LOCUS       NM_001005879            2285 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus glutamine fructose-6-phosphate transaminase 1
            (Gfpt1), mRNA.
ACCESSION   NM_001005879 XM_216205
VERSION     NM_001005879.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2285)
  AUTHORS   Nabeebaccus,A.A., Verma,S., Zoccarato,A., Emanuelli,G.,
            Santos,C.X., Streckfuss-Bomeke,K. and Shah,A.M.
  TITLE     Cardiomyocyte protein O-GlcNAcylation is regulated by GFAT1 not
            GFAT2
  JOURNAL   Biochem Biophys Res Commun 583, 121-127 (2021)
   PUBMED   34735873
  REMARK    GeneRIF: Cardiomyocyte protein O-GlcNAcylation is regulated by
            GFAT1 not GFAT2.
REFERENCE   2  (bases 1 to 2285)
  AUTHORS   Li,M.D., Ruan,H.B., Hughes,M.E., Lee,J.S., Singh,J.P., Jones,S.P.,
            Nitabach,M.N. and Yang,X.
  TITLE     O-GlcNAc signaling entrains the circadian clock by inhibiting
            BMAL1/CLOCK ubiquitination
  JOURNAL   Cell Metab 17 (2), 303-310 (2013)
   PUBMED   23395176
REFERENCE   3  (bases 1 to 2285)
  AUTHORS   Rogacka,D., Piwkowska,A., Jankowski,M., Kocbuch,K.,
            Dominiczak,M.H., Stepinski,J.K. and Angielski,S.
  TITLE     Expression of GFAT1 and OGT in podocytes: transport of glucosamine
            and the implications for glucose uptake into these cells
  JOURNAL   J Cell Physiol 225 (2), 577-584 (2010)
   PUBMED   20506529
  REMARK    GeneRIF: results suggest that cultured podocytes possess limited
            ability to synthesize glucosamine (GlcN) internally and therefore
            may need to receive GlcN from the extracellular environment.
REFERENCE   4  (bases 1 to 2285)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 2285)
  AUTHORS   Heptulla,R.A., Rodriguez,L.M., Mason,K.J. and Haymond,M.W.
  TITLE     Twenty-four-hour simultaneous subcutaneous Basal-bolus
            administration of insulin and amylin in adolescents with type 1
            diabetes decreases postprandial hyperglycemia
  JOURNAL   J Clin Endocrinol Metab 94 (5), 1608-1611 (2009)
   PUBMED   19190104
REFERENCE   6  (bases 1 to 2285)
  AUTHORS   Huynh,Q.K., Gulve,E.A. and Dian,T.
  TITLE     Purification and characterization of glutamine:fructose 6-phosphate
            amidotransferase from rat liver
  JOURNAL   Arch Biochem Biophys 379 (2), 307-313 (2000)
   PUBMED   10898949
REFERENCE   7  (bases 1 to 2285)
  AUTHORS   Simmons,S.T., Daniels,M.C., Huddleston,E., Hebert,L.F. Jr.,
            McClain,D.A. and Crook,E.D.
  TITLE     Insulin stimulation of glutamine: fructose-6-phosphate
            amidotransferase occurs via an insulin-like growth factor-1 pathway
            in rat fibroblasts
  JOURNAL   Res Commun Mol Pathol Pharmacol 104 (1), 63-72 (1999)
   PUBMED   10604279
REFERENCE   8  (bases 1 to 2285)
  AUTHORS   Nerlich,A.G., Sauer,U., Kolm-Litty,V., Wagner,E., Koch,M. and
            Schleicher,E.D.
  TITLE     Expression of glutamine:fructose-6-phosphate amidotransferase in
            human tissues: evidence for high variability and distinct
            regulation in diabetes
  JOURNAL   Diabetes 47 (2), 170-178 (1998)
   PUBMED   9519709
REFERENCE   9  (bases 1 to 2285)
  AUTHORS   Robinson,K.A., Weinstein,M.L., Lindenmayer,G.E. and Buse,M.G.
  TITLE     Effects of diabetes and hyperglycemia on the hexosamine synthesis
            pathway in rat muscle and liver
  JOURNAL   Diabetes 44 (12), 1438-1446 (1995)
   PUBMED   7589852
REFERENCE   10 (bases 1 to 2285)
  AUTHORS   Crook,E.D., Daniels,M.C., Smith,T.M. and McClain,D.A.
  TITLE     Regulation of insulin-stimulated glycogen synthase activity by
            overexpression of glutamine: fructose-6-phosphate amidotransferase
            in rat-1 fibroblasts
  JOURNAL   Diabetes 42 (9), 1289-1296 (1993)
   PUBMED   8349040
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083889.1.
            
            On Oct 23, 2004 this sequence version replaced XM_216205.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2285
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /note="glutamine fructose-6-phosphate transaminase 1"
                     /db_xref="GeneID:297417"
                     /db_xref="RGD:1549703"
     exon            1..106
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2145
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /EC_number="2.6.1.16"
                     /note="glutamine:fructose-6-phosphate amidotransferase 1;
                     glucosamine--fructose-6-phosphate aminotransferase
                     [isomerizing] 1; GFAT 1; hexosephosphate aminotransferase
                     1; D-fructose-6-phosphate amidotransferase 1"
                     /codon_start=1
                     /product="glutamine--fructose-6-phosphate aminotransferase
                     [isomerizing] 1"
                     /protein_id="NP_001005879.1"
                     /db_xref="GeneID:297417"
                     /db_xref="RGD:1549703"
                     /translation="MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDG
                     GNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEP
                     SPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMY
                     DNWESQDVSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLS
                     TDHIPILYRTGKDKKGSCGLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFL
                     EDDDVAAVVDGRLSIHRIKRTARDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPE
                     SVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGMATRQVLEELT
                     ELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTV
                     GSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIML
                     GLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMH
                     SEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKED
                     TETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE"
     exon            107..214
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            215..322
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            323..448
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            449..507
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            508..642
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            643..704
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            705..784
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            785..890
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1054
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1150
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1248
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1369
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1527
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1642
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1770
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1938
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2100
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2260
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggagtcc atctcattgc cgccacccgg cccgagctca tcctcgcttc cgaagctctc
       61 gcgcgcccga cagctcgtcc ctcgccagtg accaacatca tgtgtggtat atttgcttat
      121 ttaaattacc atgttcctcg aacaagacga gaaatcttgg agacattaat caaaggcctt
      181 cagagattgg agtacagagg atatgattct gctggtgtgg gacttgacgg aggcaatgac
      241 aaagactggg aagccaacgc ctgcaaaatc cagctcatca agaagaaagg aaaagttaag
      301 gctctggatg aagaagttca caaacaacaa gatatggact tggatataga atttgatgtg
      361 catcttggaa tagctcatac ccgttgggcg acacatggag aacctagccc tgtcaatagt
      421 cacccccagc gctctgataa aaataacgaa ttcatcgtta ttcataatgg aatcatcacc
      481 aactacaaag acttgaaaaa gtttctggaa agcaaaggct atgactttga atctgaaaca
      541 gacacagaga ccatcgctaa gctagtcaag tacatgtatg acaactggga aagccaggac
      601 gtcagtttta ctaccttggt ggagagagtt atccagcaat tggaaggcgc ctttgctctt
      661 gtgtttaaaa gtgtccattt tccggggcaa gcagttggca caaggcgagg tagccctctc
      721 ttgattggtg tgcggagcga acataagctt tctacagatc acattccgat tctgtacaga
      781 acaggcaaag acaagaaagg aagctgtggt ctttcccgag tggacagcac gacatgcctt
      841 ttccctgttg aggaaaaggc ggttgaatat tactttgctt ctgatgcaag tgccgtgata
      901 gagcacacca atcgtgtcat ctttctggag gatgatgatg ttgcagccgt ggtggacggc
      961 cgtctctcga tccaccgaat taaacggact gcaagggacc accctggccg agcagtgcaa
     1021 accctccaga tggaactcca gcagatcatg aagggcaact ttagttcatt tatgcagaag
     1081 gaaatttttg agcagccaga atctgttgtg aacacaatga gaggaagagt caattttgat
     1141 gactacactg tgaacttggg aggtctgaaa gaccacatta aggagatcca gcggtgtcgg
     1201 cggttgattc tgattgcttg tggcacaagt taccacgctg gtatggcaac ccgtcaggtc
     1261 ctagaggagc tgacagagtt accagtgatg gtggagcttg ccagcgactt cttggataga
     1321 aacactccag tcttccgaga tgatgtttgc tttttcatca gtcaatcagg cgagacagct
     1381 gacaccctga tgggtcttcg ctactgtaag gagagaggag ccttaactgt ggggattaca
     1441 aatactgtcg gcagttcgat atcacgggag acagattgtg gggttcatat caatgctggt
     1501 cctgagatcg gcgtggccag tacaaaggct tacaccagcc agttcgtgtc ccttgtgatg
     1561 tttgccctca tgatgtgtga tgacagaatc tccatgcaag aaagacgcaa agagatcatg
     1621 ctgggactga agcgactgcc ggacttgatt aaggaagtgt tgagcatgga tgatgaaatt
     1681 cagaagctgg cgacagagct ttaccaccag aagtcggtcc tgataatggg ccgaggctat
     1741 cattatgcta catgtcttga aggagccctg aaaatcaagg agattacata tatgcattct
     1801 gaaggcatcc ttgctggtga gctaaaacac ggccctctgg ccttggtgga caagttgatg
     1861 cctgtcatca tgatcatcat gcgagaccac acttacgcca agtgccagaa tgctcttcag
     1921 caagtcgttg cacggcaggg gcgtccagtc gtgatctgtg ataaggagga tactgagacc
     1981 attaagaata caaaaaggac aatcaaggtg ccccactcag tggactgctt gcagggcatt
     2041 ctcagcgtga tccccttaca gctgctggcc ttccatctgg ctgtgctgag aggctacgat
     2101 gtcgatttcc cacggaatct tgccaaatct gtaaccgtag agtaaaagac acctgaaact
     2161 taagacagct aagcaacaca agataccttt tgtatttaaa tttttgattt aaaatattgc
     2221 ctcctgaaag ccttttttag taaatcttat ttatatatca aaaaaaaaaa aaaaaaaaaa
     2281 aaaaa
//
