LOCUS       NM_001399290            8342 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus growth differentiation factor 7 (Gdf7),
            transcript variant 1, mRNA.
ACCESSION   NM_001399290 XM_006239878
VERSION     NM_001399290.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8342)
  AUTHORS   Jelinsky SA, Li L, Ellis D, Archambault J, Li J, St Andre M, Morris
            C and Seeherman H.
  TITLE     Treatment with rhBMP12 or rhBMP13 increase the rate and the quality
            of rat Achilles tendon repair
  JOURNAL   J Orthop Res 29 (10), 1604-1612 (2011)
   PUBMED   21469182
  REMARK    GeneRIF: expression regulated during tendon healing
REFERENCE   2  (bases 1 to 8342)
  AUTHORS   Lee JY, Zhou Z, Taub PJ, Ramcharan M, Li Y, Akinbiyi T, Maharam ER,
            Leong DJ, Laudier DM, Ruike T, Torina PJ, Zaidi M, Majeska RJ,
            Schaffler MB, Flatow EL and Sun HB.
  TITLE     BMP-12 treatment of adult mesenchymal stem cells in vitro augments
            tendon-like tissue formation and defect repair in vivo
  JOURNAL   PLoS One 6 (3), e17531 (2011)
   PUBMED   21412429
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8342)
  AUTHORS   Mazerbourg S, Sangkuhl K, Luo CW, Sudo S, Klein C and Hsueh AJ.
  TITLE     Identification of receptors and signaling pathways for orphan bone
            morphogenetic protein/growth differentiation factor ligands based
            on genomic analyses
  JOURNAL   J Biol Chem 280 (37), 32122-32132 (2005)
   PUBMED   16049014
REFERENCE   4  (bases 1 to 8342)
  AUTHORS   Lo L, Dormand EL and Anderson DJ.
  TITLE     Late-emigrating neural crest cells in the roof plate are restricted
            to a sensory fate by GDF7
  JOURNAL   Proc Natl Acad Sci U S A 102 (20), 7192-7197 (2005)
   PUBMED   15883363
REFERENCE   5  (bases 1 to 8342)
  AUTHORS   Butler SJ and Dodd J.
  TITLE     A role for BMP heterodimers in roof plate-mediated repulsion of
            commissural axons
  JOURNAL   Neuron 38 (3), 389-401 (2003)
   PUBMED   12741987
REFERENCE   6  (bases 1 to 8342)
  AUTHORS   Sena K, Morotome Y, Baba O, Terashima T, Takano Y and Ishikawa I.
  TITLE     Gene expression of growth differentiation factors in the developing
            periodontium of rat molars
  JOURNAL   J Dent Res 82 (3), 166-171 (2003)
   PUBMED   12598543
  REMARK    GeneRIF: involved in the formation of periodontal ligament
REFERENCE   7  (bases 1 to 8342)
  AUTHORS   Settle S, Marker P, Gurley K, Sinha A, Thacker A, Wang Y, Higgins
            K, Cunha G and Kingsley DM.
  TITLE     The BMP family member Gdf7 is required for seminal vesicle growth,
            branching morphogenesis, and cytodifferentiation
  JOURNAL   Dev Biol 234 (1), 138-150 (2001)
   PUBMED   11356025
REFERENCE   8  (bases 1 to 8342)
  AUTHORS   Nef S, Lush ME, Shipman TE and Parada LF.
  TITLE     Neurotrophins are not required for normal embryonic development of
            olfactory neurons
  JOURNAL   Dev Biol 234 (1), 80-92 (2001)
   PUBMED   11356021
REFERENCE   9  (bases 1 to 8342)
  AUTHORS   Lee KJ, Dietrich P and Jessell TM.
  TITLE     Genetic ablation reveals that the roof plate is essential for
            dorsal interneuron specification
  JOURNAL   Nature 403 (6771), 734-740 (2000)
   PUBMED   10693795
REFERENCE   10 (bases 1 to 8342)
  AUTHORS   Li W, Cogswell CA and LoTurco JJ.
  TITLE     Neuronal differentiation of precursors in the neocortical
            ventricular zone is triggered by BMP
  JOURNAL   J Neurosci 18 (21), 8853-8862 (1998)
   PUBMED   9786991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000164.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001399290.2.
            
            On Jan 6, 2022 this sequence version replaced XM_006239878.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071,
                              SAMN12840107 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               JACYVU010000164.1  7470223-7470647     c
            426-8342            JACYVU010000164.1  7459658-7467574     c
FEATURES             Location/Qualifiers
     source          1..8342
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..8342
                     /gene="Gdf7"
                     /note="growth differentiation factor 7"
                     /db_xref="GeneID:252833"
                     /db_xref="RGD:620105"
     exon            1..425
                     /gene="Gdf7"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1429
                     /gene="Gdf7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="growth/differentiation factor 7 isoform 1
                     precursor"
                     /protein_id="NP_001386219.1"
                     /db_xref="GeneID:252833"
                     /db_xref="RGD:620105"
                     /translation="MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPAWSPGGGG
                     GGRTLAPAPGPSALQAAAVPGPRAVRRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAA
                     ATSGHGRVDTITGFTDQATQEESAAEPGQSFLFDVSSLSDSDEVVNAELRVLRRRSPE
                     PDRDSATLPPLLLLSTCPDEAGTAHLLHSRAAEPLDSARWEAFDVTDAVQSHRRWPRT
                     SRKFCLVLRAVTGAESSPLALRRLGFGWPGGGDGGGTAAEERALLVISSRTHRKESLF
                     REIRAQARALRAAAELPPDPGLGAGSRKATPGGRRRRRTALAGTRGAQGSGGGGGGGG
                     GGGGGGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGVCDFPL
                     RSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVV
                     EACGCR"
     exon            426..8342
                     /gene="Gdf7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggacttc ccggagccac ggagcccgtg tcgcgcggcc ggccggccca cggagcccat
       61 ggacctgagc gctgccgccg cgctgtgtct ctggctgctg agcgcttgcc gtccccgcga
      121 cgggctggaa gctgccgcgg tgctccgagc ggcgggagca ggaccagcct ggagcccggg
      181 gggcggcggc ggcgggcgga ccctcgcccc agctccaggc ccttcagctc tccaggccgc
      241 tgcggttccc ggtccccgcg ctgtgcgccg cgccgcgggc tccggcttca ggaacggctc
      301 ggtggtgcca caccacttca tgatgtcgct ttaccggagc ctggcgggga gggctcctgc
      361 cgcggcaact tcagggcacg ggcgcgtgga cacgatcacc ggcttcacag accaagcaac
      421 tcaagaggaa tcggcggccg agccaggcca gagcttctta ttcgacgtat ccagcctctc
      481 ggactccgac gaggtggtga atgccgagct gcgcgtgctg cgccggaggt ctccggagcc
      541 agacagggac agtgcgaccc tccctccgct gctgctgctg tccacgtgcc cggacgaggc
      601 cggcacagct cacttgctgc actcgcgggc cgccgagccc ctagacagcg cgcgctggga
      661 agcgttcgac gtgacggacg cggtgcagag tcaccgccgc tggccgcgca cctcccgcaa
      721 gttctgcctg gtgctgcgcg cggtgacggg cgccgagagc agcccgctgg ccctgagaag
      781 actgggcttc ggctggcctg gcggtggcga cggcggcggc acggcagccg aggagcgcgc
      841 gctgttggtg atctcctccc gcacgcacag gaaagagagt ctgttccggg agatacgcgc
      901 ccaggcccgc gctctccggg ccgccgcaga gctgccacca gatccaggac taggcgctgg
      961 atctcggaaa gccaccccgg gcggtcgcag gcggcgacgg accgcgctgg ctgggactcg
     1021 gggagcgcag ggaagcggtg gcggcggtgg gggcggtggc ggcggcggcg gcggcggcgg
     1081 tggcgcaggc aggggccacg ggcgcagagg caggagccgc tgcagtcgca agccactgca
     1141 tgtggacttt aaggagctgg gctgggacga ctggatcatc gcgccattag actacgaggc
     1201 ataccactgc gagggcgttt gcgactttcc tctgcgctcg cacctggagc ctaccaacca
     1261 cgccatcatc cagacgctgc tcaactccat ggcgccggat gcggcgccag cctcctgctg
     1321 cgtgcccgca cgtctcagcc ccatcagcat cctctacatc gacgccgcca acaacgtggt
     1381 ctacaagcag tacgaggaca tggtggtaga ggcctgcggc tgcaggtagc atgaggtctg
     1441 gggagggttt tgctgcccag gaccctagcc gaagagcgtg agtcaccagg cccgagggaa
     1501 ggcggacaat gttctctgcc agcagaggag agcacacagt taacactcac atttacacac
     1561 tccttcactc gcgcacatgt ttactgtgga tgccaggcgc tgaaagcctt ggacagagat
     1621 agtatgcagc gacttgatgt catagccgtg ttcgtttgct gacgttgata caaacctctg
     1681 tccctttggg gagagggaag ggtgtctgtg tttatgttgc ggtaattggc actaaatcca
     1741 agtagaaacg ggttagcatt ggattctcct tttatttgga ggccgtgtgg ctctgctagg
     1801 tggctggatt cctgacactg gacgtggagt tccactgtag ggctgtaata cccagattct
     1861 cttggggggt gggcattggg aatcttcaaa aaggacccgc tgggggtcgc aaggaggcgc
     1921 acatctccta gacacgtctc acgtggtact gtctcagttt tgaaaaggaa gctttatgca
     1981 aacgaatggg ttgtgctgca aaagccaaga ccgacttaaa aacatcaatt ccaattagga
     2041 atgatcggga aagtaggaag aacagctttc tcctgaggat gtgtgtgaaa tggaggagac
     2101 aggtgaggaa taggatagga tctgccaggt ttagaagcgt ctagaaggca gtagcaggag
     2161 gaagatagag caatggctgt atacggggta gtggaggatt gtgccaagag gatttcctaa
     2221 gaggctggaa acggctgtct gtcagggagt cagtgtccca gggccaccag cttcagcttc
     2281 tcaccttcag aagtcaagcg catttgtcag gtaggcacag tcccttccaa aagacaatga
     2341 gtgcttgtgc ttagcttccc tttgttagca catctgtggt ggcctgtgtg tgccttgtgc
     2401 ctttgactgt gttccttgct tttttttttt tttttttttt tttttttttg gcagtgtgac
     2461 aatgatgagg gggagtgaag ccacacaaat gcctttgtca gacctaaaca cacagtctgg
     2521 gaggagtcgg gtccttgctc ctagatggtg gaatgagtgg gttgcaggcc tgtctcccag
     2581 ctccagaatt ttttgttctg cagaggcatt tgatttcttg gtaccggttc atcctctggg
     2641 gcctcctgtc aatggctggg gaaacagaaa caagctgggc tgcacctgtc agagggctca
     2701 gaggacctct ttaacattac tctaggtttt ctaatttagg ctttgggaga ggagttaatt
     2761 ctgtcttgaa tgccaaggcc cagggcagtt tacaggtatt ttattttagt tcttagtgga
     2821 tactcctgag agacaggaag gatgaaaatt tagattcagt gaattttata tttaagagtc
     2881 acatctgagt ccttttcatc ccctcccccc atgtataatt tatcctttta gaatgtgaac
     2941 ttattgactg gggatctctg taatcggaaa acacaacact ttcatcattt tttttctttt
     3001 tcacaaagtg gctactcttg atacaatttc tttctttctt tttttctttc tttctttctt
     3061 tctttttctt ttcttttttc tttttttggc gcctgggcag agatgtacat ccagatttct
     3121 ggattctgcc aggaaacttc cctcttctgt ttaagatgat ttaatagtgg ctgttctcgt
     3181 gtcacaatgg agaataaaat gcttgaaaag ctaaaagctg tattagaaag tttagaaaaa
     3241 aaatgaaaat ttacagttga ctattatttt ttgagaaaaa cttagagtgt ttactacttt
     3301 tgtatagaag caaacatttt aatacttttt ttgtgactag gccaaacaac ttttggggga
     3361 aaataacttg atttagcttg gttgttatac agtagggaaa tatccattag ccctgcccct
     3421 tttaacttga tgacttcttt ctaacaagac atattgcatg tgacgttttg agagtgggtt
     3481 ttcccctgtg ttgaggttgt acccacaaga gggtactgtc cttagaatgg tcaccattgt
     3541 cttctgtctc tgagacctcc ggtgctcttt gtttactgaa tgatcggaac ttctcccagg
     3601 tttcccttga acctttgtag aactatccct agcaacagtg cccctcttct ggttctattt
     3661 cctatggcca tcttctagag gatgtatttt gtgaccacaa aagggctaac cgcatgtggg
     3721 gcagatggga tgtggttaaa ctagcttgcc aagaggcgga gaaagactgc tgcctgcaca
     3781 gttgggaaca ctcttcatca tctgcctgtc acctagggtt tagtggggct gggtgaccag
     3841 gacaaactca gctgaaatcc ttggttggat gctgtggtca gcacagacta tgtctgttag
     3901 ggtgttccct catccccagc ctgagatcac caaaatcttc ctgctgaagt aaacagaatt
     3961 ctccatgttg ctggggaaca gtgcacagct acttgagata acctgaacca ctacttcaag
     4021 tgagtggaga ctgacagtcc cagctcagga agcaggggca ggccagctgg gcctacaggc
     4081 ttgccagaca ctaagctggt ctggtttgct gcttgaagcc ataatttatg gattaaagta
     4141 actcctccat tggcaggaaa gcattttcag gattcctaga ctctggcctt gtgggatttg
     4201 gggttaccaa gcagctgggc tggacctttg cagagagggt ggtcggttac ttaatcttat
     4261 tgtgaggaaa aatggctgga tctgtgctgg gctgtgtagt gttcatgctc ggcctttgcc
     4321 cactttcctg gcatttccat gctcaagcgg catggggtaa taagcttgtg cattgtgggt
     4381 ggtagcgctg ccgaaggtca gcggatctgt ctgtcccatg ctgatcttcc ctgacaatca
     4441 tcatggtgtc agcagggaca gaagctggat gtgagtcttg aagagagctt gggcatgctc
     4501 tggatgccaa tcctacaggt ccccacctcc ccagctactc ccactcaagg ccaacacaag
     4561 tgcgactgta gattgcattt cttcttaaat tagggtatcc aggcacattc tttccaagag
     4621 catcttgtgc cccaagaggc tcgctcctcc tttgagtcta ccttgaaaag gcaatagaaa
     4681 gtagaggaca cactgccttg atggttcccc agagagtgtc ctcttggggg ccacatatag
     4741 ggaggcaggg cccttgccaa tggactcagc acaggggcct cagcaagtgg gttgagaagg
     4801 tagaggtctg gaggatggag gtctgaaagc agctttctgt cagggagcag tgggtctcca
     4861 tttccctttt gtaagtgtca ggggtgggaa gggaagaaag aatgtggata agatgtcaaa
     4921 gttgttaccc aatttgagga gtgggtgaga cattactaga tctccatagg gtggtcagct
     4981 gatgtctctg gttagcctta gaatgaaggc ttctctatac ccaggagtta gttctcttca
     5041 tagtgtagcc tggactcacc ttgtaggaga ccatgcaggc atcaggtctc tacaggtgcc
     5101 tctcttgaga gacatctgag acactcagtc atgggcagtc atctccctgc ctagatcttc
     5161 agcatctgtc ccttacatga caactgctcc agtcccaagg ttccaagatt cttcttagaa
     5221 agttgtccag acactccaag acaaataatc ctagccacag ccgcatcacc agagttctga
     5281 gagtgtgggc ttgtgcactt atctgaatgc tggagcttag caaacactgc ttcagttttc
     5341 tacccagggt ggagcaggtg caggagaggc caggatctgg gtcctgggct ttggctcccc
     5401 aacagccagg agctgctctg tgccccctgg ttggagagtg tgcttgtgtt cacattgagt
     5461 cacatccagg ctgagcttgc caggtgactt tttgaaaatg gtggcagagt caagcattaa
     5521 aagaaacact aaatgggaag agttcagaag aggtttattt agatcctccc tccccaccag
     5581 ctctgctttt tgtagcagat ccctttgcag ctttaggctg aagccaagtt ttttctcccc
     5641 cctccttttt tgggccagag ctaaggacag cacaaagggg taccccaatt ggggcagtgg
     5701 tgagggaact gttcttaaga ggaccaaatc ccaggctgcc atgagctctc ttgagtcagc
     5761 tgctgtgagc tctgagatca tccagggact gagagatgct ctgcttctga cgtgcacaca
     5821 tccttcttca ggagccctgc tgcccgtgct gtgcttgcag acagcttaca acttggctgt
     5881 agacctccag ccaggcagaa ctggggatgg tgcctcctgg cagcagtggc agtcattaca
     5941 acaaagtgta agtcagcatg ggcagtggaa ggtgtgaggt cactgaagac cagtctgcat
     6001 ttcaaggctc tcttgctatt gtcagtcagt cgatgtactc tcttagcagc aaacccgttc
     6061 acctggcaat ggtcctgttc agtgctgagc ttacaggcct cctccagcat ctgtgaggca
     6121 aacacaggac tggtttcttt cacatgcatc cctttcaatg gtaagagggc tgtggcaacc
     6181 atagacactt cctgagactc gtttctgtgt ttggtgtgaa ggtgtgagga acacattttg
     6241 ctccagcagg tgaagtccct tccagagtga aaacgccgct tttagaggga gtggcgagag
     6301 agaatctgta gctcagaatt tcttatccct tttggtggat actgaaataa gctgcctaaa
     6361 gaaatcagaa aagactgaat gccaaaccca ggcaccgtga gtgctgtgct acaaacgtcc
     6421 agaacaaggt cagctattgt gttttcgcta gctgttttgc tattatttga atggtggtgg
     6481 ctggagatgt gaccaggcag gaggtgggca tggagttgtc ttcttgtagt tatgtagtgc
     6541 tccatctgac caacactgga atccacctcc ctagttccaa tgtctagcga tgggatgaga
     6601 tgccatgttt tatatctagg gccctcagac tctcctctgt cagtttccag aactatctgg
     6661 cccgtctagc atgtgtacat agtggaccaa aacaagagtt gtgggaaagg tgttgcagaa
     6721 gtcctgctga gttagaagca aatgtgaatt gatccctcca aagcacacaa tctcaactcc
     6781 cttggtgtgc gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     6841 gtgtgtgtcc atgcctgcaa gctattcatt cgaagcgatt gcgtataacc tgtccctact
     6901 tagacagtta gtacttctag acccctgtga cggcctggct cctttaagac aactcatgtg
     6961 ggcaatagga aacccttaca ggacttctca gtggatcaag tctgcaaggc agtgacaaga
     7021 tgttctgggg ttagatgtgg ggggctttcc ctgaggcagg agtgaggtcc tagattcctt
     7081 ccgaggtgca gcagcctttt gctttgagga ctatgggatg gcttgaggaa tgggccttac
     7141 ttttggagtc agcctgtcag agtcatacag agtcaaccaa tctgcactgt gtataaccga
     7201 tgatccagtt tggtgagaag gttcagcatg caacatgctt ccaggccggg caacaggtta
     7261 gtgttccaag ctgggaactg agactctctt gagaggagtt tctctggcat tctccacctc
     7321 tgataaatca cagactaaac agagcaccct tagggtcctt ttatttttgc atttcacatt
     7381 atatgatagg acaaacagct tttatgtttt tgggttcttg gataaagtca tcattaggtc
     7441 ttttagttgg gaatttttgt ttttgttttt ttctcactcc aaatgagcag ttgatgcaat
     7501 aaaaacaaaa aatagggtat aacacagtct gtgacttgcc cttttagcgg atgaggtaag
     7561 cagttctggg aagtttggga tatgttttca ccctgcctta tgtataaata aagaagtaga
     7621 tccttccagt cctctcactg gggaggttgt tgctgaatcc tgaacctgct cgtggcatga
     7681 tgctgtgtaa gcaggtcctg ggtgggcgat ggaatgcggc acacacggtg agtggcccgc
     7741 agcttaaaaa gtaaatttaa tctgattcct gatactgtta ttttaaggaa atggcaaagc
     7801 tggagcgatg taatgccacc aaagctcagt tccacgctgt tccctcagca gctaaagaca
     7861 gaattaatta gtttcagggg aagtagcttt cattttgcaa tgacacctac tgttcctcag
     7921 gaggtggagc aggcgctggg agggagaggt ttttaaaacc cgaaatctcc ttgttggcaa
     7981 tcttccagct cggatttggc cagagcagag ctccgtagct tgcaggctac agttgagcat
     8041 ctgcctgctg cccagactgg ccactcaggc ggtccccaat gacactgtgc aatgctgttg
     8101 tgaccagact agctagcaga gaaccaaccc ttggagggcg ggcgtgaatc catgtgtata
     8161 tgtattcttg aatttaagta ggttgtacat attgaaatgt aaatgacctg taaaacagca
     8221 agctattttt tcttaaccat tacatagcag tatatatttg ctaaacagct tgtacgccca
     8281 tcattcacca ctttaatatt ttgtacagac agacaaagtc gattaaatat tttattcata
     8341 aa
//
