LOCUS       NP_001005879             681 aa            linear   ROD 04-DEC-2024
DEFINITION  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
            [Rattus norvegicus].
ACCESSION   NP_001005879 XP_216205
VERSION     NP_001005879.1
DBSOURCE    REFSEQ: accession NM_001005879.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 681)
  AUTHORS   Nabeebaccus,A.A., Verma,S., Zoccarato,A., Emanuelli,G.,
            Santos,C.X., Streckfuss-Bomeke,K. and Shah,A.M.
  TITLE     Cardiomyocyte protein O-GlcNAcylation is regulated by GFAT1 not
            GFAT2
  JOURNAL   Biochem Biophys Res Commun 583, 121-127 (2021)
   PUBMED   34735873
  REMARK    GeneRIF: Cardiomyocyte protein O-GlcNAcylation is regulated by
            GFAT1 not GFAT2.
REFERENCE   2  (residues 1 to 681)
  AUTHORS   Li,M.D., Ruan,H.B., Hughes,M.E., Lee,J.S., Singh,J.P., Jones,S.P.,
            Nitabach,M.N. and Yang,X.
  TITLE     O-GlcNAc signaling entrains the circadian clock by inhibiting
            BMAL1/CLOCK ubiquitination
  JOURNAL   Cell Metab 17 (2), 303-310 (2013)
   PUBMED   23395176
REFERENCE   3  (residues 1 to 681)
  AUTHORS   Rogacka,D., Piwkowska,A., Jankowski,M., Kocbuch,K.,
            Dominiczak,M.H., Stepinski,J.K. and Angielski,S.
  TITLE     Expression of GFAT1 and OGT in podocytes: transport of glucosamine
            and the implications for glucose uptake into these cells
  JOURNAL   J Cell Physiol 225 (2), 577-584 (2010)
   PUBMED   20506529
  REMARK    GeneRIF: results suggest that cultured podocytes possess limited
            ability to synthesize glucosamine (GlcN) internally and therefore
            may need to receive GlcN from the extracellular environment.
REFERENCE   4  (residues 1 to 681)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (residues 1 to 681)
  AUTHORS   Heptulla,R.A., Rodriguez,L.M., Mason,K.J. and Haymond,M.W.
  TITLE     Twenty-four-hour simultaneous subcutaneous Basal-bolus
            administration of insulin and amylin in adolescents with type 1
            diabetes decreases postprandial hyperglycemia
  JOURNAL   J Clin Endocrinol Metab 94 (5), 1608-1611 (2009)
   PUBMED   19190104
REFERENCE   6  (residues 1 to 681)
  AUTHORS   Huynh,Q.K., Gulve,E.A. and Dian,T.
  TITLE     Purification and characterization of glutamine:fructose 6-phosphate
            amidotransferase from rat liver
  JOURNAL   Arch Biochem Biophys 379 (2), 307-313 (2000)
   PUBMED   10898949
REFERENCE   7  (residues 1 to 681)
  AUTHORS   Simmons,S.T., Daniels,M.C., Huddleston,E., Hebert,L.F. Jr.,
            McClain,D.A. and Crook,E.D.
  TITLE     Insulin stimulation of glutamine: fructose-6-phosphate
            amidotransferase occurs via an insulin-like growth factor-1 pathway
            in rat fibroblasts
  JOURNAL   Res Commun Mol Pathol Pharmacol 104 (1), 63-72 (1999)
   PUBMED   10604279
REFERENCE   8  (residues 1 to 681)
  AUTHORS   Nerlich,A.G., Sauer,U., Kolm-Litty,V., Wagner,E., Koch,M. and
            Schleicher,E.D.
  TITLE     Expression of glutamine:fructose-6-phosphate amidotransferase in
            human tissues: evidence for high variability and distinct
            regulation in diabetes
  JOURNAL   Diabetes 47 (2), 170-178 (1998)
   PUBMED   9519709
REFERENCE   9  (residues 1 to 681)
  AUTHORS   Robinson,K.A., Weinstein,M.L., Lindenmayer,G.E. and Buse,M.G.
  TITLE     Effects of diabetes and hyperglycemia on the hexosamine synthesis
            pathway in rat muscle and liver
  JOURNAL   Diabetes 44 (12), 1438-1446 (1995)
   PUBMED   7589852
REFERENCE   10 (residues 1 to 681)
  AUTHORS   Crook,E.D., Daniels,M.C., Smith,T.M. and McClain,D.A.
  TITLE     Regulation of insulin-stimulated glycogen synthase activity by
            overexpression of glutamine: fructose-6-phosphate amidotransferase
            in rat-1 fibroblasts
  JOURNAL   Diabetes 42 (9), 1289-1296 (1993)
   PUBMED   8349040
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083889.1.
            
            On Oct 23, 2004 this sequence version replaced XP_216205.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     Protein         1..681
                     /product="glutamine--fructose-6-phosphate aminotransferase
                     [isomerizing] 1"
                     /EC_number="2.6.1.16"
                     /note="glutamine:fructose-6-phosphate amidotransferase 1;
                     glucosamine--fructose-6-phosphate aminotransferase
                     [isomerizing] 1; GFAT 1; hexosephosphate aminotransferase
                     1; D-fructose-6-phosphate amidotransferase 1"
                     /calculated_mol_wt=76697
     Region          1..681
                     /region_name="PLN02981"
                     /note="glucosamine:fructose-6-phosphate aminotransferase"
                     /db_xref="CDD:215531"
     Site            103
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06210; propagated from
                     UniProtKB/Swiss-Prot (P82808.3)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P82808.3)"
     Region          295..662
                     /region_name="Isomerase. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P82808.3)"
     CDS             1..681
                     /gene="Gfpt1"
                     /gene_synonym="GFA; GFAT; GFAT1; GFAT1m; Gfpt"
                     /coded_by="NM_001005879.1:100..2145"
                     /db_xref="GeneID:297417"
                     /db_xref="RGD:1549703"
ORIGIN      
        1 mcgifaylny hvprtrreil etlikglqrl eyrgydsagv gldggndkdw eanackiqli
       61 kkkgkvkald eevhkqqdmd ldiefdvhlg iahtrwathg epspvnshpq rsdknnefiv
      121 ihngiitnyk dlkkfleskg ydfesetdte tiaklvkymy dnwesqdvsf ttlverviqq
      181 legafalvfk svhfpgqavg trrgspllig vrsehklstd hipilyrtgk dkkgscglsr
      241 vdsttclfpv eekaveyyfa sdasavieht nrvifleddd vaavvdgrls ihrikrtard
      301 hpgravqtlq melqqimkgn fssfmqkeif eqpesvvntm rgrvnfddyt vnlgglkdhi
      361 keiqrcrrli liacgtsyha gmatrqvlee ltelpvmvel asdfldrntp vfrddvcffi
      421 sqsgetadtl mglryckerg altvgitntv gssisretdc gvhinagpei gvastkayts
      481 qfvslvmfal mmcddrismq errkeimlgl krlpdlikev lsmddeiqkl atelyhqksv
      541 limgrgyhya tclegalkik eitymhsegi lagelkhgpl alvdklmpvi miimrdhtya
      601 kcqnalqqvv arqgrpvvic dkedtetikn tkrtikvphs vdclqgilsv iplqllafhl
      661 avlrgydvdf prnlaksvtv e
//
