LOCUS       NM_019235               2636 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus gamma-glutamyltransferase 5 (Ggt5), mRNA.
ACCESSION   NM_019235
VERSION     NM_019235.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Wickham,S., West,M.B., Cook,P.F. and Hanigan,M.H.
  TITLE     Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl
            transpeptidase enzymes
  JOURNAL   Anal Biochem 414 (2), 208-214 (2011)
   PUBMED   21447318
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Han,B., Luo,G., Shi,Z.Z., Barrios,R., Atwood,D., Liu,W.,
            Habib,G.M., Sifers,R.N., Corry,D.B. and Lieberman,M.W.
  TITLE     Gamma-glutamyl leukotrienase, a novel endothelial membrane protein,
            is specifically responsible for leukotriene D(4) formation in vivo
  JOURNAL   Am J Pathol 161 (2), 481-490 (2002)
   PUBMED   12163373
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Carter,B.Z., Shi,Z.Z., Barrios,R. and Lieberman,M.W.
  TITLE     gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene
            family member, is expressed primarily in spleen
  JOURNAL   J Biol Chem 273 (43), 28277-28285 (1998)
   PUBMED   9774450
REFERENCE   4  (bases 1 to 2636)
  AUTHORS   Potdar,P.D., Andrews,K.L., Nettesheim,P. and Ostrowski,L.E.
  TITLE     Expression and regulation of gamma-glutamyl transpeptidase-related
            enzyme in tracheal cells
  JOURNAL   Am J Physiol 273 (5), L1082-L1089 (1997)
   PUBMED   9374738
REFERENCE   5  (bases 1 to 2636)
  AUTHORS   Heisterkamp,N., Rajpert-De Meyts,E., Uribe,L., Forman,H.J. and
            Groffen,J.
  TITLE     Identification of a human gamma-glutamyl cleaving enzyme related
            to, but distinct from, gamma-glutamyl transpeptidase
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6303-6307 (1991)
   PUBMED   1676842
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087018.1.
            
            On Dec 26, 2004 this sequence version replaced NM_019235.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087018.1, U76252.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132276,
                                           SAMD00132292 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2636
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /note="gamma-glutamyltransferase 5"
                     /db_xref="GeneID:29566"
                     /db_xref="RGD:2684"
     exon            1..436
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1982
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="gamma-glutamyltransferase-like activity 1; GGL; GGT
                     5; GGT-rel; gamma-glutamyl leukotrienase;
                     gamma-glutamyltranspeptidase 5; gamma-glutamyl
                     transpeptidase-related enzyme; leukotriene-C4 hydrolase"
                     /codon_start=1
                     /product="glutathione hydrolase 5 proenzyme"
                     /protein_id="NP_062108.2"
                     /db_xref="GeneID:29566"
                     /db_xref="RGD:2684"
                     /translation="MAWGHRTTVCLVLLGVSLGLAIIVLAVVLPHHQASCRPDAFTRA
                     AVAADSKICSDIGRVILQQQGSPVDAAIAALICTGVVNPQSMGLGGGVVFTIYNASTG
                     KVEVINARETVPASHDQRLLDQCTNALPLCTGAQWIGVPGELRGYAEAHRRYGRLPWA
                     QLFQPTIALLREGFRVPPILSQFLNTSFLQPCLNSSTLRQLFFNGTETLRSQDPLPWP
                     ALANTLETVAKEGAEVLYTGKLGQTLVEDIAWQGSQLTVQDLAAFRPKVVEPLEMALG
                     NYTLYSPPPPAGGAILSFILNVLKGFNFSAETVAGPEGKVNMYHHLVEALKFAVGQRW
                     RLWDPYSHPGIQNISQDLLRETLAQHIRQQIDGRGDHQLSHYNLSGVRGNSMGTSHVS
                     VLGEDGSAVAATSTINTPFGAMVYSPRTGILLNNELLDLCWRHKPGSTVTPPPVPGEQ
                     PPSSMVPSILINEVQGSKLVIGGAGGELIISAVTQAIVNKLWLGFSLTDAIAAPILHV
                     NSKGHVEYEPKFNQEVRKGLQDRGQSQSQSQRPVFLNSVQAVFQEGPCVYAASDLRKA
                     GKASGY"
     exon            437..567
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..663
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..859
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1017
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1164
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1301
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1492
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1599
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1718
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1829
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2594
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcagtgg aggaggtagc aacagtctgg ctggccagct tcccggttgc tcctccgtaa
       61 cctgcctggc tacctatctg taagcctgtc cgttatcctt cctatccagt tgtctgatct
      121 gtgcaactgt ctcttgctgg acccatcgat ctttcccatc tgtccaatcg cctgagttca
      181 cccttcatct ggcagtcagt ttgtccctct gtctgcccac tgccctgtgt gtccagctgc
      241 ctctctccct ggaccactga gccatggcat ggggccatag gaccacagtc tgcctggtcc
      301 tgctgggtgt gagtctgggt ctggccatca ttgtgctggc tgtggtcctt cctcatcacc
      361 aagcctcttg ccgtcccgat gccttcactc gtgctgccgt agctgctgat tctaagatct
      421 gctcagatat tggacgagtc atcctccagc agcagggctc acctgtggac gccgccattg
      481 ctgccctcat ctgtaccggt gttgttaacc ctcagagcat gggcctgggc ggaggggtcg
      541 tcttcaccat ctacaatgca tctacaggga aggtggaggt catcaatgct cgggagacag
      601 tgccagccag ccatgaccag agactgctag accagtgtac aaatgccctg ccactgtgca
      661 caggggccca gtggatcggg gttcctggtg agctccgcgg ctatgctgag gcgcaccgcc
      721 gatacggccg cctgccttgg gctcagcttt tccagcccac cattgccctg ctccgagagg
      781 gtttccgtgt gccccctatc ctcagtcagt tcctcaacac cagcttcctg cagccctgct
      841 tgaattcatc aaccctgaga cagctcttct tcaatgggac agaaaccttg agatctcagg
      901 acccactccc atggcctgcg ctggccaaca ccttggagac tgtggctaag gagggtgcag
      961 aggtcttata caccggaaag ctgggacaaa cgctggtgga agacattgcc tggcaaggaa
     1021 gccagctgac ggttcaggac ttggctgcct tccggccgaa agtggtggaa cccctggaga
     1081 tggccctagg aaactatacc ctgtactctc caccgccgcc ggcagggggc gctattctta
     1141 gcttcattct caacgtgctg aaagggttca acttctctgc agagacggtg gccgggcctg
     1201 aagggaaggt gaacatgtac caccaccttg tagaggctct caagttcgca gtagggcaga
     1261 ggtggcggct atgggacccc tacagccacc cagggataca gaacatctcc caggaccttc
     1321 tccgggagac tctagcccag cacatccgcc agcagattga tggccgtggt gaccaccagc
     1381 tcagccatta caacctgtcc ggggtcaggg gcaacagcat gggcacgtct catgtgtctg
     1441 tgttgggaga agacggcagc gctgtggcag ccaccagcac catcaacaca ccctttggag
     1501 cgatggtgta ctccccacgg acaggcatcc tcctcaacaa cgagctacta gacttatgct
     1561 ggagacacaa gccaggttca acggtcaccc ctccccctgt tccaggtgag cagccaccat
     1621 catccatggt accctccatc ttgatcaacg aagtccaggg gtcgaagctg gtgatcggtg
     1681 gggctggtgg ggagcttatc atctctgctg tgacccaggc tatcgtgaat aagctgtggc
     1741 ttggctttag cctgacagac gccatcgcag cgcccatcct acatgtgaat agcaagggcc
     1801 acgtggaata tgagcccaag tttaaccagg aggttcggaa ggggctacag gaccgaggcc
     1861 agagccagag ccagagccag aggccggttt tcctgaattc ggtccaggct gtgtttcagg
     1921 aagggccctg tgtctatgca gcatctgacc tgaggaaggc tggaaaggct tcaggatact
     1981 aagacagctc tgcccagggc taggatctgg cccactgtga gtcctgtgcc tgacatggat
     2041 gatgctgtac gtctaaatac tccaggaccc ggatcccttg ctctgagacc tacctgggac
     2101 caaaagaaca gggatcagcc cagccgatga atgaatgaag agggaaggat tgacttgtcc
     2161 ctggtcccgt cccaacacct cctgtggccc tgccctgttt cttctagcct tgccctccct
     2221 ggcctcatgc tcacactcca aatggtgtac ctcccagtcc acagtgtgaa ctgatttagt
     2281 ggttctaagc agttaaaggg accctcggat agttcccagt gatatgcaac acaccacaga
     2341 ctcctacggt ccttcatgac ttgccatcgg ggccaagaga tgagccaggc ttcacaaggc
     2401 tcagcggaca ggggcaagca caccgcccac gtctactctg ctcctgctac aatatctctt
     2461 ccgggggttt cgcaatgtgt ctgctccccc caccctctgt cttgcctgct ggtgggaaga
     2521 caggagtgtg gcttgtagta cttatgtttt gctccactca ggaaaaggtt ggataaagca
     2581 gagctcggtc ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
