LOCUS       NM_032075               1350 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus growth hormone secretagogue receptor (Ghsr),
            mRNA.
ACCESSION   NM_032075
VERSION     NM_032075.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Zhu,L., Dou,Z., Wu,W., Hou,Q., Wang,S., Yuan,Z., Li,B. and Liu,J.
  TITLE     Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal
            Barrier Dysfunction in a Sepsis Rat Model by Inactivating
            E2F1/NF-kappaB Signaling
  JOURNAL   Can J Gastroenterol Hepatol 2023, 1629777 (2023)
   PUBMED   38187112
  REMARK    GeneRIF: Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated
            Intestinal Barrier Dysfunction in a Sepsis Rat Model by
            Inactivating E2F1/NF-kappaB Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Han,F., Xu,F., Zhu,Q., Sun,P., Zhou,Y. and Yu,M.
  TITLE     Virus-mediated GHS-R1a expression in the basolateral amygdala
            blocks extinction of conditioned taste aversion memory in rats
  JOURNAL   Biochem Biophys Res Commun 602, 57-62 (2022)
   PUBMED   35255434
  REMARK    GeneRIF: Virus-mediated GHS-R1a expression in the basolateral
            amygdala blocks extinction of conditioned taste aversion memory in
            rats.
REFERENCE   3  (bases 1 to 1350)
  AUTHORS   Wellman,M., Budin,R., Woodside,B. and Abizaid,A.
  TITLE     Energetic demands of lactation produce an increase in the
            expression of growth hormone secretagogue receptor in the
            hypothalamus and ventral tegmental area of the rat despite a
            reduction in circulating ghrelin
  JOURNAL   J Neuroendocrinol 34 (4), e13126 (2022)
   PUBMED   35365872
  REMARK    GeneRIF: Energetic demands of lactation produce an increase in the
            expression of growth hormone secretagogue receptor in the
            hypothalamus and ventral tegmental area of the rat despite a
            reduction in circulating ghrelin.
REFERENCE   4  (bases 1 to 1350)
  AUTHORS   Furness,J.B., Pustovit,R.V., Syder,A.J., Ringuet,M.T., Yoo,E.J.,
            Fanjul,A., Wykosky,J., Fothergill,L.J., Whitfield,E.A. and
            Furness,S.G.B.
  TITLE     Dopamine and ghrelin receptor co-expression and interaction in the
            spinal defecation centers
  JOURNAL   Neurogastroenterol Motil 33 (5), e14051 (2021)
   PUBMED   33264473
  REMARK    GeneRIF: Dopamine and ghrelin receptor co-expression and
            interaction in the spinal defecation centers.
REFERENCE   5  (bases 1 to 1350)
  AUTHORS   Sales da Silva,E., Ferreira,P.M., Castro,C.H., Pacheco,L.F.,
            Graziani,D., Pontes,C.N.R., Bessa,A.S.M., Fernandes,E., Naves,L.M.,
            Ribeiro,L.C.D.S., Mendonca,M.M., Gomes,R.M., Pedrino,G.R.,
            Ferreira,R.N. and Xavier,C.H.
  TITLE     Brain and kidney GHS-R1a underexpression is associated with changes
            in renal function and hemodynamics during neurogenic hypertension
  JOURNAL   Mol Cell Endocrinol 518, 110984 (2020)
   PUBMED   32814069
  REMARK    GeneRIF: Brain and kidney GHS-R1a underexpression is associated
            with changes in renal function and hemodynamics during neurogenic
            hypertension.
REFERENCE   6  (bases 1 to 1350)
  AUTHORS   Kamegai,J., Wakabayashi,I., Miyamoto,K., Unterman,T.G.,
            Kineman,R.D. and Frohman,L.A.
  TITLE     Growth hormone-dependent regulation of pituitary GH secretagogue
            receptor (GHS-R) mRNA levels in the spontaneous dwarf Rat
  JOURNAL   Neuroendocrinology 68 (5), 312-318 (1998)
   PUBMED   9822798
REFERENCE   7  (bases 1 to 1350)
  AUTHORS   Yokote,R., Sato,M., Matsubara,S., Ohye,H., Niimi,M., Murao,K. and
            Takahara,J.
  TITLE     Molecular cloning and gene expression of growth hormone-releasing
            peptide receptor in rat tissues
  JOURNAL   Peptides 19 (1), 15-20 (1998)
   PUBMED   9437732
REFERENCE   8  (bases 1 to 1350)
  AUTHORS   McKee,K.K., Palyha,O.C., Feighner,S.D., Hreniuk,D.L., Tan,C.P.,
            Phillips,M.S., Smith,R.G., Van der Ploeg,L.H. and Howard,A.D.
  TITLE     Molecular analysis of rat pituitary and hypothalamic growth hormone
            secretagogue receptors
  JOURNAL   Mol Endocrinol 11 (4), 415-423 (1997)
   PUBMED   9092793
REFERENCE   9  (bases 1 to 1350)
  AUTHORS   Howard,A.D., Feighner,S.D., Cully,D.F., Arena,J.P., Liberator,P.A.,
            Rosenblum,C.I., Hamelin,M., Hreniuk,D.L., Palyha,O.C., Anderson,J.,
            Paress,P.S., Diaz,C., Chou,M., Liu,K.K., McKee,K.K., Pong,S.S.,
            Chaung,L.Y., Elbrecht,A., Dashkevicz,M., Heavens,R., Rigby,M.,
            Sirinathsinghji,D.J., Dean,D.C., Melillo,D.G., Patchett,A.A.,
            Nargund,R., Griffin,P.R., DeMartino,J.A., Gupta,S.K.,
            Schaeffer,J.M., Smith,R.G. and Van der Ploeg,L.H.
  TITLE     A receptor in pituitary and hypothalamus that functions in growth
            hormone release
  JOURNAL   Science 273 (5277), 974-977 (1996)
   PUBMED   8688086
REFERENCE   10 (bases 1 to 1350)
  AUTHORS   Banerjee,S.A., Roffler-Tarlov,S., Szabo,M., Frohman,L. and
            Chikaraishi,D.M.
  TITLE     DNA regulatory sequences of the rat tyrosine hydroxylase gene
            direct correct catecholaminergic cell-type specificity of a human
            growth hormone reporter in the CNS of transgenic mice causing a
            dwarf phenotype
  JOURNAL   Brain Res Mol Brain Res 24 (1-4), 89-106 (1994)
   PUBMED   7968381
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB001982.1.
            
            On Sep 3, 2003 this sequence version replaced NM_032075.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB001982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..1350
                     /gene="Ghsr"
                     /note="growth hormone secretagogue receptor"
                     /db_xref="GeneID:84022"
                     /db_xref="RGD:621397"
     CDS             1..1095
                     /gene="Ghsr"
                     /note="GHRP; GHS-R; ghrelin receptor; GH-releasing peptide
                     receptor"
                     /codon_start=1
                     /product="growth hormone secretagogue receptor type 1"
                     /protein_id="NP_114464.1"
                     /db_xref="GeneID:84022"
                     /db_xref="RGD:621397"
                     /translation="MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAG
                     VTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRL
                     WQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVK
                     LVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSV
                     FFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLP
                     FHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFK
                     LLGFESFSQRKLSTLKDESSRAWTKSSINT"
     exon            1..790
                     /gene="Ghsr"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1350
                     /gene="Ghsr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggaacg cgacccccag cgaggagccg gagcctaacg tcacgttgga cctggattgg
       61 gacgcttccc ccggcaacga ctcactgcct gacgaactgc tgccgctgtt ccccgctccg
      121 ctgctggcag gcgtcaccgc cacctgcgtg gcgctcttcg tggtgggcat ctcaggcaac
      181 ctgctcacta tgctggtggt gtcccgcttc cgcgagctgc gcaccaccac caacctctac
      241 ctgtccagca tggccttctc ggatctgctc atcttcctgt gcatgccgct ggacctcgtc
      301 cgcctctggc agtaccggcc ctggaacttc ggcgacctgc tctgcaaact cttccagttt
      361 gtcagcgaga gctgcaccta cgccacggtc ctcaccatca ccgcgctgag cgtcgagcgc
      421 tacttcgcca tctgcttccc tctgcgggcc aaggtggtgg tcactaaggg ccgcgtgaag
      481 ctggtcatcc ttgtcatctg ggccgtggct ttctgcagcg cggggcccat cttcgtgctg
      541 gtgggcgtgg agcacgaaaa cggcacagat ccccgggaca ccaacgaatg ccgcgccacc
      601 gagttcgctg tgcgctctgg gctgctcacc gtcatggtgt gggtgtccag cgtcttcttc
      661 tttctaccgg tcttctgcct cactgtgctc tacagtctca tcgggaggaa gctatggcgg
      721 agacgcggag atgcagcggt gggcgcctcg ctccgggacc agaaccacaa gcagacagtg
      781 aagatgcttg ctgtggtggt gtttgctttc atcctctgct ggctgccctt ccacgtggga
      841 agatacctct tttccaagtc cttcgagcct ggctctctgg agatcgctca gatcagccag
      901 tactgcaacc tggtgtcctt tgtcctcttc tacctcagcg ctgccatcaa ccccattctg
      961 tacaacatca tgtccaagaa gtaccgggtg gcagtgttca aactgctagg atttgaatcc
     1021 ttctcccaga gaaagctttc cactctgaag gatgagagtt cccgggcctg gacaaagtcg
     1081 agcatcaaca catgacagca catcccatct ctccgccatc gctcattgct ctacacccga
     1141 agccgtagcc aagcgggact tgggaggagg cagaacctca gtttggggat tagagacaaa
     1201 tgggtctgga aacaattggg ggtggggagt agagccagat gggcagggtc cacgcagatt
     1261 gatctgcttg tgcgcccacc agagcactca tgtgcaaccc ctgcacaccc gtgattttat
     1321 tattggggct actggcagct ttgcagctca
//
