LOCUS       NM_053840               2068 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus gamma-glutamyltransferase 1 (Ggt1), mRNA.
ACCESSION   NM_053840
VERSION     NM_053840.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2068)
  AUTHORS   Ihn,K., Ho,I.G., Chang,E.Y. and Han,S.J.
  TITLE     Correlation between gamma-glutamyl transpeptidase activity and
            outcomes after Kasai portoenterostomy for biliary atresia
  JOURNAL   J Pediatr Surg 53 (3), 461-467 (2018)
   PUBMED   29056230
REFERENCE   2  (bases 1 to 2068)
  AUTHORS   Moreira,A.J., Rodrigues,G.R., Bona,S., Fratta,L.X., Weber,G.R.,
            Picada,J.N., Dos Santos,J.L., Cerski,C.T., Marroni,C.A. and
            Marroni,N.P.
  TITLE     Ductular reaction, cytokeratin 7 positivity, and gamma-glutamyl
            transferase in multistage hepatocarcinogenesis in rats
  JOURNAL   Protoplasma 254 (2), 911-920 (2017)
   PUBMED   27525410
  REMARK    GeneRIF: an extensive ductular reaction in advanced Hepatocellular
            carcinoma (HCC) and a strong correlation between PCK7 and levels of
            gammaGT and the poor prognosis and aggressiveness of HCC, is
            reported.
REFERENCE   3  (bases 1 to 2068)
  AUTHORS   Wu,S.J., Lin,Y.X., Ye,H., Xiong,X.Z., Li,F.Y. and Cheng,N.S.
  TITLE     Prognostic value of alkaline phosphatase, gamma-glutamyl
            transpeptidase and lactate dehydrogenase in hepatocellular
            carcinoma patients treated with liver resection
  JOURNAL   Int J Surg 36 (Pt A), 143-151 (2016)
   PUBMED   27793641
REFERENCE   4  (bases 1 to 2068)
  AUTHORS   Eminler,A.T., Irak,K., Ayyildiz,T., Keskin,M., Kiyici,M., Gurel,S.,
            Gulten,M., Dolar,E. and Nak,S.G.
  TITLE     The relation between liver histopathology and GGT levels in viral
            hepatitis: more important in hepatitis B
  JOURNAL   Turk J Gastroenterol 25 (4), 411-415 (2014)
   PUBMED   25254524
REFERENCE   5  (bases 1 to 2068)
  AUTHORS   Jarcuska,P., Janicko,M., Drazilova,S., Senajova,G., Veseliny,E.,
            Fedacko,J., Siegfried,L., Kristian,P., Tkac,M. Jr., Pella,D.,
            Marekova,M., Geckova,A.M. and Jarcuska,P.
  CONSRTM   HepaMeta Team
  TITLE     Gamma-glutamyl transpeptidase level associated with metabolic
            syndrome and proinflammatory parameters in the young Roma
            population in eastern Slovakia: a population-based study
  JOURNAL   Cent Eur J Public Health 22 Suppl, S43-S50 (2014)
   PUBMED   24847614
REFERENCE   6  (bases 1 to 2068)
  AUTHORS   Kurauchi,O., Lahuna,O., Darbouy,M., Aggerbeck,M., Chobert,M.N. and
            Laperche,Y.
  TITLE     Organization of the 5' end of the rat gamma-glutamyl transpeptidase
            gene: structure of a promoter active in the kidney
  JOURNAL   Biochemistry 30 (6), 1618-1623 (1991)
   PUBMED   1671556
REFERENCE   7  (bases 1 to 2068)
  AUTHORS   Jain,V.K., Archana, Seth,S., Chaudhary,S.D. and Lal,H.
  TITLE     Gamma-glutamyl transpeptidase in leprosy
  JOURNAL   Indian J Lepr 63 (1), 93-96 (1991)
   PUBMED   1680936
REFERENCE   8  (bases 1 to 2068)
  AUTHORS   Rajagopalan,S., Park,J.H., Patel,P.D., Lebovitz,R.M. and
            Lieberman,M.W.
  TITLE     Cloning and analysis of the rat gamma-glutamyltransferase gene
  JOURNAL   J Biol Chem 265 (20), 11721-11725 (1990)
   PUBMED   1973164
REFERENCE   9  (bases 1 to 2068)
  AUTHORS   Chobert,M.N., Lahuna,O., Lebargy,F., Kurauchi,O., Darbouy,M.,
            Bernaudin,J.F., Guellaen,G., Barouki,R. and Laperche,Y.
  TITLE     Tissue-specific expression of two gamma-glutamyl transpeptidase
            mRNAs with alternative 5' ends encoded by a single copy gene in the
            rat
  JOURNAL   J Biol Chem 265 (4), 2352-2357 (1990)
   PUBMED   1967609
REFERENCE   10 (bases 1 to 2068)
  AUTHORS   Tate,S.S. and Meister,A.
  TITLE     Subunit structure and isozymic forms of gamma-glutamyl
            transpeptidase
  JOURNAL   Proc Natl Acad Sci U S A 73 (8), 2599-2603 (1976)
   PUBMED   8776
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078768.1.
            
            [WARNING] On Nov 14, 2024 this sequence was replaced by
            NM_053840.3.
            
            On Apr 16, 2007 this sequence version replaced NM_053840.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078768.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2068
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /note="gamma-glutamyltransferase 1"
                     /db_xref="GeneID:116568"
                     /db_xref="RGD:2683"
     exon            1..55
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            56..193
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            194..358
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1904
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="gamma-glutamyl transpeptidase;
                     gamma-glutamyltranspeptidase 1; gamma glutamyl-transferase
                     1; GGT 1; leukotriene-C4 hydrolase"
                     /codon_start=1
                     /product="glutathione hydrolase 1 proenzyme"
                     /protein_id="NP_446292.2"
                     /db_xref="GeneID:116568"
                     /db_xref="RGD:2683"
                     /translation="MKNRFLVLGLVAVVLVFVIIGLCIWLPTTSGKPDHVYSRAAVAT
                     DAKRCSEIGRDMLQEGGSVVDAAIASLLCMGLINAHSMGIGGGLFFTIYNSTTRKAEV
                     INAREMAPRLANTSMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSI
                     QLARHGFPVGKGLARALDKKRDIIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQI
                     LAQEGARAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAEVIEHPMSIGLGDSTLYVP
                     SAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKF
                     VDVSQVIRNMSSEFYATQLRARITDETTHPTAYYEPEFYLPDDGGTAHLSVVSEDGSA
                     VAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFTNQFGVAPSPANFIKPGKQPLS
                     SMCPSIIVDKDGKVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLL
                     PNTTTVEKNIDQVVTAGLKTRHHHTEVTPDFIAVVQAVVRTSGGWAAASDSRKGGEPA
                     GY"
     exon            359..489
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            490..576
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            577..769
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            770..927
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1077
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1214
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1402
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1530
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1643
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1757
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..2042
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccatcctg gaggaccaca cacttggcta cgtaaaggct ccactcacac caaaggagta
       61 ccagcctgct ctaacggttt cagggaagat tggctgtggg tttccgcaga gtgtggggga
      121 gttcctgctt atccatacag ctgattttca agaaccacct ccccaagaaa ggtttggggg
      181 ctcctactgg acgagccatg aagaatcggt ttctggtgct gggcctggtg gcggtggttc
      241 tggtgttcgt catcatcggc ctctgcatct ggctacccac cacctctggg aagcctgacc
      301 atgtgtactc cagggcggcc gtggccacag atgccaagcg ttgctcagag attgggcggg
      361 atatgctaca ggaaggcggc tccgtagtgg acgcggccat cgcaagcctg ctgtgtatgg
      421 ggctcattaa tgcccacagt atgggcatcg ggggcggcct cttcttcacc atctacaaca
      481 gcaccacacg aaaagctgaa gttatcaatg cccgtgaaat ggctcccagg ttggccaata
      541 ccagcatgtt caataattct aaggactctg aagaaggagg cctttcagtg gcagttcctg
      601 gtgaaatccg tggctatgag ctggcacacc aacggcatgg ccggctaccc tgggctcgcc
      661 tcttccaacc cagcatccaa ctggctcgcc atggcttccc tgtgggcaag ggcttggcaa
      721 gagccctgga caaaaaacgg gacatcattg agaagacacc tgctttgtgc gaggtgttct
      781 gccggcaagg gaaggtgctt caggaaggag agacagtaac tatgccgaag ttggccgata
      841 cgttgcaaat actggcccag gaaggggcca gggccttcta caatgggagc ctcacagccc
      901 agattgtgaa agacatccag gaggctgggg gcattatgac ggttgaggac cttaacaact
      961 atcgtgcgga agtgatcgag catccgatga gcatcggcct cggggactcc accctgtacg
     1021 tgcccagcgc cccactcagc gggcccgtgc tgattctcat cttgaacatc ctcaaaggat
     1081 acaacttctc tccaaagagc gtggcaaccc cagaacagaa ggcgctgacg tatcaccgta
     1141 tcgtggaggc ctttcggttt gcctatgcca agaggaccat gctcggtgac ccaaagtttg
     1201 tcgatgtgtc tcaggtcatc cgcaacatga gttctgagtt ctacgctact cagcttcgag
     1261 cccgcatcac tgatgaaacc actcacccaa ccgcctacta tgagcctgaa ttctaccttc
     1321 cagacgatgg gggtaccgct cacctgtccg tggtttccga ggatggcagt gctgtggccg
     1381 ccaccagtac catcaacctc tactttggct ccaaggtcct ctctcgggtc agtggcatcc
     1441 tgtttaatga cgagatggat gacttcagct cgcccaactt caccaaccag tttggggtag
     1501 cgccctcacc agccaacttc atcaagccag gtaagcaacc gctttcatcc atgtgcccct
     1561 caatcatcgt ggataaggac ggcaaggttc ggatggtggt tggagcctcg ggaggtaccc
     1621 agatcaccac gtctgttgca ctggccatca tcaacagcct gtggttcggg tatgatgtga
     1681 agagagctgt ggaggagccc cgtcttcaca accagctttt gcccaatacc acaacagtag
     1741 agaaaaatat tgatcaggtg gtgactgcag gtctgaagac tcggcaccac catacagagg
     1801 tcacacccga cttcatcgct gtggttcagg ccgtcgttcg aacgtcaggt ggttgggcag
     1861 ctgcctcaga ttccagaaaa ggcggggagc ccgctggcta ctgagtgccc ggaaggggca
     1921 agactgacct gcagccaaga gacgagagtg ggactctgga gaacatgctg cccctgggtg
     1981 ggagagagca ggataataaa cagaggccgc cgccaagttg cgggaagcct ttgcaggctg
     2041 gaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
