LOCUS       NM_021672               1388 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus growth differentiation factor 9 (Gdf9), mRNA.
ACCESSION   NM_021672
VERSION     NM_021672.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1388)
  AUTHORS   Findik,D.G., Kaplanoglu,G.T., Arik,G.N. and Alemari,N.B.A.
  TITLE     Decreased growth differentiation factor 9, bone morphogenetic
            protein 15, and forkhead box O3a expressions in the ovary via
            ulipristal acetate
  JOURNAL   Rev Assoc Med Bras (1992) 69 (8), e20230381 (2023)
   PUBMED   37585996
  REMARK    GeneRIF: Decreased growth differentiation factor 9, bone
            morphogenetic protein 15, and forkhead box O3a expressions in the
            ovary via ulipristal acetate.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1388)
  AUTHORS   Lin,Z.L., Li,Y.H., Xu,Y.N., Wang,Q.L., Namgoong,S., Cui,X.S. and
            Kim,N.H.
  TITLE     Effects of growth differentiation factor 9 and bone morphogenetic
            protein 15 on the in vitro maturation of porcine oocytes
  JOURNAL   Reprod Domest Anim 49 (2), 219-227 (2014)
   PUBMED   24313324
REFERENCE   3  (bases 1 to 1388)
  AUTHORS   Xue,K., Kim,J.Y., Liu,J.Y. and Tsang,B.K.
  TITLE     Insulin-like 3-induced rat preantral follicular growth is mediated
            by growth differentiation factor 9
  JOURNAL   Endocrinology 155 (1), 156-167 (2014)
   PUBMED   24169563
  REMARK    GeneRIF: INSL3 is a key theca cell-derived growth factor for
            preantral follicle and its action is mediated by GDF9
REFERENCE   4  (bases 1 to 1388)
  AUTHORS   Shi,F.T., Cheung,A.P., Klausen,C., Huang,H.F. and Leung,P.C.
  TITLE     Growth differentiation factor 9 reverses activin A suppression of
            steroidogenic acute regulatory protein expression and progesterone
            production in human granulosa-lutein cells
  JOURNAL   J Clin Endocrinol Metab 95 (10), E172-E180 (2010)
   PUBMED   20660033
REFERENCE   5  (bases 1 to 1388)
  AUTHORS   Kobayashi,N., Orisaka,M., Cao,M., Kotsuji,F., Leader,A.,
            Sakuragi,N. and Tsang,B.K.
  TITLE     Growth differentiation factor-9 mediates follicle-stimulating
            hormone-thyroid hormone interaction in the regulation of rat
            preantral follicular development
  JOURNAL   Endocrinology 150 (12), 5566-5574 (2009)
   PUBMED   19833718
  REMARK    GeneRIF: Findings support the concept that thyroid hormone
            regulates ovarian follicular development and promotes FSH-induced
            preantral follicular growth through up-regulation of FSHR, a
            mechanism dependent on the expression and action of oocyte-derived
            GDF-9.
REFERENCE   6  (bases 1 to 1388)
  AUTHORS   Orisaka,M., Orisaka,S., Jiang,J.Y., Craig,J., Wang,Y., Kotsuji,F.
            and Tsang,B.K.
  TITLE     Growth differentiation factor 9 is antiapoptotic during follicular
            development from preantral to early antral stage
  JOURNAL   Mol Endocrinol 20 (10), 2456-2468 (2006)
   PUBMED   16740654
  REMARK    GeneRIF: Growth differentiation factor 9 is antiapoptotic during
            follicular development from preantral to early antral stage.
REFERENCE   7  (bases 1 to 1388)
  AUTHORS   Liao,W.X., Moore,R.K. and Shimasaki,S.
  TITLE     Functional and molecular characterization of naturally occurring
            mutations in the oocyte-secreted factors bone morphogenetic
            protein-15 and growth and differentiation factor-9
  JOURNAL   J Biol Chem 279 (17), 17391-17396 (2004)
   PUBMED   14970198
  REMARK    GeneRIF: BMP-15 and GDF-9 have roles in fertility; critical
            sequences are determined by mutagenesis
REFERENCE   8  (bases 1 to 1388)
  AUTHORS   Yamamoto,N., Christenson,L.K., McAllister,J.M. and Strauss,J.F.
            3rd.
  TITLE     Growth differentiation factor-9 inhibits 3'5'-adenosine
            monophosphate-stimulated steroidogenesis in human granulosa and
            theca cells
  JOURNAL   J Clin Endocrinol Metab 87 (6), 2849-2856 (2002)
   PUBMED   12050262
  REMARK    Erratum:[J Clin Endocrinol Metab 2002 Oct;87(10):4495]
REFERENCE   9  (bases 1 to 1388)
  AUTHORS   Jaatinen,R., Laitinen,M.P., Vuojolainen,K., Aaltonen,J., Louhio,H.,
            Heikinheimo,K., Lehtonen,E. and Ritvos,O.
  TITLE     Localization of growth differentiation factor-9 (GDF-9) mRNA and
            protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel
            homolog GDF-9B
  JOURNAL   Mol Cell Endocrinol 156 (1-2), 189-193 (1999)
   PUBMED   10612437
REFERENCE   10 (bases 1 to 1388)
  AUTHORS   Hayashi,M., McGee,E.A., Min,G., Klein,C., Rose,U.M., van Duin,M.
            and Hsueh,A.J.
  TITLE     Recombinant growth differentiation factor-9 (GDF-9) enhances growth
            and differentiation of cultured early ovarian follicles
  JOURNAL   Endocrinology 140 (3), 1236-1244 (1999)
   PUBMED   10067849
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF099912.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF099912.1, X81899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132283, SAMD00155331
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1388
                     /gene="Gdf9"
                     /note="growth differentiation factor 9"
                     /db_xref="GeneID:59304"
                     /db_xref="RGD:71038"
     CDS             1..1323
                     /gene="Gdf9"
                     /codon_start=1
                     /product="growth/differentiation factor 9 precursor"
                     /protein_id="NP_067704.1"
                     /db_xref="GeneID:59304"
                     /db_xref="RGD:71038"
                     /translation="MAFPSRFLLGVCCFAWLCLLISLSSQASTGESQAGASENLESEA
                     DPWSLLLPVDGTDRSGLLPPLFKVLSDRRSETPKLQPDSRALYYMKKLYKTYATKEGV
                     PKPSRSHLYNTVRLFSPCAQQEQAPSNQMTGPLPMVDLLFNLDRVTAMEHLLKSVLLY
                     TLNNSAASSSTVTCVCDLVVKEPMSSSKATPRAPYSFTLRKHRWIEMDVTSLLQPLVA
                     SSERSIHLSVNFTCTRDQAPENGTFNMPLSVPPSLILYLNDTSTQAYHSWQSLQSTQR
                     HSQHPGQDSVTTRPVEEEATEVERSPRHRRGQKTLSSETKKPLTASFNLSEYFRQFLF
                     PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVRHRYGSPVHTMVQNII
                     YEKLDPSVPRPSCVPGKYSPLSVLTIEPDGSIAYKEYEDMIATRCTCR"
     exon            1..397
                     /gene="Gdf9"
                     /inference="alignment:Splign:2.1.0"
     exon            398..1388
                     /gene="Gdf9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcatttc ccagcagatt cctgttgggg gtttgctgct ttgcctggct gtgtcttctt
       61 attagcctta gctctcaggc ttccacggga gaatcccagg ctggagccag tgaaaatttg
      121 gagtctgagg cagacccctg gtccttgctg ttgcctgtag atgggactga caggtctggc
      181 ctcttgcccc ccctcttcaa ggttctctct gataggcgaa gtgagacccc taagctgcag
      241 cctgactcca gagctctcta ctacatgaaa aagctctata agacgtatgc taccaaagag
      301 ggggttccta aacccagcag aagtcacctc tacaataccg tccggctctt cagcccctgt
      361 gcccagcagg agcaggctcc cagcaaccag atgacaggac ccctgccaat ggtggacctg
      421 ctatttaacc tggaccgggt gactgccatg gaacacttac tcaaatcggt cttgctatac
      481 actctgaaca actccgctgc ttcctcctcc actgtgacct gtgtgtgtga ccttgtggta
      541 aaggagccca tgtcttccag caaggctacc ccaagagcgc catactcatt taccctgagg
      601 aaacacaggt ggattgagat ggatgtgacc tccctccttc agcccctggt ggcctcaagc
      661 gagaggagca ttcacctatc tgtcaatttt acatgcacaa gagaccaggc cccagagaat
      721 ggaacgttta atatgcctct ctcagtgccg ccctcgctca tcttgtatct caatgacacg
      781 agtacccagg cctaccattc ctggcagtcc cttcagtcca cccagaggca ttcacagcat
      841 cccggccagg acagtgtgac tacccgtcct gtggaagagg aggctactga ggtagaaaga
      901 tctcctcggc accgtcgggg acagaaaacc ctcagctcag aaacaaagaa gccacttaca
      961 gcatccttca atctcagtga atacttcaga cagtttcttt tccctcaaaa cgagtgtgaa
     1021 ctccatgatt tcagactgag ttttagtcag ctcaaatggg acaactggat cgtggccccg
     1081 cacagataca accctaggta ctgtaaaggg gactgtcccc gggcagtcag gcatcggtac
     1141 ggctctcctg tgcacaccat ggtccagaat atcatctatg agaagctaga cccctcagtg
     1201 ccaaggcctt catgtgtgcc cggcaaatac agccccttga gcgtgttgac cattgaaccc
     1261 gatggctcca ttgcttacaa agagtacgaa gatatgatag ctacaaggtg cacctgtcgt
     1321 tagcatgggg ctctctacaa cacctgagcc tgtctggcag agcagtgcca tgggccttag
     1381 agggcctg
//
