LOCUS       NP_058784                447 aa            linear   ROD 03-APR-2024
DEFINITION  rab GDP dissociation inhibitor alpha [Rattus norvegicus].
ACCESSION   NP_058784
VERSION     NP_058784.2
DBSOURCE    REFSEQ: accession NM_017088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 447)
  AUTHORS   Kirsten,M.L., Baron,R.A., Seabra,M.C. and Ces,O.
  TITLE     Rab1a and Rab5a preferentially bind to binary lipid compositions
            with higher stored curvature elastic energy
  JOURNAL   Mol Membr Biol 30 (4), 303-314 (2013)
   PUBMED   23815289
REFERENCE   2  (residues 1 to 447)
  AUTHORS   Strobl-Wildemann,G., Kalscheuer,V.M., Hu,H., Wrogemann,K.,
            Ropers,H.H. and Tzschach,A.
  TITLE     Novel GDI1 mutation in a large family with nonsyndromic X-linked
            intellectual disability
  JOURNAL   Am J Med Genet A 155A (12), 3067-3070 (2011)
   PUBMED   22002931
REFERENCE   3  (residues 1 to 447)
  AUTHORS   Wang,T., Liu,Y., Xu,X.H., Deng,C.Y., Wu,K.Y., Zhu,J., Fu,X.Q.,
            He,M. and Luo,Z.G.
  TITLE     Lgl1 activation of rab10 promotes axonal membrane trafficking
            underlying neuronal polarization
  JOURNAL   Dev Cell 21 (3), 431-444 (2011)
   PUBMED   21856246
REFERENCE   4  (residues 1 to 447)
  AUTHORS   Pavlos,N.J., Gronborg,M., Riedel,D., Chua,J.J., Boyken,J.,
            Kloepper,T.H., Urlaub,H., Rizzoli,S.O. and Jahn,R.
  TITLE     Quantitative analysis of synaptic vesicle Rabs uncovers distinct
            yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered
            exocytosis
  JOURNAL   J Neurosci 30 (40), 13441-13453 (2010)
   PUBMED   20926670
REFERENCE   5  (residues 1 to 447)
  AUTHORS   Kimura,A., Kanoh,Y., Sakurai,T., Koumura,A., Yamada,M., Hayashi,Y.,
            Tanaka,Y., Hozumi,I., Takemura,M., Seishima,M. and Inuzuka,T.
  TITLE     Antibodies in patients with neuropsychiatric systemic lupus
            erythematosus
  JOURNAL   Neurology 74 (17), 1372-1379 (2010)
   PUBMED   20421581
REFERENCE   6  (residues 1 to 447)
  AUTHORS   Caillol,N., Pasqualini,E., Lloubes,R. and Lombardo,D.
  TITLE     Impairment of bile salt-dependent lipase secretion in human
            pancreatic tumoral SOJ-6 cells
  JOURNAL   J Cell Biochem 79 (4), 628-647 (2000)
   PUBMED   10996854
REFERENCE   7  (residues 1 to 447)
  AUTHORS   Bienvenu,T., des Portes,V., Saint Martin,A., McDonell,N.,
            Billuart,P., Carrie,A., Vinet,M.C., Couvert,P., Toniolo,D.,
            Ropers,H.H., Moraine,C., van Bokhoven,H., Fryns,J.P., Kahn,A.,
            Beldjord,C. and Chelly,J.
  TITLE     Non-specific X-linked semidominant mental retardation by mutations
            in a Rab GDP-dissociation inhibitor
  JOURNAL   Hum Mol Genet 7 (8), 1311-1315 (1998)
   PUBMED   9668174
REFERENCE   8  (residues 1 to 447)
  AUTHORS   D'Adamo,P., Menegon,A., Lo Nigro,C., Grasso,M., Gulisano,M.,
            Tamanini,F., Bienvenu,T., Gedeon,A.K., Oostra,B., Wu,S.K.,
            Tandon,A., Valtorta,F., Balch,W.E., Chelly,J. and Toniolo,D.
  TITLE     Mutations in GDI1 are responsible for X-linked non-specific mental
            retardation
  JOURNAL   Nat Genet 19 (2), 134-139 (1998)
   PUBMED   9620768
  REMARK    Erratum:[Nat Genet 1998 Jul;19(3):303]
REFERENCE   9  (residues 1 to 447)
  AUTHORS   Nishimura,N., Nakamura,H., Takai,Y. and Sano,K.
  TITLE     Molecular cloning and characterization of two rab GDI species from
            rat brain: brain-specific and ubiquitous types
  JOURNAL   J Biol Chem 269 (19), 14191-14198 (1994)
   PUBMED   8188702
REFERENCE   10 (residues 1 to 447)
  AUTHORS   Shisheva,A., Sudhof,T.C. and Czech,M.P.
  TITLE     Cloning, characterization, and expression of a novel GDP
            dissociation inhibitor isoform from skeletal muscle
  JOURNAL   Mol Cell Biol 14 (5), 3459-3468 (1994)
   PUBMED   7513052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099763.1.
            
            On Jul 31, 2005 this sequence version replaced NP_058784.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099763.1, X74402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     Protein         1..447
                     /product="rab GDP dissociation inhibitor alpha"
                     /note="GDI-1; rab GDI alpha; guanosine diphosphate
                     dissociation inhibitor 1"
                     /calculated_mol_wt=50406
     Region          1..436
                     /region_name="GDI"
                     /note="GDP dissociation inhibitor; pfam00996"
                     /db_xref="CDD:395792"
     Site            427
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P50396; propagated from
                     UniProtKB/Swiss-Prot (P50398.1)"
     CDS             1..447
                     /gene="Gdi1"
                     /coded_by="NM_017088.2:125..1468"
                     /db_xref="GeneID:25183"
                     /db_xref="RGD:2676"
ORIGIN      
        1 mdeeydvivl gtgltecils gimsvngkkv lhmdrnpyyg gesssitple elykrfqlle
       61 gppesmgrgr dwnvdlipkf lmangqlvkm llytevtryl dfkvvegsfv ykggkiykvp
      121 stetealasn lmgmfekrrf rkflvfvanf dendpktfeg vdpqttsmrd vyrkfdlgqd
      181 vidftghala lyrtddyldq pcletinrik lyseslaryg kspylyplyg lgelpqgfar
      241 lsaiyggtym lnkpvddiim engkvvgvks egevarckql icdpsyipdr vrkagqviri
      301 icilshpikn tndanscqii ipqnqvnrks diyvcmisya hnvaaqgkyi aiasttveta
      361 epekevepal ellepidqkf vaisdlyepi ddgsesqvfc scsydatthf ettcndikdi
      421 ykrmagsafd fenmkrkqnd vfgeadq
//
