LOCUS       NM_012960               1385 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus gamma-glutamyl hydrolase (Ggh), mRNA.
ACCESSION   NM_012960
VERSION     NM_012960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   Wein,S.A., Laviano,A. and Wolffram,S.
  TITLE     Quercetin induces hepatic gamma-glutamyl hydrolase expression in
            rats by suppressing hepatic microRNA rno-miR-125b-3p
  JOURNAL   J Nutr Biochem 26 (12), 1660-1663 (2015)
   PUBMED   26432773
  REMARK    GeneRIF: hepatic microRNA rno-miR-125b-3p is suppressed by
            quercetin-induced hepatic gamma-glutamyl hydrolase expression in
            rats
REFERENCE   2  (bases 1 to 1385)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   3  (bases 1 to 1385)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 1385)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1385)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1385)
  AUTHORS   Galivan,J. and Rhee,M.S.
  TITLE     Insulin-dependent suppression in glutamyl hydrolase activity and
            elevated cellular methotrexate polyglutamates
  JOURNAL   Biochem Pharmacol 50 (10), 1659-1663 (1995)
   PUBMED   7503769
REFERENCE   7  (bases 1 to 1385)
  AUTHORS   Wang,Y., Nimec,Z., Ryan,T.J., Dias,J.A. and Galivan,J.
  TITLE     The properties of the secreted gamma-glutamyl hydrolases from H35
            hepatoma cells
  JOURNAL   Biochim Biophys Acta 1164 (3), 227-235 (1993)
   PUBMED   8343522
REFERENCE   8  (bases 1 to 1385)
  AUTHORS   Canton,M.C. and Cremin,F.M.
  TITLE     The effect of dietary zinc depletion and repletion on rats: Zn
            concentration in various tissues and activity of pancreatic
            gamma-glutamyl hydrolase (EC 3.4.22.12) as indices of Zn status
  JOURNAL   Br J Nutr 64 (1), 201-209 (1990)
   PUBMED   2400760
REFERENCE   9  (bases 1 to 1385)
  AUTHORS   Morris,W.B., Smith,G.D. and Peters,T.J.
  TITLE     Subcellular fractionation of liver organelles from
            phenobarbital-treated rats by counter-current partition and sucrose
            gradient centrifugation
  JOURNAL   Biochem Pharmacol 35 (13), 2187-2191 (1986)
   PUBMED   3015147
REFERENCE   10 (bases 1 to 1385)
  AUTHORS   Halsall,S. and Peters,T.J.
  TITLE     Effect of chronic ethanol consumption on the cellular and
            subcellular distribution of gamma-glutamyltransferase in rat liver
  JOURNAL   Enzyme 31 (4), 221-228 (1984)
   PUBMED   6147245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087602.1.
            
            On Dec 26, 2004 this sequence version replaced NM_012960.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087602.1, U38379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132267
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..1385
                     /gene="Ggh"
                     /note="gamma-glutamyl hydrolase"
                     /db_xref="GeneID:25455"
                     /db_xref="RGD:2682"
     exon            1..264
                     /gene="Ggh"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1109
                     /gene="Ggh"
                     /EC_number="3.4.19.9"
                     /note="GH; conjugase; gamma-Glu-X carboxypeptidase;
                     gamma-glutamyl hydrolase (conjugase,
                     folylpolygammaglutamyl hydrolase)"
                     /codon_start=1
                     /product="gamma-glutamyl hydrolase precursor"
                     /protein_id="NP_037092.1"
                     /db_xref="GeneID:25455"
                     /db_xref="RGD:2682"
                     /translation="MASLGRLLCAWVLLLCGLASPGLSGSYERGSKRPIIGIIMQECY
                     GNMTKLGRFYIAASYVKFIESAGARVVPIRLDLNDAQYETLFRSINGVLLPGGGANLT
                     HSGYSRVAKIFFTKALESFDNGDYFPVWGTCLGLEELSVLVSNDNLLTLTNTSSVKLP
                     LNFTRDSKQSRMFRNLPEELLNSLASENLTANFHKWSLSVKNFTENEKLKKFFNILTV
                     NTDGKTEFISSMEGYKYPIYAVQWHPEKAPFEWKKLRGISHAPNAVKTSFYLAKFFIS
                     EALKNDHHFENELEETESLIYQFCPVYTGNISSFQQAYMFN"
     exon            265..376
                     /gene="Ggh"
                     /inference="alignment:Splign:2.1.0"
     exon            377..427
                     /gene="Ggh"
                     /inference="alignment:Splign:2.1.0"
     exon            428..512
                     /gene="Ggh"
                     /inference="alignment:Splign:2.1.0"
     exon            513..651
                     /gene="Ggh"
                     /inference="alignment:Splign:2.1.0"
     exon            652..758
                     /gene="Ggh"
                     /inference="alignment:Splign:2.1.0"
     exon            759..849
                     /gene="Ggh"
                     /inference="alignment:Splign:2.1.0"
     exon            850..987
                     /gene="Ggh"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1361
                     /gene="Ggh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggcctt gcgcgcccta gagctcggag tacagcccag gcggccggac tgtgggaccg
       61 cgcccccgcc gggcagccgc gcgcgcgccg cgccgcgccg cgccgcagaa cctttttaag
      121 tggcggccgg aggccggata gcgatcgtga acgcgatggc aagcctgggc cgcctgctgt
      181 gcgcatgggt tttgctgctg tgcgggcttg caagccccgg gctgtccgga tcctatgagc
      241 gcggctccaa gcgtcccatc atcggaataa taatgcaaga atgttatggg aacatgacga
      301 agttgggaag attctacatt gctgcgtcct atgtgaagtt tatagagtct gcgggtgcaa
      361 gagtcgtgcc cataaggctc gaccttaatg atgcacagta tgaaacactt tttagatcta
      421 ttaatggagt cctcttgcct ggagggggtg ctaacctaac acattcaggt tattcccgtg
      481 tggccaaaat atttttcacc aaggctctag agagttttga taatggagac tattttcctg
      541 tgtggggaac atgcctggga ttggaggagc tttccgtcct ggttagtaat gacaacttac
      601 tgacactcac aaacaccagc tcagtgaaat tgcctttgaa cttcacgaga gattcaaagc
      661 agagcagaat gttccggaat cttcctgagg agttattgaa ttcattagca tcagaaaatc
      721 tgactgcaaa ttttcacaag tggagcctgt ctgtgaagaa ctttacagaa aacgagaagt
      781 taaagaagtt tttcaatata ttaacagtca atacagatgg caagactgag ttcatttcat
      841 ccatggaagg atataagtat ccaatatatg ctgtccagtg gcatcctgag aaagcaccat
      901 ttgagtggaa gaaactgcga ggcatttccc atgcaccgaa tgctgtgaag acttcatttt
      961 acttagcaaa attttttatt tctgaagctc tgaaaaatga tcaccacttt gagaacgaac
     1021 ttgaagagac tgaatccttg atttaccagt tctgtccagt ttatactgga aatatttctt
     1081 catttcagca agcttatatg tttaactgaa agacttcaat atggtaacag agcaactttg
     1141 agtaattccg tgattgaatt gctaacactg ctcagggcag tgtgagaaag ccacacagat
     1201 gcctttgctg tgtgcctggt tctgattcat ggcttaataa tgattatttt tatcagattt
     1261 gataacccga caatgaaaaa gataaaaaaa aatcatagtg tttttagtga aaatgccttc
     1321 ttaggtctga agattctaaa atacaagttt ttgaaaatat aaaaaaaaaa aaaaaaaaaa
     1381 aaaaa
//
