LOCUS       NP_446292                568 aa            linear   ROD 05-MAY-2025
DEFINITION  glutathione hydrolase 1 proenzyme precursor [Rattus norvegicus].
ACCESSION   NP_446292 XP_063135001
VERSION     NP_446292.2
DBSOURCE    REFSEQ: accession NM_053840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 568)
  AUTHORS   Ihn,K., Ho,I.G., Chang,E.Y. and Han,S.J.
  TITLE     Correlation between gamma-glutamyl transpeptidase activity and
            outcomes after Kasai portoenterostomy for biliary atresia
  JOURNAL   J Pediatr Surg 53 (3), 461-467 (2018)
   PUBMED   29056230
REFERENCE   2  (residues 1 to 568)
  AUTHORS   Moreira,A.J., Rodrigues,G.R., Bona,S., Fratta,L.X., Weber,G.R.,
            Picada,J.N., Dos Santos,J.L., Cerski,C.T., Marroni,C.A. and
            Marroni,N.P.
  TITLE     Ductular reaction, cytokeratin 7 positivity, and gamma-glutamyl
            transferase in multistage hepatocarcinogenesis in rats
  JOURNAL   Protoplasma 254 (2), 911-920 (2017)
   PUBMED   27525410
  REMARK    GeneRIF: an extensive ductular reaction in advanced Hepatocellular
            carcinoma (HCC) and a strong correlation between PCK7 and levels of
            gammaGT and the poor prognosis and aggressiveness of HCC, is
            reported.
REFERENCE   3  (residues 1 to 568)
  AUTHORS   Wu,S.J., Lin,Y.X., Ye,H., Xiong,X.Z., Li,F.Y. and Cheng,N.S.
  TITLE     Prognostic value of alkaline phosphatase, gamma-glutamyl
            transpeptidase and lactate dehydrogenase in hepatocellular
            carcinoma patients treated with liver resection
  JOURNAL   Int J Surg 36 (Pt A), 143-151 (2016)
   PUBMED   27793641
REFERENCE   4  (residues 1 to 568)
  AUTHORS   Eminler,A.T., Irak,K., Ayyildiz,T., Keskin,M., Kiyici,M., Gurel,S.,
            Gulten,M., Dolar,E. and Nak,S.G.
  TITLE     The relation between liver histopathology and GGT levels in viral
            hepatitis: more important in hepatitis B
  JOURNAL   Turk J Gastroenterol 25 (4), 411-415 (2014)
   PUBMED   25254524
REFERENCE   5  (residues 1 to 568)
  AUTHORS   Jarcuska,P., Janicko,M., Drazilova,S., Senajova,G., Veseliny,E.,
            Fedacko,J., Siegfried,L., Kristian,P., Tkac,M. Jr., Pella,D.,
            Marekova,M., Geckova,A.M. and Jarcuska,P.
  CONSRTM   HepaMeta Team
  TITLE     Gamma-glutamyl transpeptidase level associated with metabolic
            syndrome and proinflammatory parameters in the young Roma
            population in eastern Slovakia: a population-based study
  JOURNAL   Cent Eur J Public Health 22 Suppl, S43-S50 (2014)
   PUBMED   24847614
REFERENCE   6  (residues 1 to 568)
  AUTHORS   Kurauchi,O., Lahuna,O., Darbouy,M., Aggerbeck,M., Chobert,M.N. and
            Laperche,Y.
  TITLE     Organization of the 5' end of the rat gamma-glutamyl transpeptidase
            gene: structure of a promoter active in the kidney
  JOURNAL   Biochemistry 30 (6), 1618-1623 (1991)
   PUBMED   1671556
REFERENCE   7  (residues 1 to 568)
  AUTHORS   Jain,V.K., Archana, Seth,S., Chaudhary,S.D. and Lal,H.
  TITLE     Gamma-glutamyl transpeptidase in leprosy
  JOURNAL   Indian J Lepr 63 (1), 93-96 (1991)
   PUBMED   1680936
REFERENCE   8  (residues 1 to 568)
  AUTHORS   Rajagopalan,S., Park,J.H., Patel,P.D., Lebovitz,R.M. and
            Lieberman,M.W.
  TITLE     Cloning and analysis of the rat gamma-glutamyltransferase gene
  JOURNAL   J Biol Chem 265 (20), 11721-11725 (1990)
   PUBMED   1973164
REFERENCE   9  (residues 1 to 568)
  AUTHORS   Chobert,M.N., Lahuna,O., Lebargy,F., Kurauchi,O., Darbouy,M.,
            Bernaudin,J.F., Guellaen,G., Barouki,R. and Laperche,Y.
  TITLE     Tissue-specific expression of two gamma-glutamyl transpeptidase
            mRNAs with alternative 5' ends encoded by a single copy gene in the
            rat
  JOURNAL   J Biol Chem 265 (4), 2352-2357 (1990)
   PUBMED   1967609
REFERENCE   10 (residues 1 to 568)
  AUTHORS   Tate,S.S. and Meister,A.
  TITLE     Subunit structure and isozymic forms of gamma-glutamyl
            transpeptidase
  JOURNAL   Proc Natl Acad Sci U S A 73 (8), 2599-2603 (1976)
   PUBMED   8776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Nov 14, 2024 this sequence version replaced
            XP_063135001.1, NP_446292.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.63988.1,
                                           SRR23984936.474905.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..568
                     /product="glutathione hydrolase 1 proenzyme precursor"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="gamma-glutamyl transpeptidase;
                     gamma-glutamyltranspeptidase 1; gamma glutamyl-transferase
                     1; GGT 1; leukotriene-C4 hydrolase; glutathione hydrolase
                     1 proenzyme"
                     /calculated_mol_wt=61479
     mat_peptide     1..379
                     /product="Glutathione hydrolase 1 heavy chain.
                     /id=PRO_0000011064"
                     /note="propagated from UniProtKB/Swiss-Prot (P07314.4)"
                     /calculated_mol_wt=41569
     Site            5..26
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P07314.4)"
     Region          54..563
                     /region_name="G_glu_transpept"
                     /note="Gamma-glutamyltranspeptidase; pfam01019"
                     /db_xref="CDD:425991"
     Site            94
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P07314.4)"
     Site            114
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P07314.4)"
     Site            119
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P07314.4)"
     Site            229
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P07314.4)"
     Site            343
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P07314.4)"
     mat_peptide     380..568
                     /product="Glutathione hydrolase 1 light chain.
                     /evidence=ECO:0000269|PubMed:2869484. /id=PRO_0000011065"
                     /note="propagated from UniProtKB/Swiss-Prot (P07314.4)"
                     /calculated_mol_wt=20059
     Site            427
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P07314.4)"
     Site            510
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0007744|PubMed:24090084; propagated from
                     UniProtKB/Swiss-Prot (P07314.4)"
     CDS             1..568
                     /gene="Ggt1"
                     /gene_synonym="GGLUT; Ggt; Ggtp"
                     /coded_by="NM_053840.3:535..2241"
                     /db_xref="GeneID:116568"
                     /db_xref="RGD:2683"
ORIGIN      
        1 mknrflvlgl vavvlvfvii glciwlptts gkpdhvysra avatdakrcs eigrdmlqeg
       61 gsvvdaaias llcmglinah smgiggglff tiynsttrka evinaremap rlantsmfnn
      121 skdseeggls vavpgeirgy elahqrhgrl pwarlfqpsi qlarhgfpvg kglaraldkk
      181 rdiiektpal cevfcrqgkv lqegetvtmp kladtlqila qegarafyng sltaqivkdi
      241 qeaggimtve dlnnyraevi ehpmsiglgd stlyvpsapl sgpvlililn ilkgynfspk
      301 svatpeqkal tyhriveafr fayakrtmlg dpkfvdvsqv irnmssefya tqlraritde
      361 tthptayyep efylpddggt ahlsvvsedg savaatstin lyfgskvlsr vsgilfndem
      421 ddfsspnftn qfgvapspan fikpgkqpls smcpsiivdk dgkvrmvvga sggtqittsv
      481 alaiinslwf gydvkravee prlhnqllpn tttveknidq vvtaglktrh hhtevtpdfi
      541 avvqavvrts ggwaaasdsr kggepagy
//
