LOCUS       NM_001127455            1288 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus GDP-L-fucose synthase (Gfus), transcript variant
            2, mRNA.
ACCESSION   NM_001127455 XM_001070202 XM_216968
VERSION     NM_001127455.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1288)
  AUTHORS   Zhou H, Sun L, Li J, Xu C, Yu F, Liu Y, Ji C and He J.
  TITLE     The crystal structure of human GDP-L-fucose synthase
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 45 (9), 720-725 (2013)
   PUBMED   23774504
REFERENCE   2  (bases 1 to 1288)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1288)
  AUTHORS   Moehler TM, Sauer S, Witzel M, Andrulis M, Garcia-Vallejo JJ,
            Grobholz R, Willhauck-Fleckenstein M, Greiner A, Goldschmidt H and
            Schwartz-Albiez R.
  TITLE     Involvement of alpha 1-2-fucosyltransferase I (FUT1) and
            surface-expressed Lewis(y) (CD174) in first endothelial cell-cell
            contacts during angiogenesis
  JOURNAL   J Cell Physiol 215 (1), 27-36 (2008)
   PUBMED   18205178
REFERENCE   4  (bases 1 to 1288)
  AUTHORS   Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ,
            Boodhoo A, Potvin B and Cumming DA.
  TITLE     Molecular cloning of human GDP-mannose 4,6-dehydratase and
            reconstitution of GDP-fucose biosynthesis in vitro
  JOURNAL   J Biol Chem 273 (14), 8193-8202 (1998)
   PUBMED   9525924
REFERENCE   5  (bases 1 to 1288)
  AUTHORS   Tonetti M, Sturla L, Bisso A, Benatti U and De Flora A.
  TITLE     Synthesis of GDP-L-fucose by the human FX protein
  JOURNAL   J Biol Chem 271 (44), 27274-27279 (1996)
   PUBMED   8910301
REFERENCE   6  (bases 1 to 1288)
  AUTHORS   Lurquin C, Van Pel A, Mariame B, De Plaen E, Szikora JP, Janssens
            C, Reddehase MJ, Lejeune J and Boon T.
  TITLE     Structure of the gene of tum- transplantation antigen P91A: the
            mutated exon encodes a peptide recognized with Ld by cytolytic T
            cells
  JOURNAL   Cell 58 (2), 293-303 (1989)
   PUBMED   2568889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF289545.1 and BC158885.1.
            
            On Aug 1, 2012 this sequence version replaced NM_001127455.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229919.1, FQ221078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-504               BF289545.1         2-505
            505-1288            BC158885.1         414-1197
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1288
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /note="GDP-L-fucose synthase"
                     /db_xref="GeneID:300036"
                     /db_xref="RGD:1307028"
     exon            1..35
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     exon            36..193
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1013
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /EC_number="1.1.1.271"
                     /note="isoform a is encoded by transcript variant 2;
                     tissue specific transplantation antigen P35B;
                     GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase"
                     /codon_start=1
                     /product="GDP-L-fucose synthase isoform a"
                     /protein_id="NP_001120927.1"
                     /db_xref="GeneID:300036"
                     /db_xref="RGD:1307028"
                     /translation="MGEPHGSMRILVTGGSGLVGRAIQKVVADGAGLPGEEWVFVSSK
                     DADLTDAAQTQALFQKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHINDNVLHSAF
                     EVGTRKVVSCLSTCIFPDKTTYPIDETMIHNGPPHSSNFGYSYAKRMIDVQNRAYFQQ
                     HGCTFTSVIPTNVFGPYDNFNIEDGHVLPGLIHKVHLAKSSGSALTVWGTGKPRRQFI
                     YSLDLARLFIWVLREYNEVEPIILSVGEEDEVSIKEAAEAVVEAMDFSGEVTFDSTKS
                     DGQYKKTASNGKLRSYLPDFCFTPFKQAVKETCAWFTENYEQARK"
     exon            194..308
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     exon            309..437
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..511
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..645
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     exon            646..710
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..777
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..857
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     exon            858..957
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1274
                     /gene="Gfus"
                     /gene_synonym="Tsta3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtagct cttggactag tggaacccat cgcaggtgca gaccataatg ggtgaacccc
       61 acggatccat gaggatccta gtaacagggg gctctggact ggtgggcaga gccatccaga
      121 aggtggtcgc agatggggcc ggcttgcctg gagaggaatg ggtgtttgtc tcctccaaag
      181 atgcagatct gacggatgca gcgcaaaccc aagctctgtt ccagaaggta cagcccaccc
      241 acgtcatcca tcttgctgca atggtaggcg gccttttccg gaatattaaa tacaacttgg
      301 atttctggag gaagaacgtg cacatcaatg acaacgtcct acattcagcc ttcgaggtgg
      361 gcacacgcaa ggtggtctcc tgcctgtcca cctgcatctt ccctgacaag accacctatc
      421 ctattgatga gaccatgatc cacaacgggc cgcctcacag cagcaatttt gggtactcat
      481 atgccaagag gatgattgac gtgcagaaca gggcctactt ccagcagcat ggctgtacct
      541 tcacctctgt catccctacc aatgtctttg ggccttacga caacttcaac atcgaagatg
      601 gccacgtgct gccgggcctc atccataagg tgcacctggc caagagcagt ggttcagcct
      661 tgactgtgtg gggtacgggg aagccgcgga gacagttcat ctactcactg gacctagccc
      721 ggctcttcat ctgggtcctt cgggagtaca atgaggtgga gcccatcatc ctctcagtgg
      781 gcgaggaaga tgaagtgtct atcaaggagg cagctgaggc tgtggtggag gccatggact
      841 tctctgggga agtcactttt gattcaacaa agtcagatgg gcagtataag aagacagcca
      901 gcaatggcaa gttgcggtcc tacttgcctg acttctgttt cacacccttc aagcaggctg
      961 tgaaggaaac ttgtgcttgg ttcactgaaa actacgagca ggcccggaag taaagcacgg
     1021 gccaagcagg tgctcacctg gctacaccca gtcagtggtc acctcctcgc ttcttgccaa
     1081 gaactgagga tagtatccag caacctgagc cacacgctga cctctctgcc aggtgctccg
     1141 tgccgctgtc cagtagggcc catgtccatc cctggggaaa ggccagacca acaccttgct
     1201 tgtctgcttc tgcccaacct cagtgtgtcc ctgctggtct agaaagcaat aaaatgaatt
     1261 ttcatgagcc tggaaaaaaa aaaaaaaa
//
