LOCUS       NM_001013038            1576 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus growth differentiation factor 6 (Gdf6), mRNA.
ACCESSION   NM_001013038 XM_345501
VERSION     NM_001013038.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1576)
  AUTHORS   Wang,J., Yu,T., Wang,Z., Ohte,S., Yao,R.E., Zheng,Z., Geng,J.,
            Cai,H., Ge,Y., Li,Y., Xu,Y., Zhang,Q., Gusella,J.F., Fu,Q.,
            Pregizer,S., Rosen,V. and Shen,Y.
  TITLE     A New Subtype of Multiple Synostoses Syndrome Is Caused by a
            Mutation in GDF6 That Decreases Its Sensitivity to Noggin and
            Enhances Its Potency as a BMP Signal
  JOURNAL   J Bone Miner Res 31 (4), 882-889 (2016)
   PUBMED   26643732
REFERENCE   2  (bases 1 to 1576)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   3  (bases 1 to 1576)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 1576)
  AUTHORS   Jelinsky,S.A., Li,L., Ellis,D., Archambault,J., Li,J., St Andre,M.,
            Morris,C. and Seeherman,H.
  TITLE     Treatment with rhBMP12 or rhBMP13 increase the rate and the quality
            of rat Achilles tendon repair
  JOURNAL   J Orthop Res 29 (10), 1604-1612 (2011)
   PUBMED   21469182
  REMARK    GeneRIF: expression regulated during tendon healing
REFERENCE   5  (bases 1 to 1576)
  AUTHORS   Chiquet,B.T., Hashmi,S.S., Henry,R., Burt,A., Mulliken,J.B.,
            Stal,S., Bray,M., Blanton,S.H. and Hecht,J.T.
  TITLE     Genomic screening identifies novel linkages and provides further
            evidence for a role of MYH9 in nonsyndromic cleft lip and palate
  JOURNAL   Eur J Hum Genet 17 (2), 195-204 (2009)
   PUBMED   18716610
REFERENCE   6  (bases 1 to 1576)
  AUTHORS   Mazerbourg,S., Sangkuhl,K., Luo,C.W., Sudo,S., Klein,C. and
            Hsueh,A.J.
  TITLE     Identification of receptors and signaling pathways for orphan bone
            morphogenetic protein/growth differentiation factor ligands based
            on genomic analyses
  JOURNAL   J Biol Chem 280 (37), 32122-32132 (2005)
   PUBMED   16049014
REFERENCE   7  (bases 1 to 1576)
  AUTHORS   Sena,K., Morotome,Y., Baba,O., Terashima,T., Takano,Y. and
            Ishikawa,I.
  TITLE     Gene expression of growth differentiation factors in the developing
            periodontium of rat molars
  JOURNAL   J Dent Res 82 (3), 166-171 (2003)
   PUBMED   12598543
  REMARK    GeneRIF: involved in the formation of periodontal ligament
REFERENCE   8  (bases 1 to 1576)
  AUTHORS   Li,W., Cogswell,C.A. and LoTurco,J.J.
  TITLE     Neuronal differentiation of precursors in the neocortical
            ventricular zone is triggered by BMP
  JOURNAL   J Neurosci 18 (21), 8853-8862 (1998)
   PUBMED   9786991
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ537426.2.
            
            On Apr 20, 2005 this sequence version replaced XM_345501.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ537426.2, BE098696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1576
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..1576
                     /gene="Gdf6"
                     /gene_synonym="BMP-13; gdf16"
                     /note="growth differentiation factor 6"
                     /db_xref="GeneID:252834"
                     /db_xref="RGD:620104"
     exon            1..517
                     /gene="Gdf6"
                     /gene_synonym="BMP-13; gdf16"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1467
                     /gene="Gdf6"
                     /gene_synonym="BMP-13; gdf16"
                     /note="growth differentiation factor 16; GDF-6; bone
                     morphogenetic protein 13"
                     /codon_start=1
                     /product="growth/differentiation factor 6 precursor"
                     /protein_id="NP_001013056.1"
                     /db_xref="GeneID:252834"
                     /db_xref="RGD:620104"
                     /translation="MDTPRVLLWAIFLISFLWDLPGFQQASISSSSSTELDSTKDVEN
                     RKGGKMQRTPQESAEGRTPKEHRPRPNELRRRLPGQSLGQEPPGRGPRVVPHEYMLSI
                     YRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSTLSDKE
                     ELVGAELRLYRQAPPTPWGPQTRPLHLQLFPCLSPLLLDSRTLDPQGPTEAGWEVFDV
                     WQVLRPQPWKQLCLELRAVWGELDARDSGARPRGPQQSPPLDLRSLGFGRRVRPPQER
                     ALLVVFTRSQRKNLFTEMHEQLGSAEAAGAEGSWPAPSGAPDAGSWLPSPGRRRRRTA
                     LSSRHGKRHGKKSRLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHL
                     EPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCG
                     CR"
     exon            518..1576
                     /gene="Gdf6"
                     /gene_synonym="BMP-13; gdf16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaggaacg cggcccccgc cgctgtccag ctgctccgtg cctttcgcgc ccggcgcagc
       61 caccgctgtc gccgccgcct ctcggagaaa ctcagccact ctctcgccat ggacactcct
      121 agggtccttc tctgggcgat cttcctcatc agcttcctct gggatttgcc gggtttccag
      181 caggcttcca tctcctcgtc ctcctccacc gaattggact ccaccaagga cgtggagaac
      241 cgcaagggag ggaagatgca gcggactccc caagagagtg ccgagggccg gacgcccaag
      301 gagcaccggc cgcggccgaa tgagctcagg cggcgactgc cgggacaatc tctggggcag
      361 gagccgccgg gcagggggcc gcgcgtggtg cctcacgagt acatgctgtc aatctacagg
      421 acttactcca ttgccgagaa gctgggcatc aatgccagct ttttccagtc ttccaagtca
      481 gctaatacga tcactagctt tgtagacaga ggactggacg atctctcgca cactcctctc
      541 cggagacaga agtatttgtt tgatgtgtcc acgctctcag acaaagaaga gctggtgggc
      601 gcagagctga ggctttatcg ccaggcgccc ccaacgccct gggggccaca aacccgaccg
      661 ctgcatttgc agctcttccc ctgtttgtcc ccattgttac tggactctag gaccctggat
      721 cctcaggggc caacagaagc tggctgggaa gttttcgacg tgtggcaggt cctgcgccct
      781 cagccgtgga agcagctgtg cttggagctt cgggcagtct ggggtgagct ggacgccagg
      841 gattcaggag cgcgcccgag gggtccccaa cagtcaccgc ccctggacct gcggagtctg
      901 ggcttcggcc ggagggtgcg gccgccccag gagcgcgccc tgcttgtcgt gttcaccaga
      961 tcgcagcgca agaacctgtt cactgagatg catgagcagc tgggctctgc agaggctgcc
     1021 ggagccgagg ggtcatggcc agcgccgtcg ggcgccccag acgccgggtc ttggctgccc
     1081 tcgcccggcc gccggcggcg acgcaccgcc ctcagcagcc gtcacggcaa gcgacacggc
     1141 aagaagtcca ggctgcgctg cagcagaaaa cctctgcacg tgaattttaa ggagttaggc
     1201 tgggacgatt ggattatcgc gcccctagag tacgaggcct atcactgcga gggcgtgtgc
     1261 gactttccgc tgcgctcgca cctggagccc accaaccatg ccatcatcca aacgctgatg
     1321 aactccatgg acccgggctc caccccaccc agctgctgtg ttcccaccaa attgactccc
     1381 atcagcatcc tgtacatcga tgcgggcaat aatgtggtct acaagcagta cgaggacatg
     1441 gtggtggagt cctgtggttg taggtagcgg tgctgtcccg cctcctgggc cagggaccac
     1501 ggaggaaggc ctaactgctg agagagaagc aggagctgtc ctggaagagg ccacaggtgg
     1561 gggacagcat gaaagt
//
