
     3241 agctaatcag tttgatgtgt tcttaaaatt agagggcatg aaatgtgtag taaagggagg
     3301 gagggaggtc ctctctgtac gggttatcca caaatacaca gaagcttgtt gcatgtataa
     3361 aatgttcagt ggctataaga cagtgagttg acaacttact agcacttcag tcaatagctt
     3421 agtcagccag tgccacagtt gtcagtggct tgaagaatgt cagctagaac tgcttgcttg
     3481 tccacaatct gttagtgcct agaaaccccc ttccaaggag tcacatgtag tcatttcctg
     3541 ttgcagcaga caaagtagct ttatttcttt ctgcaccttt tgatggaaag tgccttgaaa
     3601 taaatgagac acgaatattc tggtactctg ctccaatatc atagagctgt acaaggaaca
     3661 acccagtttg aaattttcta aagcatggta attatttcac actaaagatg agaatttgtt
     3721 ttgtcacttg acttatggtt tgggtttggt gtttgagacc tcccacagta tgtagttgaa
     3781 gactttgtaa agtgactttg aggcgggcct gtggaactga ggtgggcagt atgttgtcat
     3841 tattgtcttt tgtgctatta gttttggaga ggagaatcca ggagagtcct tccagaagga
     3901 ttcttctatg ttccatgata aagacactga tatgatcaag agaatgacgt gggatttcct
     3961 tccaggttgt tgctctccag tctcagaaag aacaaaagac caaattccaa atgtcagggt
     4021 aacaacattg tctacacacc tgcatttcaa ggtgctgagt tgtatacagg gcttcatgca
     4081 gggggcagcc tgctcaccag gctttactca ctgctgcatt gttggcaggt ctcgttctga
     4141 caccatgcat aattattttt gtttcacaaa tattgctttt ttcagacact tagtaagctg
     4201 cattgccagc aaggatgtgg ggtctgtatc agtccttagc tcgctggagc actcatgcgc
     4261 acacttcgtt ataattcttc attcagtggc atttatacct ctgccacata tcatctgaga
     4321 agtccaggtt gggtagcttc tgggtgcctg ctatgaattt gttagtaaaa gttttcatgt
     4381 ttttcccaga atggttgtct gaaagctctt ttcccactcc ttcactgaag aggtacagca
     4441 ggagaagaga attactgacc acgcttgtca gcatattaga gctggaagag tgggaaagtg
     4501 tagctgcatg ctagctttgc tctgttccca tgccagcagt gccacagcat agagccagtc
     4561 tactccgctg acggctgcag ccttcctgga ccccaggatg tgatgactgt gggggccctg
     4621 tatgcagtat gcagaggctc ccaagacgga cttctgtctc cattgccatt ttctcaggca
     4681 ggtctgaggg aaatgcagtg agatgaaacc tccaagggaa ccaagcagcg cactacggag
     4741 cgtcctgcac tgtgtagtgg gttgtgaccg cacacaggaa gggccttgtc atccccaaac
     4801 cctgtggcag ggtcaccctc ttcaccattg ctcactcgtc cctcacattc ccagagggta
     4861 atgctccaca tgccgatggg tggtagagac ctctgctgtg cttgaatgtg agctcttgta
     4921 tgttaaatct gagaggcttg aggtaccatc tgcctatcat gaatgaattc ccatgatttt
     4981 ggaatgccat cctgacttga gactttatat ttacatgaaa gaagaaagaa tttgaatgac
     5041 ccctgatatt accatctatt gcagactcac cacacttcag tgcactgagt aatatgtcct
     5101 gagacagtct gcctgttctg gaagctaaga atggctatag tggtattaag acctggacaa
     5161 taaacccatc aatagggtta catgtgaatc tggtggactg gtggggcagg gatgtccagt
     5221 gtcatggcag gtatgactgg aattctgcaa ctgttgtctg cagctcatcc atgcccccta
     5281 gatccatgcc aggttaaggt ccaggatgac actaatagag aagaaaactg cagaactgct
     5341 tgtgcccaac tgtaaccaag agatgtgact actggatgct tactgtctgt gacttttttt
     5401 ttttttaagg ttttttgttt tgttttaaag aaaacttgtg tgtatgtgtg ttctgcctgg
     5461 gtgtatatcc aggtaccatg tgtgtgcctc gtgcccacag aggtcaaaag agggcatcag
     5521 atctcttgga actcaaatta tggacagttg tgagctgcat tgtatgttct agaaaccaaa
     5581 ctctgtaaga acaagggctc ctggtcagct ccttgcatgt aacttttcac gggagtacct
     5641 tcttagatac aggttctgat gaacgtt
//
