LOCUS       NM_001034848             826 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus growth hormone 1 (Gh1), mRNA.
ACCESSION   NM_001034848
VERSION     NM_001034848.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 826)
  AUTHORS   Ortiz,J.B., Tellez,S., Rampal,G., Mannino,G.S., Couillard,N.,
            Mendez,M., Green,T.R.F., Murphy,S.M. and Rowe,R.K.
  TITLE     Diffuse traumatic brain injury substantially alters plasma growth
            hormone in the juvenile rat
  JOURNAL   J Endocrinol 260 (1), e230157 (2023)
   PUBMED   37855319
  REMARK    GeneRIF: Diffuse traumatic brain injury substantially alters plasma
            growth hormone in the juvenile rat.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 826)
  AUTHORS   Barrios,V., Frago,L.M., Canelles,S., Guerra-Cantera,S.,
            Arilla-Ferreiro,E., Chowen,J.A. and Argente,J.
  TITLE     Leptin Modulates the Response of Brown Adipose Tissue to Negative
            Energy Balance: Implication of the GH/IGF-I Axis
  JOURNAL   Int J Mol Sci 22 (6), 2827 (2021)
   PUBMED   33799501
  REMARK    GeneRIF: Leptin Modulates the Response of Brown Adipose Tissue to
            Negative Energy Balance: Implication of the GH/IGF-I Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 826)
  AUTHORS   Martin-Rodriguez,J.F., Ramos-Herrero,V.D., Parras,G.G.,
            Flores-Martinez,A., Madrazo-Atutxa,A., Cano,D.A., Gruart,A.,
            Delgado-Garcia,J.M., Leal-Cerro,A. and Leal-Campanario,R.
  TITLE     Chronic adult-onset of growth hormone/IGF-I hypersecretion improves
            cognitive functions and LTP and promotes neuronal differentiation
            in adult rats
  JOURNAL   Acta Physiol (Oxf) 229 (2), e13293 (2020)
   PUBMED   31059193
  REMARK    GeneRIF: Chronic adult-onset of growth hormone/IGF-I hypersecretion
            improves cognitive functions and LTP and promotes neuronal
            differentiation in adult rats.
REFERENCE   4  (bases 1 to 826)
  AUTHORS   Cheng,Y., Chen,T., Song,J., Qi,Q., Wang,C., Xi,Q., Liu,S., Hao,L.
            and Zhang,Y.
  TITLE     miR-709 inhibits GHRP6 induced GH synthesis by targeting PRKCA in
            pituitary
  JOURNAL   Mol Cell Endocrinol 506, 110763 (2020)
   PUBMED   32084499
  REMARK    GeneRIF: miR-709 inhibits GHRP6 induced GH synthesis by targeting
            PRKCA in pituitary.
REFERENCE   5  (bases 1 to 826)
  AUTHORS   Di Pasquale,C., Gentilin,E., Falletta,S., Bellio,M., Buratto,M.,
            Degli Uberti,E. and Chiara Zatelli,M.
  TITLE     PI3K/Akt/mTOR pathway involvement in regulating growth hormone
            secretion in a rat pituitary adenoma cell line
  JOURNAL   Endocrine 60 (2), 308-316 (2018)
   PUBMED   29080043
  REMARK    GeneRIF: IGF1 exerts a negative feedback on GH secretion by a
            transcriptional mechanism.
REFERENCE   6  (bases 1 to 826)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Adrenocorticotropic cell distribution in adult and embryonic
            pituitaries of the little (lit) mutant mouse
  JOURNAL   Anat Embryol (Berl) 186 (4), 347-353 (1992)
   PUBMED   1329576
REFERENCE   7  (bases 1 to 826)
  AUTHORS   de Vos,A.M., Ultsch,M. and Kossiakoff,A.A.
  TITLE     Human growth hormone and extracellular domain of its receptor:
            crystal structure of the complex
  JOURNAL   Science 255 (5042), 306-312 (1992)
   PUBMED   1549776
REFERENCE   8  (bases 1 to 826)
  AUTHORS   Bouillon,R.
  TITLE     Diabetic bone disease. Low turnover osteoporosis related to
            decreased IGF-I production
  JOURNAL   Verh K Acad Geneeskd Belg 54 (4), 365-91 (1992)
   PUBMED   1466160
REFERENCE   9  (bases 1 to 826)
  AUTHORS   Seeburg,P.H., Shine,J., Martial,J.A., Baxter,J.D. and Goodman,H.M.
  TITLE     Nucleotide sequence and amplification in bacteria of structural
            gene for rat growth hormone
  JOURNAL   Nature 270 (5637), 486-494 (1977)
   PUBMED   339105
REFERENCE   10 (bases 1 to 826)
  AUTHORS   Navalesi,R., Pilo,A. and Vigneri,R.
  TITLE     Growth hormone kinetics in diabetic patients
  JOURNAL   Diabetes 24 (4), 317-327 (1975)
   PUBMED   1132599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB316202.1, BC166872.1 and BI278832.1.
            
            On Mar 24, 2010 this sequence version replaced NM_001034848.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB314606.1, BC166872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663594, SAMN13663595
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               CB316202.1         4-508
            506-808             BC166872.1         506-808
            809-826             BI278832.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..826
                     /gene="Gh1"
                     /gene_synonym="Gh; Ghb1; RNGHGP"
                     /note="growth hormone 1"
                     /db_xref="GeneID:24391"
                     /db_xref="RGD:2686"
     exon            1..71
                     /gene="Gh1"
                     /gene_synonym="Gh; Ghb1; RNGHGP"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..712
                     /gene="Gh1"
                     /gene_synonym="Gh; Ghb1; RNGHGP"
                     /note="somatotropin; growth hormone b1"
                     /codon_start=1
                     /product="somatotropin precursor"
                     /protein_id="NP_001030020.2"
                     /db_xref="GeneID:24391"
                     /db_xref="RGD:2686"
                     /translation="MAADSQTPWLLTFSLLCLLWPQEAGAFPAMPLSSLFANAVLRAQ
                     HLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKEEAQQRTDMELLR
                     FSLLLIQSWLGPVQFLSRIFTNSLMFGTSDRVYEKLKDLEEGIQALMQELEDGSPRIG
                     QILKQTYDKFDANMRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFAESSCAF"
     exon            72..232
                     /gene="Gh1"
                     /gene_synonym="Gh; Ghb1; RNGHGP"
                     /inference="alignment:Splign:2.1.0"
     exon            233..349
                     /gene="Gh1"
                     /gene_synonym="Gh; Ghb1; RNGHGP"
                     /inference="alignment:Splign:2.1.0"
     exon            350..511
                     /gene="Gh1"
                     /gene_synonym="Gh; Ghb1; RNGHGP"
                     /inference="alignment:Splign:2.1.0"
     exon            512..811
                     /gene="Gh1"
                     /gene_synonym="Gh; Ghb1; RNGHGP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcaccctc gagcccagat tccaaactgc tcaggtcctg tggacagatc actgagtggc
       61 gatggctgca gactctcaga ctccctggct cctgaccttc agcctgctct gcctgctgtg
      121 gcctcaagag gctggtgctt tccctgccat gcccttgtcc agtctgtttg ccaatgctgt
      181 gctccgagcc cagcacctgc accagctggc tgctgacacc tacaaagagt tcgagcgtgc
      241 ctacattccc gagggacagc gctattccat tcagaatgcc caggctgcgt tctgcttctc
      301 agagaccatc ccagccccca ccggcaagga ggaggcccag cagagaactg acatggaatt
      361 gcttcgcttc tcgctgctgc tcatccagtc atggctgggg cccgtgcagt ttctcagcag
      421 gatctttacc aacagcctga tgtttggtac ctcggaccgc gtctatgaga aactgaagga
      481 cctggaagag ggcatccagg ctctgatgca ggagctggaa gacggcagcc cccgtattgg
      541 gcagatcctc aagcaaacct atgacaagtt tgacgccaac atgcgcagcg atgacgctct
      601 gctcaaaaac tatgggctgc tctcctgctt caagaaggac ctgcacaagg cagagaccta
      661 cctgcgggtc atgaagtgtc gccgctttgc ggaaagcagc tgtgctttct aggcacacac
      721 tggtgtctct gcggcactcc cccgttaccc ccctgtactc tggcaactgc cacccctaca
      781 ctttgtccta ataaaattaa gatgcatcat aaaaaaaaaa aaaaaa
//
