LOCUS       NM_001002819            3024 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutamine-fructose-6-phosphate transaminase 2
            (Gfpt2), mRNA.
ACCESSION   NM_001002819 XM_579087
VERSION     NM_001002819.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3024)
  AUTHORS   Nabeebaccus,A.A., Verma,S., Zoccarato,A., Emanuelli,G.,
            Santos,C.X., Streckfuss-Bomeke,K. and Shah,A.M.
  TITLE     Cardiomyocyte protein O-GlcNAcylation is regulated by GFAT1 not
            GFAT2
  JOURNAL   Biochem Biophys Res Commun 583, 121-127 (2021)
   PUBMED   34735873
  REMARK    GeneRIF: Cardiomyocyte protein O-GlcNAcylation is regulated by
            GFAT1 not GFAT2.
REFERENCE   2  (bases 1 to 3024)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   3  (bases 1 to 3024)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   4  (bases 1 to 3024)
  AUTHORS   Zhang,H., Jia,Y., Cooper,J.J., Hale,T., Zhang,Z. and Elbein,S.C.
  TITLE     Common variants in glutamine:fructose-6-phosphate amidotransferase
            2 (GFPT2) gene are associated with type 2 diabetes, diabetic
            nephropathy, and increased GFPT2 mRNA levels
  JOURNAL   J Clin Endocrinol Metab 89 (2), 748-755 (2004)
   PUBMED   14764791
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098630.1.
            
            On Jul 13, 2005 this sequence version replaced NM_001002819.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..3024
                     /gene="Gfpt2"
                     /note="glutamine-fructose-6-phosphate transaminase 2"
                     /db_xref="GeneID:360518"
                     /db_xref="RGD:1303097"
     exon            1..107
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2149
                     /gene="Gfpt2"
                     /EC_number="2.6.1.16"
                     /note="glucosamine--fructose-6-phosphate aminotransferase
                     [isomerizing] 2; GFAT2; GFAT 2; hexosephosphate
                     aminotransferase 2; D-fructose-6-phosphate
                     amidotransferase 2; glutamine:fructose-6-phosphate
                     amidotransferase 2"
                     /codon_start=1
                     /product="glutamine--fructose-6-phosphate aminotransferase
                     [isomerizing] 2"
                     /protein_id="NP_001002819.2"
                     /db_xref="GeneID:360518"
                     /db_xref="RGD:1303097"
                     /translation="MCGIFAYMNYRVPKTRKEIFETLIRGLQRLEYRGYDSAGVAIDG
                     NNHEVKERHIHLVKKKGKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPNVV
                     NSHPQRSDKDNEFVVIHNGIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNR
                     ETEDITFSTLVERVIQQLEGAFALVFKSIHYPGEAVATRRGSPLLIGVRSKYKLSTEQ
                     IPVLYRTCTIENVKNICKTRLKRLDSSTCLHAVGDKAVEFFFASDASAIIEHTNRVIF
                     LEDDDIAAVADGKLSIHRVKRSASDDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQP
                     ESVFNTMRGRVNFETNTVLLGGLKDHLKEIRRCRRLIVIGCGTSYHAAVATRQVLEEL
                     TELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYCKDRGALTVGITNT
                     VGSSISRETDCGVHINAGPEIGVASTKAYTSQFISLVMFGLMMSEDRISLQTRRQEII
                     RGLRSLPELIKEVLSLDEKIHDLALELYTQRSLLVMGRGYNYATCLEGALKIKEITYM
                     HSEGILAGELKHGPLALVDKQMPVIMVIMKDPCFAKCQNALQQVTARQGRPIILCSKD
                     DTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFHLAVLRGYDVDFPRNLAKSVTVE
                     "
     exon            108..215
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..314
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..440
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..499
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..634
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..696
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..776
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..894
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1058
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1154
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1252
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1373
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1531
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1646
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1774
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1942
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2104
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2992
                     /gene="Gfpt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggctggct ataagggcag gaggccgagc ggcgggagcc tgagccaggg agcgcgaggc
       61 gcagcgagtc gtccgggcgt ctggagctat cggagccacc atgtgcggaa tctttgccta
      121 tatgaattac agagttccca agacgaggaa ggagattttt gaaaccctca tcaggggcct
      181 gcagcggctg gagtaccggg gttatgactc ggcaggtgtg gccattgacg ggaataacca
      241 tgaagtcaaa gaaagacaca tccatcttgt gaagaagaag ggaaaagtga aggctctgga
      301 tgaagaactt tacaagcaag atagcatgga cttgaaggta gagtttgaga cacacttcgg
      361 catagcccac acacgttggg ccacccatgg ggtccccaat gtggtcaaca gtcacccaca
      421 gcgttcagac aaagacaatg aatttgtcgt catccacaac ggaatcatca ctaattacaa
      481 ggatctaagg aaatttctgg aaagcaaggg ctacgagttt gagtcagaaa cagacacgga
      541 gaccatcgcc aagctgatta aatacgtatt cgacaacaga gagactgagg acattacgtt
      601 ttccacattg gtcgaaagag tcattcagca gttggaaggc gcctttgccc tggtcttcaa
      661 gagcatccac tacccgggag aagctgttgc cacaaggaga ggcagccccc tgctcatcgg
      721 ggtacgaagc aaatacaaac tctccacaga gcagatcccc gtcttatatc ggacatgcac
      781 tattgagaat gtgaagaata tctgtaagac caggctgaag agactggaca gctccacctg
      841 cctgcatgca gtgggggata aagccgtgga gttcttcttt gcttctgatg caagtgccat
      901 catagaacac accaaccggg tcatcttctt agaagatgat gatattgctg cagtggctga
      961 tgggaaactc tccattcacc gagtcaaacg ctcagctagt gatgacccct cccgagccat
     1021 ccagaccttg cagatggaac tacagcaaat aatgaaaggt aacttcagtg catttatgca
     1081 gaaggagatc ttcgagcagc cagaatctgt ttttaatacc atgagaggtc gggtaaattt
     1141 tgagaccaac acagtgctcc tgggtggctt gaaggaccat ttgaaggaga ttcgtcgatg
     1201 ccgaaggctc attgtgatag gctgtggaac cagctaccat gccgctgtgg ctacacggca
     1261 agtgttagag gaactgaccg agctccctgt gatggttgaa cttgccagtg actttctgga
     1321 caggaacaca cctgtgttca gggatgatgt ttgctttttc ataagccagt caggagagac
     1381 tgcagacacg ctcctggcgc tgcgatactg taaggatcgc ggtgcgctga ccgtgggcat
     1441 caccaacacc gtgggcagct ccatctcccg agagaccgac tgtggcgtcc acatcaacgc
     1501 agggcccgag attggggtgg ctagcaccaa ggcctacacc agccagttca tctctctggt
     1561 gatgtttggt ttgatgatgt ctgaagatcg aatttctcta cagaccagga gacaagagat
     1621 catccgtggc ctcagatctt tacctgagct gatcaaagaa gtattatccc tggatgagaa
     1681 gatccacgac ttggccctgg agctctacac acagaggtca ctcctagtga tgggacgagg
     1741 atataactat gccacatgcc tggaaggtgc cttgaaaatt aaagagataa cctacatgca
     1801 ttcagaaggt atcctggccg gagagctgaa gcacgggccc cttgctctcg tcgacaagca
     1861 gatgccagtc atcatggtga tcatgaagga tccttgcttt gccaagtgcc agaatgccct
     1921 gcagcaggtc actgcccgcc agggtcgccc aatcattctg tgctccaagg atgacacgga
     1981 gagttccaag tttgcatata aaaccattga acttccccac acggtggact gtctccaggg
     2041 tatcctgagc gtgattccac tccagcttct gtccttccac ctggctgtcc tccgaggtta
     2101 tgatgttgac ttcccgagaa acctagccaa gtctgtcact gtggaatgag aacaggactt
     2161 ccacgacaag accatcatca cccgcagtct gatttaagac ctggaggaac tgcaaagatg
     2221 ccacgtggga gaggaagtgg gcctccatgg gcccctcatg cttccagtag ggcttgacag
     2281 ctttgatgtg ccttgtaccc aagtgctttg cttacagcaa atgctgtttc tctgtgtcct
     2341 gacgtcactg aggagaaggg attgtttaca cacggggatg ggagcagact ttccactact
     2401 gtgcaataga gataccgctc tcttcagagt aactgtgaac ctttttttaa ccaacactag
     2461 ctagttttaa aagtcgaaat atttatgatg acgattgtat agcttttaag ttatttttct
     2521 aacgtgtggc ttttctgtag ccatggtagc gccctagatg tgcatctggg ctacccagag
     2581 tgctgtctct gggcacaatt gtggcaggtg tcattcatct cggttttgga cactaggcat
     2641 gagtcctgtc tcctttctcc ttattctccc tccacaagct gctcctgatt cctgtttcct
     2701 gacaccgagt cccctctacc cttttgctat gcttcctttg aacccagtta aagtctctcc
     2761 tgtcagtatt ctcagatgga ctcagatccc tcagctccct gacttctgcg taatcagata
     2821 acggttcttt ttaattccca ggcagcactt tggtcccggc tccctactca tagtaaacca
     2881 gccttaaatg ccccacacaa gagggtggtt ccataggggc taccctgctc tatttaaaag
     2941 cgtacacaat caatgtacta tgcaagttta caataaagac agtgcaactt ttaaaaaaaa
     3001 aaaaaaaaaa aaaaaaaaaa aaaa
//
