LOCUS       NM_001415686            3731 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus golgi associated, gamma adaptin ear containing,
            ARF binding protein 3 (Gga3), mRNA.
ACCESSION   NM_001415686 XM_006247719
VERSION     NM_001415686.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3731)
  AUTHORS   Zhang,M., Huang,W., Gao,J., Terry,A.V. and Wu,G.
  TITLE     Regulation of alpha2B-Adrenergic Receptor Cell Surface Transport by
            GGA1 and GGA2
  JOURNAL   Sci Rep 6, 37921 (2016)
   PUBMED   27901063
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3731)
  AUTHORS   Li,X., Lavigne,P. and Lavoie,C.
  TITLE     GGA3 mediates TrkA endocytic recycling to promote sustained Akt
            phosphorylation and cell survival
  JOURNAL   Mol Biol Cell 26 (24), 4412-4426 (2015)
   PUBMED   26446845
REFERENCE   3  (bases 1 to 3731)
  AUTHORS   Kizuka,Y., Kitazume,S., Fujinawa,R., Saito,T., Iwata,N.,
            Saido,T.C., Nakano,M., Yamaguchi,Y., Hashimoto,Y., Staufenbiel,M.,
            Hatsuta,H., Murayama,S., Manya,H., Endo,T. and Taniguchi,N.
  TITLE     An aberrant sugar modification of BACE1 blocks its lysosomal
            targeting in Alzheimer's disease
  JOURNAL   EMBO Mol Med 7 (2), 175-189 (2015)
   PUBMED   25592972
REFERENCE   4  (bases 1 to 3731)
  AUTHORS   Walker,K.R., Kang,E.L., Whalen,M.J., Shen,Y. and Tesco,G.
  TITLE     Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1
  JOURNAL   J Neurosci 32 (30), 10423-10437 (2012)
   PUBMED   22836275
REFERENCE   5  (bases 1 to 3731)
  AUTHORS   Kang,E.L., Cameron,A.N., Piazza,F., Walker,K.R. and Tesco,G.
  TITLE     Ubiquitin regulates GGA3-mediated degradation of BACE1
  JOURNAL   J Biol Chem 285 (31), 24108-24119 (2010)
   PUBMED   20484053
REFERENCE   6  (bases 1 to 3731)
  AUTHORS   Tesco,G., Koh,Y.H., Kang,E.L., Cameron,A.N., Das,S.,
            Sena-Esteves,M., Hiltunen,M., Yang,S.H., Zhong,Z., Shen,Y.,
            Simpkins,J.W. and Tanzi,R.E.
  TITLE     Depletion of GGA3 stabilizes BACE and enhances beta-secretase
            activity
  JOURNAL   Neuron 54 (5), 721-737 (2007)
   PUBMED   17553422
REFERENCE   7  (bases 1 to 3731)
  AUTHORS   Boman,A.L., Zhang,Cj., Zhu,X. and Kahn,R.A.
  TITLE     A family of ADP-ribosylation factor effectors that can alter
            membrane transport through the trans-Golgi
  JOURNAL   Mol Biol Cell 11 (4), 1241-1255 (2000)
   PUBMED   10749927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 22, 2022 this sequence version replaced XM_006247719.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.46475.1,
                                           SRR26643298.65133.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000010.1  101342318-101342373 c
            57-141              JAXUCZ010000010.1  101334934-101335018 c
            142-217             JAXUCZ010000010.1  101334751-101334826 c
            218-316             JAXUCZ010000010.1  101332400-101332498 c
            317-440             JAXUCZ010000010.1  101331452-101331575 c
            441-544             JAXUCZ010000010.1  101331094-101331197 c
            545-625             JAXUCZ010000010.1  101330720-101330800 c
            626-763             JAXUCZ010000010.1  101330251-101330388 c
            764-845             JAXUCZ010000010.1  101329171-101329252 c
            846-962             JAXUCZ010000010.1  101328958-101329074 c
            963-1208            JAXUCZ010000010.1  101328404-101328649 c
            1209-1276           JAXUCZ010000010.1  101328014-101328081 c
            1277-1587           JAXUCZ010000010.1  101327467-101327777 c
            1588-1808           JAXUCZ010000010.1  101327130-101327350 c
            1809-1978           JAXUCZ010000010.1  101326502-101326671 c
            1979-2089           JAXUCZ010000010.1  101326268-101326378 c
            2090-3731           JAXUCZ010000010.1  101324378-101326019 c
FEATURES             Location/Qualifiers
     source          1..3731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3731
                     /gene="Gga3"
                     /note="golgi associated, gamma adaptin ear containing, ARF
                     binding protein 3"
                     /db_xref="GeneID:360658"
                     /db_xref="RGD:1309553"
     exon            1..56
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2200
                     /gene="Gga3"
                     /note="Golgi-localized, gamma ear-containing, ARF-binding
                     protein 3"
                     /codon_start=1
                     /product="ADP-ribosylation factor-binding protein GGA3"
                     /protein_id="NP_001402615.1"
                     /db_xref="GeneID:360658"
                     /db_xref="RGD:1309553"
                     /translation="MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQ
                     IAVRLLAHKIQSPQEWEAVQALTVLEACMKNCGRRLHNEVGKFRFLNELIKVVSPKYL
                     GDRVSEKVKAKVIELLFSWTLALPEEAKIKDAYHMLKRQGIVQSDPPIPMDRTLIPSP
                     PPRPKNPVFDDEEKSKLLAKLLRSKNPDDLQEANQLIKSMVKEDEARIQKVTKRLHTL
                     EEVNNNVKLLHEMLLHYSQEFSSEADKELMKELFDRCENKRRTLFKLASETEDNDNSL
                     GDILQASDNLSRVINSYKTIIEGQIINGEVTTSTVPDSEGNSHCGNQGALIDLAELDT
                     PSSSSPVLAPAPAPPTSGIPILPPPPQTSGPPRSRSSSQAEAPSGPDSTNNALSLLDE
                     ELLCLGLSDPAPTAPKESAGNSPWHLFQNEPSSDLDFFSPRLVSAASCPSEGSLLPPP
                     VSTSSLSQAPLPAAFPAPVVPASAVTHSTGSFTFSSGPAPALVPKAEPEGPEYPSSSI
                     SHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASTPARPLLPFSTGPGSPLF
                     QSPAFQSQGSPQKGPELSLASVHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPG
                     RPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQ
                     VMLLANPMKEKVRLRYKLTFALGEQLSTELGEVDQFPPVEQWGNL"
     exon            57..141
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            142..217
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            218..316
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            317..440
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..544
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            545..625
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..763
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            764..845
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            846..962
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1208
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1276
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1587
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1808
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1978
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2089
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..3731
                     /gene="Gga3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgggcggc tgcaatatgg cggaggcgga aggggagagc ctggaatcct ggctgaataa
       61 agctaccaat ccttccaacc gccaggaaga ctgggaatac atcattggct tctgtgatca
      121 gatcaacaaa gagcttgaag ggccccagat tgctgtgcga ctcctggctc acaagatcca
      181 gtctccacag gaatgggagg cagtgcaggc cctcacggtg ctggaggcgt gtatgaagaa
      241 ttgcggcagg agacttcata atgaagtggg aaagttccga tttttgaatg aattaatcaa
      301 agtcgtctct ccaaagtact tgggagacag ggtgtctgaa aaggtgaagg ctaaggtcat
      361 cgagttgctt tttagctgga cactggcctt gccggaagaa gcaaagatca aagacgccta
      421 ccatatgttg aagagacaag gcatagtgca gtcggacccc cctatcccca tggacagaac
      481 actgatcccc tctcctccac ctcgtcccaa aaaccctgtt tttgatgatg aggaaaaatc
      541 caagctctta gccaagctgc tgagaagcaa gaacccagat gacttacaag aagccaacca
      601 actcatcaag tccatggtga aggaagatga ggcgcgcatc cagaaagtga ccaagcgcct
      661 acacacgttg gaggaagtta acaacaatgt caagctgctc catgagatgc ttcttcacta
      721 cagccaagag ttctcatcag aggccgacaa agagctcatg aaggagctct ttgatcgttg
      781 tgagaataag agacggacat tatttaaact agccagtgag acagaagaca atgacaatag
      841 tttgggggac atcctgcagg ccagtgacaa cctgtccagg gtcatcaact cttacaaaac
      901 aattattgaa gggcagatca tcaatggtga ggtgaccacc tcaaccgtgc ctgactctga
      961 aggaaatagt cactgcggta accaaggcgc cctcatcgac cttgccgagt tggacacccc
     1021 cagcagctca tccccagtgt tggccccagc acctgcccca cccacctcag gcatccctat
     1081 ccttccccca cctccccaaa cctccgggcc tccacgaagc cgttcatcca gccaggctga
     1141 ggctccctca gggcctgaca gcacgaacaa tgccctctcc ttgctggatg aggagctcct
     1201 ctgtctaggc ctcagtgacc cagcccccac tgctcccaaa gagtcagctg gaaatagtcc
     1261 atggcacctg ttccagaatg aaccatcatc agatctggac ttcttcagtc ccaggctagt
     1321 gtctgcagcc tcctgcccct cagagggatc cctgctccct cccccagttt ctacctcaag
     1381 tctgtcccaa gctccactgc ctgctgcctt cccagctcct gtggtcccag cgagcgcagt
     1441 gacccacagc actggttcct ttacgttctc ttctggacct gccccagcct tggttccaaa
     1501 ggctgagccc gaaggcccag agtaccccag ctccagcatc tcacaccgcc tggatgccct
     1561 tgatcagctt ctggaagagg ccaaagtgac ttcaggcctg gtgaaacctg tttcttgctt
     1621 ctctcctggg cccaccgcct ccccactgct tcctgcctct accccagcca ggcctctcct
     1681 gcccttctca actgggcccg gaagtcctct cttccagtcg ccagccttcc agtcccaagg
     1741 cagccctcag aagggcccag agctctccct ggctagtgtc catgtgcccc tggaatcgat
     1801 caagcctagc agtgcccttc ctgtgacagc ctatgataaa aatggcttcc gcatcctttt
     1861 ccactttgct aaggagtgtc cgccaggacg gcctgatgtg ctggtggtgg tggtttccat
     1921 gctgaataca gctcccttgc cagtcaagag tatagtgcta caggccgcag tgcccaagtc
     1981 aatgaaagtg aagttgcagc caccctctgg gacagaactt tctccattta gtcccatcca
     2041 gccacctgca gccatcaccc aggtcatgct gctggccaat ccaatgaagg aaaaggtacg
     2101 gcttcggtat aaattgacct ttgctctggg ggagcagctg agcacagagc tgggtgaagt
     2161 ggaccagttt cctcctgtgg agcagtgggg gaacctatga ccccagcaaa tgttgccatc
     2221 tctacttgga aggcaggcag cccgagacag gctctggcta gtccagccgc tgtacaccct
     2281 ggacagtgtt tatagcttgg tgtggatcgg ggccctggac acttctgtca ggaaccaagc
     2341 tgctgctttg gtcatctctt cctgggcccc taaaagcacc tgtgttatct acctgtgtga
     2401 cttgaagtag ccgtgctgtg tgggtgggga gtcccctgtg gcttcactgg ccactctggg
     2461 atggtggact ctggtcgcgg agtaggattt ccctttatta ctggcattcc ttgataccag
     2521 gaagagggct ctgaacagtg cctctccaac cccttcaaga actccatctt tacaccctga
     2581 agaggcatgg ccgggagact atacctcccg tggtggtcca tggttctttg tagtgggcgc
     2641 tgctgctccc tggactgaag tgggcagcag tggcccggac agagtgggaa atgtggagtg
     2701 ctgtagtctt cacgttctgc aagcagcagc atcctgcagt agctactgag tgagtgacgt
     2761 gcttgtgctt acagtggctg gttgtgtcct atggacatcg tagcaggaca gggaacttgg
     2821 cccgataggg acaggaagca aaacacaagt gccagtgttt ccctccagaa gcaggtactg
     2881 tggctttctg ggaaaggcat acctcctgca gtgggaatag gccatcctac tcactacctc
     2941 ttgcttggca tgaaataaac tgctgtgctc cccgtaagcc ttttagggga agacacctct
     3001 tgccactctg catctgcttt cactccctct ccccgccaca cggaatgtgg tgtggcagct
     3061 atggctggac ccagtaagtc tcagggtcac acatgttgca ctagactttt gtgttcttct
     3121 gtgctgcacc caaacacccc ttttcctcag ctaaagaggg gcactgtcgg cgacatgttg
     3181 ggtctggagg tgatgagatg aggcctgtgc ttgaactgat taccagaccc tattgcttcc
     3241 acagtgctgg gcctcagcac caccccgctg ctccaggcca gagactctta cactcatagg
     3301 gaactgagca gggaaagggt ggacagcagt ccattgggct ccgctgtccg ttacctttag
     3361 gaaaagaaag gcgtcacaac tgtctcccgt tctcactgca tttttggagc atccttgttc
     3421 tctacagagt tcgtctggcc tccctcctag ctactgtcct tagccagcag gttttatagt
     3481 ttccttagga caagtcaaaa aaaaaaaaaa aatcattttc actgatgatg gaataaatca
     3541 agagctttcc agagactggt tacttcggtt ctggaacatc tgtgggatta ctgtgtcatt
     3601 acagtcgtta catacttaaa ttatgagtgt tctcgcgatt gctgaggtca ctgcttcagt
     3661 caacagctgt actggatgga ccacctcctg cccttgtttt gctgcatgtg aaataaaacc
     3721 atttcacccg g
//
