LOCUS       NM_001395069            1418 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus GDNF family receptor alpha 4 (Gfra4), transcript
            variant 1, mRNA.
ACCESSION   NM_001395069 XM_006235045
VERSION     NM_001395069.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1418)
  AUTHORS   Lindfors,P.H., Lindahl,M., Rossi,J., Saarma,M. and Airaksinen,M.S.
  TITLE     Ablation of persephin receptor glial cell line-derived neurotrophic
            factor family receptor alpha4 impairs thyroid calcitonin production
            in young mice
  JOURNAL   Endocrinology 147 (5), 2237-2244 (2006)
   PUBMED   16497798
REFERENCE   2  (bases 1 to 1418)
  AUTHORS   Masure,S., Cik,M., Hoefnagel,E., Nosrat,C.A., Van der Linden,I.,
            Scott,R., Van Gompel,P., Lesage,A.S., Verhasselt,P., Ibanez,C.F.
            and Gordon,R.D.
  TITLE     Mammalian GFRalpha -4, a divergent member of the GFRalpha family of
            coreceptors for glial cell line-derived neurotrophic factor family
            ligands, is a receptor for the neurotrophic factor persephin
  JOURNAL   J Biol Chem 275 (50), 39427-39434 (2000)
   PUBMED   10958791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jun 1, 2021 this sequence version replaced XM_006235045.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ294475.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000003.1  138710833-138710956 c
            125-479             JAXUCZ010000003.1  138709918-138710272 c
            480-589             JAXUCZ010000003.1  138709759-138709868 c
            590-724             JAXUCZ010000003.1  138709544-138709678 c
            725-816             JAXUCZ010000003.1  138708711-138708802 c
            817-1418            JAXUCZ010000003.1  138707970-138708571 c
FEATURES             Location/Qualifiers
     source          1..1418
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1418
                     /gene="Gfra4"
                     /note="GDNF family receptor alpha 4"
                     /db_xref="GeneID:66023"
                     /db_xref="RGD:620503"
     exon            1..124
                     /gene="Gfra4"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..867
                     /gene="Gfra4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GFR-alpha-4; persephin receptor; GDNFR-alpha-4; GDNF
                     receptor alpha-4; glial cell line derived neurotrophic
                     factor family receptor alpha 4"
                     /codon_start=1
                     /product="GDNF family receptor alpha-4 isoform 1"
                     /protein_id="NP_001381998.1"
                     /db_xref="GeneID:66023"
                     /db_xref="RGD:620503"
                     /translation="MLSGAYLRVLNERPGQAVLWSLGCQRGSASSTEGNRCVEAAEAC
                     TADEQCQQLRSEYVAQCLGRAGWRGPGSCVRSRCRRALRRFFARGPPALTHALLFCGC
                     EGPACAERRRQTFAPACAFSGPQLAPPSCLKPLDRCERSRRCRPRLFAFQASCAPAPG
                     SRDGCPEEGGPRCLRAYAGLVGTVVTPNYLDNVSARVAPWCGCEASGNRREECEAFRK
                     LFTRNPCLDGAIQAFDSSQPSVLQDQWNPYQNAGCCFLRVSSMSILTALALQALL"
     exon            125..479
                     /gene="Gfra4"
                     /inference="alignment:Splign:2.1.0"
     exon            480..589
                     /gene="Gfra4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..724
                     /gene="Gfra4"
                     /inference="alignment:Splign:2.1.0"
     exon            725..816
                     /gene="Gfra4"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1418
                     /gene="Gfra4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtaagct ttaaggcaga ggagacctaa gagctgagac atgctatgtt gagtggagcg
       61 tatttacggg tgctgaatga gaggccaggc caggcagttt tatggagtct tggatgccag
      121 agagggtcag cgagctccac tgaggggaat cgctgcgtgg aagcagccga ggcgtgcaca
      181 gcagacgagc agtgccagca gctgcgctcc gagtacgtgg cgcaatgcct gggccgggcg
      241 ggctggcggg gacccgggag ctgcgtgcgc tcccgctgcc gccgtgccct gcgccgcttc
      301 ttcgcccgcg ggcctccggc gctcacgcac gcgctgctct tctgcggatg cgaaggcccc
      361 gcgtgcgccg agcgccggcg ccagacattc gcgcccgcct gcgcgttctc cggcccccag
      421 ctggcgccac cttcctgcct gaagcccttg gaccgctgcg agcgaagccg ccggtgccgg
      481 ccccgtctct ttgccttcca ggcctcatgc gctcccgcgc ccggctcccg cgacggctgt
      541 ccggaggagg ggggcccgcg gtgtctgcgc gcctacgcag gccttgtagg caccgtggtc
      601 acccccaact acctggacaa cgtgagcgcg cgcgttgcgc cctggtgcgg ctgtgaggcc
      661 agcggaaacc ggcgcgaaga gtgcgaagcc ttccgcaagc tttttacaag gaacccctgc
      721 ttggatggtg ccatacaagc ctttgacagc tcgcaaccat cagttctgca ggaccagtgg
      781 aacccctacc agaatgctgg gtgctgtttc ctgcgggtgt cctcgatgtc catactcact
      841 gccctggctc tccaggccct gctctaatta ggaaggtgaa ccatggacaa cacagctgac
      901 tgccatgtct ctggattatg ctcactgaac tgaaactccc ttgccctcag gtctgctgtc
      961 ctttgcagtt ctggacccct gcatggctgt ctcctggact gggagctgga ggctagggcc
     1021 cgactgttag gttcccctgt tagtaggcat ctcacctgtt ttcttcacca tccttgagat
     1081 gatggtagat gatatttagc acctgtagac agggcctcat tgggcccctt gggcttacag
     1141 agcagaacag agactagcct cctgctctta gaattgggta gtgttctttt ccaagaagac
     1201 atggcactaa ggtgatcata tgaacagact gacagactgc agtctaaata cccatgcccc
     1261 agggccagcg ctgaccttgc ttgtcaccta tgacatggcg ctgtgtaggg attaaagaga
     1321 gagattcagg tccctcctgc tggacatccc actggcctcc cagactctcc cagcacctgc
     1381 agtggcacag cagctcaata aacccatgtg cactgaga
//
