LOCUS       NM_012959               3602 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus GDNF family receptor alpha 1 (Gfra1), mRNA.
ACCESSION   NM_012959
VERSION     NM_012959.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3602)
  AUTHORS   Kasanga,E.A., Han,Y., Navarrete,W., McManus,R., Shifflet,M.K.,
            Parry,C., Barahona,A., Manfredsson,F.P., Nejtek,V.A.,
            Richardson,J.R. and Salvatore,M.F.
  TITLE     Differential expression of RET and GDNF family receptor,
            GFR-alpha1, between striatum and substantia nigra following
            nigrostriatal lesion: A case for diminished GDNF-signaling
  JOURNAL   Exp Neurol 366, 114435 (2023)
   PUBMED   37178997
  REMARK    GeneRIF: Differential expression of RET and GDNF family receptor,
            GFR-alpha1, between striatum and substantia nigra following
            nigrostriatal lesion: A case for diminished GDNF-signaling.
REFERENCE   2  (bases 1 to 3602)
  AUTHORS   Hu,X.B., Fu,S.H., Luo,Q.I., He,J.Z., Qiu,Y.F., Lai,W. and Zhong,M.
  TITLE     Down-regulation of microRNA-216a confers protection against yttrium
            aluminium garnet laser-induced retinal injury via the GDNF-mediated
            GDNF/GFRalpha1/RET signalling pathway
  JOURNAL   J Biosci 43 (5), 985-1000 (2018)
   PUBMED   30541958
  REMARK    GeneRIF: The findings demonstrate that elevated GDNF levels can
            reduce the retinal injury, whereby down-regulated miR-216a
            aggravates the YAG laser-induced retinal injury by targeting the
            GDNF level through the GDNF/GFRa1/RET signaling pathway.
REFERENCE   3  (bases 1 to 3602)
  AUTHORS   Arnold,J.C. and Salvatore,M.F.
  TITLE     Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is
            Accompanied by Increased Nigral GFR-alpha1 and EAAC1 Expression in
            Aging Rats
  JOURNAL   ACS Chem Neurosci 7 (2), 227-239 (2016)
   PUBMED   26599339
  REMARK    GeneRIF: Exercise-Mediated Increase in Nigral gfra1 in aging rats.
REFERENCE   4  (bases 1 to 3602)
  AUTHORS   Forrest,S.L., Osborne,P.B. and Keast,J.R.
  TITLE     Characterization of axons expressing the artemin receptor in the
            female rat urinary bladder: a comparison with other major neuronal
            populations
  JOURNAL   J Comp Neurol 522 (17), 3900-3927 (2014)
   PUBMED   25043933
  REMARK    GeneRIF: these studies reveal a diverse range of potential targets
            by which artemin could influence bladder function, nerve
            regeneration, and pain.
REFERENCE   5  (bases 1 to 3602)
  AUTHORS   Goodman,K.M., Kjaer,S., Beuron,F., Knowles,P.P., Nawrotek,A.,
            Burns,E.M., Purkiss,A.G., George,R., Santoro,M., Morris,E.P. and
            McDonald,N.Q.
  TITLE     RET recognition of GDNF-GFRalpha1 ligand by a composite binding
            site promotes membrane-proximal self-association
  JOURNAL   Cell Rep 8 (6), 1894-1904 (2014)
   PUBMED   25242331
REFERENCE   6  (bases 1 to 3602)
  AUTHORS   Burazin,T.C. and Gundlach,A.L.
  TITLE     Up-regulation of GDNFR-alpha and c-ret mRNA in facial motor neurons
            following facial nerve injury in the rat
  JOURNAL   Brain Res Mol Brain Res 55 (2), 331-336 (1998)
   PUBMED   9582449
REFERENCE   7  (bases 1 to 3602)
  AUTHORS   Klein,R.D., Sherman,D., Ho,W.H., Stone,D., Bennett,G.L., Moffat,B.,
            Vandlen,R., Simmons,L., Gu,Q., Hongo,J.A., Devaux,B., Poulsen,K.,
            Armanini,M., Nozaki,C., Asai,N., Goddard,A., Phillips,H.,
            Henderson,C.E., Takahashi,M. and Rosenthal,A.
  TITLE     A GPI-linked protein that interacts with Ret to form a candidate
            neurturin receptor
  JOURNAL   Nature 387 (6634), 717-721 (1997)
   PUBMED   9192898
  REMARK    Erratum:[Nature 1998 Mar 12;392(6672):210]
REFERENCE   8  (bases 1 to 3602)
  AUTHORS   Sanicola,M., Hession,C., Worley,D., Carmillo,P., Ehrenfels,C.,
            Walus,L., Robinson,S., Jaworski,G., Wei,H., Tizard,R., Whitty,A.,
            Pepinsky,R.B. and Cate,R.L.
  TITLE     Glial cell line-derived neurotrophic factor-dependent RET
            activation can be mediated by two different cell-surface accessory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6238-6243 (1997)
   PUBMED   9177201
REFERENCE   9  (bases 1 to 3602)
  AUTHORS   Treanor,J.J., Goodman,L., de Sauvage,F., Stone,D.M., Poulsen,K.T.,
            Beck,C.D., Gray,C., Armanini,M.P., Pollock,R.A., Hefti,F.,
            Phillips,H.S., Goddard,A., Moore,M.W., Buj-Bello,A., Davies,A.M.,
            Asai,N., Takahashi,M., Vandlen,R., Henderson,C.E. and Rosenthal,A.
  TITLE     Characterization of a multicomponent receptor for GDNF
  JOURNAL   Nature 382 (6586), 80-83 (1996)
   PUBMED   8657309
REFERENCE   10 (bases 1 to 3602)
  AUTHORS   Jing,S., Wen,D., Yu,Y., Holst,P.L., Luo,Y., Fang,M., Tamir,R.,
            Antonio,L., Hu,Z., Cupples,R., Louis,J.C., Hu,S., Altrock,B.W. and
            Fox,G.M.
  TITLE     GDNF-induced activation of the ret protein tyrosine kinase is
            mediated by GDNFR-alpha, a novel receptor for GDNF
  JOURNAL   Cell 85 (7), 1113-1124 (1996)
   PUBMED   8674117
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012959.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U97142.1, SRR26360176.1728841.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAXUCZ010000001.1  267555523-267555811 c
            290-583             JAXUCZ010000001.1  267554356-267554649 c
            584-667             JAXUCZ010000001.1  267553106-267553189 c
            668-682             JAXUCZ010000001.1  267492881-267492895 c
            683-1019            JAXUCZ010000001.1  267394654-267394990 c
            1020-1129           JAXUCZ010000001.1  267366037-267366146 c
            1130-1264           JAXUCZ010000001.1  267362934-267363068 c
            1265-1446           JAXUCZ010000001.1  267352757-267352938 c
            1447-1500           JAXUCZ010000001.1  267328141-267328194 c
            1501-3602           JAXUCZ010000001.1  267325297-267327398 c
FEATURES             Location/Qualifiers
     source          1..3602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..3602
                     /gene="Gfra1"
                     /note="GDNF family receptor alpha 1"
                     /db_xref="GeneID:25454"
                     /db_xref="RGD:2681"
     exon            1..289
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1656
                     /gene="Gfra1"
                     /note="GDNFR-alpha; GFR-alpha-1; RET ligand 1; GDNF
                     receptor alpha; TGF-beta-related neurotrophic factor
                     receptor 1; GDNFR-alpha-1; GDNF receptor alpha-1; Glial
                     cell line-derived neurotrophic factor receptor alpha;
                     glial cell line derived neurotrophic factor family
                     receptor alpha 1; GDNF family receptor alpha-1-like"
                     /codon_start=1
                     /product="GDNF family receptor alpha-1 precursor"
                     /protein_id="NP_037091.1"
                     /db_xref="GeneID:25454"
                     /db_xref="RGD:2681"
                     /translation="MFLATLYFALPLLDLLMSAEVSGGDRLDCVKASDQCLKEQSCST
                     KYRTLRQCVAGKETNFSLTSGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRI
                     YWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRAVPFISDVFQQVEHISKGNNCLDAAKA
                     CNLDDTCKKYRSAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRD
                     IACTERRRQTIVPVCSYEERERPNCLSLQDSCKTNYICRSRLADFFTNCQPESRSVSN
                     CLKENYADCLLAYSGLIGTVMTPNYVDSSSLSVAPWCDCSNSGNDLEDCLKFLNFFKD
                     NTCLKNAIQAFGNGSDVTMWQPAPPVQTTTATTTTAFRVKNKPLGPAGSENEIPTHVL
                     PPCANLQAQKLKSNVSGSTHLCLSDSDFGKDGLAGASSHITTKSMAAPPSCSLSSLPV
                     LMLTALAALLSVSLAETS"
     exon            290..583
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..667
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..682
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..1019
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1129
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1264
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1446
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1500
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..3602
                     /gene="Gfra1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggttgggt cggaactgaa cccctgaaag cgggtccgcc tcccgccctc gcgcccgccc
       61 ggatctgagt cgctggcggc ggtgggcggc agagcgacgg ggagtctgct ctcaccctgg
      121 atggagctga actttgagtg gccagaggag cgcagtcgcc cggggatcgc tgcacgctga
      181 gctctctccc cgagaccggg cggcggcttt ggattttggg ggggcgggga ccagctgcgc
      241 ggcggcacca tgttcctagc cactctgtac ttcgcgctgc cactcctgga tttgctgatg
      301 tccgccgagg tgagtggtgg agaccgtctg gactgtgtga aagccagcga tcagtgcctg
      361 aaggaacaga gctgcagcac caagtaccgc acactaaggc agtgcgtggc gggcaaggaa
      421 accaacttca gcctgacatc cggccttgag gccaaggatg agtgccgtag cgccatggag
      481 gccttgaagc agaagtctct gtacaactgc cgctgcaagc ggggcatgaa gaaagagaag
      541 aattgtctgc gtatctactg gagcatgtac cagagcctgc agggaaatga cctcctggaa
      601 gattccccgt atgagccggt taacagcagg ttgtcagata tattccgggc agtcccgttc
      661 atatcagatg ttttccagca agtggaacac atttccaaag ggaacaactg cctggacgca
      721 gccaaggcct gcaacctgga cgacacctgt aagaagtaca ggtcggccta catcaccccc
      781 tgcaccacca gcatgtccaa cgaggtctgc aaccgccgta agtgccacaa ggccctcagg
      841 cagttcttcg acaaggttcc ggccaagcac agctacggga tgctcttctg ctcctgccgg
      901 gacatcgcct gcaccgagcg gcggcgacag actatcgtcc ccgtgtgctc ctatgaagaa
      961 cgagagaggc ccaactgcct gagtctgcaa gactcctgca agaccaatta catctgcaga
     1021 tctcgccttg cagatttttt taccaactgc cagccagagt caaggtctgt cagcaactgt
     1081 cttaaggaga actacgcaga ctgcctcctg gcctactcgg gactgattgg cacagtcatg
     1141 actcccaact acgtagactc cagcagcctc agcgtggcac catggtgtga ctgcagcaac
     1201 agcggcaatg acctggaaga ctgcttgaaa tttctgaatt tttttaagga caatacttgt
     1261 ctcaaaaatg caattcaagc ctttggcaat ggctcagatg tgaccatgtg gcagccagcc
     1321 cctccagtcc agaccaccac tgccaccact accactgcct tccgggtcaa gaacaagcct
     1381 ctggggccag cagggtctga gaatgagatc cccacacacg ttttaccacc ctgtgcgaat
     1441 ttgcaggctc agaagctgaa atccaatgtg tcgggtagca cacacctctg tctttctgat
     1501 agtgatttcg gaaaggatgg tctcgctggt gcctccagcc acataaccac aaaatcaatg
     1561 gctgctcctc ccagctgcag tctgagctca ctgccggtgc tgatgctcac cgcccttgct
     1621 gccctgttat ctgtatcgtt ggcagaaacg tcgtagctgc atccgggaaa acagtatgaa
     1681 aagacaaaag agaaccaagt attctgtccc tgtcctcttg tatatctgaa aatccagttt
     1741 taaaagctcc gttgagaagc agtttcaccc aactggaact ctttccttgt ttttaagaaa
     1801 gcttgtggcc ctcaggggct tctgttgaag aactgctaca gggctaattc caaacccata
     1861 aggctctggg gcgtggtgcg gcttaagggg accatttgca ccatgtaaag caagctgggc
     1921 ttatcatgtg tttgatggtg aggatggtag tggtgatgat gatggtaatt ttaacagctt
     1981 gaaccctgtt ctctctactg gttaggaaca ggagatacta ttgataaaga ttcttccatg
     2041 tcttactcag cagcattgcc ttctgaagac aggcccgcag cctagtgtga atgacaagtg
     2101 gaggttggcc tcaagagtgg acttggcaga ctctaccttg tagtaatgtt cacctttccg
     2161 tgtatggtct ccacagagtg tttatgtatt tacagactgt tctgtgatcc cccaacaaca
     2221 acaaccacaa attccttggt cacctccaaa tgtaaccggt cctttagccc agtagaggag
     2281 ggtgggtgtg gccctggcac agctcccgga ttgttgatgg gcactctcct gagctttgct
     2341 tgagtgagaa gctgaatgta gctgaaaatc aactcttctt acacttctta ctgcttcgtt
     2401 cacttacgag gtcacatata gaacaaacat caccaactat tagcttaccg ttagcttccc
     2461 aactattagc tttctatgtt ttgaaagcag tgttgctgac cccatgtttt aatgatggtt
     2521 taatacacgc agccctttcc tctcatcggt aacactagct ccaacatcaa cttcatgcat
     2581 gtggctctca aaagcaggcc ccaggaagcc cagttcttta ggagaaagct gcgtcctgtt
     2641 tctgtggaca ggcaggagga aacagagcag cctgcccgtg gtgtctttat ctgttttgaa
     2701 atcaaggctg cctgtgtgta aggaatggtt caattcttat aaagggtgcc actgttgatg
     2761 ccacaactgg cagttggtct agctccagga caccggtttc catgttgcct ggcagagaca
     2821 gctttgattg ggactggctg gccacaaggg atgggatgaa gatgtgctgc cctctctttc
     2881 aaagttgagc cctgccaggg cacatagaag catctttgct cctgaccaca acgtagaaca
     2941 gcttggattc aaggtcatca agcgtctcct gtacattgct ctgtgacctt cataacagac
     3001 tgtcccgcac aaaaggaacg gcagtttatg gatctagagt gggagcacag ggtctggaaa
     3061 ggtgaaccgg ttggcaaaat acacagaaca ggagggagag tctcaagccg agacatcttg
     3121 cttactagcc acacgccatc tcctggagcc ctcctcctga cctgggcaga cccttaggtg
     3181 tatatctaaa gacctcttca atgttcaggt tcagaatctg taaatggttt cgtcctggca
     3241 cccattcctg aaaactgaac aaaggagagg agaatctttc ctccattgag ccctgaaagt
     3301 atgactggct tctcaccctc ccacagagca gggagccctg gtgcacacag tctcctgata
     3361 tcctccctgc tctttgaggt ttgccttggg agaaaatgat tcacctcggg aggggacgct
     3421 ttggtgtctg aagtacattt atatcgaaat gttaatgaat acccatgtaa aatactcaat
     3481 agccaccttt cttcccttca caatgttttc gaggggaatg catccaacat ccaagtgtac
     3541 ctggtcagtg ggaagttcca tgaagactca tacattgaat aaacatattc gatgtgccga
     3601 aa
//
