LOCUS       NM_017276               2230 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus GDP dissociation inhibitor 2 (Gdi2), mRNA.
ACCESSION   NM_017276
VERSION     NM_017276.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2230)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   2  (bases 1 to 2230)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2230)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   4  (bases 1 to 2230)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   5  (bases 1 to 2230)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2230)
  AUTHORS   Weitzdoerfer,R., Stolzlechner,D., Dierssen,M., Ferreres,J.,
            Fountoulakis,M. and Lubec,G.
  TITLE     Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation
            inhibitor beta and histidine triad nucleotide-binding protein in
            fetal Down syndrome brain
  JOURNAL   J Neural Transm Suppl (61), 347-359 (2001)
   PUBMED   11771757
REFERENCE   7  (bases 1 to 2230)
  AUTHORS   Antony,C., Huchet,M., Changeux,J.P. and Cartaud,J.
  TITLE     Developmental regulation of membrane traffic organization during
            synaptogenesis in mouse diaphragm muscle
  JOURNAL   J Cell Biol 130 (4), 959-968 (1995)
   PUBMED   7642711
REFERENCE   8  (bases 1 to 2230)
  AUTHORS   Janoueix-Lerosey,I., Jollivet,F., Camonis,J., Marche,P.N. and
            Goud,B.
  TITLE     Two-hybrid system screen with the small GTP-binding protein Rab6.
            Identification of a novel mouse GDP dissociation inhibitor isoform
            and two other potential partners of Rab6
  JOURNAL   J Biol Chem 270 (24), 14801-14808 (1995)
   PUBMED   7782346
REFERENCE   9  (bases 1 to 2230)
  AUTHORS   Araki,K., Nakanishi,H., Hirano,H., Kato,M., Sasaki,T. and Takai,Y.
  TITLE     Purification and characterization of Rab GDI beta from rat brain
  JOURNAL   Biochem Biophys Res Commun 211 (1), 296-305 (1995)
   PUBMED   7779099
REFERENCE   10 (bases 1 to 2230)
  AUTHORS   Nishimura,N., Nakamura,H., Takai,Y. and Sano,K.
  TITLE     Molecular cloning and characterization of two rab GDI species from
            rat brain: brain-specific and ubiquitous types
  JOURNAL   J Biol Chem 269 (19), 14191-14198 (1994)
   PUBMED   8188702
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061767.1.
            
            On Dec 20, 2003 this sequence version replaced NM_017276.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061767.1, X74401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.2"
     gene            1..2230
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /note="GDP dissociation inhibitor 2"
                     /db_xref="GeneID:29662"
                     /db_xref="RGD:61802"
     exon            1..145
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1438
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /note="guanosine diphosphate dissociation inhibitor 3;
                     GDI-2; GDI-3; guanosine diphosphate dissociation inhibitor
                     2; guanosine diphosphate (GDP) dissociation inhibitor 3;
                     rab GDI beta"
                     /codon_start=1
                     /product="rab GDP dissociation inhibitor beta"
                     /protein_id="NP_058972.2"
                     /db_xref="GeneID:29662"
                     /db_xref="RGD:61802"
                     /translation="MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDQNPYYGGESA
                     SITPLEDLYKRFKLPGQPPASMGRGRDWNVDLIPKFLMANGQLVKMLLFTEVTRYMDF
                     KVIEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEG
                     VDPKKTSMRDVYKKFDLGQDVIDFTGHSLALYRTDDYLDQPCCETINRIKLYSESLAR
                     YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVVGVKSEGEIAR
                     CKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYV
                     CMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLFVPKDL
                     GTDSQIFISRAYDATTHFETTCDDIKDIYKRMTGSEFDFEEMKRKKNDIYGED"
     exon            146..253
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            254..353
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            354..488
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..687
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            688..819
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            820..919
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1091
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1236
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1291
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..2184
                     /gene="Gdi2"
                     /gene_synonym="Gdi3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcttttttc cctcttcccc ccggggccca gaacggccgg acttctcgct cccttctcta
       61 cggtggcctc cgagcccttg tgtgcgctcc tttccccgcc atgaatgagg aatacgacgt
      121 gatcgtgctg ggcaccggcc tgacggaatg tatcctgtcg gggataatgt cagtgaatgg
      181 aaagaaggtt cttcatatgg atcagaaccc atactatgga ggagaaagtg catctataac
      241 accgctggaa gatttataca aaagatttaa attaccagga caaccaccag catcgatggg
      301 gagaggaaga gactggaatg ttgacttaat tcccaagttc cttatggcca atggtcagtt
      361 ggtgaagatg ctgcttttca cagaggtcac tcgttatatg gacttcaaag tgatcgaagg
      421 gagctttgtc tacaagggag ggaaaatcta caaggttcct tccactgaag cagaagccct
      481 ggcgtctagc ttaatgggac tgtttgagaa acgccgcttc aggaagttcc tagtttatgt
      541 tgccaacttt gatgaaaaag atcctagaac ttttgagggt gtggatccta agaagacctc
      601 catgagagat gtgtataaga agtttgattt gggccaggat gttatagact ttactggcca
      661 ttctcttgca ttgtacagaa cagatgacta cttagaccag ccatgttgtg aaacgattaa
      721 cagaattaaa ctttacagcg agtctttggc aagatatggt aaaagcccat acctctatcc
      781 actttatggt cttggggaat tgccacaagg atttgcaagg ttaagtgcta tatatggagg
      841 tacctacatg ttgaataagc caattgaaga aatcattgtg caaaatggaa aagtggttgg
      901 cgtgaaatct gaaggagaga ttgctcgctg taagcagctc atctgtgatc ccagctatgt
      961 caaggatcgg gttgaaaaag taggccaggt aatcagagtg atctgtatcc ttagccaccc
     1021 catcaagaac accaacgatg ctaactcctg ccagatcatc attccacaga accaagtcaa
     1081 ccgcaagtca gatatctatg tttgcatgat ctcctttgca cataatgtgg cagcacaggg
     1141 caagtatatt gccattgtaa gtacaactgt ggagactaag gaaccagaga aagaaatcag
     1201 accagctttg gagctcttgg aaccaattga acaaaaattt gtcagcatca gcgacctctt
     1261 tgtacctaaa gatttgggaa cagatagtca gatctttatt tcccgtgcct atgatgctac
     1321 cacacacttt gagacaacct gtgatgacat caaagatatc tataagagga tgacagggtc
     1381 tgagtttgac tttgaagaaa tgaagcgcaa gaagaatgac atttatggag aagactaaca
     1441 gcagtacata ttatgtaatt aggacaaact taaaatttgg caaataatgt atattgtatg
     1501 aaatcaatat tgtaagccct gcttttatga tcgaagtgga gattgaagag tgctatacca
     1561 gtgaatgctc cctcactttt ctaatatcat gtattaactt gttttcatgg aatggctagt
     1621 cagaattggt tggttctgtt cagtttaacc aaactgcatt tttttttttt tgtagtgaag
     1681 gagctgttct aaacatatat tgatatcgat agagaacttg atacagtact tgtatctttt
     1741 aatcactgta gcctttacga ttgtgtgatg ttgcccaaga gctggatcca tacaatttgt
     1801 tgccatcctg atattgggag tcaaattgaa tatcctttgg tttctgaaaa cgttcagttt
     1861 tcgctatttt gttatgtcaa gtattacagc agggcccaga taggagagcc acatgttttg
     1921 tttatgtggg tataaacttt aaccaaactt cagacttagg gagttgtttg gagaagccaa
     1981 tatgtggtat tttaacctac aattgctgag aaagggaaag caggtaaaaa tatagaagca
     2041 ccttttatcc caggtatggc ttcttcaacg gaccaagctg caatgcagta ttgatttgac
     2101 agagcctcaa tttcgatgat gtctgttcca aaatggctcc aaatgatttc tgtactgcaa
     2161 aataaagcca aactctggaa accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2221 aaaaaaaaaa
//
