LOCUS       NP_062108                572 aa            linear   ROD 03-APR-2024
DEFINITION  glutathione hydrolase 5 proenzyme [Rattus norvegicus].
ACCESSION   NP_062108
VERSION     NP_062108.2
DBSOURCE    REFSEQ: accession NM_019235.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 572)
  AUTHORS   Wickham,S., West,M.B., Cook,P.F. and Hanigan,M.H.
  TITLE     Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl
            transpeptidase enzymes
  JOURNAL   Anal Biochem 414 (2), 208-214 (2011)
   PUBMED   21447318
REFERENCE   2  (residues 1 to 572)
  AUTHORS   Han,B., Luo,G., Shi,Z.Z., Barrios,R., Atwood,D., Liu,W.,
            Habib,G.M., Sifers,R.N., Corry,D.B. and Lieberman,M.W.
  TITLE     Gamma-glutamyl leukotrienase, a novel endothelial membrane protein,
            is specifically responsible for leukotriene D(4) formation in vivo
  JOURNAL   Am J Pathol 161 (2), 481-490 (2002)
   PUBMED   12163373
REFERENCE   3  (residues 1 to 572)
  AUTHORS   Carter,B.Z., Shi,Z.Z., Barrios,R. and Lieberman,M.W.
  TITLE     gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene
            family member, is expressed primarily in spleen
  JOURNAL   J Biol Chem 273 (43), 28277-28285 (1998)
   PUBMED   9774450
REFERENCE   4  (residues 1 to 572)
  AUTHORS   Potdar,P.D., Andrews,K.L., Nettesheim,P. and Ostrowski,L.E.
  TITLE     Expression and regulation of gamma-glutamyl transpeptidase-related
            enzyme in tracheal cells
  JOURNAL   Am J Physiol 273 (5), L1082-L1089 (1997)
   PUBMED   9374738
REFERENCE   5  (residues 1 to 572)
  AUTHORS   Heisterkamp,N., Rajpert-De Meyts,E., Uribe,L., Forman,H.J. and
            Groffen,J.
  TITLE     Identification of a human gamma-glutamyl cleaving enzyme related
            to, but distinct from, gamma-glutamyl transpeptidase
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6303-6307 (1991)
   PUBMED   1676842
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087018.1.
            
            On Dec 26, 2004 this sequence version replaced NP_062108.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087018.1, U76252.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132276,
                                           SAMD00132292 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..572
                     /product="glutathione hydrolase 5 proenzyme"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="gamma-glutamyltransferase-like activity 1; GGL; GGT
                     5; GGT-rel; gamma-glutamyl leukotrienase;
                     gamma-glutamyltranspeptidase 5; gamma-glutamyl
                     transpeptidase-related enzyme; leukotriene-C4 hydrolase"
                     /calculated_mol_wt=61439
     Site            7..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWE9.2)"
     Region          58..567
                     /region_name="G_glu_transpept"
                     /note="Gamma-glutamyltranspeptidase; pfam01019"
                     /db_xref="CDD:425991"
     Site            98
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QWE9.2)"
     Site            185
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QWE9.2)"
     Site            194
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QWE9.2)"
     Site            204
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QWE9.2)"
     Site            277
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QWE9.2)"
     Site            303
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QWE9.2)"
     Site            347
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QWE9.2)"
     Site            377
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QWE9.2)"
     CDS             1..572
                     /gene="Ggt5"
                     /gene_synonym="Ggta1; Ggtla1"
                     /coded_by="NM_019235.2:264..1982"
                     /db_xref="GeneID:29566"
                     /db_xref="RGD:2684"
ORIGIN      
        1 mawghrttvc lvllgvslgl aiivlavvlp hhqascrpda ftraavaads kicsdigrvi
       61 lqqqgspvda aiaalictgv vnpqsmglgg gvvftiynas tgkvevinar etvpashdqr
      121 lldqctnalp lctgaqwigv pgelrgyaea hrrygrlpwa qlfqptiall regfrvppil
      181 sqflntsflq pclnsstlrq lffngtetlr sqdplpwpal antletvake gaevlytgkl
      241 gqtlvediaw qgsqltvqdl aafrpkvvep lemalgnytl ysppppagga ilsfilnvlk
      301 gfnfsaetva gpegkvnmyh hlvealkfav gqrwrlwdpy shpgiqnisq dllretlaqh
      361 irqqidgrgd hqlshynlsg vrgnsmgtsh vsvlgedgsa vaatstintp fgamvysprt
      421 gillnnelld lcwrhkpgst vtpppvpgeq ppssmvpsil inevqgsklv iggaggelii
      481 savtqaivnk lwlgfsltda iaapilhvns kghveyepkf nqevrkglqd rgqsqsqsqr
      541 pvflnsvqav fqegpcvyaa sdlrkagkas gy
//
