LOCUS       NM_001398661            2245 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus growth differentiation factor 5 (Gdf5), mRNA.
ACCESSION   NM_001398661 XM_003749600
VERSION     NM_001398661.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2245)
  AUTHORS   Zhu,C., Zhou,Q., Wang,Z., Zhang,J., Xu,C. and Ruan,D.
  TITLE     Growth differentiation factor 5 inhibits
            lipopolysaccharide-mediated pyroptosis of nucleus pulposus
            mesenchymal stem cells via RhoA signaling pathway
  JOURNAL   Mol Biol Rep 50 (8), 6337-6347 (2023)
   PUBMED   37310547
  REMARK    GeneRIF: Growth differentiation factor 5 inhibits
            lipopolysaccharide-mediated pyroptosis of nucleus pulposus
            mesenchymal stem cells via RhoA signaling pathway.
REFERENCE   2  (bases 1 to 2245)
  AUTHORS   Garciadiego-Cazares,D., Aguirre-Sanchez,H.I., Abarca-Buis,R.F.,
            Kouri,J.B., Velasquillo,C. and Ibarra,C.
  TITLE     Regulation of alpha5 and alphaV Integrin Expression by GDF-5 and
            BMP-7 in Chondrocyte Differentiation and Osteoarthritis
  JOURNAL   PLoS One 10 (5), e0127166 (2015)
   PUBMED   26010756
  REMARK    GeneRIF: Gdf-5 induced the expression of the alpha5 sub-unit, while
            Bmp-7 induced the expression of the alphaV sub-unit.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2245)
  AUTHORS   Degenkolbe,E., Schwarz,C., Ott,C.E., Konig,J., Schmidt-Bleek,K.,
            Ellinghaus,A., Schmidt,T., Lienau,J., Ploger,F., Mundlos,S.,
            Duda,G.N., Willie,B.M. and Seemann,P.
  TITLE     Improved bone defect healing by a superagonistic GDF5 variant
            derived from a patient with multiple synostoses syndrome
  JOURNAL   Bone 73, 111-119 (2015)
   PUBMED   25543012
REFERENCE   4  (bases 1 to 2245)
  AUTHORS   Thieme,T., Patzschke,R., Job,F., Liebold,J., Seemann,P., Lilie,H.,
            Balbach,J. and Schwarz,E.
  TITLE     Biophysical and structural characterization of a folded core domain
            within the proregion of growth and differentiation factor-5
  JOURNAL   FEBS J 281 (21), 4866-4877 (2014)
   PUBMED   25174448
REFERENCE   5  (bases 1 to 2245)
  AUTHORS   Stange,K., Thieme,T., Hertel,K., Kuhfahl,S., Janecke,A.R.,
            Piza-Katzer,H., Penttinen,M., Hietala,M., Dathe,K., Mundlos,S.,
            Schwarz,E. and Seemann,P.
  TITLE     Molecular analysis of two novel missense mutations in the GDF5
            proregion that reduce protein activity and are associated with
            brachydactyly type C
  JOURNAL   J Mol Biol 426 (19), 3221-3231 (2014)
   PUBMED   25092592
REFERENCE   6  (bases 1 to 2245)
  AUTHORS   Faiyaz-Ul-Haque,M., Ahmad,W., Zaidi,S.H., Haque,S., Teebi,A.S.,
            Ahmad,M., Cohn,D.H. and Tsui,L.C.
  TITLE     Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1)
            gene in a kindred affected with fibular hypoplasia and complex
            brachydactyly (DuPan syndrome)
  JOURNAL   Clin Genet 61 (6), 454-458 (2002)
   PUBMED   12121354
REFERENCE   7  (bases 1 to 2245)
  AUTHORS   Sato,M., Ochi,T., Nakase,T., Hirota,S., Kitamura,Y., Nomura,S. and
            Yasui,N.
  TITLE     Mechanical tension-stress induces expression of bone morphogenetic
            protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA,
            during distraction osteogenesis
  JOURNAL   J Bone Miner Res 14 (7), 1084-1095 (1999)
   PUBMED   10404008
REFERENCE   8  (bases 1 to 2245)
  AUTHORS   You,L., Kruse,F.E., Pohl,J. and Volcker,H.E.
  TITLE     Bone morphogenetic proteins and growth and differentiation factors
            in the human cornea
  JOURNAL   Invest Ophthalmol Vis Sci 40 (2), 296-311 (1999)
   PUBMED   9950587
REFERENCE   9  (bases 1 to 2245)
  AUTHORS   Tsumaki,N., Tanaka,K., Arikawa-Hirasawa,E., Nakase,T., Kimura,T.,
            Thomas,J.T., Ochi,T., Luyten,F.P. and Yamada,Y.
  TITLE     Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal
            cell recruitment and chondrocyte differentiation
  JOURNAL   J Cell Biol 144 (1), 161-173 (1999)
   PUBMED   9885252
REFERENCE   10 (bases 1 to 2245)
  AUTHORS   Storm,E.E., Huynh,T.V., Copeland,N.G., Jenkins,N.A., Kingsley,D.M.
            and Lee,S.J.
  TITLE     Limb alterations in brachypodism mice due to mutations in a new
            member of the TGF beta-superfamily
  JOURNAL   Nature 368 (6472), 639-643 (1994)
   PUBMED   8145850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 21, 2021 this sequence version replaced XM_003749600.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.899350.1,
                                           SRR22582419.2073997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680441
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-851               JAXUCZ010000003.1  164917743-164918593 c
            852-2245            JAXUCZ010000003.1  164914401-164915794 c
FEATURES             Location/Qualifiers
     source          1..2245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2245
                     /gene="Gdf5"
                     /gene_synonym="Cdmp1"
                     /note="growth differentiation factor 5"
                     /db_xref="GeneID:252835"
                     /db_xref="RGD:620102"
     exon            1..851
                     /gene="Gdf5"
                     /gene_synonym="Cdmp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1726
                     /gene="Gdf5"
                     /gene_synonym="Cdmp1"
                     /note="cartilage-derived morphogenetic protein 1"
                     /codon_start=1
                     /product="growth/differentiation factor 5 preproprotein"
                     /protein_id="NP_001385590.1"
                     /db_xref="GeneID:252835"
                     /db_xref="RGD:620102"
                     /translation="MRLPKLLTLLLWHLAWLDLGLVCTVLGAPDLGQRPPGARPGLAK
                     AEAKERPPLTRNIFRPGGHSYGVGATSARAKGSSGQTQAKKDEPRKVPPRASGSETKP
                     GPSPQTRQAAARTVTPKGQLSGGKASAKAGSAPSSFLLKKTREPGTPREPKEPFRPPP
                     ITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVF
                     DISALEKDGLLGAELRILRKKPLDVAKPAVPSSGRVAQLKLSSCPSGRQPAALLDVRS
                     VPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFERAARQVHEKA
                     LFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLANRQGKRPSKNLKA
                     RCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSM
                     DPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR"
     exon            852..2245
                     /gene="Gdf5"
                     /gene_synonym="Cdmp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagacggtg cacgtctgga cacgggagca tttccactat gggactggat acagacacac
       61 gcccggcgga cttcaagacg ctcactctga ggagaaagcc ctgcctgccg ctgctgctac
      121 tgctgccacc gctgcctctg aagacccact cctttcatgg tttttcctgc caagccagag
      181 acaccttcgc tgctgctgct gcctttctct gtggtgtcat tcagcggctg gccagaggat
      241 gagactcccc aaactcctca ctttgttgct ttggcacctg gcgtggctgg acctgggact
      301 cgtctgcact gtgttgggtg cccctgactt aggccagaga cccccagggg ccaggccagg
      361 gttggccaag gcggaggcca aggagaggcc acctctgact cggaatatct ttaggccagg
      421 gggtcacagc tatggtgtgg gggccaccag tgccagggca aagggaagct ctgggcagac
      481 acaggccaag aaggatgaac ccagaaaggt gccccccaga gccagtggct ctgaaaccaa
      541 gccaggaccc tctccccaga ctaggcaggc tgcagcccgg actgtaaccc caaaaggaca
      601 gctttctggg ggcaaagcat ctgcaaaagc aggatctgcc cccagctcct tcttgctgaa
      661 gaagaccaga gagcctggga cccctcgaga gcctaaggag ccattccgcc cgccccccat
      721 cacaccccac gaatatatgc tctcgctgta caggacgctg tccgatgctg acagaaaggg
      781 aggcaacagc agcgtgaagc tggaggctgg cctggccaac accatcacca gctttattga
      841 caaagggcaa gatgaccgag gccctgtggt caggaagcag aggtacgtgt ttgacatcag
      901 tgccttggag aaggatgggc tgttgggggc tgaactgcgg atcttacgga agaagccctt
      961 ggacgtggcc aagccagcgg tccccagtag cgggcgggtt gcccagctga agctgtccag
     1021 ctgccccagc ggccggcagc cggcagcctt gctggatgtg cgctccgtgc caggcctgga
     1081 tggatctggc tgggaggtgt tcgacatctg gaaactcttc cgaaatttta agaactcagc
     1141 gcagctgtgc ctggagctgg aggcctggga acggggccgg gccgtggacc tccgtggcct
     1201 gggctttgaa cgtgctgccc gacaggtcca cgagaaagcc ctgttcctgg tgtttgggcg
     1261 tactaagaaa cgggacctgt tctttaatga gattaaggcc cgctctggcc aggatgacaa
     1321 gactgtgtat gaatatttgt tcagccagag gcggaaacgg cgggcaccat tggccaatcg
     1381 ccagggcaag cgacccagca agaacctcaa ggctcgctgc agtcgcaagg ccttacatgt
     1441 taactttaag gacatgggct gggacgactg gatcatcgca cccctagagt atgaggcctt
     1501 ccactgcgaa ggactgtgtg agttcccctt gcgctcccac ttggagccca caaaccatgc
     1561 agtcattcag accctgatga actctatgga ccctgaatcc acaccgccta cctgttgcgt
     1621 gcctacgcgg ctgagtccca ttagcatcct gttcattgac tctgccaaca acgtggtata
     1681 taaacagtac gaggacatgg tcgtggaatc ttgtggctgt aggtagcagt gctagtcctc
     1741 ttgtcttcca gggtggcaca tccagagaga accccttccg caggctcctg gaatcacaga
     1801 gaggttgtga agctacggcc ggaagtatcc cggaagcctg caggaaagag ttttcagcag
     1861 gcttactctc tggatgtgtt ctgggttcaa gagacccccg tctgaagagt tctgcctaag
     1921 gaacagactc tgagtgggcc tgaggccccg ggaaggtgtt cttctatgag actcagttca
     1981 ccgtctctcc tgcccaggcc tcctcactcc agactctcca gagaagctgg ggctatgtcc
     2041 tgagcacatc gtacgagagc tacgagtgcc atcccttcct tgaatcacct ttgtgcctgg
     2101 tgactttctg tcacgagatg ttcattgcag gggctgggca agaaggggaa aggacttggg
     2161 caggggtgag gagtatgaac ctaattagac tgttagatta aaatgtacat cgatgagata
     2221 aaaagctgaa tcttcatggc taaaa
//
