LOCUS       NM_001399734            2676 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus golgi associated, gamma adaptin ear containing,
            ARF binding protein 1 (Gga1), transcript variant 1, mRNA.
ACCESSION   NM_001399734 XM_008765679
VERSION     NM_001399734.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2676)
  AUTHORS   Zhang,M., Huang,W., Gao,J., Terry,A.V. and Wu,G.
  TITLE     Regulation of alpha2B-Adrenergic Receptor Cell Surface Transport by
            GGA1 and GGA2
  JOURNAL   Sci Rep 6, 37921 (2016)
   PUBMED   27901063
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2676)
  AUTHORS   Kim,H., Xu,H., Yao,Q., Li,W., Huang,Q., Outeda,P., Cebotaru,V.,
            Chiaravalli,M., Boletta,A., Piontek,K., Germino,G.G., Weinman,E.J.,
            Watnick,T. and Qian,F.
  TITLE     Ciliary membrane proteins traffic through the Golgi via a
            Rabep1/GGA1/Arl3-dependent mechanism
  JOURNAL   Nat Commun 5, 5482 (2014)
   PUBMED   25405894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2676)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   4  (bases 1 to 2676)
  AUTHORS   Walker,K.R., Kang,E.L., Whalen,M.J., Shen,Y. and Tesco,G.
  TITLE     Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1
  JOURNAL   J Neurosci 32 (30), 10423-10437 (2012)
   PUBMED   22836275
REFERENCE   5  (bases 1 to 2676)
  AUTHORS   Borgonovo,J., Capella,P., Seltzer,A. and Sosa,M.A.
  TITLE     Expression of coat proteins changes during postnatal development in
            selected areas of the rat brain
  JOURNAL   Int J Dev Neurosci 30 (4), 333-341 (2012)
   PUBMED   22306374
  REMARK    GeneRIF: the expression of the GGA1 increased substantially between
            the 15th and 30th day after birth in all areas studied, excepting
            the cerebellum and cortex.
REFERENCE   6  (bases 1 to 2676)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2676)
  AUTHORS   Wahle,T., Prager,K., Raffler,N., Haass,C., Famulok,M. and Walter,J.
  TITLE     GGA proteins regulate retrograde transport of BACE1 from endosomes
            to the trans-Golgi network
  JOURNAL   Mol Cell Neurosci 29 (3), 453-461 (2005)
   PUBMED   15886016
REFERENCE   8  (bases 1 to 2676)
  AUTHORS   Zhu,G., Zhai,P., He,X., Terzyan,S., Zhang,R., Joachimiak,A.,
            Tang,J. and Zhang,X.C.
  TITLE     Crystal structure of the human GGA1 GAT domain
  JOURNAL   Biochemistry 42 (21), 6392-6399 (2003)
   PUBMED   12767220
REFERENCE   9  (bases 1 to 2676)
  AUTHORS   Shiba,T., Kawasaki,M., Takatsu,H., Nogi,T., Matsugaki,N.,
            Igarashi,N., Suzuki,M., Kato,R., Nakayama,K. and Wakatsuki,S.
  TITLE     Molecular mechanism of membrane recruitment of GGA by ARF in
            lysosomal protein transport
  JOURNAL   Nat Struct Biol 10 (5), 386-393 (2003)
   PUBMED   12679809
REFERENCE   10 (bases 1 to 2676)
  AUTHORS   Suer,S., Misra,S., Saidi,L.F. and Hurley,J.H.
  TITLE     Structure of the GAT domain of human GGA1: a syntaxin
            amino-terminal domain fold in an endosomal trafficking adaptor
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4451-4456 (2003)
   PUBMED   12668765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 13, 2022 this sequence version replaced XM_008765679.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.404214.1,
                                           SRR26360190.1986812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000007.1  112316530-112316604
            76-160              JAXUCZ010000007.1  112319552-112319636
            161-236             JAXUCZ010000007.1  112320733-112320808
            237-335             JAXUCZ010000007.1  112321861-112321959
            336-459             JAXUCZ010000007.1  112322717-112322840
            460-560             JAXUCZ010000007.1  112323561-112323661
            561-641             JAXUCZ010000007.1  112324183-112324263
            642-779             JAXUCZ010000007.1  112326109-112326246
            780-861             JAXUCZ010000007.1  112326393-112326474
            862-969             JAXUCZ010000007.1  112326986-112327093
            970-1122            JAXUCZ010000007.1  112327770-112327922
            1123-1187           JAXUCZ010000007.1  112329070-112329134
            1188-1360           JAXUCZ010000007.1  112329562-112329734
            1361-1548           JAXUCZ010000007.1  112330081-112330268
            1549-1718           JAXUCZ010000007.1  112330818-112330987
            1719-1829           JAXUCZ010000007.1  112331192-112331302
            1830-2676           JAXUCZ010000007.1  112331403-112332249
FEATURES             Location/Qualifiers
     source          1..2676
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2676
                     /gene="Gga1"
                     /note="golgi associated, gamma adaptin ear containing, ARF
                     binding protein 1"
                     /db_xref="GeneID:300066"
                     /db_xref="RGD:1307770"
     exon            1..75
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1940
                     /gene="Gga1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor-binding protein GGA1"
                     /codon_start=1
                     /product="ADP-ribosylation factor-binding protein GGA1
                     isoform 1"
                     /protein_id="NP_001386663.1"
                     /db_xref="GeneID:300066"
                     /db_xref="RGD:1307770"
                     /translation="MEPAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGP
                     PLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKY
                     LGSRTSEKVKNKILELLYSWTVGLPEEVKIAEAYQMLKKQGIVKSDPKLPEDAIFPLP
                     PPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAI
                     EEVNNNVKLLTEMVMSHSQGAASSSSEDLMKELYQRCERMRPTLFRLASDTEDNDEAL
                     AEILQANDNLTQVINLYKQLVRGEELNGEATAGSIPGSTSALLDLSGLDLPSSGTTYP
                     ATPTRPGNQNSPEQLSASVSLLDDELMSLGLSDPTPPSAPSSDSVGWNGFQSSDGTEP
                     SVPPPAQAPCMDSRPPAQASPPTSSGLDDLDLLGKTLMQQALPPEAQQVRWEKQQPAP
                     RLTLRDLQSKSSSPNPGATSLLHTTSPEPPGPQPQAIPTELSLTNITVPLESIKPSSI
                     LPVTVYDQHGFRVLFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKV
                     RLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLIFTMGDQTYNEMGDVD
                     QFPPPETWGSL"
     exon            76..160
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..236
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..335
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..459
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..560
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..641
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..779
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..861
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..969
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1122
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1187
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1360
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1548
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1718
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1829
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2676
                     /gene="Gga1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggcggtg ccgaggcggg ggcccgtggc ggatggagcc cgcgatggag ccggagactc
       61 tggaggcacg aatcaacaga gccacaaatc ccctgaacaa ggagctggac tgggccagca
      121 tcaacggttt ctgtgagcag ctcaacgaag actttgaggg gcctccactt gctacccgct
      181 tgctggccca caagatccag tccccacagg aatgggaagc catccaggcc ttgacggttc
      241 tggaaacatg catgaagagc tgtggcaaga ggttccatga cgaagtgggc aagttccgct
      301 tcctgaatga gctcatcaag gttgtgtctc ccaagtactt gggctcccgg acatcagaga
      361 aggtgaagaa taagatcttg gagctgctgt acagctggac agtcggcctc cctgaggagg
      421 tgaagattgc cgaagcctac cagatgctga agaagcaggg gatcgtgaag tctgacccca
      481 agcttccaga ggatgccatc tttcccctcc cccctccccg gcccaagaat gtgatctttg
      541 aagatgagga gaagtccaag atgctggccc gccttctgaa gagctcacac cccgaagacc
      601 tccgggctgc caataagctc atcaaagaga tggtgcagga ggaccagaag cggatggaga
      661 agatctcaaa gcgggtaaat gccattgagg aggtcaacaa caatgtgaag ctgctgacag
      721 agatggtgat gagccacagc cagggtgctg catccagcag cagtgaggac ctcatgaagg
      781 aactgtacca gcgctgtgag cgcatgcggc ccacactctt ccgactggcc agtgacacag
      841 aagacaatga tgaggcctta gctgagatcc tgcaggctaa cgacaatctc acccaggtga
      901 tcaacctgta caagcagctg gtccggggtg aggagctcaa tggtgaagcc acagccggct
      961 ccattcctgg aagcacctca gccctgctgg acctctcagg cctggacctc ccttcctccg
     1021 gcaccacata cccagccacg cccactcgcc ctggcaacca gaacagtcca gagcaactga
     1081 gtgcctcagt gtccttgctc gatgatgagc tcatgtcttt gggcctaagt gaccccacac
     1141 caccttcagc tcccagctca gatagtgtcg ggtggaacgg cttccagtca tcagatggca
     1201 ctgaaccctc agtccctcct ccagcccagg ccccctgcat ggacagccga cccccagccc
     1261 aggcatcccc accaacgagc agcggcctgg atgacctgga cctcttgggg aaaaccctta
     1321 tgcaacaggc actgcccccg gaagcccagc aagtgcggtg ggagaagcag cagccagccc
     1381 cccggctcac cctccgtgac ctgcagagca agagcagctc gcccaatcca ggagccacca
     1441 gcctcctcca caccacgtcc ccagagcccc ctgggcctca gcctcaggcc atacccactg
     1501 agctctcctt aaccaacatc actgtgccct tggagtctat caaacccagc agcatcttgc
     1561 cagtgaccgt ttatgaccag catggcttcc gtgtcctctt ccattttgct cgcgacccac
     1621 tgcccggacg ctctgatgtg ctggtggtgg tggtctctat gctgagcacg gctccccagc
     1681 ccatccgaaa cattgttttc cagtcagctg tccccaaggt catgaaggtg aggctgcagc
     1741 caccctccgg cacagagctg ccagcattta accccatcgt ccacccctcc gccatcaccc
     1801 aggtcctgct ccttgctaac ccccagaagg agaaggtccg cctccgctac aagctcatct
     1861 tcactatggg tgaccagacc tacaatgaga tgggagatgt ggatcagttc cccccaccag
     1921 aaacctgggg aagcctctag gacaggggct ggagagagga ggggcagcag gacctgtacc
     1981 tgttcatcct ggtgcttctc tccttcctgt ggcccccagt gactcttccc cctccctctt
     2041 cccctgctga gccaaaccca gcaggaggct gtgcctgggt ttgccatagc tgctgggacc
     2101 tccatcacca gtgggagcct ggagcaggga ggggctgtat gccctagaaa ggactctggg
     2161 gtgagggaag aagcatggct gtgaggccca gccctgaacc ccagcctgag gtggggttgt
     2221 cctcacctgt cttttatgcc ttatggaaag gcccagccat aacttggagg ccatgctgga
     2281 actgggacca gcccaggcct cctctgtggg aacccagtga ctgggggtga cgcccatgac
     2341 ctagctgttt gcacttggtg tgtggtttgg ctctttgctt ttcttttgga atggccctgt
     2401 ggtcacagag ctgaaggagc tctccactca gcccccagtg cctccagagg cctccctttg
     2461 ctctcaggct cctagggacc atggaaactt gaaagcaaag ccagaggaca tgccccctgg
     2521 agggccatgg aactcccaga gttctgtgct tcatttatca gcttctgctg gggcctccca
     2581 tgagcacctc acatctgcca cccatctgtg atcaaagtag ggtcagtaag ggtgaccatg
     2641 ggagtattta tgaaaataaa atgacttttt cctgga
//
