LOCUS       NM_001109037            3387 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus gem (nuclear organelle) associated protein 4
            (Gemin4), mRNA.
ACCESSION   NM_001109037 XM_001080744 XM_573146
VERSION     NM_001109037.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Yang J, Fuller PJ, Morgan J, Shibata H, Clyne CD and Young MJ.
  TITLE     GEMIN4 functions as a coregulator of the mineralocorticoid receptor
  JOURNAL   J Mol Endocrinol 54 (2), 149-160 (2015)
   PUBMED   25555524
  REMARK    GeneRIF: These findings indicate that GEMIN4 functions as a novel
            coregulator of the MR.
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Gedik H, Erdal ME, Yilmaz SG, Sengul C, Sengul CB and Herken H.
  TITLE     Association of microRNA biogenesis pathway gene variants and
            alcohol dependence risk
  JOURNAL   DNA Cell Biol 34 (3), 220-226 (2015)
   PUBMED   25495208
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Yong J, Kasim M, Bachorik JL, Wan L and Dreyfuss G.
  TITLE     Gemin5 delivers snRNA precursors to the SMN complex for snRNP
            biogenesis
  JOURNAL   Mol Cell 38 (4), 551-562 (2010)
   PUBMED   20513430
REFERENCE   4  (bases 1 to 3387)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3387)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3387)
  AUTHORS   Chari A, Golas MM, Klingenhager M, Neuenkirchen N, Sander B,
            Englbrecht C, Sickmann A, Stark H and Fischer U.
  TITLE     An assembly chaperone collaborates with the SMN complex to generate
            spliceosomal SnRNPs
  JOURNAL   Cell 135 (3), 497-509 (2008)
   PUBMED   18984161
REFERENCE   7  (bases 1 to 3387)
  AUTHORS   Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann
            M and Dreyfuss G.
  TITLE     Gemin4. A novel component of the SMN complex that is found in both
            gems and nucleoli
  JOURNAL   J Cell Biol 148 (6), 1177-1186 (2000)
   PUBMED   10725331
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080744.1, XM_573146.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3387
                     /gene="Gemin4"
                     /gene_synonym="RGD1563715"
                     /note="gem (nuclear organelle) associated protein 4"
                     /db_xref="GeneID:497958"
                     /db_xref="RGD:1563715"
     exon            1..35
                     /gene="Gemin4"
                     /gene_synonym="RGD1563715"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3202
                     /gene="Gemin4"
                     /gene_synonym="RGD1563715"
                     /note="component of gems 4"
                     /codon_start=1
                     /product="gem-associated protein 4"
                     /protein_id="NP_001102507.1"
                     /db_xref="GeneID:497958"
                     /db_xref="RGD:1563715"
                     /translation="MDLGPLNICEEMTILHGGFLMAEQLFHPKALEQLTKSDWEHVGQ
                     PIVEALKEISSATAHSQPFAWKKKALIIIWAKVLQPSPVSPSDTDTRWQEDVFFSVGN
                     MIPTINHTVLFELLKSLEASGLFIQLLMALPTTIGRSELQSFLEHMTIDTSSKDVAFF
                     LDVWWEMMKHKGDEQDPLLSQFRTMAHKYLPSSDEFSHPPKRFKSDPDVGPTMPLLAM
                     LLNGLKQIQKRILSLGMKCCALANLADMLSVFALMEDDTQEVSATVYLDKLATVISVW
                     NSDTQNPYHQQALADKVKEAERDVSLTSLAKLPSETVFMGFELMYNLLQEWGTELQDM
                     LNSSQGTNYDTYRLCDSLTSFSQNLELYLDTASLPKEEREVVLELAKCVRDFLRKTSR
                     MLNDKGLEDITASIAMAIIEQKMDRYMEMCYIFASEKKWAFSDEWVACLVNNRCLFRE
                     PDLVLSLLETVMEVINSNRVIPQTHIKQVICLTLECYEDLSLPDKNKVLSGVLHYLGP
                     KGLSDRLSNYLEGFQEDLNTTFNQLAQSTSEQGLAKAVASVAHLVILNPEVVVKKMCS
                     LAVTNLGTHRFLAQILTAFPALKFTEEQGPNPYTSFMVSCLKETVWTKFSTPKEEKQF
                     LELVSCLMNPVKPQGIPIAALLEPDEVLKEFVLPFLMLDMEEVGLSLKLFIQTLEANA
                     GLEEYWLQTCSPFPLLFSLCQLLDSFSKFWQLPREKRYLTLDSKDLVTHILELLCEIV
                     LANIETFSPDTWAKSLSWLHRKLDQLDWTVGLRLKDFFEGHFKCEVPATLFEICKLSE
                     AQWTSQAHEGYGPGTGLLAWMECCSISNSVTEQMLSLLVVNVGNPEEVRLFSKGFLVA
                     LVQVMPWCSPQEWQYLQQLTRKLLEKQLLHVPYSLEYVQFVPLLNLRPFAQELQLSVL
                     SLRAFQFLCSQSCCNWLPLDGWSHVVKLLCSSLTSVLDAVRLIQSVGPWAQGQEGDLT
                     QETLFVYTQMFCHVLHIMAMLPQEVCEPLYVLALEILTCYETLSKTNPSVSSLLQKVD
                     EQRFLKSIAKNISPEERRQTLLQKINNF"
     exon            36..3387
                     /gene="Gemin4"
                     /gene_synonym="RGD1563715"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagcccgcc gccagcgtcg ccgccatgga cctaggaccc ttgaatatct gtgaggaaat
       61 gactattctg catgggggct tcttgatggc tgaacagcta ttccacccca aagccctgga
      121 acagttgaca aagtctgatt gggaacacgt gggacagccc attgtagagg ccttgaagga
      181 gatctcctca gccacagcac attcccagcc atttgcctgg aagaagaaag cattaatcat
      241 catctgggcc aaggttcttc agccctcccc tgtcagccct tctgacactg atactcggtg
      301 gcaggaagat gtattctttt ccgtgggcaa catgatccct accatcaacc acacagtcct
      361 ttttgagctg cttaagtccc tggaagcttc tggactcttc attcagctcc taatggccct
      421 gcctaccacc atcggccgct cagaactaca gagctttctg gagcacatga ctattgacac
      481 ttcttccaag gatgtggctt tcttcctaga tgtctggtgg gaaatgatga agcacaaggg
      541 tgatgaacag gaccccttgc tttcccagtt caggacgatg gcccataaat acttgccatc
      601 ctcagatgag ttttcccatc ctccgaagag gtttaagtct gacccagatg taggtcccac
      661 catgccactt ttggctatgc tgcttaacgg gctgaagcag atccaaaaga gaatcctgtc
      721 ccttggaatg aagtgctgtg cattagctaa cttggctgac atgctgagcg tgtttgcatt
      781 gatggaggat gacacccagg aggtgtctgc cactgtgtac ctagacaaac tagcgacggt
      841 gatctctgtg tggaattcag acacccagaa cccataccat caacaggccc tggcagacaa
      901 ggtaaaggag gcagagcggg acgtgagtct cacctcactg gctaaactcc ccagtgagac
      961 tgttttcatg gggtttgagc ttatgtacaa cctgctgcag gagtggggta cagaactaca
     1021 ggacatgctc aacagcagtc aggggacaaa ttatgacacc taccggctgt gtgacagtct
     1081 gacttccttc agccagaatt tggagctcta cctggatact gccagcctgc ccaaggagga
     1141 gagggaggtg gtcttagaac tggctaagtg tgtcagggac ttcctgagga aaaccagcag
     1201 aatgctgaac gacaagggcc ttgaggacat cactgcctcc attgctatgg ccatcattga
     1261 acagaagatg gaccggtaca tggagatgtg ctacattttt gcctctgaga agaagtgggc
     1321 cttttcagac gagtgggttg cctgcctggt taacaacagg tgtctcttca gagaaccaga
     1381 cttggtcttg agtctgctgg aaacagtgat ggaagtcata aactctaata gggttatccc
     1441 ccagactcac atcaagcagg taatctgctt gactctggaa tgctatgaag acctctctct
     1501 accagataaa aataaagtcc tttctggtgt cctgcattat ttggggccaa agggcctctc
     1561 agacaggttg tctaattact tggagggttt tcaggaagat ctcaatacaa cgtttaacca
     1621 actcgcacag agcacctctg aacagggcct ggctaaagct gtggcctctg tggcccacct
     1681 ggtgatcctg aacccagaag ttgtggtgaa gaagatgtgt agcctcgctg tgaccaacct
     1741 tggcacacat aggtttttgg ctcagattct cactgccttc cctgccctga agttcacaga
     1801 agaacaaggg ccaaatccat ataccagttt catggtgtcc tgcctcaaag aaactgtgtg
     1861 gaccaagttc tctacaccca aagaagagaa gcagtttctg gagctggtga gctgcctgat
     1921 gaatcctgtg aaaccacagg ggattccaat tgctgctctt ttggagccag atgaggtgct
     1981 gaaggagttt gtcctgcctt tcttgatgtt ggacatggag gaggtaggcc tgagtctgaa
     2041 gctcttcatc cagacccttg aagccaatgc aggcttggaa gagtattggc tgcaaacttg
     2101 ctccccattc ccactgctct tcagcttgtg ccagctcctg gatagcttta gcaagttctg
     2161 gcagctcccc cgggagaagc gctacctcac tctggacagc aaggatcttg tgacccacat
     2221 tctggaactc ctgtgtgaga tcgttctagc caacatagaa accttctccc cagacacctg
     2281 ggccaagtcc ctgtcctggc tccaccgcaa attagaccag ctagactgga ccgtgggcct
     2341 ccgactgaag gacttctttg aaggccactt caagtgtgag gtgccagcta ccctttttga
     2401 gatctgtaag ctctctgagg cccagtggac gtcacaggct cacgaaggat atgggcctgg
     2461 tacaggactt ctcgcctgga tggagtgctg ttcaatctcc aacagtgtca ctgaacagat
     2521 gctttccctc ctggtagtga atgtgggcaa tcctgaggag gtcagattgt ttagcaaggg
     2581 ctttctggtg gccctggtac aagtcatgcc ttggtgtagc ccccaggagt ggcaatacct
     2641 tcagcagctg accaggaagc tgttggagaa acagcttctt catgtccctt acagtctaga
     2701 gtatgttcaa tttgttcccc tgctcaacct gaggcctttt gcccaggagc ttcagctctc
     2761 tgttctttcc ttgagagctt tccagtttct ctgcagccag agctgttgta actggcttcc
     2821 tttggatggt tggagccatg tggtcaaact cctctgtagc agtctgacca gtgtcctgga
     2881 tgcagtcagg ttgattcagt cagtgggtcc ctgggcccag ggacaagaag gggatcttac
     2941 tcaggaaacc ttgtttgtct atacccaaat gttctgtcac gttctgcata tcatggccat
     3001 gctccctcag gaggtctgtg aacccctcta cgtactggcc ttggaaatcc ttacctgcta
     3061 tgagacccta agcaaaacca acccttctgt cagctccttg ctccagaagg tagatgagca
     3121 gcgcttctta aagtctattg ccaagaacat tagccctgag gagcggcgcc aaaccctgct
     3181 acaaaagatc aacaacttct gacctgtgga gggcagaaca aagctacgcc tccaacatgg
     3241 tttttctgca gggcccagag ctaagaacaa accttacagt tatatgagaa tgtacacagt
     3301 gaaaggaata caagagcagt gtaaagaaat agtttcttag gtatttgtca tatactactt
     3361 caataaaatt cttttgggtt taatctt
//
