LOCUS       NM_031577                616 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus growth hormone releasing hormone (Ghrh), mRNA.
ACCESSION   NM_031577
VERSION     NM_031577.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 616)
  AUTHORS   Sapkota,S., Haider Ali,M., Alshamrani,A.A., Napit,P.R., Roy,S.C.,
            Pasula,M.B. and Briski,K.P.
  TITLE     GHRH Neurons from the Ventromedial Hypothalamic Nucleus Provide
            Dynamic and Sex-Specific Input to the Brain Glucose-Regulatory
            Network
  JOURNAL   Neuroscience 529, 73-87 (2023)
   PUBMED   37572878
  REMARK    GeneRIF: GHRH Neurons from the Ventromedial Hypothalamic Nucleus
            Provide Dynamic and Sex-Specific Input to the Brain
            Glucose-Regulatory Network.
REFERENCE   2  (bases 1 to 616)
  AUTHORS   Kiscsatari,L., Varga,Z., Schally,A.V., Gaspar,R., Nagy,C.T.,
            Giricz,Z., Ferdinandy,P., Fabian,G., Kahan,Z. and Gorbe,A.
  TITLE     Protection of neonatal rat cardiac myocytes against
            radiation-induced damage with agonists of growth hormone-releasing
            hormone
  JOURNAL   Pharmacol Res 111, 859-866 (2016)
   PUBMED   27480202
  REMARK    GeneRIF: GHRH agonistic analogs, JI-34 and MR-356 alleviated
            radiation-induced damage of cardiac myocytes.
REFERENCE   3  (bases 1 to 616)
  AUTHORS   Romero,M.J., Lucas,R., Dou,H., Sridhar,S., Czikora,I.,
            Mosieri,E.M., Rick,F.G., Block,N.L., Sridhar,S., Fulton,D.,
            Weintraub,N.L., Bagi,Z. and Schally,A.V.
  TITLE     Role of growth hormone-releasing hormone in dyslipidemia associated
            with experimental type 1 diabetes
  JOURNAL   Proc Natl Acad Sci U S A 113 (7), 1895-1900 (2016)
   PUBMED   26831066
  REMARK    GeneRIF: findings support the hypothesis that antagonizing the
            signaling of GHRH in T1D may improve GLP-1 function in the small
            intestine, which, in turn, diminishes TRL and reduces renal and
            vascular complications
REFERENCE   4  (bases 1 to 616)
  AUTHORS   Cai,R., Schally,A.V., Cui,T., Szalontay,L., Halmos,G., Sha,W.,
            Kovacs,M., Jaszberenyi,M., He,J., Rick,F.G., Popovics,P.,
            Kanashiro-Takeuchi,R., Hare,J.M., Block,N.L. and Zarandi,M.
  TITLE     Synthesis of new potent agonistic analogs of growth
            hormone-releasing hormone (GHRH) and evaluation of their endocrine
            and cardiac activities
  JOURNAL   Peptides 52, 104-112 (2014)
   PUBMED   24373935
  REMARK    GeneRIF: JI-38 had shown promising results in multiple fields
            including cardiology, diabetes and wound healing, our new, more
            potent, GHRH agonists should manifest additional efficacy for
            possible medical applications.
REFERENCE   5  (bases 1 to 616)
  AUTHORS   Leggett,J., Harper,E., Waite,E., Marks,P., Martinez,A. and
            Lightman,S.
  TITLE     GHRH receptor-targeted botulinum neurotoxin selectively inhibits
            pulsatile GH secretion in male rats
  JOURNAL   Endocrinology 154 (9), 3305-3318 (2013)
   PUBMED   23825127
REFERENCE   6  (bases 1 to 616)
  AUTHORS   Lin,C., Lin,S.C., Chang,C.P. and Rosenfeld,M.G.
  TITLE     Pit-1-dependent expression of the receptor for growth hormone
            releasing factor mediates pituitary cell growth
  JOURNAL   Nature 360 (6406), 765-768 (1992)
   PUBMED   1334535
REFERENCE   7  (bases 1 to 616)
  AUTHORS   Asa,S.L., Kovacs,K., Stefaneanu,L., Horvath,E., Billestrup,N.,
            Gonzalez-Manchon,C. and Vale,W.
  TITLE     Pituitary adenomas in mice transgenic for growth hormone-releasing
            hormone
  JOURNAL   Endocrinology 131 (5), 2083-2089 (1992)
   PUBMED   1425411
REFERENCE   8  (bases 1 to 616)
  AUTHORS   Mayo,K.E.
  TITLE     Molecular cloning and expression of a pituitary-specific receptor
            for growth hormone-releasing hormone
  JOURNAL   Mol Endocrinol 6 (10), 1734-1744 (1992)
   PUBMED   1333056
REFERENCE   9  (bases 1 to 616)
  AUTHORS   Bagnato,A., Moretti,C., Ohnishi,J., Frajese,G. and Catt,K.J.
  TITLE     Expression of the growth hormone-releasing hormone gene and its
            peptide product in the rat ovary
  JOURNAL   Endocrinology 130 (3), 1097-1102 (1992)
   PUBMED   1537276
REFERENCE   10 (bases 1 to 616)
  AUTHORS   Gonzalez-Crespo,S. and Boronat,A.
  TITLE     Expression of the rat growth hormone-releasing hormone gene in
            placenta is directed by an alternative promoter
  JOURNAL   Proc Natl Acad Sci U S A 88 (19), 8749-8753 (1991)
   PUBMED   1924334
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M73486.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M73486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..616
                     /gene="Ghrh"
                     /gene_synonym="GHRF"
                     /note="growth hormone releasing hormone"
                     /db_xref="GeneID:29446"
                     /db_xref="RGD:61883"
     exon            1..175
                     /gene="Ghrh"
                     /gene_synonym="GHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            176..275
                     /gene="Ghrh"
                     /gene_synonym="GHRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..510
                     /gene="Ghrh"
                     /gene_synonym="GHRF"
                     /note="somatoliberin; GRF; growth hormone-releasing
                     factor"
                     /codon_start=1
                     /product="somatoliberin precursor"
                     /protein_id="NP_113765.1"
                     /db_xref="GeneID:29446"
                     /db_xref="RGD:61883"
                     /translation="MPLWVFFVLLTLTSGSHCSLPPSPPFRVRRHADAIFTSSYRRIL
                     GQLYARKLLHEIMNRQQGERNQEQRSRFNRHLDRVWAEDKQMALESILQGFPRMKLSA
                     EA"
     exon            276..380
                     /gene="Ghrh"
                     /gene_synonym="GHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            381..471
                     /gene="Ghrh"
                     /gene_synonym="GHRF"
                     /inference="alignment:Splign:2.1.0"
     exon            472..608
                     /gene="Ghrh"
                     /gene_synonym="GHRF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgtgctc tggaacatgc aggcccagga cggagaagga ggcgtcctgc tcctgccagc
       61 cttaagatgg gaattttagg gtctggacat cactggtgct ccaggtcagc tttcctggtt
      121 gcagatctct cctggtcaag gctcccagct cgcctggatc ccacaactgc acagtgtccc
      181 gcccaggagt gaaggatgcc actctgggtg ttctttgtgc tcctcaccct caccagtggc
      241 tcccactgct cactgccccc ctcacctccc ttcagggtgc ggcggcatgc agacgccatc
      301 ttcaccagca gctaccggag aatcctgggc caattatatg cccgcaaact gctgcacgaa
      361 atcatgaaca ggcagcaagg ggagaggaac caggaacaaa gatccaggtt caaccgccat
      421 ttggacagag tgtgggcaga ggacaagcag atggccctgg agagcatctt gcagggattc
      481 ccaaggatga agctttcagc ggaggcttga gccctcggcc cccaaacata gctggaccct
      541 gttacttcta cttcagttct gatcttctcc ttcctctgtg aatacaataa agacccatct
      601 catctgcaaa aaaaaa
//
