LOCUS       NM_012566               2408 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus growth factor independent 1 transcriptional
            repressor (Gfi1), mRNA.
ACCESSION   NM_012566
VERSION     NM_012566.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2408)
  AUTHORS   Kok,C.H., Watkins,D.B., Leclercq,T., D'Andrea,R.J., Hughes,T.P. and
            White,D.L.
  TITLE     Low GFI1 expression in white blood cells of CP-CML patients at
            diagnosis is strongly associated with subsequent blastic
            transformation
  JOURNAL   Leukemia 27 (6), 1427-1430 (2013)
   PUBMED   23411466
REFERENCE   2  (bases 1 to 2408)
  AUTHORS   Khandanpour,C., Krongold,J., Schutte,J., Bouwman,F., Vassen,L.,
            Gaudreau,M.C., Chen,R., Calero-Nieto,F.J., Diamanti,E., Hannah,R.,
            Meyer,S.E., Grimes,H.L., van der Reijden,B.A., Jansen,J.H.,
            Patel,C.V., Peeters,J.K., Lowenberg,B., Duhrsen,U., Gottgens,B. and
            Moroy,T.
  TITLE     The human GFI136N variant induces epigenetic changes at the Hoxa9
            locus and accelerates K-RAS driven myeloproliferative disorder in
            mice
  JOURNAL   Blood 120 (19), 4006-4017 (2012)
   PUBMED   22932805
REFERENCE   3  (bases 1 to 2408)
  AUTHORS   Ordonez-Rueda,D., Jonsson,F., Mancardi,D.A., Zhao,W., Malzac,A.,
            Liang,Y., Bertosio,E., Grenot,P., Blanquet,V., Sabrautzki,S., de
            Angelis,M.H., Meresse,S., Duprez,E., Bruhns,P., Malissen,B. and
            Malissen,M.
  TITLE     A hypomorphic mutation in the Gfi1 transcriptional repressor
            results in a novel form of neutropenia
  JOURNAL   Eur J Immunol 42 (9), 2395-2408 (2012)
   PUBMED   22684987
REFERENCE   4  (bases 1 to 2408)
  AUTHORS   Khandanpour,C., Kosan,C., Gaudreau,M.C., Duhrsen,U., Hebert,J.,
            Zeng,H. and Moroy,T.
  TITLE     Growth factor independence 1 protects hematopoietic stem cells
            against apoptosis but also prevents the development of a
            myeloproliferative-like disease
  JOURNAL   Stem Cells 29 (2), 376-385 (2011)
   PUBMED   21732494
REFERENCE   5  (bases 1 to 2408)
  AUTHORS   Wang,T.T., Chen,Z.X., Cen,J.N., He,J., Sheng,H.J. and Yao,L.
  TITLE     [Expression of growth-factor independence 1 in patients with
            leukemia and its significance]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 18 (4), 834-837 (2010)
   PUBMED   20723283
REFERENCE   6  (bases 1 to 2408)
  AUTHORS   Duan,Z. and Horwitz,M.
  TITLE     Targets of the transcriptional repressor oncoprotein Gfi-1
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 5932-5937 (2003)
   PUBMED   12721361
  REMARK    GeneRIF: This protein targets a subset of genes differentiating
            hematopoietic lineages and plays a role in the hierarchy of factors
            governing stem cell differentiation.
            Erratum:[Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16134]
REFERENCE   7  (bases 1 to 2408)
  AUTHORS   Wallis,D., Hamblen,M., Zhou,Y., Venken,K.J., Schumacher,A.,
            Grimes,H.L., Zoghbi,H.Y., Orkin,S.H. and Bellen,H.J.
  TITLE     The zinc finger transcription factor Gfi1, implicated in
            lymphomagenesis, is required for inner ear hair cell
            differentiation and survival
  JOURNAL   Development 130 (1), 221-232 (2003)
   PUBMED   12441305
REFERENCE   8  (bases 1 to 2408)
  AUTHORS   Karsunky,H., Zeng,H., Schmidt,T., Zevnik,B., Kluge,R., Schmid,K.W.,
            Duhrsen,U. and Moroy,T.
  TITLE     Inflammatory reactions and severe neutropenia in mice lacking the
            transcriptional repressor Gfi1
  JOURNAL   Nat Genet 30 (3), 295-300 (2002)
   PUBMED   11810106
REFERENCE   9  (bases 1 to 2408)
  AUTHORS   Rodel,B., Tavassoli,K., Karsunky,H., Schmidt,T., Bachmann,M.,
            Schaper,F., Heinrich,P., Shuai,K., Elsasser,H.P. and Moroy,T.
  TITLE     The zinc finger protein Gfi-1 can enhance STAT3 signaling by
            interacting with the STAT3 inhibitor PIAS3
  JOURNAL   EMBO J 19 (21), 5845-5855 (2000)
   PUBMED   11060035
REFERENCE   10 (bases 1 to 2408)
  AUTHORS   Gilks,C.B., Bear,S.E., Grimes,H.L. and Tsichlis,P.N.
  TITLE     Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma
            lines to IL-2-independent growth following activation of a gene
            (Gfi-1) encoding a novel zinc finger protein
  JOURNAL   Mol Cell Biol 13 (3), 1759-1768 (1993)
   PUBMED   8441411
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012566.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L06986.1, SRR26643292.50901.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                JAXUCZ010000014.1  2187349-2187364
            17-179              JAXUCZ010000014.1  2189381-2189543
            180-365             JAXUCZ010000014.1  2189845-2190030
            366-853             JAXUCZ010000014.1  2191366-2191853
            854-991             JAXUCZ010000014.1  2191975-2192112
            992-1157            JAXUCZ010000014.1  2192974-2193139
            1158-2408           JAXUCZ010000014.1  2195477-2196727
FEATURES             Location/Qualifiers
     source          1..2408
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2408
                     /gene="Gfi1"
                     /note="growth factor independent 1 transcriptional
                     repressor"
                     /db_xref="GeneID:24388"
                     /db_xref="RGD:2680"
     exon            1..16
                     /gene="Gfi1"
                     /inference="alignment:Splign:2.1.0"
     exon            17..179
                     /gene="Gfi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1336
                     /gene="Gfi1"
                     /note="growth factor independent protein 1; Growth factor
                     independent-1; growth factor independent 1 transcription
                     repressor"
                     /codon_start=1
                     /product="zinc finger protein Gfi-1"
                     /protein_id="NP_036698.1"
                     /db_xref="GeneID:24388"
                     /db_xref="RGD:2680"
                     /translation="MPRSFLVKSKKAHSYHQPRSPGPDYSLRLETVPVPGRADGGAVS
                     AGESKMEPRERLSPESQLTEAPDRASASPNSCEGSVCDPSSEFEDYWRPPSPSVSPAS
                     EKSLCRSLDEAQPYTLPFKPYAWSGLAGSDLRHLVQSYRQCSALERSAGLSLFCERGA
                     ESGRPAARYGSEQAAGGAGAGQPGSCGAASGATSAGGLGLYGDFAPAAAGLFERPSTA
                     AGRLYQDRGHELHADKSVGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVR
                     RSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLI
                     HSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHT
                     GFKPFGCDLCGKGFQRKVDLRRHRETQHGLK"
     exon            180..365
                     /gene="Gfi1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..853
                     /gene="Gfi1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..991
                     /gene="Gfi1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1157
                     /gene="Gfi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..2408
                     /gene="Gfi1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccctgacc ccgcagaact cagagtaacc gagggtccaa acatccgacc agcggctggc
       61 caccatgccg cgctcattcc tggtcaagag caagaaggcg cacagctacc accagccgcg
      121 ttctccgggg ccggactact ccctgcgcct ggagaccgtg cctgtgccgg gcagagcaga
      181 cggcggcgct gtgagtgcag gagagtcgaa gatggagccc cgagagcgtt tgtcccccga
      241 gtctcagctt accgaggctc cagacagagc ctccgcgtcc cccaacagct gcgaaggcag
      301 cgtttgtgac ccgagctccg agttcgagga ctactggagg cccccttctc cctctgtatc
      361 tccagcgtcg gagaagtcgc tgtgtcgctc tctggacgaa gcccagccct acacgctgcc
      421 tttcaagccc tacgcgtgga gcggcctcgc ggggtctgac ctgcggcacc tggtgcagag
      481 ctaccggcag tgcagcgcgc tggagcgcag cgctggcctg agcctcttct gcgagcgcgg
      541 cgcggagtcc ggccgcccgg ccgcgcgcta cggctcggag caggctgcgg gcggagcggg
      601 tgcgggacag cctgggagct gcggagcagc cagcggcgcc accagcgctg ggggcctggg
      661 gctctatggc gacttcgcgc ctgcggcggc cgggctgttc gagcggccga gcacagccgc
      721 aggccggctg taccaagatc gcggccacga gctgcacgcg gacaagagtg tgggagtcaa
      781 ggtggagtcc gagctgctgt gcacccgcct gctgctgggc ggcggctcct acaaatgcat
      841 caagtgcagc aaggtgtttt ccacaccgca tgggctggag gtgcacgtgc gccggtccca
      901 cagcggcacg agaccctttg cgtgcgagat gtgcggcaag actttcgggc acgcggtgag
      961 cctggagcaa cacaaggccg tacactcgca ggaacgcagc tttgactgta agatctgtgg
     1021 caagagcttc aagaggtcat ccacactgtc cacacatcta ctcattcact cggatacccg
     1081 gccctacccc tgtcagtact gtggcaagag gttccaccag aagtcagaca tgaagaaaca
     1141 cactttcatc cacacaggtg agaagcccca caaatgccag gtgtgtggca aagccttcag
     1201 tcagagctcc aacctcatca ctcatagcag aaagcacaca ggtttcaagc cctttggctg
     1261 tgacctgtgt gggaagggct tccagaggaa ggtggatctc aggaggcacc gagagactca
     1321 gcatggactc aaatgagtac cctggcagtc tgcaacacca actgtctaac actactgtga
     1381 gggatgtctt ccctgcctcc ctccagcccc ttctcaggcc ctgagtccag tgtgcaaagc
     1441 tcatcttggt tattcccctt cgtcttcctt cccggagctc ctggaggaga tgaactcctg
     1501 tttctaaggt cagcccagtg tgggatccac agaaatcgtt tgtgctttgg gcttccctac
     1561 agctgaagcc gggaatcaaa tgagatcttg cacctcccag ttcttccctt ttctgccctt
     1621 ctcacaggcg gggaagaact ctgggcagct gctaaaaggg gaggcatcac cgcttgaact
     1681 ttggacacca ccgatgcttt tattgagaaa gactgacctt tctggggaga ctgctgacct
     1741 ctttgtcctc caccagacac cggtttaggg aaggaaacgt atccctttga aatcatcaga
     1801 agcaccatca ggcctgccag gagaaggagc aggaaaaggc ggacttggcg atgagaggga
     1861 gtcagaggtc ccgtggagcc aatcagagtg ggtgaaacgg cagaggagca gctcctctca
     1921 gaggaacggg ctcctctttt actcagcgcg tggttgttgg ccacaggtta tcagagtaaa
     1981 aaaccgcatt aggtatggga gagccagagg ttaaaatcga cgctcctaac ccccaaaagc
     2041 tatcagtagg accccaacat agctagaacc cgtgttctcc gcctccaagg gagttctgaa
     2101 aaaggccaca caaacattcg aacttctttt tgacacttct ggagtttttc aagcataaac
     2161 gaaacagaac tggagagtta tttcaaaaat tcatgagcaa atccagtttt tattgttagg
     2221 tggaatttta taagatgccc aagctggcag gtgtggagca aaggctgtgg cctcaactgc
     2281 cgccccttat catctaggaa gaacgcattt cctgtgcggg tgtaaatgtt tctaaatctc
     2341 ctgagtgcat tgtgaactag cataatcata tttattagaa tgttgtttta acttaataaa
     2401 gtattaag
//
