LOCUS       NM_013222               1227 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus growth factor, augmenter of liver regeneration
            (Gfer), mRNA.
ACCESSION   NM_013222
VERSION     NM_013222.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1227)
  AUTHORS   Goyal,S., Tiwari,S., Seth,B., Tandon,A., Shankar,J., Sinha,M.,
            Singh,S.J., Priya,S. and Chaturvedi,R.K.
  TITLE     Bisphenol-A inhibits mitochondrial biogenesis via impairment of
            GFER mediated mitochondrial protein import in the rat brain
            hippocampus
  JOURNAL   Neurotoxicology 85, 18-32 (2021)
   PUBMED   33878312
  REMARK    GeneRIF: Bisphenol-A inhibits mitochondrial biogenesis via
            impairment of GFER mediated mitochondrial protein import in the rat
            brain hippocampus.
REFERENCE   2  (bases 1 to 1227)
  AUTHORS   Mordas,A. and Tokatlidis,K.
  TITLE     The MIA pathway: a key regulator of mitochondrial oxidative protein
            folding and biogenesis
  JOURNAL   Acc Chem Res 48 (8), 2191-2199 (2015)
   PUBMED   26214018
REFERENCE   3  (bases 1 to 1227)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   4  (bases 1 to 1227)
  AUTHORS   Chen,G.T., Zhang,L., Liao,X.H., Yan,R.Y., Li,Y., Sun,H., Guo,H. and
            Liu,Q.
  TITLE     Augmenter of liver regeneration ameliorates renal fibrosis in rats
            with obstructive nephropathy
  JOURNAL   Biosci Rep 34 (5), e00135 (2014)
   PUBMED   24844766
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1227)
  AUTHORS   Francavilla,A., Pesetti,B., Barone,M., Morgano,A., Bovenga,F.,
            Napoli,A., Resta,L., Russo,F., Linsalata,M., Minoia,M., Bianco,G.,
            Tafaro,A. and Polimeno,L.
  TITLE     Transient GFER knockdown in vivo impairs liver regeneration after
            partial hepatectomy
  JOURNAL   Int J Biochem Cell Biol 53, 343-351 (2014)
   PUBMED   24880092
  REMARK    GeneRIF: our results demonstrate that Growth Factor Erv1-Like gene
            knock-down, i.e., the lack of Augmenter of Liver Regeneration,
            modifies the expression of genes involved in cell apoptosis and
            inhibits early phase of DNA synthesis.
REFERENCE   6  (bases 1 to 1227)
  AUTHORS   Gandhi,C.R., Kuddus,R., Subbotin,V.M., Prelich,J., Murase,N.,
            Rao,A.S., Nalesnik,M.A., Watkins,S.C., DeLeo,A., Trucco,M. and
            Starzl,T.E.
  TITLE     A fresh look at augmenter of liver regeneration in rats
  JOURNAL   Hepatology 29 (5), 1435-1445 (1999)
   PUBMED   10216127
REFERENCE   7  (bases 1 to 1227)
  AUTHORS   Suzuki,K., Koh,Y.H., Mizuno,H., Hamaoka,R. and Taniguchi,N.
  TITLE     Overexpression of aldehyde reductase protects PC12 cells from the
            cytotoxicity of methylglyoxal or 3-deoxyglucosone
  JOURNAL   J Biochem 123 (2), 353-357 (1998)
   PUBMED   9538214
REFERENCE   8  (bases 1 to 1227)
  AUTHORS   Francavilla,A., Vujanovic,N.L., Polimeno,L., Azzarone,A.,
            Iacobellis,A., Deleo,A., Hagiya,M., Whiteside,T.L. and Starzl,T.E.
  TITLE     The in vivo effect of hepatotrophic factors augmenter of liver
            regeneration, hepatocyte growth factor, and insulin-like growth
            factor-II on liver natural killer cell functions
  JOURNAL   Hepatology 25 (2), 411-415 (1997)
   PUBMED   9021955
REFERENCE   9  (bases 1 to 1227)
  AUTHORS   Hagiya,M., Francavilla,A., Polimeno,L., Ihara,I., Sakai,H.,
            Seki,T., Shimonishi,M., Porter,K.A. and Starzl,T.E.
  TITLE     Cloning and sequence analysis of the rat augmenter of liver
            regeneration (ALR) gene: expression of biologically active
            recombinant ALR and demonstration of tissue distribution
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 3076 (1995)
   PUBMED   7708779
  REMARK    Correction to:[Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8142-6.
            doi: 10.1073/pnas.91.17.8142.. PMID: 8058770]
REFERENCE   10 (bases 1 to 1227)
  AUTHORS   Hagiya,M., Francavilla,A., Polimeno,L., Ihara,I., Sakai,H.,
            Seki,T., Shimonishi,M., Porter,K.A. and Starzl,T.E.
  TITLE     Cloning and sequence analysis of the rat augmenter of liver
            regeneration (ALR) gene: expression of biologically active
            recombinant ALR and demonstration of tissue distribution
  JOURNAL   Proc Natl Acad Sci U S A 91 (17), 8142-8146 (1994)
   PUBMED   8058770
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3076. doi:
            10.1073/pnas.92.7.3076d.. PMID: 7708779]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 27, 2011 this sequence version replaced NM_013222.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D30735.1, SRR26360194.587100.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               JAXUCZ010000010.1  14225062-14225379   c
            319-515             JAXUCZ010000010.1  14224494-14224690   c
            516-1227            JAXUCZ010000010.1  14223023-14223734   c
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1227
                     /gene="Gfer"
                     /gene_synonym="ALR"
                     /note="growth factor, augmenter of liver regeneration"
                     /db_xref="GeneID:27100"
                     /db_xref="RGD:61845"
     exon            1..318
                     /gene="Gfer"
                     /gene_synonym="ALR"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..678
                     /gene="Gfer"
                     /gene_synonym="ALR"
                     /EC_number="1.8.3.2"
                     /note="growth factor, erv1 homolog; growth factor,
                     erv1-like (augmenter of liver regeneration); FAD-linked
                     sulfhydryl oxidase ALR-like; translation initiation factor
                     IF-2-like"
                     /codon_start=1
                     /product="FAD-linked sulfhydryl oxidase ALR"
                     /protein_id="NP_037354.2"
                     /db_xref="GeneID:27100"
                     /db_xref="RGD:61845"
                     /translation="MAAPSEPAGFPRGSRFSFLPGGAHSEMTDDLVTDARGRGARHRK
                     DNAPAAAPAPKGLEHGKRPCRACVDFKSWMRTQQKRDIKFREDCPQDREELGRNTWAF
                     LHTLAAYYPDMPTPEQQQDMAQFIHIFSKFYPCEECAEDIRKRIDRSQPDTSTRVSFS
                     QWLCRLHNEVNRKLGKPDFDCSRVDERWRDGWKDGSCD"
     exon            319..515
                     /gene="Gfer"
                     /gene_synonym="ALR"
                     /inference="alignment:Splign:2.1.0"
     exon            516..1227
                     /gene="Gfer"
                     /gene_synonym="ALR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcgctgg cggtggcatg cgcgctgctc tgtcccgtct cctgcacgcc ctcttggccc
       61 cgctgctcgt acgccagcaa tatggcggcg cccagcgaac ccgcaggttt ccctcgcggc
      121 agtcgcttct ccttcctgcc gggcggcgcg cactcggaga tgaccgacga cctggtgact
      181 gacgcgcggg gccgcggcgc aaggcataga aaagacaacg cccctgccgc ggccccggcg
      241 ccgaaaggtt tggagcacgg gaagcgaccg tgccgggcct gcgtggactt caagtcgtgg
      301 atgcggaccc agcagaagcg ggacatcaag tttagggagg actgtccaca ggatcgggaa
      361 gaattgggtc gcaacacctg ggctttcctt catacgctgg ccgcctatta cccggacatg
      421 cccacgccag aacaacagca ggatatggcc cagttcatac atatattttc caagttttac
      481 ccctgtgagg agtgtgcaga agacataagg aagaggatag acaggagcca gccagacaca
      541 agcactcgag tgtccttcag ccagtggctg tgccgccttc acaatgaagt gaaccggaag
      601 ctgggcaagc ctgattttga ctgctcaaga gttgatgagc gatggcgtga cggctggaag
      661 gacggctcct gtgactaagg attaccacag accgtgcagg gcaacgccgg gttctatggg
      721 caacagcctg actgacgatt aaagtgcatc tgagccaaag cttgtttctg tggtggggga
      781 gggatcccta gaacactgcc tatgggaacc ctacccacag actcagaaac ggaggtgccc
      841 actatagaca gttgggtggc ttcctcaggt cttaaagccc catgggactg aagatgagag
      901 gcaggagtgg tccagggcac cccatacccc ttatgatacc cattatacat ttgggacata
      961 gttgcctcaa aggaaggtgg gctagaccat tgccttccta ctacatatcc ccagctgcct
     1021 acagaactgt gaccctggca actctgccat ttcagaattg aagcagggtt ccagctctag
     1081 ttgggttttt ctcttagggt aaaccaacca tggtgcccac tgtcagcctg gcacatggtc
     1141 ttctgcagcc aggacaaaca tgtcagcaga ggatcctggg aagggcttcc ttagcgtttg
     1201 agaccaaaat aaaatgaagt gacttaa
//
