LOCUS       NM_001401789            2585 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus GDNF family receptor alpha like (Gfral),
            transcript variant 1, mRNA.
ACCESSION   NM_001401789 XM_006243416
VERSION     NM_001401789.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2585)
  AUTHORS   Zhang,S.Y., Danaei,Z., Bruce,K., Chiu,J.F.M. and Lam,T.K.T.
  TITLE     Acute Activation of GFRAL in the Area Postrema Contributes to
            Glucose Regulation Independent of Weight
  JOURNAL   Diabetes 73 (3), 426-433 (2024)
   PUBMED   38064571
  REMARK    GeneRIF: Acute Activation of GFRAL in the Area Postrema Contributes
            to Glucose Regulation Independent of Weight.
REFERENCE   2  (bases 1 to 2585)
  AUTHORS   Hsu,J.Y., Crawley,S., Chen,M., Ayupova,D.A., Lindhout,D.A.,
            Higbee,J., Kutach,A., Joo,W., Gao,Z., Fu,D., To,C., Mondal,K.,
            Li,B., Kekatpure,A., Wang,M., Laird,T., Horner,G., Chan,J.,
            McEntee,M., Lopez,M., Lakshminarasimhan,D., White,A., Wang,S.P.,
            Yao,J., Yie,J., Matern,H., Solloway,M., Haldankar,R., Parsons,T.,
            Tang,J., Shen,W.D., Alice Chen,Y., Tian,H. and Allan,B.B.
  TITLE     Non-homeostatic body weight regulation through a
            brainstem-restricted receptor for GDF15
  JOURNAL   Nature 550 (7675), 255-259 (2017)
   PUBMED   28953886
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24481.. PMID: 29144449]
REFERENCE   3  (bases 1 to 2585)
  AUTHORS   Yang,L., Chang,C.C., Sun,Z., Madsen,D., Zhu,H., Padkjaer,S.B.,
            Wu,X., Huang,T., Hultman,K., Paulsen,S.J., Wang,J., Bugge,A.,
            Frantzen,J.B., Norgaard,P., Jeppesen,J.F., Yang,Z., Secher,A.,
            Chen,H., Li,X., John,L.M., Shan,B., He,Z., Gao,X., Su,J.,
            Hansen,K.T., Yang,W. and Jorgensen,S.B.
  TITLE     GFRAL is the receptor for GDF15 and is required for the
            anti-obesity effects of the ligand
  JOURNAL   Nat Med 23 (10), 1158-1166 (2017)
   PUBMED   28846099
REFERENCE   4  (bases 1 to 2585)
  AUTHORS   Emmerson,P.J., Wang,F., Du,Y., Liu,Q., Pickard,R.T., Gonciarz,M.D.,
            Coskun,T., Hamang,M.J., Sindelar,D.K., Ballman,K.K., Foltz,L.A.,
            Muppidi,A., Alsina-Fernandez,J., Barnard,G.C., Tang,J.X., Liu,X.,
            Mao,X., Siegel,R., Sloan,J.H., Mitchell,P.J., Zhang,B.B.,
            Gimeno,R.E., Shan,B. and Wu,X.
  TITLE     The metabolic effects of GDF15 are mediated by the orphan receptor
            GFRAL
  JOURNAL   Nat Med 23 (10), 1215-1219 (2017)
   PUBMED   28846098
REFERENCE   5  (bases 1 to 2585)
  AUTHORS   Mullican,S.E., Lin-Schmidt,X., Chin,C.N., Chavez,J.A., Furman,J.L.,
            Armstrong,A.A., Beck,S.C., South,V.J., Dinh,T.Q., Cash-Mason,T.D.,
            Cavanaugh,C.R., Nelson,S., Huang,C., Hunter,M.J. and Rangwala,S.M.
  TITLE     GFRAL is the receptor for GDF15 and the ligand promotes weight loss
            in mice and nonhuman primates
  JOURNAL   Nat Med 23 (10), 1150-1157 (2017)
   PUBMED   28846097
REFERENCE   6  (bases 1 to 2585)
  AUTHORS   Li,Z., Wang,B., Wu,X., Cheng,S.Y., Paraoan,L. and Zhou,J.
  TITLE     Identification, expression and functional characterization of the
            GRAL gene
  JOURNAL   J Neurochem 95 (2), 361-376 (2005)
   PUBMED   16086688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 25, 2022 this sequence version replaced XM_006243416.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840105
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000008.1  85843480-85843705   c
            227-361             JAXUCZ010000008.1  85839699-85839833   c
            362-451             JAXUCZ010000008.1  85837337-85837426   c
            452-604             JAXUCZ010000008.1  85836929-85837081   c
            605-1015            JAXUCZ010000008.1  85829471-85829881   c
            1016-1346           JAXUCZ010000008.1  85824277-85824607   c
            1347-1597           JAXUCZ010000008.1  85820750-85821000   c
            1598-1690           JAXUCZ010000008.1  85801843-85801935   c
            1691-1763           JAXUCZ010000008.1  85801334-85801406   c
            1764-2585           JAXUCZ010000008.1  85798342-85799163   c
FEATURES             Location/Qualifiers
     source          1..2585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2585
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /note="GDNF family receptor alpha like"
                     /db_xref="GeneID:501023"
                     /db_xref="RGD:1565220"
     exon            1..226
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1827
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="GDNF family receptor alpha-like isoform 1"
                     /protein_id="NP_001388718.1"
                     /db_xref="GeneID:501023"
                     /db_xref="RGD:1565220"
                     /translation="MLVFIFLAVRLSSENESSSQTNDCAYFMRQCLTDTDGCKQSWRS
                     MEDACLVSVRPPSVDSAFGGQKTGLLWRSLRKLRTKGPGDSCKINNPLPCNLSIQSLV
                     EKHFQFKGCLCTDDLHCTVNKIFGKKCTNKTEDSPLPSNLAPRSNVPRWFPRRDSSSL
                     AVRKADCVAAAEACQESEHCALLHENFKNACDTGTAQCRTLSGRLKCVGLRQRLRQTV
                     LWECRCGLPLEKDCVQIRKSLFGDICVQDAQMEQIPTFSQDNQDGFKEDVASGFKQMQ
                     SCLEVTEACVGDVVCNAQLALYLKACTANGNLCDVKHCQAAIRFFYQNMPFNTAQMLA
                     FCDCAQSDIPCQQSKETLHSKPCALNVVPPPTCLSVIHTCRNDELCRTYYRTFQTECW
                     PHVAGKCREDETCISMLGKQDLTCSGSDSCRAAYLGTFGTVLQVPCACRSITQGEEPL
                     CMAFQHMLHSKSCFNYPTPNVKDISSYERKHSKEITLTGFNSPFSGELIYVVVCMVVT
                     SGILSLVMLKLRIPSKKRDPAPIEIAGAVIIQ"
     exon            227..361
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
     exon            362..451
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
     exon            452..604
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
     exon            605..1015
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1346
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1597
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1690
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1763
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2585
                     /gene="Gfral"
                     /gene_synonym="RGD1565220"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caattgaatt tgaacataat taggaaagtt cacagctcaa aacaaattgg tgaggaacca
       61 gtgacatcag aagctgacta actgaatatg ctcttaggaa gcaaaagcag acacggaacc
      121 atttattcag gaatttcagt cgggatgttg gtcggtgtca gttcatctgc ctttctccca
      181 ggtgaccagc tccagttggc caacatgcta gtgttcattt tcctggccgt gaggctaagc
      241 tcagaaaacg aatcctcttc ccaaacaaat gattgtgcat atttcatgcg gcaatgcttg
      301 actgatacag atggctgtaa gcagtcatgg agatcaatgg aagacgcctg ccttgtctca
      361 gtgcgccctc ccagtgttga ctcagcgttt gggggacaaa agacaggact tctttggaga
      421 tctctgagga aattaaggac caaggggcct ggtgactcct gcaagataaa taatccattg
      481 ccttgtaacc tgagtatcca gtctttggtg gaaaaacatt ttcaatttaa agggtgtctt
      541 tgcactgatg atctccactg tacagtaaac aaaatttttg gaaaaaagtg caccaataag
      601 acagaagact caccactgcc ctccaatctg gcgccaaggt caaatgttcc ccgatggttc
      661 ccaaggagag attcgtcttc actggctgta aggaaggctg actgcgtcgc ggctgccgag
      721 gcctgccagg aatcggagca ctgcgcactg ctccatgaga actttaagaa cgcctgtgac
      781 acaggaacag ctcagtgtcg cactcttagc ggccgactga agtgtgtggg cctaagacag
      841 cgcctgagac agacggtcct gtgggagtgt cgctgcggtc tccctttaga aaaagactgc
      901 gttcagatta ggaaaagcct gtttggagac atttgcgtac aggatgctca aatggaacaa
      961 attcccacct tcagtcaaga caaccaagat ggattcaagg aggacgttgc ttcaggattc
     1021 aaacagatgc agtcttgttt ggaagtgaca gaggcgtgtg taggggatgt ggtttgtaat
     1081 gcacagttgg ccctttacct taaagcatgc acagcaaatg gaaatctgtg tgatgtgaaa
     1141 cactgccaag cggccatacg gttcttctat caaaatatgc cttttaacac tgcccagatg
     1201 ttggcttttt gtgactgtgc tcaatctgat ataccctgtc aacaatccaa agaaactctt
     1261 cacagcaagc catgtgcact gaacgtagtt ccacccccca cttgcctcag tgtaattcac
     1321 acttgccgaa atgatgaatt atgcaggaca tactaccgaa cattccagac agaatgctgg
     1381 ccccatgtgg ctgggaagtg tcgtgaagat gagacctgca ttagtatgct gggcaagcaa
     1441 gaccttactt gttctgggag tgacagctgc agggcagcct acctaggaac cttcgggaca
     1501 gtccttcagg tgccgtgtgc ttgcagaagc atcacacagg gtgaagaacc cttgtgcatg
     1561 gctttccagc acatgcttca cagcaaatca tgtttcaatt acccaactcc taatgtcaaa
     1621 gacatttcct catatgaaag aaagcattca aaagaaatta ccctgactgg attcaattct
     1681 cccttcagtg gagaactaat ctatgttgtt gtgtgcatgg tagttaccag cgggattctt
     1741 tccttggtga tgctcaagct aaggatacct agtaagaaaa gagaccccgc gcccatcgaa
     1801 atagctggag ctgtcatcat tcagtgagct gcagctcgct atcaaccaca cgtccgagtg
     1861 gctaaccaat ggaagattac atttccaata atctgattta agatggattt gacaatactt
     1921 actcattata tataacaatg cctggtacat taaagtagca taaggatcac aaatctgttt
     1981 ttgttttcta aaattatttg agtaaatact tgtagctgtg tcataactag ttgataacat
     2041 tttctttaaa ggcaacaggt gtcatgtaaa atgtgacagt taagctggaa gactgtcagt
     2101 gcacataaca acttctatct tataggactc atcatagtgt gcgtattttt ctgaacaatt
     2161 ctgtagtttc tcattaagtt tggacatttg ctatttgcat attcttagtg tccaatcatt
     2221 aaacaaattg gtaacattga acagatttgg ttagataact gtttataaaa ataaaaactg
     2281 acatcctatg aattttatag tttaaataat attgaatttt acttttggtt tggtgtgtgt
     2341 tttttttctt tttctttttt cttttttttt ttttttttcg gagctgggga ccgaacccag
     2401 ggccttgcgc ttgctaggca agcgctctac cgctgagcta aatccccaac ccctggtgtg
     2461 tttttaagta tataaagcaa ctacattgtt tgagaaaagt caatgtttgc tccaataatg
     2521 atatattttg tgaatttatt tatttttgct gattaatcat catgaaataa taaagacatc
     2581 cttaa
//
