LOCUS       NM_001106637            2093 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus GTP binding protein overexpressed in skeletal
            muscle (Gem), mRNA.
ACCESSION   NM_001106637 XM_001054224 XM_232788
VERSION     NM_001106637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2093)
  AUTHORS   Wang J, Qu D, An J, Yuan G and Liu Y.
  TITLE     Integrated microarray analysis provided novel insights to the
            pathogenesis of glaucoma
  JOURNAL   Mol Med Rep 16 (6), 8735-8746 (2017)
   PUBMED   28990066
REFERENCE   2  (bases 1 to 2093)
  AUTHORS   Xu F, Huang H, Wu Y, Lu L, Jiang L, Chen L, Zeng S, Li L and Li M.
  TITLE     Upregulation of Gem relates to retinal ganglion cells apoptosis
            after optic nerve crush in adult rats
  JOURNAL   J Mol Histol 45 (5), 565-571 (2014)
   PUBMED   24948002
  REMARK    GeneRIF: Data suggest that GTP-binding protein Gem might play a
            crucial role in retinal ganglion cells (RGCs) apoptosis after nerve
            crush (ONC).
REFERENCE   3  (bases 1 to 2093)
  AUTHORS   Wen H, Cao J, Yu X, Sun B, Ding T, Li M, Li D, Wu H, Long L, Xu G
            and Zhang F.
  TITLE     Spatiotemporal patterns of Gem expression after rat spinal cord
            injury
  JOURNAL   Brain Res 1516, 11-19 (2013)
   PUBMED   23602967
  REMARK    GeneRIF: The results of tjis study suggested that Gem may be
            implicated in the proliferation of microglia and astrocytes after
            spinal cord injury.
REFERENCE   4  (bases 1 to 2093)
  AUTHORS   Wang Y, Cheng X, Zhou Z, Wu H, Long L, Gu X and Xu G.
  TITLE     Increased expression of Gem after rat sciatic nerve injury
  JOURNAL   J Mol Histol 44 (1), 27-36 (2013)
   PUBMED   23076376
  REMARK    GeneRIF: Increased expression of Gem after rat sciatic nerve
            injury.
REFERENCE   5  (bases 1 to 2093)
  AUTHORS   Andrieu G, Quaranta M, Leprince C and Hatzoglou A.
  TITLE     The GTPase Gem and its partner Kif9 are required for chromosome
            alignment, spindle length control, and mitotic progression
  JOURNAL   FASEB J 26 (12), 5025-5034 (2012)
   PUBMED   22964304
REFERENCE   6  (bases 1 to 2093)
  AUTHORS   Feng J, Lawson MA and Melamed P.
  TITLE     A proteomic comparison of immature and mature mouse gonadotrophs
            reveals novel differentially expressed nuclear proteins that
            regulate gonadotropin gene transcription and RNA splicing
  JOURNAL   Biol Reprod 79 (3), 546-561 (2008)
   PUBMED   18480465
REFERENCE   7  (bases 1 to 2093)
  AUTHORS   Splingard A, Menetrey J, Perderiset M, Cicolari J, Regazzoni K,
            Hamoudi F, Cabanie L, El Marjou A, Wells A, Houdusse A and de
            Gunzburg J.
  TITLE     Biochemical and structural characterization of the gem GTPase
  JOURNAL   J Biol Chem 282 (3), 1905-1915 (2007)
   PUBMED   17107948
REFERENCE   8  (bases 1 to 2093)
  AUTHORS   Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y,
            Selinger Z, Kelly K and Hirsch JA.
  TITLE     Structure-function studies of the G-domain from human gem, a novel
            small G-protein
  JOURNAL   FEBS Lett 580 (25), 5959-5964 (2006)
   PUBMED   17052716
REFERENCE   9  (bases 1 to 2093)
  AUTHORS   Beguin P, Mahalakshmi RN, Nagashima K, Cher DH, Takahashi A, Yamada
            Y, Seino Y and Hunziker W.
  TITLE     14-3-3 and calmodulin control subcellular distribution of Kir/Gem
            and its regulation of cell shape and calcium channel activity
  JOURNAL   J Cell Sci 118 (Pt 9), 1923-1934 (2005)
   PUBMED   15860732
  REMARK    GeneRIF: binding of 14-3-3, calmodulin and calcium channel
            beta-subunits to Kir/Gem is mutually exclusive
REFERENCE   10 (bases 1 to 2093)
  AUTHORS   Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J and Kelly
            K.
  TITLE     Gem: an induced, immediate early protein belonging to the Ras
            family
  JOURNAL   Science 265 (5169), 241-244 (1994)
   PUBMED   7912851
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_232788.4, XM_001054224.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132266,
                              SAMD00132269 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..2093
                     /gene="Gem"
                     /note="GTP binding protein overexpressed in skeletal
                     muscle"
                     /db_xref="GeneID:297902"
                     /db_xref="RGD:1307386"
     exon            1..137
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            138..474
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1034
                     /gene="Gem"
                     /EC_number="3.6.5.2"
                     /note="GTP binding protein (gene overexpressed in skeletal
                     muscle)"
                     /codon_start=1
                     /product="GTP-binding protein GEM"
                     /protein_id="NP_001100107.1"
                     /db_xref="GeneID:297902"
                     /db_xref="RGD:1307386"
                     /translation="MTLNNVTMRQGTVGMQPQQRWSIPADGRHLMVQKDPHPCNPHNH
                     HSTAPDDHCRRSWSSESTDSVISSESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSMD
                     SDCEVLGEDTYERTLVVDGESATIILLDMWENKGENEWLHDHCMQVGDAYLIVYSITD
                     RASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIE
                     TSAAVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQKRRESIPRKARRFWGKIVAKN
                     NKNMAFKLKSKSCHDLSVL"
     exon            475..551
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            552..756
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
     exon            757..2093
                     /gene="Gem"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaggcgg cactgccagc ggacatcaca cagccttaga ctgcggaacc cgcatcggca
       61 ggcggcaagc attgcagcag gcagcaggca ttgtccggac cgacggcaaa cgcccaccca
      121 gcgcccagta cagccaagat cccacaatga ctctgaataa cgtcaccatg cgccaaggca
      181 ctgtgggcat gcagccacag caacgctgga gcatccctgc tgatggcagg catctgatgg
      241 tccagaagga tccccacccc tgcaaccccc acaaccacca ctccactgct cccgatgacc
      301 actgccggcg gagctggtcc tccgagtcca cagactcggt tatctcttcc gagtcaggaa
      361 acacctacta ccgagtggtg cttattgggg agcaaggagt gggcaagtcc accctggcca
      421 acatctttgc aggtgtacat gacagcatgg acagcgactg tgaggtcttg ggagaagata
      481 catatgagcg taccctggtc gttgatggag agagtgcaac cattatccta ctggacatgt
      541 gggaaaataa gggggagaat gaatggctcc acgaccactg catgcaggtc ggggacgcct
      601 acctgatcgt ctactccatc acagaccggg cgagctttga gaaggcgtct gagctgagga
      661 tccagctccg cagggcccgg cagacagaag acattcctat aattttggtt ggcaacaaaa
      721 gcgacttagt gcggtgtcga gaagtgtctg tgtcagaagg gagagcttgt gccgtggtgt
      781 tcgactgcaa attcatcgag acctctgcag ccgtgcagca caacgtgaag gaactgtttg
      841 agggcattgt gcggcaggtc cgtctgcgtc gggacagcaa ggaaaagaac gagaggaggc
      901 tggcctacca gaagaggcgg gagagtatcc ccaggaaagc cagacgcttc tggggcaaaa
      961 ttgtagccaa aaacaacaag aacatggctt tcaagctcaa gtcaaaatcc tgccatgacc
     1021 tgtctgtgct ctaggcaccc agtgtcgtcc agatgtcccc ttgatggacg tcgttgaagg
     1081 cttttgggac cagtgatcta tattagattg gatacagaag cattgttaag acgcggcttc
     1141 ccctactaca gatgggaacc aagaggttag cctcatgggc aaccaagtgc atgggtggcg
     1201 aaagatctct gtcgagagtc agtatttatt tgtaggaaaa gcttgacctg ctatgctaga
     1261 tggatgcccc agactcactt aagggcacgt ttggggttca cacgagtttt tctctccttt
     1321 gggcagcaga atattgaatc ttgtgaagaa tgcctaggac agaagtgttt catcattgaa
     1381 gttttgctca gtgttctgtg tgaatctgag gtccttgggt cataaagaaa tgtaggaaaa
     1441 tggtgtttat tggaaggaga agggctctct gcaaacttat actcctggaa ctgcagctgc
     1501 ggaactggcc tccttgcagt ttttactgct ctatcgaact gtggagagaa ttgttagaat
     1561 ttgctagaaa ctgaggctta ctgacagttt ttgtttaaag accacagaga ttcctagact
     1621 tagacgctga tatgcgtgta ccacttatag gttcaaaaaa ttgtttactt atgtgtctta
     1681 gaagtgttta ttttgaggaa actatttttt ttttgccaga tcctacttag tcaaatcatc
     1741 ttttatgtct tttttttgaa atcatgaagc tgtcataaaa tattttttta aaaaaatctc
     1801 aactatattg ataacttgga gtgcaaaatt ttaaatatag tcagaagcct gcttttcccc
     1861 cccaaacata aagatgcccc atcctttggg ttgctccttg tacgccacag ccgaattata
     1921 tttattatta ttttgcaaat aaccatttta acctttgata aagcctattt atgagcatat
     1981 ttcttactga gaaaaatgtc tgttttgtta ccttttttat atttttcaaa atatgcaagt
     2041 ttttacctat atgtcttata ataaaataaa taaaatcttt gaaaaggaaa gca
//
