LOCUS       NP_114464                364 aa            linear   ROD 03-APR-2024
DEFINITION  growth hormone secretagogue receptor type 1 [Rattus norvegicus].
ACCESSION   NP_114464
VERSION     NP_114464.1
DBSOURCE    REFSEQ: accession NM_032075.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Zhu,L., Dou,Z., Wu,W., Hou,Q., Wang,S., Yuan,Z., Li,B. and Liu,J.
  TITLE     Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal
            Barrier Dysfunction in a Sepsis Rat Model by Inactivating
            E2F1/NF-kappaB Signaling
  JOURNAL   Can J Gastroenterol Hepatol 2023, 1629777 (2023)
   PUBMED   38187112
  REMARK    GeneRIF: Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated
            Intestinal Barrier Dysfunction in a Sepsis Rat Model by
            Inactivating E2F1/NF-kappaB Signaling.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 364)
  AUTHORS   Han,F., Xu,F., Zhu,Q., Sun,P., Zhou,Y. and Yu,M.
  TITLE     Virus-mediated GHS-R1a expression in the basolateral amygdala
            blocks extinction of conditioned taste aversion memory in rats
  JOURNAL   Biochem Biophys Res Commun 602, 57-62 (2022)
   PUBMED   35255434
  REMARK    GeneRIF: Virus-mediated GHS-R1a expression in the basolateral
            amygdala blocks extinction of conditioned taste aversion memory in
            rats.
REFERENCE   3  (residues 1 to 364)
  AUTHORS   Wellman,M., Budin,R., Woodside,B. and Abizaid,A.
  TITLE     Energetic demands of lactation produce an increase in the
            expression of growth hormone secretagogue receptor in the
            hypothalamus and ventral tegmental area of the rat despite a
            reduction in circulating ghrelin
  JOURNAL   J Neuroendocrinol 34 (4), e13126 (2022)
   PUBMED   35365872
  REMARK    GeneRIF: Energetic demands of lactation produce an increase in the
            expression of growth hormone secretagogue receptor in the
            hypothalamus and ventral tegmental area of the rat despite a
            reduction in circulating ghrelin.
REFERENCE   4  (residues 1 to 364)
  AUTHORS   Furness,J.B., Pustovit,R.V., Syder,A.J., Ringuet,M.T., Yoo,E.J.,
            Fanjul,A., Wykosky,J., Fothergill,L.J., Whitfield,E.A. and
            Furness,S.G.B.
  TITLE     Dopamine and ghrelin receptor co-expression and interaction in the
            spinal defecation centers
  JOURNAL   Neurogastroenterol Motil 33 (5), e14051 (2021)
   PUBMED   33264473
  REMARK    GeneRIF: Dopamine and ghrelin receptor co-expression and
            interaction in the spinal defecation centers.
REFERENCE   5  (residues 1 to 364)
  AUTHORS   Sales da Silva,E., Ferreira,P.M., Castro,C.H., Pacheco,L.F.,
            Graziani,D., Pontes,C.N.R., Bessa,A.S.M., Fernandes,E., Naves,L.M.,
            Ribeiro,L.C.D.S., Mendonca,M.M., Gomes,R.M., Pedrino,G.R.,
            Ferreira,R.N. and Xavier,C.H.
  TITLE     Brain and kidney GHS-R1a underexpression is associated with changes
            in renal function and hemodynamics during neurogenic hypertension
  JOURNAL   Mol Cell Endocrinol 518, 110984 (2020)
   PUBMED   32814069
  REMARK    GeneRIF: Brain and kidney GHS-R1a underexpression is associated
            with changes in renal function and hemodynamics during neurogenic
            hypertension.
REFERENCE   6  (residues 1 to 364)
  AUTHORS   Kamegai,J., Wakabayashi,I., Miyamoto,K., Unterman,T.G.,
            Kineman,R.D. and Frohman,L.A.
  TITLE     Growth hormone-dependent regulation of pituitary GH secretagogue
            receptor (GHS-R) mRNA levels in the spontaneous dwarf Rat
  JOURNAL   Neuroendocrinology 68 (5), 312-318 (1998)
   PUBMED   9822798
REFERENCE   7  (residues 1 to 364)
  AUTHORS   Yokote,R., Sato,M., Matsubara,S., Ohye,H., Niimi,M., Murao,K. and
            Takahara,J.
  TITLE     Molecular cloning and gene expression of growth hormone-releasing
            peptide receptor in rat tissues
  JOURNAL   Peptides 19 (1), 15-20 (1998)
   PUBMED   9437732
REFERENCE   8  (residues 1 to 364)
  AUTHORS   McKee,K.K., Palyha,O.C., Feighner,S.D., Hreniuk,D.L., Tan,C.P.,
            Phillips,M.S., Smith,R.G., Van der Ploeg,L.H. and Howard,A.D.
  TITLE     Molecular analysis of rat pituitary and hypothalamic growth hormone
            secretagogue receptors
  JOURNAL   Mol Endocrinol 11 (4), 415-423 (1997)
   PUBMED   9092793
REFERENCE   9  (residues 1 to 364)
  AUTHORS   Howard,A.D., Feighner,S.D., Cully,D.F., Arena,J.P., Liberator,P.A.,
            Rosenblum,C.I., Hamelin,M., Hreniuk,D.L., Palyha,O.C., Anderson,J.,
            Paress,P.S., Diaz,C., Chou,M., Liu,K.K., McKee,K.K., Pong,S.S.,
            Chaung,L.Y., Elbrecht,A., Dashkevicz,M., Heavens,R., Rigby,M.,
            Sirinathsinghji,D.J., Dean,D.C., Melillo,D.G., Patchett,A.A.,
            Nargund,R., Griffin,P.R., DeMartino,J.A., Gupta,S.K.,
            Schaeffer,J.M., Smith,R.G. and Van der Ploeg,L.H.
  TITLE     A receptor in pituitary and hypothalamus that functions in growth
            hormone release
  JOURNAL   Science 273 (5277), 974-977 (1996)
   PUBMED   8688086
REFERENCE   10 (residues 1 to 364)
  AUTHORS   Banerjee,S.A., Roffler-Tarlov,S., Szabo,M., Frohman,L. and
            Chikaraishi,D.M.
  TITLE     DNA regulatory sequences of the rat tyrosine hydroxylase gene
            direct correct catecholaminergic cell-type specificity of a human
            growth hormone reporter in the CNS of transgenic mice causing a
            dwarf phenotype
  JOURNAL   Brain Res Mol Brain Res 24 (1-4), 89-106 (1994)
   PUBMED   7968381
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB001982.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB001982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Rattus norvegicus"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     Protein         1..364
                     /product="growth hormone secretagogue receptor type 1"
                     /note="GHRP; GHS-R; ghrelin receptor; GH-releasing peptide
                     receptor"
                     /calculated_mol_wt=40832
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08725.1)"
     Site            26
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08725.1)"
     Site            41..66
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O08725.1)"
     Region          44..332
                     /region_name="7tmA_GHSR"
                     /note="growth hormone secretagogue receptor, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; cd15131"
                     /db_xref="CDD:320259"
     Region          44..70
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320259"
     Site            73..96
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O08725.1)"
     Region          77..102
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320259"
     Site            order(102,119,181,196..199,280..281,284..285,299,303)
                     /site_type="other"
                     /note="putative peptide ligand binding site [polypeptide
                     binding]"
                     /db_xref="CDD:320259"
     Region          115..145
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320259"
     Site            118..139
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O08725.1)"
     Region          157..179
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320259"
     Site            163..183
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O08725.1)"
     Site            187
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O08725.1)"
     Region          208..237
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320259"
     Site            212..235
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O08725.1)"
     Region          254..284
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320259"
     Site            264..285
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O08725.1)"
     Region          300..325
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320259"
     Site            303..326
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O08725.1)"
     CDS             1..364
                     /gene="Ghsr"
                     /coded_by="NM_032075.3:1..1095"
                     /db_xref="GeneID:84022"
                     /db_xref="RGD:621397"
ORIGIN      
        1 mwnatpseep epnvtldldw daspgndslp dellplfpap llagvtatcv alfvvgisgn
       61 lltmlvvsrf relrtttnly lssmafsdll iflcmpldlv rlwqyrpwnf gdllcklfqf
      121 vsesctyatv ltitalsver yfaicfplra kvvvtkgrvk lvilviwava fcsagpifvl
      181 vgvehengtd prdtnecrat efavrsgllt vmvwvssvff flpvfcltvl ysligrklwr
      241 rrgdaavgas lrdqnhkqtv kmlavvvfaf ilcwlpfhvg rylfsksfep gsleiaqisq
      301 ycnlvsfvlf ylsaainpil ynimskkyrv avfkllgfes fsqrklstlk dessrawtks
      361 sint
//
