LOCUS       NM_001398565            1739 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus growth hormone releasing hormone receptor
            (Ghrhr), transcript variant 3, mRNA.
ACCESSION   NM_001398565 XM_017592482
VERSION     NM_001398565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1739)
  AUTHORS   Florea,V., Majid,S.S., Kanashiro-Takeuchi,R.M., Cai,R.Z.,
            Block,N.L., Schally,A.V., Hare,J.M. and Rodrigues,C.O.
  TITLE     Agonists of growth hormone-releasing hormone stimulate self-renewal
            of cardiac stem cells and promote their survival
  JOURNAL   Proc Natl Acad Sci U S A 111 (48), 17260-17265 (2014)
   PUBMED   25404316
  REMARK    GeneRIF: Data show that cardiac stem cells (CSCs) isolated from
            mouse, rat and pig myocardium express growth hormone-releasing
            hormone receptor (GHRH-R) and agonists of GHRH-R stimulate their
            proliferation and survival.
REFERENCE   2  (bases 1 to 1739)
  AUTHORS   Epitacio-Pereira,C.C., Silva,G.M., Salvatori,R., Santana,J.A.,
            Pereira,F.A., Gois-Junior,M.B., Britto,A.V., Oliveira,C.R.,
            Souza,A.H., Santos,E.G., Campos,V.C., Pereira,R.M., Valenca,E.H.,
            Barbosa,R.A., Farias,M.I., de Paula,F.J., Ribeiro,T.V.,
            Oliveira,M.C. and Aguiar-Oliveira,M.H.
  TITLE     Isolated GH deficiency due to a GHRH receptor mutation causes hip
            joint problems and genu valgum, and reduces size but not density of
            trabecular and mixed bone
  JOURNAL   J Clin Endocrinol Metab 98 (11), E1710-E1715 (2013)
   PUBMED   24057284
REFERENCE   3  (bases 1 to 1739)
  AUTHORS   Leggett,J., Harper,E., Waite,E., Marks,P., Martinez,A. and
            Lightman,S.
  TITLE     GHRH receptor-targeted botulinum neurotoxin selectively inhibits
            pulsatile GH secretion in male rats
  JOURNAL   Endocrinology 154 (9), 3305-3318 (2013)
   PUBMED   23825127
REFERENCE   4  (bases 1 to 1739)
  AUTHORS   Weigent,D.A.
  TITLE     Expression of lymphocyte-derived growth hormone (GH) and
            GH-releasing hormone receptors in aging rats
  JOURNAL   Cell Immunol 282 (2), 71-78 (2013)
   PUBMED   23770714
  REMARK    GeneRIF: Data show alterations in growth hormone (GH) synthesis and
            expression of GH-releasing hormone receptor (GHRH receptor) on
            cells of the immune system that may play a role in the immune
            response in aging.
REFERENCE   5  (bases 1 to 1739)
  AUTHORS   Penna,C., Settanni,F., Tullio,F., Trovato,L., Pagliaro,P.,
            Alloatti,G., Ghigo,E. and Granata,R.
  TITLE     GH-releasing hormone induces cardioprotection in isolated male rat
            heart via activation of RISK and SAFE pathways
  JOURNAL   Endocrinology 154 (4), 1624-1635 (2013)
   PUBMED   23417421
  REMARK    GeneRIF: GHRH protects the heart from I/R injury through
            GHRHR-mediated mechanisms, leading to activation of RISK and SAFE
            pathways, which converge on mitochondria and possibly on
            AMP-activated protein kinase.
REFERENCE   6  (bases 1 to 1739)
  AUTHORS   Lin,C., Lin,S.C., Chang,C.P. and Rosenfeld,M.G.
  TITLE     Pit-1-dependent expression of the receptor for growth hormone
            releasing factor mediates pituitary cell growth
  JOURNAL   Nature 360 (6406), 765-768 (1992)
   PUBMED   1334535
REFERENCE   7  (bases 1 to 1739)
  AUTHORS   Mayo,K.E.
  TITLE     Molecular cloning and expression of a pituitary-specific receptor
            for growth hormone-releasing hormone
  JOURNAL   Mol Endocrinol 6 (10), 1734-1744 (1992)
   PUBMED   1333056
REFERENCE   8  (bases 1 to 1739)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Adrenocorticotropic cell distribution in adult and embryonic
            pituitaries of the little (lit) mutant mouse
  JOURNAL   Anat Embryol (Berl) 186 (4), 347-353 (1992)
   PUBMED   1329576
REFERENCE   9  (bases 1 to 1739)
  AUTHORS   Beamer,W.H. and Eicher,E.M.
  TITLE     Stimulation of growth in the little mouse
  JOURNAL   J Endocrinol 71 (1), 37-45 (1976)
   PUBMED   978118
REFERENCE   10 (bases 1 to 1739)
  AUTHORS   Eicher,E.M. and Beamer,W.G.
  TITLE     Inherited ateliotic dwarfism in mice. Characteristics of the
            mutation, little, on chromosome 6
  JOURNAL   J Hered 67 (2), 87-91 (1976)
   PUBMED   1270792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 20, 2021 this sequence version replaced XM_017592482.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF122055.1, SRR26360172.463744.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               JAXUCZ010000004.1  85849905-85850046
            143-245             JAXUCZ010000004.1  85852628-85852730
            246-353             JAXUCZ010000004.1  85852841-85852948
            354-451             JAXUCZ010000004.1  85853500-85853597
            452-549             JAXUCZ010000004.1  85854594-85854691
            550-682             JAXUCZ010000004.1  85855490-85855622
            683-836             JAXUCZ010000004.1  85856948-85857101
            837-897             JAXUCZ010000004.1  85857388-85857448
            898-967             JAXUCZ010000004.1  85857867-85857936
            968-1059            JAXUCZ010000004.1  85858502-85858593
            1060-1189           JAXUCZ010000004.1  85859134-85859263
            1190-1231           JAXUCZ010000004.1  85860617-85860658
            1232-1336           JAXUCZ010000004.1  85862489-85862593
            1337-1739           JAXUCZ010000004.1  85862725-85863127
FEATURES             Location/Qualifiers
     source          1..1739
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1739
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /note="growth hormone releasing hormone receptor"
                     /db_xref="GeneID:25321"
                     /db_xref="RGD:2688"
     exon            1..142
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1405
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; GRFR; GRF receptor; GHRH receptor; growth
                     hormone-releasing factor receptor; Growth hormone -
                     releasing receptor"
                     /codon_start=1
                     /product="growth hormone-releasing hormone receptor
                     isoform 3 precursor"
                     /protein_id="NP_001385494.1"
                     /db_xref="GeneID:25321"
                     /db_xref="RGD:2688"
                     /translation="MDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQA
                     AEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWS
                     DPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCP
                     RNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFS
                     WLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLD
                     DSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYWRLSKSTLLL
                     IPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWY
                     GHDPELLPARRTCTEWTTPPRSRVKVPVYQPPTFSVPVCPHLFFLPI"
     exon            143..245
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            246..353
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            354..451
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            452..549
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            550..682
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            683..836
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            837..897
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            898..967
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1059
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1189
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1231
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1336
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1739
                     /gene="Ghrhr"
                     /gene_synonym="GHRHREC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagatgcag cttggtggca tcgccagaga cagcctggga gggaagggcc acggctcttt
       61 ggggcggact acaggcacca ctgccatgga cagcctgttg tgggctacct gggtcctctg
      121 cttgctgaac ctgtggggag ttgcactggg tcacctccac ctagaatgtg acttcatcac
      181 tcagctgaga gacgatgagc ttgcatgcct tcaggcggca gaggggacca acaactcgtc
      241 catgggatgc cctgggacct gggatgggct gctgtgctgg cccccaactg gctctggcca
      301 gtgggtctcc ctcccctgcc ctgaattctt ctctcatttt ggctcagacc caggggctgt
      361 gaaaagggac tgcaccatca cgggttggtc tgatcccttc ccaccatatc ccgtggcctg
      421 tcctgtgccc ttggaactgc taacagagga gaagtcttac ttctccacgg tgaagatcat
      481 ctacaccaca ggccacagca tctccattgt agccctctgc gtggctattg ccatcctggt
      541 tgctctcagg aggctccact gccccaggaa ctacatccac acgcagctgt ttgctacttt
      601 catcctcaag gccagtgctg tgttcctgaa ggatgctgct gtcttccagg gtgatagcac
      661 ggaccactgc agcatgtcca ctattctgtg caaggtctct gtggccgtct cacattttgc
      721 caccatgacc aacttcagct ggctgctggc agaagccgtc tacctgagct gtctgttggc
      781 ctccacatct cctaggtcca aaccagcttt ctggtggctg gttctcgctg gctggggact
      841 ccctgtgcta tgcactggta cgtgggtggg ctgcaaactg gcttttgagg acactgcgtg
      901 ctgggaccta gacgacagct ccccctactg gtggatcatc aaagggccca tagtcctctc
      961 tgttggggtg aactttgggc tgtttctcaa tataatttgc atcctgctga ggaagctggg
     1021 gcctgcacaa ggcggcttac acacacgggc tcagtactgg cggctttcca aatcaacact
     1081 tctccttatc ccgctgtttg gaattcatta catcatcttc aacttcctgc ctgacagtgc
     1141 tggccttggc atccgtctac ccctggagct gggactgggg tccttccagg gttttgttgt
     1201 tgctgtcctc tactgcttcc tcaatcaaga ggtgaggacg gagatttcac gcaaatggta
     1261 tggccatgac cctgaacttc tgccagctcg gcggacctgc actgagtgga ccacacctcc
     1321 ccgatcgaga gtgaaggtcc ctgtatacca acctccgact ttctcagttc ctgtatgccc
     1381 ccatctgttc tttcttccta tctagggcta ttgcccaagg cccagggaaa ccaataaact
     1441 tgtacatgag tgatctgcag ttgagtcaat gtggctctga aggggagctc ttgtcagcag
     1501 ccattatttg cacttccggt gcattcctca tcccttggct gcagctgcct cattgccatt
     1561 tgtctctata tgaattctca tgttttattt attttttaaa agcactcttt tgtctcaacc
     1621 cccactcccc ttcccctcct cccgcaggca aagatgtgaa tctttgcttc tctgtcttgc
     1681 aagtgtggag tgtaccacat gtctgtattt ggatgtaaat aaatgctatc tgttatgtg
//
