LOCUS       NM_019139               4452 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Rattus norvegicus glial cell derived neurotrophic factor (Gdnf),
            transcript variant 1, mRNA.
ACCESSION   NM_019139
VERSION     NM_019139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4452)
  AUTHORS   Mostafaee,H., Idoon,F., Mohasel-Roodi,M., Alipour,F., Lotfi,N. and
            Sadeghi,A.
  TITLE     The effects of induced type I diabetes on developmental regulation
            of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat
            offspring
  JOURNAL   J Chem Neuroanat 136, 102391 (2024)
   PUBMED   38219812
  REMARK    GeneRIF: The effects of induced type I diabetes on developmental
            regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of
            male rat offspring.
REFERENCE   2  (bases 1 to 4452)
  AUTHORS   Staszkiewicz,R., Sobanski,D., Brys,K., Och,W., Garczarek,M.,
            Ulasavets,U., Stasiowski,M., Dammermann,W., Strojny,D. and
            Grabarek,B.O.
  TITLE     Effect of Glycemic Disorders and Habits on the Concentration of
            Selected Neurotrophic Factors in Patients with Lumbosacral
            Intervertebral Disc Degeneration
  JOURNAL   Curr Pharm Biotechnol 25 (7), 908-923 (2024)
   PUBMED   37888810
REFERENCE   3  (bases 1 to 4452)
  AUTHORS   H,Z. R, H,J. S, R C,S. B, Kr,R., R,R.D. and M,E. B.
  TITLE     Physical Exercise Promotes Beneficial Changes on Neurotrophic
            Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement
            of the Endogenous Opioid System
  JOURNAL   Neurotox Res 41 (6), 741-751 (2023)
   PUBMED   37904065
REFERENCE   4  (bases 1 to 4452)
  AUTHORS   Kasanga,E.A., Han,Y., Navarrete,W., McManus,R., Shifflet,M.K.,
            Parry,C., Barahona,A., Manfredsson,F.P., Nejtek,V.A.,
            Richardson,J.R. and Salvatore,M.F.
  TITLE     Differential expression of RET and GDNF family receptor,
            GFR-alpha1, between striatum and substantia nigra following
            nigrostriatal lesion: A case for diminished GDNF-signaling
  JOURNAL   Exp Neurol 366, 114435 (2023)
   PUBMED   37178997
  REMARK    GeneRIF: Differential expression of RET and GDNF family receptor,
            GFR-alpha1, between striatum and substantia nigra following
            nigrostriatal lesion: A case for diminished GDNF-signaling.
REFERENCE   5  (bases 1 to 4452)
  AUTHORS   Zou,Z., Liu,R., Wang,Y., Tan,H., An,G., Zhang,B., Wang,Y. and
            Dong,D.
  TITLE     Protein arginine methyltransferase 8 regulates ferroptosis and
            macrophage polarization in spinal cord injury via glial
            cell-derived neurotrophic factor
  JOURNAL   CNS Neurosci Ther 29 (8), 2145-2161 (2023)
   PUBMED   36914965
REFERENCE   6  (bases 1 to 4452)
  AUTHORS   Sanchez,M.P., Silos-Santiago,I., Frisen,J., He,B., Lira,S.A. and
            Barbacid,M.
  TITLE     Renal agenesis and the absence of enteric neurons in mice lacking
            GDNF
  JOURNAL   Nature 382 (6586), 70-73 (1996)
   PUBMED   8657306
REFERENCE   7  (bases 1 to 4452)
  AUTHORS   Springer,J.E., Seeburger,J.L., He,J., Gabrea,A., Blankenhorn,E.P.
            and Bergman,L.W.
  TITLE     cDNA sequence and differential mRNA regulation of two forms of
            glial cell line-derived neurotrophic factor in Schwann cells and
            rat skeletal muscle
  JOURNAL   Exp Neurol 131 (1), 47-52 (1995)
   PUBMED   7895811
REFERENCE   8  (bases 1 to 4452)
  AUTHORS   Suter-Crazzolara,C. and Unsicker,K.
  TITLE     GDNF is expressed in two forms in many tissues outside the CNS
  JOURNAL   Neuroreport 5 (18), 2486-2488 (1994)
   PUBMED   7696586
REFERENCE   9  (bases 1 to 4452)
  AUTHORS   Schaar,D.G., Sieber,B.A., Sherwood,A.C., Dean,D., Mendoza,G.,
            Ramakrishnan,L., Dreyfus,C.F. and Black,I.B.
  TITLE     Multiple astrocyte transcripts encode nigral trophic factors in rat
            and human
  JOURNAL   Exp Neurol 130 (2), 387-393 (1994)
   PUBMED   7867768
REFERENCE   10 (bases 1 to 4452)
  AUTHORS   Lin,L.F., Doherty,D.H., Lile,J.D., Bektesh,S. and Collins,F.
  TITLE     GDNF: a glial cell line-derived neurotrophic factor for midbrain
            dopaminergic neurons
  JOURNAL   Science 260 (5111), 1130-1132 (1993)
   PUBMED   8493557
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 24, 2022 this sequence version replaced NM_019139.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.7229.1,
                                           SRR26643293.10695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1049              JAXUCZ010000002.1  58621327-58622375
            1050-1226           JAXUCZ010000002.1  58626840-58627016
            1227-4452           JAXUCZ010000002.1  58644015-58647240
FEATURES             Location/Qualifiers
     source          1..4452
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..4452
                     /gene="Gdnf"
                     /gene_synonym="gndf"
                     /note="glial cell derived neurotrophic factor"
                     /db_xref="GeneID:25453"
                     /db_xref="RGD:2677"
     exon            1..1049
                     /gene="Gdnf"
                     /gene_synonym="gndf"
                     /inference="alignment:Splign:2.1.0"
     CDS             989..1711
                     /gene="Gdnf"
                     /gene_synonym="gndf"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glial cell line-derived neurotrophic factor;
                     ATF; astrocyte-derived trophic factor; Glial cell line
                     derived neutrophic factor"
                     /codon_start=1
                     /product="glial cell line-derived neurotrophic factor
                     isoform 1 precursor"
                     /protein_id="NP_062012.2"
                     /db_xref="GeneID:25453"
                     /db_xref="RGD:2677"
                     /translation="MGFGPLGVNVQLGVYGDRIRGAAAGRDSKMKLWDVVAVCLVLLH
                     TASAFPLPAGKRLLEAPAEDHSLGHRRVPFALTSDSNMPEDYPDQFDDVMDFIQATIK
                     RLKRSPDKQAAALPRRERNRQAAAASPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLG
                     LGYETKEELIFRYCSGSCEAAETMYDKILKNLSRSRRLTSDKVGQACCRPVAFDDDLS
                     FLDDSLVYHILRKHSAKRCGCI"
     exon            1050..1226
                     /gene="Gdnf"
                     /gene_synonym="gndf"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..4452
                     /gene="Gdnf"
                     /gene_synonym="gndf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaaacact ctgttctcct ctcctggctg ttccgcgctt cttcttggtg ctgggaaaac
       61 ttcggcaggc tgcttgtctt ctcgccactg ccttctgccc tgcagaaaac cgggagggca
      121 cgacactcga ggaggaagga cagccttcga aggggacgag gaaagccccg aggtagcctc
      181 cagcagacag agcgccctcc ctcggagcgc aggacgccgt caccaagttg cgattgcccc
      241 cttgggctgc tgtgagccga gctccgcgcg cgttcctgtg gatctacccc gctagaaagc
      301 gcgagccccg aggcggttcc tgcacccccg ggagaggctc acggagtcac ccactcgcac
      361 cccgtactgc gcccccgcag ctccggtgcc tcttcccggg atctccgtcc ctcccccaca
      421 ctcaggccgc cgttgccgcc ggacccctcc cttccccctc ccggttccgc gccccccact
      481 ccccaatccc ggccctctgg cccgggctct ccaccaccag cctgcgctcc tggcgccctc
      541 atgtcttcaa gggactgccg gcgcggtttg acgtggtgtc tcgttcggat ctccaggcaa
      601 gacttcggca tccgcagaca ggcccgcctc gtactcgcag ccaccgcgcc ccgaggaggt
      661 gcagagtgag gcgactgcct cggagccacc cgcagcgccc gggcccggtg ctgctccagc
      721 ccagagcgcc gcgcgcgcag ccgtgccacc cctcagccaa ggcaggggaa gctgctcaga
      781 cttagtcttc ttgggatcca agaggccggt gtgcgaggtg tcggcagcct tcgccctcct
      841 cgcggcggcg gcggcggcgg ctgacacggt ggccgccgcc tcctgcgtgt cctcgctgcc
      901 cggcgcgacc cctggattgc gtgctcttgc tcccgacctc ctgggcgggg ccccgcgctc
      961 ctgcccgcgg tccggatggg tctcctggat gggattcggg ccacttggag ttaatgtcca
     1021 actgggggtc tacggagacc ggatccgagg tgccgccgcc ggacgggact ctaagatgaa
     1081 gttatgggat gtcgtggctg tctgcctggt gttgctccac accgcgtctg ccttcccgct
     1141 gcccgccggt aagaggcttc tcgaagcgcc cgccgaagac cactccctcg gccaccgccg
     1201 cgtgcccttc gcgctgacca gtgactccaa tatgcccgaa gattatcctg accagtttga
     1261 tgacgtcatg gattttattc aagccaccat caaaagactg aaaaggtcac cagataaaca
     1321 agcggcggca cttcctcgaa gagagaggaa ccggcaagct gcagctgcca gcccagagaa
     1381 ttccagaggg aaaggtcgca gaggccagag gggcaaaaat cgggggtgcg tcttaactgc
     1441 aatacactta aatgtcactg acttgggttt gggctacgaa accaaggagg aactgatctt
     1501 tcgatattgt agcggttcct gtgaagcggc cgagacaatg tacgacaaaa tactaaaaaa
     1561 tctgtctcga agtagaaggc taacaagtga caaggtaggc caggcatgtt gcaggccggt
     1621 cgccttcgac gacgacctgt cgtttttaga cgacagcctg gtttaccata tcctaagaaa
     1681 gcattccgct aaacggtgtg gatgtatctg accctggctc cagagactgc tgtgtattgc
     1741 attcctgcta cagtgcgaag aaagggacca aggttcccag gaaatgtttg cccagaaagg
     1801 aagataagga ccaagaaggc agaggcagag gcggaagaag aagaagaaaa gaaggacgaa
     1861 ggcagccatc gtgggagcct ggtagaagga ggcccagcta caggaaactg gataggagtg
     1921 agaacagccg tctgagcact ccaggatggc agctgatgtc accagaagct cagggctggt
     1981 gtccttgctt agctgttgcc agcgtttatc tgatacagtc catggtcacc gatggtggtc
     2041 cgagtcgcag atgcacgcaa agaaccaagc cggtgtatct cctgtggttc attttcacgt
     2101 gtcggaagac accagggaaa cgtgacgatt ctggtgtcac ctcttgtcac tacattttac
     2161 tgctgaaaat aagaaagatg tattttcctg tcactccatg gattcacacc ctggaaagga
     2221 aagggggtgg gggtggggga caaaagtaga gacgtgaaaa aatgacaacc tttgaatttg
     2281 aaaaccgggg cctgaggttt actacattac cagcattttg ggggacattt ggtggttgat
     2341 tttggacgca gagtgtgaga tatggagaag ttggctagga acccagaaag ctgtcctcgt
     2401 acttagaaac aaacctggag gcatttcctt cacgccctca gaaacaggaa gcgagttgtg
     2461 gttttcggca ggattcttgt aggagagcta gaggggaagc cccccagctg ccccagccag
     2521 ggagaccccg gggcctgttg gtttacagag acggacgtta catacacagc tccgtttatg
     2581 cgtggtcacc agtgaccaga gaagctactc gatgcaatgc atctgtttca aatacagaga
     2641 tatagagaag atatttattg agatttaagt tattgttatt tattaccatt cactaatgaa
     2701 tttctctctt ttcttccctt atttattaaa gtctcttttc aaaggtgcca aagtatatgt
     2761 gctcacaaaa tacaaaggtg acagaaggaa atattaacat tgagaacaag ggtccattct
     2821 cttcagagta ctaagagggt ttttgctagg caaaaatcac ttactttacc tttataagac
     2881 agtccttcgc caactgccac aggttgcagc attttcccac ccccctttct gtggacagga
     2941 tctcctatag cctaggctga ccttgaactc actgcttgat caaggatgac cttggcctta
     3001 tgatcctctg acttcctgtg gtcttggcat ggcagacatc acaccataac cacacgatag
     3061 agatcgaatc cggggcttcg tctatgccag gcaactgtag gtaccaagaa agttacacac
     3121 cagcccctac tttttatctg tgaaaggaaa gggtcaggag ggtcatctca gccccaccac
     3181 ctcactggga ataccagtgg gactgccttg tgtttgcatc tcctcttata tccacctgag
     3241 cagcgaggct ccgagctcca ctgtccgttg agtgaagttc ttcttcccct ccatcacatg
     3301 caatatcata accacacatt cagaaggctg aactcccctc agaagtcctg aagttattgt
     3361 cacctaaaag tgaaatgaag gcccctgcca ggtaggcaag gtttaacccc tcctggcggt
     3421 atctcttcct ccattcttga ccgcctgcct tcttcctgag gtcgcacagg caggagaaca
     3481 aggggaaccg cgcagggaga ggtcatctgc cttgtccttt tccagggctt gggtgtcacc
     3541 tgggcttgac atttgctacc ccttccaacc ctgtgggctc tagggagaaa gacgtacagg
     3601 aagagacatc tgactggcca taggacatat aagaggccct ccctccttgt ttggagggaa
     3661 gaagcagaca gaggcaatgg cacctctccc tgtaccccac agtgtacctg tctggcagct
     3721 gacaaacagg tcatgccttt gagtcctatg ttagagcttg ttacacattt cataaatgga
     3781 atttttatgt agaagttaat gtatcactac ctttgtggct gctatccccc ccaaagtagg
     3841 acagagagct ctaaaataat aaatgaccaa tcgattggcc tctctcaaat catcatgtca
     3901 aattttcaaa gtaaccaaga ggtaaaagtc gctaggcatc cccttccccc tcccatggct
     3961 ctaaagaccc aagttatgag tgggtcctca ccctctgcag gactgggaag tggaggtatg
     4021 tatttactgc tctcttaccc tctcctgctc aaaacggtga caacctcaac tgcccagcac
     4081 aattcagatg tagtcccaga ccctccgttg aattcagaga atcctgacag atgtggttgc
     4141 tgatgtcccc aggtccagac acagcctcca gctcctgggg gagtccctgg cgagcttagc
     4201 atcatccgca catctgcagc aggttttaac aggagcaagc cgctccgccc agtccacaga
     4261 aggggaaggt ttgcgattgt ttcccttcac tgttgtgatg agcgtctgcc acagtaagga
     4321 gcacacttct ttggaagttc tgacctctct gatgtctcgg tcgtttgtgt tatacaacca
     4381 aagttctcta cagactttat ttttgtacaa tatcattttg taacttttta caaataaaag
     4441 ctcatttcta tt
//
