LOCUS       NM_017094               2941 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Rattus norvegicus growth hormone receptor (Ghr), mRNA.
ACCESSION   NM_017094
VERSION     NM_017094.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2941)
  AUTHORS   Klammt,J., Shen,S., Kiess,W., Kratzsch,J., Stobbe,H., Vogel,M.,
            Luo,F. and Pfaffle,R.
  TITLE     Clinical and biochemical consequences of an intragenic growth
            hormone receptor (GHR) deletion in a large Chinese pedigree
  JOURNAL   Clin Endocrinol (Oxf) 82 (3), 453-461 (2015)
   PUBMED   25196842
REFERENCE   2  (bases 1 to 2941)
  AUTHORS   Deng,H.Z., Deng,H., Cen,C.Q., Chen,K.Y. and Du,M.L.
  TITLE     Post-receptor crosstalk between growth hormone and insulin signal
            in rats born small for gestational age with catch-up growth
  JOURNAL   PLoS One 9 (6), e100459 (2014)
   PUBMED   24963636
  REMARK    GeneRIF: receptor crosstalk between growth hormone and insulin
            signal in rats born small for gestational age with catch-up growth
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2941)
  AUTHORS   Claessen,K.M., Kloppenburg,M., Kroon,H.M., Bijsterbosch,J.,
            Pereira,A.M., Romijn,J.A., van der Straaten,T., Nelissen,R.G.,
            Hofman,A., Uitterlinden,A.G., Duijnisveld,B.J., Lakenberg,N.,
            Beekman,M., van Meurs,J.B., Slagboom,P.E., Biermasz,N.R. and
            Meulenbelt,I.
  TITLE     Relationship between the functional exon 3 deleted growth hormone
            receptor polymorphism and symptomatic osteoarthritis in women
  JOURNAL   Ann Rheum Dis 73 (2), 433-436 (2014)
   PUBMED   23740230
REFERENCE   4  (bases 1 to 2941)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 2941)
  AUTHORS   Enhamre,E., Carlsson,A., Gronbladh,A., Watanabe,H., Hallberg,M. and
            Nyberg,F.
  TITLE     The expression of growth hormone receptor gene transcript in the
            prefrontal cortex is affected in male mice with diabetes-induced
            learning impairments
  JOURNAL   Neurosci Lett 523 (1), 82-86 (2012)
   PUBMED   22750159
REFERENCE   6  (bases 1 to 2941)
  AUTHORS   Frick,G.P. and Goodman,H.M.
  TITLE     Characterization of the short isoform of the growth hormone
            receptor synthesized by rat adipocytes
  JOURNAL   Endocrinology 131 (6), 3083-3090 (1992)
   PUBMED   1446642
REFERENCE   7  (bases 1 to 2941)
  AUTHORS   de Vos,A.M., Ultsch,M. and Kossiakoff,A.A.
  TITLE     Human growth hormone and extracellular domain of its receptor:
            crystal structure of the complex
  JOURNAL   Science 255 (5042), 306-312 (1992)
   PUBMED   1549776
REFERENCE   8  (bases 1 to 2941)
  AUTHORS   Godowski,P.J., Leung,D.W., Meacham,L.R., Galgani,J.P., Hellmiss,R.,
            Keret,R., Rotwein,P.S., Parks,J.S., Laron,Z. and Wood,W.I.
  TITLE     Characterization of the human growth hormone receptor gene and
            demonstration of a partial gene deletion in two patients with
            Laron-type dwarfism
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 8083-8087 (1989)
   PUBMED   2813379
REFERENCE   9  (bases 1 to 2941)
  AUTHORS   Baumbach,W.R., Horner,D.L. and Logan,J.S.
  TITLE     The growth hormone-binding protein in rat serum is an alternatively
            spliced form of the rat growth hormone receptor
  JOURNAL   Genes Dev 3 (8), 1199-1205 (1989)
   PUBMED   2792761
REFERENCE   10 (bases 1 to 2941)
  AUTHORS   Mathews,L.S., Enberg,B. and Norstedt,G.
  TITLE     Regulation of rat growth hormone receptor gene expression
  JOURNAL   J Biol Chem 264 (17), 9905-9910 (1989)
   PUBMED   2722883
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017094.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04811.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000002.1  54431902-54432075   c
            175-253             JAXUCZ010000002.1  54418526-54418604   c
            254-319             JAXUCZ010000002.1  54351981-54352046   c
            320-449             JAXUCZ010000002.1  54304431-54304560   c
            450-622             JAXUCZ010000002.1  54298368-54298540   c
            623-801             JAXUCZ010000002.1  54285767-54285945   c
            802-970             JAXUCZ010000002.1  54279713-54279881   c
            971-1061            JAXUCZ010000002.1  54277635-54277725   c
            1062-1131           JAXUCZ010000002.1  54272313-54272382   c
            1132-2941           JAXUCZ010000002.1  54270206-54272015   c
FEATURES             Location/Qualifiers
     source          1..2941
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..2941
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="growth hormone receptor"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
     exon            1..174
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            175..253
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2100
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /note="growth hormone receptor/binding protein; GH
                     receptor; somatotropin receptor; growth hormone receptor
                     variant d5-6"
                     /codon_start=1
                     /product="growth hormone receptor precursor"
                     /protein_id="NP_058790.1"
                     /db_xref="GeneID:25235"
                     /db_xref="RGD:2687"
                     /translation="MDLWRVFLTLALAVSSDMFPGSGATPATLGKASPVLQRINPSLR
                     ESSSGKPRFTKCRSPELETFSCYWTEGDDHNLKVPGSIQLYYARRIAHEWTPEWKECP
                     DYVSAGANSCYFNSSYTSIWIPYCIKLTTNGDLLDEKCFTVDEIVQPDPPIGLNWTLL
                     NISLPGIRGDIQVSWQPPPSADVLKGWIILEYEIQYKEVNETKWKTMSPIWSTSVPLY
                     SLRLDKEHEVRVRSRQRSFEKYSEFSEVLRVTFPQMDTLAACEEDFRFPWFLIIIFGI
                     FGVAVMLFVVIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILGIHDNYK
                     PDFYNDDSWVEFIELDIDDADEKTEESDTDRLLSDDQEKSAGILGAKDDDSGRTSCYD
                     PDILDTDFHTSDMCDGTSEFAQPQKLKAEADLLCLDQKNLKNSPYDASLGSLHPSITL
                     TMEDKPQPLLGSETESTHQLPSTPMSSPVSLANIDFYAQVSDITPAGGVVLSPGQKIK
                     AGLAQGNTQLEVAAPCQENYSMNSAYFCESDAKKCIAAAPHMEATTCVKPSFNQEDIY
                     ITTESLTTTARMSETADTAPDAEPVPDYTTVHTVKSPRGLILNATALPLPDKKKFLSS
                     CGYVSTDQLNKIMQ"
     exon            254..319
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            320..449
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            450..622
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            623..801
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            802..970
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1061
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1131
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..2941
                     /gene="Ghr"
                     /gene_synonym="GHR/BP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagagacca caagatagag gattattaat ttatggggat tttttggaga tttatatacc
       61 caagcaacaa ctcctagatg ctacagacca agacaccaag aaataaccac gaaattctac
      121 tttcaaccct agcttctcta ccagatttta actaaacaag atcttcttgc aaaggtctca
      181 ggtatggatc tttggcgggt gttcttaacc ctggcactgg cagtctccag cgacatgttt
      241 cctggaagtg gggctacacc agctactctt ggcaaagctt ccccggttct gcaaagaatt
      301 aatccaagcc tgagggaaag ttcctctgga aagcctcgat tcaccaagtg tcgttcccct
      361 gaactggaga ccttttcatg ctactggaca gaaggggatg atcataattt aaaggtcccg
      421 ggatctattc agctatacta tgctagaaga attgctcatg aatggacccc ggaatggaaa
      481 gaatgccctg attatgtctc tgctggagca aacagctgtt acttcaactc atcgtatacc
      541 tccatttgga taccctactg cattaagctt actacaaatg gtgatttgtt ggacgaaaag
      601 tgtttcactg ttgatgaaat agtgcaacct gatccgccca ttggcctcaa ctggacttta
      661 ctaaacatca gtttgcctgg gatccgtgga gatatccaag tgagttggca gccaccgccc
      721 agtgccgatg ttctgaaggg atggataatt ctggagtatg aaattcagta caaagaagta
      781 aatgaaacaa aatggaaaac gatgagcccg atatggtcaa catcagtccc actgtactca
      841 ctgagactgg ataaagagca cgaagtgcgt gtgagatcca gacaacggag cttcgaaaag
      901 tacagcgagt tcagtgaagt actccgtgta acgtttcctc agatggacac actggcagca
      961 tgtgaagaag atttccggtt tccatggttc ttaattatta tctttggaat atttggagta
     1021 gcagtgatgc tatttgtagt tatattttca aagcagcaaa ggattaagat gctgatttta
     1081 cccccagtac cagttccaaa gattaaaggg attgatccag atcttctcaa ggaaggaaaa
     1141 ttggaggagg tgaacaccat cttgggcatt catgataact acaaacccga cttctacaat
     1201 gatgactcct gggttgagtt cattgagctg gatattgatg atgcggatga gaagactgaa
     1261 gagtcagaca ccgacagact tctaagcgat gaccaggaga aatcagctgg tatccttgga
     1321 gcaaaggatg acgattctgg acgtaccagc tgttatgacc ctgacatttt ggataccgat
     1381 ttccacacca gtgacatgtg cgatggtacc tcggagtttg ctcagccgca gaagttaaaa
     1441 gcagaagctg atctcttgtg ccttgaccag aagaatctga agaactcgcc ttatgatgct
     1501 tcccttggct ctctgcaccc ctccattacc ctgacaatgg aagacaaacc acagccactt
     1561 ctgggcagtg aaactgagtc aacccaccaa ctcccctcta caccaatgag cagtcccgtg
     1621 tcactggcaa acattgactt ttatgcccaa gtaagcgaca ttacaccagc aggtggtgta
     1681 gtcctttctc caggccaaaa gattaaggca gggttagccc agggcaacac ccagctggag
     1741 gtggccgcgc cctgccaaga aaattacagc atgaacagtg cctacttctg tgagtcagat
     1801 gccaaaaagt gcatcgctgc ggcccctcac atggaggcca cgacatgtgt aaaaccaagc
     1861 tttaaccaag aggacattta catcaccaca gaaagcctta ccactactgc ccgaatgtcc
     1921 gagacagcag ataccgctcc agatgctgag cctgtcccag actacaccac ggttcacacc
     1981 gtgaagtccc caaggggcct tatactcaac gcgactgctt tgcctttgcc tgacaaaaag
     2041 aagtttctct cctcatgtgg ctatgtgagc acagaccaac tgaacaaaat catgcagtag
     2101 cctttcctat ctttaatggc aaaagaaatg actgggcacg aacgcctaaa ccaaaactat
     2161 gttttaaatc tgtgttggga gagcgtgaga gtgaatgtgg attcaaaaat accttttctg
     2221 gaaacgtcga aacattatca taacgtggaa aatcaagaat atgtaatcag atagatactc
     2281 ccattgtgaa ttttaaatat tttaaagaat cgtctttaag actgtttagt ggcagtgatt
     2341 gtctgtgctg tgggtcttaa ctttgtgata ctaagtatta aatagctacg tttttcatgt
     2401 atgtagatca tgcttttttg aaaaagcaaa acaatcaggt ggcttttgca gttcaggaaa
     2461 ttgaatgcag attttagcac agactgattt ctttttcctt tttaaatagc taggagctaa
     2521 aactctaggg gagaaggtaa aactagtttg gatatgcaaa acatttattt tgacataaaa
     2581 ttgataaaga tatttttaat aatttacact gtaagcatga gtattttata atacactaca
     2641 gatatattgt agttcacaac aatccatcta cggatgtaac aactacaatg tgtagagggg
     2701 ttgatgcttt ggtcaatgaa cctaaagaaa aatgaacaag ttagattttt acaaagccct
     2761 tttttataac tcccaaaact tcttaaatct aaaaatgtct gcattattgg aacaaaccca
     2821 ttttaaattt gtaaatgaat atttttttaa ttttgaaaac tttaattttt tatacaaatt
     2881 aacgtatcat acaccaaaca gtaacagaag tgattataat aatggaagaa acagtttctt
     2941 c
//
