LOCUS       NM_017088               2346 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GDP dissociation inhibitor 1 (Gdi1), mRNA.
ACCESSION   NM_017088
VERSION     NM_017088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2346)
  AUTHORS   Kirsten,M.L., Baron,R.A., Seabra,M.C. and Ces,O.
  TITLE     Rab1a and Rab5a preferentially bind to binary lipid compositions
            with higher stored curvature elastic energy
  JOURNAL   Mol Membr Biol 30 (4), 303-314 (2013)
   PUBMED   23815289
REFERENCE   2  (bases 1 to 2346)
  AUTHORS   Strobl-Wildemann,G., Kalscheuer,V.M., Hu,H., Wrogemann,K.,
            Ropers,H.H. and Tzschach,A.
  TITLE     Novel GDI1 mutation in a large family with nonsyndromic X-linked
            intellectual disability
  JOURNAL   Am J Med Genet A 155A (12), 3067-3070 (2011)
   PUBMED   22002931
REFERENCE   3  (bases 1 to 2346)
  AUTHORS   Wang,T., Liu,Y., Xu,X.H., Deng,C.Y., Wu,K.Y., Zhu,J., Fu,X.Q.,
            He,M. and Luo,Z.G.
  TITLE     Lgl1 activation of rab10 promotes axonal membrane trafficking
            underlying neuronal polarization
  JOURNAL   Dev Cell 21 (3), 431-444 (2011)
   PUBMED   21856246
REFERENCE   4  (bases 1 to 2346)
  AUTHORS   Pavlos,N.J., Gronborg,M., Riedel,D., Chua,J.J., Boyken,J.,
            Kloepper,T.H., Urlaub,H., Rizzoli,S.O. and Jahn,R.
  TITLE     Quantitative analysis of synaptic vesicle Rabs uncovers distinct
            yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered
            exocytosis
  JOURNAL   J Neurosci 30 (40), 13441-13453 (2010)
   PUBMED   20926670
REFERENCE   5  (bases 1 to 2346)
  AUTHORS   Kimura,A., Kanoh,Y., Sakurai,T., Koumura,A., Yamada,M., Hayashi,Y.,
            Tanaka,Y., Hozumi,I., Takemura,M., Seishima,M. and Inuzuka,T.
  TITLE     Antibodies in patients with neuropsychiatric systemic lupus
            erythematosus
  JOURNAL   Neurology 74 (17), 1372-1379 (2010)
   PUBMED   20421581
REFERENCE   6  (bases 1 to 2346)
  AUTHORS   Caillol,N., Pasqualini,E., Lloubes,R. and Lombardo,D.
  TITLE     Impairment of bile salt-dependent lipase secretion in human
            pancreatic tumoral SOJ-6 cells
  JOURNAL   J Cell Biochem 79 (4), 628-647 (2000)
   PUBMED   10996854
REFERENCE   7  (bases 1 to 2346)
  AUTHORS   Bienvenu,T., des Portes,V., Saint Martin,A., McDonell,N.,
            Billuart,P., Carrie,A., Vinet,M.C., Couvert,P., Toniolo,D.,
            Ropers,H.H., Moraine,C., van Bokhoven,H., Fryns,J.P., Kahn,A.,
            Beldjord,C. and Chelly,J.
  TITLE     Non-specific X-linked semidominant mental retardation by mutations
            in a Rab GDP-dissociation inhibitor
  JOURNAL   Hum Mol Genet 7 (8), 1311-1315 (1998)
   PUBMED   9668174
REFERENCE   8  (bases 1 to 2346)
  AUTHORS   D'Adamo,P., Menegon,A., Lo Nigro,C., Grasso,M., Gulisano,M.,
            Tamanini,F., Bienvenu,T., Gedeon,A.K., Oostra,B., Wu,S.K.,
            Tandon,A., Valtorta,F., Balch,W.E., Chelly,J. and Toniolo,D.
  TITLE     Mutations in GDI1 are responsible for X-linked non-specific mental
            retardation
  JOURNAL   Nat Genet 19 (2), 134-139 (1998)
   PUBMED   9620768
  REMARK    Erratum:[Nat Genet 1998 Jul;19(3):303]
REFERENCE   9  (bases 1 to 2346)
  AUTHORS   Nishimura,N., Nakamura,H., Takai,Y. and Sano,K.
  TITLE     Molecular cloning and characterization of two rab GDI species from
            rat brain: brain-specific and ubiquitous types
  JOURNAL   J Biol Chem 269 (19), 14191-14198 (1994)
   PUBMED   8188702
REFERENCE   10 (bases 1 to 2346)
  AUTHORS   Shisheva,A., Sudhof,T.C. and Czech,M.P.
  TITLE     Cloning, characterization, and expression of a novel GDP
            dissociation inhibitor isoform from skeletal muscle
  JOURNAL   Mol Cell Biol 14 (5), 3459-3468 (1994)
   PUBMED   7513052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099763.1.
            
            On Jul 31, 2005 this sequence version replaced NM_017088.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099763.1, X74402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2346
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..2346
                     /gene="Gdi1"
                     /note="GDP dissociation inhibitor 1"
                     /db_xref="GeneID:25183"
                     /db_xref="RGD:2676"
     exon            1..169
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1468
                     /gene="Gdi1"
                     /note="GDI-1; rab GDI alpha; guanosine diphosphate
                     dissociation inhibitor 1"
                     /codon_start=1
                     /product="rab GDP dissociation inhibitor alpha"
                     /protein_id="NP_058784.2"
                     /db_xref="GeneID:25183"
                     /db_xref="RGD:2676"
                     /translation="MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESS
                     SITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDF
                     KVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEG
                     VDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETINRIKLYSESLAR
                     YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVAR
                     CKQLICDPSYIPDRVRKAGQVIRIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYV
                     CMISYAHNVAAQGKYIAIASTTVETAEPEKEVEPALELLEPIDQKFVAISDLYEPIDD
                     GSESQVFCSCSYDATTHFETTCNDIKDIYKRMAGSAFDFENMKRKQNDVFGEADQ"
     exon            170..277
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..377
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..512
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..711
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..843
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..943
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1115
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1260
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1315
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..2298
                     /gene="Gdi1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcggca gcggcagcag cagcagcagc agcagcaaca gcaacagtag aggcattggt
       61 agcagctgct gtggtgaagg aggaggagga gaagaagagc gggcgctggt accaaggcct
      121 gaccatggat gaggaatacg atgtgattgt gctggggaca ggtcttaccg aatgcatcct
      181 gtctggcatc atgtctgtga atggaaagaa ggtgttgcac atggaccgaa acccctacta
      241 tgggggtgag agctcttcta tcacacccct tgaggagcta tataagcgct ttcagttgct
      301 ggaagggccc cctgaatcaa tgggccgggg ccgagactgg aatgttgact tgatccccaa
      361 attcctcatg gccaatggtc agctggtaaa gatgctactg tatacagaag tgactcgtta
      421 tctggacttc aaggtggtag agggcagctt tgtatacaaa gggggcaaga tctacaaagt
      481 gccatctact gagactgagg ccttggcttc taatctgatg ggcatgtttg aaaaacgacg
      541 cttccgaaaa tttttggtgt ttgtggcaaa ctttgatgag aatgacccca aaacctttga
      601 gggtgttgac ccgcagacca ccagcatgcg tgatgtctac cggaagtttg acctgggcca
      661 agatgtcatt gatttcactg gccatgccct ggcgctctac cgcactgatg attacctgga
      721 tcagccatgt cttgagacta ttaaccgcat caagttgtac agtgagtccc tggcccggta
      781 tggcaagagc ccatatttgt acccactcta tggcctgggt gagctgcctc agggctttgc
      841 cagattgagt gccatctatg ggggaacata catgctgaac aaaccagtgg atgacatcat
      901 catggaaaat ggcaaggtgg tgggtgtaaa atctgaggga gaggtggccc gctgcaagca
      961 gctgatctgt gatcccagct acatcccaga ccgtgtgcga aaggctggcc aggttattcg
     1021 catcatctgc atcctcagcc accccatcaa gaataccaat gatgccaatt cctgccaaat
     1081 tatcatccct cagaatcagg tcaacaggaa gtcagacatc tatgtgtgca tgatctccta
     1141 tgcacacaac gtggccgcac aaggcaaata catcgccatt gccagcacca ccgtagagac
     1201 tgcagaacca gaaaaggagg ttgagcctgc attggagctg ttggaaccta ttgaccaaaa
     1261 gtttgtggct atcagtgatt tatatgagcc cattgatgac ggttcagaga gtcaggtgtt
     1321 ctgttcctgc tcctatgatg ctaccacaca ctttgagaca acctgcaatg acatcaaaga
     1381 tatctacaaa cgcatggctg gttctgcctt tgattttgag aacatgaagc gcaaacagaa
     1441 tgatgtcttt ggagaagccg atcagtgatt gctgactccc ctcctccagc ccctgttccc
     1501 ctctccccaa cttgtgtgtc cttctctagg gcaggggaga tggtatggct gggcatccct
     1561 gtttccagca tcttctgctt ccccccacca cattccaatc acccacctta attgatttga
     1621 ttcactgacc atatccttaa ccttagtgat ggtttgggag atgggagttg gatagtatcc
     1681 tctttcttga tctgtccttg ttctatggaa agtggaagtg tgtgtgtgtg tgtgtgtgtg
     1741 tgtgtgtgtg tgtgccccca attttgctgt ttgggaagga gtggaggaaa aactgactct
     1801 aacccccact gctcttagtc ccaaatgtag aggcctttgg agatacccca tctcctcccc
     1861 caactcttat gtgttggaga gaagggaccc tcccagcaca aaattgcatt ccttctcctt
     1921 ataatttatt ctaatttatt aactttggag tacctgtctg agccctcagc ctttctgtgc
     1981 agcctagggc tgtagagtga gctaccctgg cctctcccag cccaggcaaa gcctgggctg
     2041 ggagaaggtt tagatgtgac cccctctgga ggttggtctg ttttgaattt cttttgtatt
     2101 gtgttcactg agaaaaagta atgtgagcaa agcagaagga ggtaggaaag tggatccaaa
     2161 ccccagtgtg ccctgcccca tgccttttcc tttagtggtg ggaaaccctt accttgcaaa
     2221 gtgaatatga acccttcccc aacctctagt gtatttcaca gaaaataaaa acctcccaat
     2281 aaagttattg aaacctaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaa
//
