LOCUS       NM_012750               2793 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus GDNF family receptor alpha 2 (Gfra2), mRNA.
ACCESSION   NM_012750
VERSION     NM_012750.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Zhou,L. and Too,H.P.
  TITLE     GDNF family ligand dependent STAT3 activation is mediated by
            specific alternatively spliced isoforms of GFRalpha2 and RET
  JOURNAL   Biochim Biophys Acta 1833 (12), 2789-2802 (2013)
   PUBMED   23872421
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Zhu,X., Sun,Y., Wang,Z., Cui,W., Peng,Y. and Li,R.
  TITLE     Expression of glial cell line-derived neurotrophic factor and its
            receptors in cultured retinal Muller cells under high glucose
            circumstance
  JOURNAL   Anat Rec (Hoboken) 295 (3), 532-539 (2012)
   PUBMED   22266674
  REMARK    GeneRIF: Synthesis of GFRa2 protein is enhanced in Muller cells at
            24 hr in experimental diabetic retinopathy, and then the level of
            GFRa2 protein is downregulated.
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   Wan,G., Zhou,L., Lim,Q.'., Wong,Y.H. and Too,H.P.
  TITLE     Cyclic AMP signalling through PKA but not Epac is essential for
            neurturin-induced biphasic ERK1/2 activation and neurite outgrowths
            through GFRalpha2 isoforms
  JOURNAL   Cell Signal 23 (11), 1727-1737 (2011)
   PUBMED   21723942
  REMARK    GeneRIF: Cyclic AMP signalling through PKA but not Epac is
            essential for neurturin-induced biphasic ERK1/2 activation and
            neurite outgrowths through GFRalpha2 isoforms.
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Forrest,S.L. and Keast,J.R.
  TITLE     Expression of receptors for glial cell line-derived neurotrophic
            factor family ligands in sacral spinal cord reveals separate
            targets of pelvic afferent fibers
  JOURNAL   J Comp Neurol 506 (6), 989-1002 (2008)
   PUBMED   18085594
  REMARK    GeneRIF: GFRalpha2-labeled fibers were only in inner lamina II of
            spinal cord.
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Hisasue,S., Kato,R., Kobayashi,K., Suetomi,T., Kiyama,H. and
            Tsukamoto,T.
  TITLE     Alteration of glial cell line-derived neurotrophic factor family
            receptor alpha-2 mRNA expression and its co-expression with
            neuronal nitric oxide synthase in pelvic ganglia following
            unilateral cavernous nerve injury
  JOURNAL   Int J Urol 15 (1), 82-86 (2008)
   PUBMED   18184180
  REMARK    GeneRIF: GAP43 mRNA expression moderately increased in the intact
            Major pelvic ganglia, and GFRalpha2 mRNA was maintained in the
            intact MPG but not in the injured one.
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Rossi,J., Tomac,A., Saarma,M. and Airaksinen,M.S.
  TITLE     Distinct roles for GFRalpha1 and GFRalpha2 signalling in different
            cranial parasympathetic ganglia in vivo
  JOURNAL   Eur J Neurosci 12 (11), 3944-3952 (2000)
   PUBMED   11069590
REFERENCE   7  (bases 1 to 2793)
  AUTHORS   Baloh,R.H., Gorodinsky,A., Golden,J.P., Tansey,M.G., Keck,C.L.,
            Popescu,N.C., Johnson,E.M. Jr. and Milbrandt,J.
  TITLE     GFRalpha3 is an orphan member of the GDNF/neurturin/persephin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5801-5806 (1998)
   PUBMED   9576965
REFERENCE   8  (bases 1 to 2793)
  AUTHORS   Trupp,M., Raynoschek,C., Belluardo,N. and Ibanez,C.F.
  TITLE     Multiple GPI-anchored receptors control GDNF-dependent and
            independent activation of the c-Ret receptor tyrosine kinase
  JOURNAL   Mol Cell Neurosci 11 (1-2), 47-63 (1998)
   PUBMED   9608533
REFERENCE   9  (bases 1 to 2793)
  AUTHORS   Suvanto,P., Wartiovaara,K., Lindahl,M., Arumae,U., Moshnyakov,M.,
            Horelli-Kuitunen,N., Airaksinen,M.S., Palotie,A., Sariola,H. and
            Saarma,M.
  TITLE     Cloning, mRNA distribution and chromosomal localisation of the gene
            for glial cell line-derived neurotrophic factor receptor beta, a
            homologue to GDNFR-alpha
  JOURNAL   Hum Mol Genet 6 (8), 1267-1273 (1997)
   PUBMED   9259272
REFERENCE   10 (bases 1 to 2793)
  AUTHORS   Sanicola,M., Hession,C., Worley,D., Carmillo,P., Ehrenfels,C.,
            Walus,L., Robinson,S., Jaworski,G., Wei,H., Tizard,R., Whitty,A.,
            Pepinsky,R.B. and Cate,R.L.
  TITLE     Glial cell line-derived neurotrophic factor-dependent RET
            activation can be mediated by two different cell-surface accessory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6238-6243 (1997)
   PUBMED   9177201
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012750.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U97143.1, AF005226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000015.1  52352112-52352271
            161-475             JAXUCZ010000015.1  52357247-52357561
            476-559             JAXUCZ010000015.1  52363194-52363277
            560-914             JAXUCZ010000015.1  52386238-52386592
            915-1024            JAXUCZ010000015.1  52430753-52430862
            1025-1165           JAXUCZ010000015.1  52431566-52431706
            1166-1338           JAXUCZ010000015.1  52432819-52432991
            1339-1392           JAXUCZ010000015.1  52440819-52440872
            1393-2793           JAXUCZ010000015.1  52441969-52443369
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..2793
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /note="GDNF family receptor alpha 2"
                     /db_xref="GeneID:25136"
                     /db_xref="RGD:61809"
     exon            1..160
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1515
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /note="glial cell line derived neurotrophic factor family
                     receptor alpha 2; tyrosine kinase receptor ligand 2"
                     /codon_start=1
                     /product="GDNF family receptor alpha-2"
                     /protein_id="NP_036882.1"
                     /db_xref="GeneID:25136"
                     /db_xref="RGD:61809"
                     /translation="MILANAFCLFFFLDETLRSLASPSSLQGSELHGWRPQVDCVRAN
                     ELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKE
                     LQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGTDPAVSTKSNH
                     CLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYR
                     MLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCR
                     ASYRTITSCPADNYQACLGSYAGMIGFDMTPNYVDSNPTGIVVSPWCNCRGSGNMEEE
                     CEKFLRDFTENPCLRNAIQAFGNGTDVNMSPKGPSLPATQAPRVEKTPSLPDDLSDST
                     SLGTSVITTCTSIQEQGLKANNSKELSMCFTELTTNISPGSKKVIKLNSGSSRARLSA
                     ALTALPLLMLTLAL"
     exon            161..475
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..559
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..914
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1024
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1165
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1338
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1392
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..2793
                     /gene="Gfra2"
                     /gene_synonym="Retl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgcattg gatttggggg tcgttattgc tcggctgtta ttattatcgt tattttattt
       61 ttatttttta aacctaaggg agaaagacac atacacacaa aactgtggga tttatttaac
      121 atgatcttgg caaacgcctt ctgcctcttc ttctttttag acgaaaccct ccgctctttg
      181 gccagccctt cctccctgca gggctctgag ctccacggct ggcgccccca agtggactgt
      241 gtccgggcca atgagctgtg tgcggctgaa tccaactgca gctccaggta ccgcaccctt
      301 cggcagtgcc tggcaggccg ggatcgcaat accatgctgg ccaataagga gtgccaggca
      361 gccctggagg tcttgcagga aagcccactg tatgactgcc gctgcaagcg gggcatgaag
      421 aaggagctgc agtgtctgca gatctactgg agcatccatc tggggctgac agagggtgag
      481 gagttctatg aagcttcccc ctatgagcct gtgacctcgc gcctctcgga catcttcagg
      541 ctcgcttcaa tcttctcagg gacagggaca gacccggcgg tcagtaccaa aagcaaccac
      601 tgcctggatg ccgccaaggc ctgcaacctg aatgacaact gcaagaagct tcgctcctct
      661 tatatctcca tctgcaaccg tgagatctct cccaccgaac gctgcaaccg ccgcaagtgc
      721 cacaaggctc tgcgccagtt ctttgaccgt gtgcccagcg agtataccta ccgcatgctc
      781 ttctgctcct gtcaggacca ggcatgtgct gagcgtcgcc ggcaaaccat cctgcccagt
      841 tgctcctatg aggacaagga gaagcccaac tgcctggacc tgcgcagcct gtgtcgtaca
      901 gaccacctgt gccggtcccg actggcagat ttccacgcca actgtcgagc ctcctaccgg
      961 acaatcacca gctgtcctgc ggacaactac caggcatgtc tgggctccta tgctggcatg
     1021 attgggtttg atatgacacc caactatgtg gactccaacc ccacgggcat cgtggtgtct
     1081 ccctggtgca attgtcgtgg cagtgggaac atggaagaag agtgtgagaa gttcctcagg
     1141 gacttcacgg aaaacccatg cctccggaat gccattcagg cctttggtaa tggcacagat
     1201 gtgaacatgt ctcccaaagg cccctcactc ccagctaccc aggcccctcg ggtggagaag
     1261 actccttcac tgccagatga cctcagtgac agcaccagcc tggggaccag tgtcatcacc
     1321 acctgcacat ctatccagga gcaagggctg aaggccaaca actccaaaga gttaagcatg
     1381 tgcttcacag agctcacgac aaacatcagt ccagggagta aaaaggtgat caaacttaac
     1441 tcaggctcca gcagagccag actgtcggct gccttgactg ccctcccact cctgatgctg
     1501 accttggcct tgtaggcctt tggaacccag cacaaaagtt cttcaagcaa cccagatatg
     1561 aactcccgcc tgacaaaatg gaaacacacg catacacaca tgcacacaca cacaaacaca
     1621 cacacacaca cacacacaca cacacacaca cacacacaca cacacacccc ttgcaaaaac
     1681 actttttttc ctacattgtc tctgaacctt tctcctccca agtttcttct ctggagaagt
     1741 ttttctaaac caaacagaca agcaggcggg cagtcagaag cctgcccaga ggtcccctgc
     1801 aagggacacc cagcaccaac gagggctcaa ggctcttgag agactctttt ctcttcactg
     1861 gtgttttctc tctggacaag atgagaccct gatgtggaag gtactttgct gtgcctggtg
     1921 tggactgggg aaaggacagt tgcagctgcc tactctgggg acctgcccaa gggttcacag
     1981 agagtctcag tcagcaagga agcagggctg gccacaagga ctttgtcacc tcttcctctt
     2041 ggcttcagag atggaaatgg tttgctgcca tccccagcca ttatgtggcc tagtgggttt
     2101 aagtctggag taggaagcct catggcagct tcaggccatg gtgcctgtag tatagctggg
     2161 gttgggagct gttacaggag gaagcttctt tggggcatga gcaagccttg gttgggcacc
     2221 agctccaaga tgtaccttcc tcctttatgc caggaatctt gaagtcaaag agaaatgatc
     2281 ctctgttggc tcttttttgt ttgtttttga atttttttgt gggtccattt ggcaggtctc
     2341 tcttggggag aagggctgtt gagtggggct ggggagaccc tagctgggcg tgtgtatgga
     2401 gcactctggt gggttcccaa gcttgcccct tctctcttct tgtttctgct ttctctctca
     2461 tttctgagac attcatgcac tgtctgtaca tactgggtct cctttctcaa catatgtgta
     2521 tatccatatc catatatcct atgattttac tctttctttc atttttttta aagaaacaaa
     2581 actatggaaa taatacccta cagatgagcg aaaatgtatt attgtaaagt ttattttttt
     2641 taataatgtt gtctatgatg ggaagaaagg taccaggacc cctgagccct ggtccagttg
     2701 ggctggtggg gctgtggccg gggactcccg attgcattca ctcttaacca agctccaata
     2761 aacgtactag gaagcgagtc gccctgtgct tca
//
