LOCUS       NM_001107823            1618 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus growth factor independent 1B transcriptional
            repressor (Gfi1b), mRNA.
ACCESSION   NM_001107823 XM_001079155 XM_231109
VERSION     NM_001107823.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Monteferrario,D., Bolar,N.A., Marneth,A.E., Hebeda,K.M.,
            Bergevoet,S.M., Veenstra,H., Laros-van Gorkom,B.A., MacKenzie,M.A.,
            Khandanpour,C., Botezatu,L., Fransen,E., Van Camp,G.,
            Duijnhouwer,A.L., Salemink,S., Willemsen,B., Huls,G., Preijers,F.,
            Van Heerde,W., Jansen,J.H., Kempers,M.J., Loeys,B.L., Van Laer,L.
            and Van der Reijden,B.A.
  TITLE     A dominant-negative GFI1B mutation in the gray platelet syndrome
  JOURNAL   N Engl J Med 370 (3), 245-253 (2014)
   PUBMED   24325358
  REMARK    Erratum:[N Engl J Med. 2015 Aug 20;373(8):782. doi:
            10.1056/NEJMx150011. PMID: 26287868]
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Vassen,L., Khandanpour,C., Ebeling,P., van der Reijden,B.A.,
            Jansen,J.H., Mahlmann,S., Duhrsen,U. and Moroy,T.
  TITLE     Growth factor independent 1b (Gfi1b) and a new splice variant of
            Gfi1b are highly expressed in patients with acute and chronic
            leukemia
  JOURNAL   Int J Hematol 89 (4), 422-430 (2009)
   PUBMED   19360458
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Saleque,S., Kim,J., Rooke,H.M. and Orkin,S.H.
  TITLE     Epigenetic regulation of hematopoietic differentiation by Gfi-1 and
            Gfi-1b is mediated by the cofactors CoREST and LSD1
  JOURNAL   Mol Cell 27 (4), 562-572 (2007)
   PUBMED   17707228
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Elmaagacli,A.H., Koldehoff,M., Zakrzewski,J.L., Steckel,N.K.,
            Ottinger,H. and Beelen,D.W.
  TITLE     Growth factor-independent 1B gene (GFI1B) is overexpressed in
            erythropoietic and megakaryocytic malignancies and increases their
            proliferation rate
  JOURNAL   Br J Haematol 136 (2), 212-219 (2007)
   PUBMED   17156408
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Rodriguez,P., Bonte,E., Krijgsveld,J., Kolodziej,K.E., Guyot,B.,
            Heck,A.J., Vyas,P., de Boer,E., Grosveld,F. and Strouboulis,J.
  TITLE     GATA-1 forms distinct activating and repressive complexes in
            erythroid cells
  JOURNAL   EMBO J 24 (13), 2354-2366 (2005)
   PUBMED   15920471
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   McGhee,L., Bryan,J., Elliott,L., Grimes,H.L., Kazanjian,A.,
            Davis,J.N. and Meyers,S.
  TITLE     Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8)
            and histone deacetylase proteins, and represses transcription using
            a TSA-sensitive mechanism
  JOURNAL   J Cell Biochem 89 (5), 1005-1018 (2003)
   PUBMED   12874834
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   Tong,B., Grimes,H.L., Yang,T.Y., Bear,S.E., Qin,Z., Du,K.,
            El-Deiry,W.S. and Tsichlis,P.N.
  TITLE     The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid
            cell differentiation
  JOURNAL   Mol Cell Biol 18 (5), 2462-2473 (1998)
   PUBMED   9566867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001107823.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_231109.3, XM_001079155.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158685.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..1618
                     /gene="Gfi1b"
                     /note="growth factor independent 1B transcriptional
                     repressor"
                     /db_xref="GeneID:311832"
                     /db_xref="RGD:1311727"
     exon            1..95
                     /gene="Gfi1b"
                     /inference="alignment:Splign:2.1.0"
     exon            96..219
                     /gene="Gfi1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1112
                     /gene="Gfi1b"
                     /note="growth factor independent 1B transcription
                     repressor"
                     /codon_start=1
                     /product="zinc finger protein Gfi-1b"
                     /protein_id="NP_001101293.1"
                     /db_xref="GeneID:311832"
                     /db_xref="RGD:1311727"
                     /translation="MPRSFLVKSKKAHTYHQPRAQGDDLVWPPAVIPVAKEHTQSGSP
                     VLSTLLPSQTLDWSAVKQKQEMLLNQSLPKMASAPEGPHVTSQPQDGESPLSESPPFY
                     KPSFSWDTLASSYRHSYQQTPSTMQSAFLERSVRLYGSPLVPSTESPLDFSLRYSPGM
                     DTYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQER
                     SFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPH
                     KCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK"
     exon            220..357
                     /gene="Gfi1b"
                     /inference="alignment:Splign:2.1.0"
     exon            358..629
                     /gene="Gfi1b"
                     /inference="alignment:Splign:2.1.0"
     exon            630..767
                     /gene="Gfi1b"
                     /inference="alignment:Splign:2.1.0"
     exon            768..933
                     /gene="Gfi1b"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1618
                     /gene="Gfi1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactcataaa gttgacagag ctgagagcag tcagcgtgga ggttctcggc tctcaggact
       61 cgggcagaac tcaggagagg gacagctccc tgacggtgcg gagcacactc tgaaaaaaaa
      121 tgccgcggtc ctttctagtg aagagtaaga aggcgcacac ctaccaccag ccccgagcac
      181 agggcgatga cctggtctgg cctcctgccg taattcctgt ggcaaaagaa catacccaga
      241 gtggcagccc tgttctcagc acactgcttc caagccagac cttggactgg agcgcagtca
      301 aacagaagca ggagatgctg ctgaaccaga gccttcccaa gatggcctca gccccagagg
      361 ggcctcacgt gacatcccaa ccccaggatg gggaatcgcc actctccgag tcaccccctt
      421 tctataagcc cagcttctct tgggatacgc tggcctcctc ctacagacac agctaccaac
      481 agaccccctc caccatgcag tcagctttcc tggagcgctc cgtgaggctg tacggcagcc
      541 cgcttgtgcc cagcaccgag tcccccttgg acttcagcct ccgttattct ccgggcatgg
      601 acacttacca ctgtgtcaag tgtaacaagg tgttctccac ccctcatggg ctagaagtgc
      661 atgtccgccg ctctcacagc ggaacccggc cctttgcctg tgacatctgt ggcaaaacct
      721 ttggccacgc tgtgagtttg gagcagcaca cgcacgtgca ttcccaggag cgtagcttcg
      781 agtgccggat gtgtggcaaa gccttcaagc gctcatccac tctgtccacc cacctgctca
      841 tccattcgga cactcggccc tacccctgcc agttctgtgg gaaacgcttc caccagaagt
      901 cggacatgaa gaaacacacc tacatccaca caggtgagaa gcctcacaag tgccaggtgt
      961 gtggaaaagc cttcagccaa agctccaacc tcatcaccca cagccgcaag cacacaggct
     1021 tcaagccctt cagctgtgag ctgtgcacaa agggcttcca gcgcaaggtg gacctgcgac
     1081 gtcaccgtga gagccaacat aacctcaagt gagactactg gccagcctgc cccggtgtgt
     1141 ctcgcctgaa ggccagcctc gtgattccag tccggatcct caggccacct ggaagcagcc
     1201 ctgcccatga gcctctctgc ttccttcgag actgggtgac ctcaaccaag ccatgcctct
     1261 tctctgactg cagcgggtgt aggagtcaac tccggccttt cggaactgaa gcagtcacag
     1321 atgtgctctg gtcacttccg ctgccagagc atagaaagaa gcaacaaaac tctgtgggca
     1381 gagatggcaa aaacaggcaa gagccaggct ccaagaagcc ttcttgcttg cttctctgcg
     1441 gctggtgaat gaatttttag ggattctctt tctgcctgcc agtcagagtt gtcccctgcc
     1501 ctataggtct ggcacccctc tgctttggct agatgtactg gctgtccctc acctctgacc
     1561 acactcatct gcccactggg agtggctcca caggtgagcc accaggctgt gaaagcag
//
