LOCUS       NM_053389               1350 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Rattus norvegicus gem (nuclear organelle) associated protein 2
            (Gemin2), mRNA.
ACCESSION   NM_053389 XM_346764
VERSION     NM_053389.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Rafalowska,J., Sulejczak,D., Gadamski,R. and Dziewulska,D.
  TITLE     Immunoexpression of gemins 2 and 4 in the rat spinal cord. Is the
            SMN complex a new target in investigations of sporadic amyotrophic
            lateral sclerosis pathogenesis?
  JOURNAL   Folia Neuropathol 50 (4), 390-396 (2012)
   PUBMED   23319195
  REMARK    GeneRIF: in rat spinal cord neurons, the immunoexpression of SMN
            and gemins 2 and 4 is present through the whole animal lifespan,
            are present in the same motoneurons and immunoexpression of gemin 2
            and 4 decreases slightly with aging.
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Yong,J., Kasim,M., Bachorik,J.L., Wan,L. and Dreyfuss,G.
  TITLE     Gemin5 delivers snRNA precursors to the SMN complex for snRNP
            biogenesis
  JOURNAL   Mol Cell 38 (4), 551-562 (2010)
   PUBMED   20513430
REFERENCE   3  (bases 1 to 1350)
  AUTHORS   Chari,A., Golas,M.M., Klingenhager,M., Neuenkirchen,N., Sander,B.,
            Englbrecht,C., Sickmann,A., Stark,H. and Fischer,U.
  TITLE     An assembly chaperone collaborates with the SMN complex to generate
            spliceosomal SnRNPs
  JOURNAL   Cell 135 (3), 497-509 (2008)
   PUBMED   18984161
REFERENCE   4  (bases 1 to 1350)
  AUTHORS   Britanova,O., de Juan Romero,C., Cheung,A., Kwan,K.Y., Schwark,M.,
            Gyorgy,A., Vogel,T., Akopov,S., Mitkovski,M., Agoston,D.,
            Sestan,N., Molnar,Z. and Tarabykin,V.
  TITLE     Satb2 is a postmitotic determinant for upper-layer neuron
            specification in the neocortex
  JOURNAL   Neuron 57 (3), 378-392 (2008)
   PUBMED   18255031
REFERENCE   5  (bases 1 to 1350)
  AUTHORS   Jablonka,S., Bandilla,M., Wiese,S., Buhler,D., Wirth,B.,
            Sendtner,M. and Fischer,U.
  TITLE     Co-regulation of survival of motor neuron (SMN) protein and its
            interactor SIP1 during development and in spinal muscular atrophy
  JOURNAL   Hum Mol Genet 10 (5), 497-505 (2001)
   PUBMED   11181573
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF176072.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346764.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176072.1, BC098662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..1350
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /note="gem (nuclear organelle) associated protein 2"
                     /db_xref="GeneID:84404"
                     /db_xref="RGD:620842"
     exon            1..216
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..889
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /note="survival of motor neuron protein-interacting
                     protein 1; gemin-2; component of gems 2; SMN-interacting
                     protein 1"
                     /codon_start=1
                     /product="gem-associated protein 2"
                     /protein_id="NP_445841.1"
                     /db_xref="GeneID:84404"
                     /db_xref="RGD:620842"
                     /translation="MAWVPAESAVEELMPRLLPVEPCDLTEGFDPSVPPRTPQEYLRR
                     VQIEAAQCPDVVVAQIDPKKLKRKQSVNVSLSGCHPAPEGYSPTLQWQQQQVIQFSSV
                     RQSVHKHRNHWKSQQLDSNVTMPKSEDEEGWKKFCLGERLCAEGATGPSTDESPGIDY
                     VQVGFPPLLSIVSRMNQATITSVLEYLSNWFGERDFTPELGRWFYALLACLEKPLLPE
                     AHSLIRQLARRCSEVRLLVGSKDDERVPALNLLICLVSRYFDQRDLADEPS"
     exon            217..301
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..391
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..451
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..565
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..610
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..679
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..790
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..849
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1332
                     /gene="Gemin2"
                     /gene_synonym="Sip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgacggagg gcgcttgagc gcctgcgcgg tacctacctt gggtacaggc gccaatagag
       61 actggcggga gtaaatacca tggcgtgggt tccagccgag tctgcggtgg aagagttgat
      121 gccacggttg ttacctgtgg agccctgtga cttgacggaa ggtttcgatc cctcggtacc
      181 ccccaggacg cctcaggaat acctgaggag ggtgcagatc gaagcagccc agtgtccaga
      241 tgttgtggta gcccagattg acccaaagaa gttgaaaagg aagcaaagtg tgaatgtttc
      301 tctttcggga tgccaccctg cccctgaagg ttattcccca acactgcagt ggcagcagca
      361 acaagtgata cagttttcga gtgttcgaca gagtgtgcac aagcatagaa atcactggaa
      421 atctcaacag ttggatagta atgtgacaat gccaaaatct gaagatgaag aaggctggaa
      481 aaaattttgt ctgggtgaaa gattatgtgc tgaaggggct actggaccat ctacagacga
      541 aagccctggg attgattatg tacaagttgg ttttcctccc ttgctgagta ttgtaagcag
      601 aatgaatcag gcaaccatta ctagtgtctt ggaatatcta agtaattggt ttggagaaag
      661 agattttact ccagaattgg gaagatggtt ctatgctttg ttggcttgtc ttgagaaacc
      721 tttgctacct gaggctcact cactgattcg acagcttgcc agaaggtgtt ctgaagtgag
      781 gctcctggtg ggcagtaaag acgatgaaag agttccagct ttgaatctgc tgatctgctt
      841 agttagcagg tattttgatc aacgtgattt agctgatgag ccatcttgat agagcttacc
      901 tcctggggat ggaagagagt tctgtgaagg gagcctaagt ctgaggaagc ataattccaa
      961 cctgaggaca gagtgcatca cttcttcaag ttgtgtgaag ggtttcatct taatctgcaa
     1021 ttcaagttga tattcaaaat atagacttga ttggtttaag tgtctgaaat gtctacggaa
     1081 agcccacctg gcatctgatg agcagttgga acagttttcc tcagttgcat gcattgaaaa
     1141 taggccacgt gggacttagt acttaagcgg cttgcataaa aactgctgac attttataca
     1201 gtcccctggt gctgcttcat tggtttttta caatatacat atatatttat gttgaaatgt
     1261 attttgacta ctcaaatttt acttgactca aacaaaataa aagacaatgg atgtccttag
     1321 agttgcaatt caaaaaaaaa aaaaaaaaaa
//
