LOCUS       NM_001109671            1270 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus growth differentiation factor 3 (Gdf3), mRNA.
ACCESSION   NM_001109671 XM_001060448 XM_575661
VERSION     NM_001109671.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1270)
  AUTHORS   Denes V, Kovacs K, Lukats A, Mester A, Berta G, Szabo A and Gabriel
            R.
  TITLE     Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by
            PAC1-immunopositive retinal ganglion cells in the postnatal rat
            retina
  JOURNAL   Eur J Histochem 66 (2), 3373 (2022)
   PUBMED   35477223
  REMARK    GeneRIF: Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed
            by PAC1-immunopositive retinal ganglion cells in the postnatal rat
            retina.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1270)
  AUTHORS   Ge Y, Waldemer RJ, Nalluri R, Nuzzi PD and Chen J.
  TITLE     RNAi screen reveals potentially novel roles of cytokines in
            myoblast differentiation
  JOURNAL   PLoS One 8 (7), e68068 (2013)
   PUBMED   23844157
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1270)
  AUTHORS   Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H,
            Warner M, Vaag AA, Bork-Jensen J, Brons C, Gant TW, Willis AE,
            Siddle K, Bushell M and Ozanne SE.
  TITLE     Programming of adipose tissue miR-483-3p and GDF-3 expression by
            maternal diet in type 2 diabetes
  JOURNAL   Cell Death Differ 19 (6), 1003-1012 (2012)
   PUBMED   22223106
  REMARK    GeneRIF: GDF3 is a potential target of miR-483-3p and is
            downregulated in low-protein diet rat offspring and
            low-birth-weight men.
REFERENCE   4  (bases 1 to 1270)
  AUTHORS   Li Q, Liu X, Wu Y, An J, Hexige S, Ling Y, Zhang M, Yang X and Yu
            L.
  TITLE     The conditioned medium from a stable human GDF3-expressing CHO cell
            line, induces the differentiation of PC12 cells
  JOURNAL   Mol Cell Biochem 359 (1-2), 115-123 (2012)
   PUBMED   21805089
REFERENCE   5  (bases 1 to 1270)
  AUTHORS   Ye M, Berry-Wynne KM, Asai-Coakwell M, Sundaresan P, Footz T,
            French CR, Abitbol M, Fleisch VC, Corbett N, Allison WT, Drummond
            G, Walter MA, Underhill TM, Waskiewicz AJ and Lehmann OJ.
  TITLE     Mutation of the bone morphogenetic protein GDF3 causes ocular and
            skeletal anomalies
  JOURNAL   Hum Mol Genet 19 (2), 287-298 (2010)
   PUBMED   19864492
REFERENCE   6  (bases 1 to 1270)
  AUTHORS   Levine AJ, Levine ZJ and Brivanlou AH.
  TITLE     GDF3 is a BMP inhibitor that can activate Nodal signaling only at
            very high doses
  JOURNAL   Dev Biol 325 (1), 43-48 (2009)
   PUBMED   18823971
REFERENCE   7  (bases 1 to 1270)
  AUTHORS   Andersson O, Korach-Andre M, Reissmann E, Ibanez CF and Bertolino
            P.
  TITLE     Growth/differentiation factor 3 signals through ALK7 and regulates
            accumulation of adipose tissue and diet-induced obesity
  JOURNAL   Proc Natl Acad Sci U S A 105 (20), 7252-7256 (2008)
   PUBMED   18480259
REFERENCE   8  (bases 1 to 1270)
  AUTHORS   Andersson O, Bertolino P and Ibanez CF.
  TITLE     Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and
            GDF3 during early embryonic development
  JOURNAL   Dev Biol 311 (2), 500-511 (2007)
   PUBMED   17936261
REFERENCE   9  (bases 1 to 1270)
  AUTHORS   Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM,
            Shen MM and Brown CW.
  TITLE     The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in
            the pre-gastrulation mouse embryo
  JOURNAL   Development 133 (2), 319-329 (2006)
   PUBMED   16368929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473964.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575661.2, XM_001060448.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ372084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680421
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1270
                     /gene="Gdf3"
                     /gene_synonym="RGD1564178"
                     /note="growth differentiation factor 3"
                     /db_xref="GeneID:500311"
                     /db_xref="RGD:1564178"
     exon            1..386
                     /gene="Gdf3"
                     /gene_synonym="RGD1564178"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1216
                     /gene="Gdf3"
                     /gene_synonym="RGD1564178"
                     /codon_start=1
                     /product="growth/differentiation factor 3 precursor"
                     /protein_id="NP_001103141.1"
                     /db_xref="GeneID:500311"
                     /db_xref="RGD:1564178"
                     /translation="MQPSQRLLTLGFLLLTLARGQTSEFQDYDFLQFLGLKKAPSPHR
                     FQPVPRILRKIIRARETAAASGASQDLCYVKELGVRGNLLRLLPDQGFFLNTQKPSQD
                     GSCLQKVLSFNLSAVKEKGKLTMAQLILHLGPRSYHYLQLELVVAVSVVQDRGVWGRS
                     HPKLGRLLVQKSVLGPQGSLQFNLQGVVKDWNRHQLKNLDLYLEILVKEDRYSRVNAQ
                     LDNPCNQLMHSLHASLLVVTLNLKHCHPSSRKKRAAIPIPKGLCRNLCHRHQLFVNFQ
                     DLGWHKWVIAPKGFMANYCHGDCPFTMTTYLNSSNYAFMQALMHMADPRVPKAVCIPT
                     KLSPISMLYQDNEKNVILRHYEDMVVDECGCG"
     exon            387..1270
                     /gene="Gdf3"
                     /gene_synonym="RGD1564178"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggagctg ggaagagagc aattcacact tgattacctc ccaggctcct gaattgagca
       61 gtgaaggcta gaccgctgag ctccccagag gctgcactct ctcgctcggt cgaccatgca
      121 accttcccaa aggcttctga ctctcggctt ccttctgtta accctggccc ggggccagac
      181 atccgagttt caagactatg actttttgca atttctgggc ttaaagaaag cgccttcacc
      241 ccacaggttc caacctgtgc ctcgcatctt aaggaaaatc atacgggctc gagaaaccgc
      301 tgcagccagc ggggcctcgc aggacttatg ctacgtgaag gagctgggcg tccgtgggaa
      361 cctgcttcgg cttctcccag accagggttt tttccttaac acacagaaac cttcccaaga
      421 tggctcctgt ctacagaagg tcctctcttt taacttgtct gccgtcaaag aaaagggaaa
      481 gttgaccatg gcccagctga ttctacactt ggggcccagg tcctaccatt acctgcagct
      541 ggagctggtg gtggctgtat ctgtggttca ggatcgtggt gtgtgggggc gatcccaccc
      601 taagctgggc aggttgctcg ttcagaagtc tgtcctggga cctcaaggtt ctcttcagtt
      661 caacctgcag ggtgtggtta aggattggaa ccgccaccaa ctgaagaatt tggacttata
      721 cttagagatt ctggtcaaag aggacagata ctccagggta aatgcccagc ttgataaccc
      781 ctgtaaccag ctgatgcact ctcttcatgc ctccctgctg gtggtgaccc tcaaccttaa
      841 acactgtcac ccttcttcca gaaagaagag ggcagccatc cctattccca agggtctttg
      901 taggaacctc tgccatcgtc accaactgtt cgtcaacttc caggacctgg gttggcacaa
      961 gtgggtcatt gcccctaagg gtttcatggc aaactactgt catggagatt gccccttcac
     1021 aatgaccacg tatttgaata gctccaatta tgccttcatg caggctctga tgcatatggc
     1081 tgaccccagg gtccccaagg ctgtctgtat ccccaccaag ctgtctccaa tctccatgct
     1141 ctatcaagat aacgagaaga acgtcattct ccgacattat gaagacatgg tagtggatga
     1201 gtgtgggtgt gggtagagtg tcaggaatag gataggagtg ttcttagggt aaatccttca
     1261 ataaaaccac
//
