LOCUS       NM_001106096            2928 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus growth differentiation factor 2 (Gdf2), mRNA.
ACCESSION   NM_001106096 XM_001060244 XM_225059
VERSION     NM_001106096.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2928)
  AUTHORS   Robert,F., Certain,M.C., Baron,A., Thuillet,R., Duhaut,L.,
            Ottaviani,M., Chelgham,M.K., Normand,C., Berrebeh,N., Ricard,N.,
            Furlan,V., Desroches-Castan,A., Gonzales,E., Jacquemin,E.,
            Sitbon,O., Humbert,M., Bailly,S., Coilly,A., Guignabert,C., Tu,L.
            and Savale,L.
  TITLE     Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in
            Hepatopulmonary Syndrome
  JOURNAL   Am J Respir Crit Care Med 210 (5), 648-661 (2024)
   PUBMED   38626313
  REMARK    GeneRIF: Disrupted BMP-9 Signaling Impairs Pulmonary Vascular
            Integrity in Hepatopulmonary Syndrome.
REFERENCE   2  (bases 1 to 2928)
  AUTHORS   Song,T., Li,X., Liu,L., Zeng,Y., Song,D. and Huang,D.
  TITLE     The effect of BMP9 on inflammation in the early stage of pulpitis
  JOURNAL   J Appl Oral Sci 31, e20220313 (2023)
   PUBMED   36700591
  REMARK    GeneRIF: The effect of BMP9 on inflammation in the early stage of
            pulpitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2928)
  AUTHORS   Ogawa,C., Mikawa,S., Hayashi,Y., Masumoto,K., Katou,F. and Sato,K.
  TITLE     BMP9 expression in the adult rat brain
  JOURNAL   J Chem Neuroanat 113, 101933 (2021)
   PUBMED   33582251
  REMARK    GeneRIF: BMP9 expression in the adult rat brain.
REFERENCE   4  (bases 1 to 2928)
  AUTHORS   Zheng,W., Chen,Q., Zhang,Y., Xia,R., Gu,X., Hao,Y., Yu,Z., Sun,X.
            and Hu,D.
  TITLE     BMP9 promotes osteogenic differentiation of SMSCs by activating the
            JNK/Smad2/3 signaling pathway
  JOURNAL   J Cell Biochem 121 (4), 2851-2863 (2020)
   PUBMED   31680322
  REMARK    GeneRIF: BMP9 promotes osteogenic differentiation of SMSCs by
            activating the JNK/Smad2/3 signaling pathway.
REFERENCE   5  (bases 1 to 2928)
  AUTHORS   Feng,Y. and Hu,Y.
  TITLE     Bone morphogenetic protein 9 serves a protective role in response
            to ischemic-reperfusion in the brain by promoting ERK activation
  JOURNAL   Mol Med Rep 17 (2), 2845-2852 (2018)
   PUBMED   29257291
  REMARK    GeneRIF: Growth Differentiation Factor 2 (bone morphogenetic
            protein 9) was identified to be upregulated at mRNA and protein
            levels in cerebral ischemiareperfusion animal and cell models.
REFERENCE   6  (bases 1 to 2928)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2928)
  AUTHORS   Truksa,J., Lee,P. and Beutler,E.
  TITLE     Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the
            hepcidin promoter are critical for BMP, SMAD1, and HJV
            responsiveness
  JOURNAL   Blood 113 (3), 688-695 (2009)
   PUBMED   18997172
REFERENCE   8  (bases 1 to 2928)
  AUTHORS   Sharff,K.A., Song,W.X., Luo,X., Tang,N., Luo,J., Chen,J., Bi,Y.,
            He,B.C., Huang,J., Li,X., Jiang,W., Zhu,G.H., Su,Y., He,Y.,
            Shen,J., Wang,Y., Chen,L., Zuo,G.W., Liu,B., Pan,X., Reid,R.R.,
            Luu,H.H., Haydon,R.C. and He,T.C.
  TITLE     Hey1 basic helix-loop-helix protein plays an important role in
            mediating BMP9-induced osteogenic differentiation of mesenchymal
            progenitor cells
  JOURNAL   J Biol Chem 284 (1), 649-659 (2009)
   PUBMED   18986983
REFERENCE   9  (bases 1 to 2928)
  AUTHORS   David,L., Mallet,C., Mazerbourg,S., Feige,J.J. and Bailly,S.
  TITLE     Identification of BMP9 and BMP10 as functional activators of the
            orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
  JOURNAL   Blood 109 (5), 1953-1961 (2007)
   PUBMED   17068149
REFERENCE   10 (bases 1 to 2928)
  AUTHORS   Peng,Y., Kang,Q., Luo,Q., Jiang,W., Si,W., Liu,B.A., Luu,H.H.,
            Park,J.K., Li,X., Luo,J., Montag,A.G., Haydon,R.C. and He,T.C.
  TITLE     Inhibitor of DNA binding/differentiation helix-loop-helix proteins
            mediate bone morphogenetic protein-induced osteoblast
            differentiation of mesenchymal stem cells
  JOURNAL   J Biol Chem 279 (31), 32941-32949 (2004)
   PUBMED   15161906
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474046.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060244.1, XM_225059.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2928
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2928
                     /gene="Gdf2"
                     /note="growth differentiation factor 2"
                     /db_xref="GeneID:290921"
                     /db_xref="RGD:1586196"
     exon            1..460
                     /gene="Gdf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1410
                     /gene="Gdf2"
                     /codon_start=1
                     /product="growth/differentiation factor 2 precursor"
                     /protein_id="NP_001099566.1"
                     /db_xref="GeneID:290921"
                     /db_xref="RGD:1586196"
                     /translation="MSPGAFRVVLLTLLLLVCPTQQKPLQSWGQASPGGNARSSLGLS
                     GSREEGVFDLKMFLENMKVDFLRSLNLSGIPSQDKTRAEPPQYMIDLYNRYTTDKSST
                     PASNIVRSFSVEDAISTAATEDFPFQKHILIFNISIPRHEQITRAELRLYVSCQNHVD
                     STHGLEGNMVVYDVLDVDETWDSASGTKTFLVSQDIQDEGWETLEVSSAVKRWVRADS
                     TTNKNKLEVTVQRHREGCSTLDISVPPGSQNLPFFVVFSNDRSNGTKETRLELKEMIG
                     HEQETVLVKTSKNAYQEAGESREEEERIDGYTAVGPLLARRKRSTGAASSHCQKTSLR
                     VNFEDIGWDSWIIAPKEYDAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKA
                     CCVPTKLSPISILYKDDMGVPTLKYHYEGMSVAECGCR"
     exon            461..2928
                     /gene="Gdf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggctccc tgctgagcag tcaacaggac aatgtgggcc tgttcctcct gggctcccca
       61 ttgcacctag tgatacaaca caacggcctg cagggcagtc cccctttagg gcccaagatg
      121 tcccctgggg ccttccgggt ggtcctgctc acgctgctcc tgctggtctg tcccacgcag
      181 cagaagccgc tgcagagctg ggggcaggca tcccctgggg gaaatgcccg cagctccctg
      241 ggattgtctg gaagcagaga ggagggcgtc tttgacctga agatgtttct ggagaacatg
      301 aaagtggact tcctgcgcag ccttaacctg agtggcattc cctctcagga caaaaccaga
      361 gcggagccac cccagtacat gatcgacttg tacaacagat acactacgga caagtcgtcc
      421 acgcctgcct ccaacatcgt gcggagcttc agcgtggaag atgctatatc gacagctgcc
      481 acagaggact tccccttcca gaaacacatc ctgatcttca acatctccat ccctaggcac
      541 gagcagatca ccagggctga gctccgtctc tatgtctcct gtcaaaatca cgtggactcc
      601 actcacgggc tggaaggaaa catggtcgtt tacgatgttc tggatgttga tgagacttgg
      661 gacagtgcct cggggaccaa gaccttcttg gtatcccagg acattcagga tgagggctgg
      721 gagaccctgg aagtgtcgag tgccgtgaag cgttgggtca gggcagactc cacgaccaac
      781 aaaaacaagc tggaggtgac ggtgcagaga catagggagg gctgtagcac actggacatc
      841 agtgtccctc cgggctccca aaacctgccc ttctttgtcg tcttctccaa tgaccgcagc
      901 aatgggacca aggagaccag actggagctg aaggagatga ttggccacga gcaggagacc
      961 gtgcttgtga agacatccaa aaatgcctac caggaggctg gggagagccg tgaggaggag
     1021 gagcgtatag atgggtacac agctgtggga ccgcttttag ctagaaggaa gaggagcact
     1081 ggtgcagcca gcagccactg ccagaagact tctctcaggg tgaactttga ggacatcggc
     1141 tgggacagct ggatcatcgc acccaaggaa tatgatgcct acgagtgtaa aggaggctgc
     1201 ttcttcccgc tggctgatga cgtgacaccc accaaacacg ccatcgtgca gaccctggtg
     1261 catctcaagt tccccacgaa ggtgggcaaa gcctgctgcg tccccaccaa actgagtcct
     1321 atctccatcc tctacaagga tgacatgggc gtgccaaccc tcaagtacca ctacgagggg
     1381 atgagtgtgg ccgagtgtgg gtgcaggtag tccctgcggc cacccagggt gagggtacag
     1441 aacagggaag aggtcctgat aaggtcctgc atcctcctgg gcacgacatg cctatgtgga
     1501 tctgaagcca tcctagagaa gaaaagggac cagttgccat tctgtgccca gtgggttcct
     1561 ctgctgaagt gacaatgact ggggtatatg ggtctgtggg cagagcagaa gactttggaa
     1621 ggtttggtag gtagaaagta gatgacgaga agggaactgg cagaagatga tctggggata
     1681 gcagaaaacc agacagaaac tagcagaaga tacaggtgat gtgcagagag tcaagggagt
     1741 cacagggtcc aggaagctga gactcattcc agcaatctct ggggtgaagg aaagggggac
     1801 tccagttgtc gtttcacccc actgagatgt gtgtcgtgac ctctgactgt caattataga
     1861 aaccaaaatt cagcaagcca atggctgtga ctcagaggta ggattcgact ccgagtctgt
     1921 gggttcccaa agtccgagac cttcccaagt gccacctgct atttagcaga tcagtgtgtg
     1981 ttgatggaat cattagatat tgaaggccta gcatgaggcc aggcagggct aagccaggtc
     2041 cacatccacc actatgcata ggctgcttgc tgtgctccaa cacgatctcc ttgctccatg
     2101 cctgtgctca ctctgtggcc acgtgatttc tgataaaacc cctcccttga agaaatatcc
     2161 ccaagcagaa atagtccccc caaacaacca cagaacagag agaggcagtt caggacctca
     2221 gccctctgac gctcactgtg acccgagaca ctttgacccc ggtgcagtcc tcaaaagttc
     2281 caagagtcat ataaggtcag ttgcaatcct ttattaacaa ttctgtggcc atctgggagg
     2341 aactgcttat ggcttgggcc tctgaccgtc tcctgcctaa ggaccccatg gaggacaagg
     2401 ccgggactca agtctgtcag gatcaaatgt gcctctggtt aactatggaa cttaactatt
     2461 ttccttccct ggtgacctgc actccagaga ttagaagttc agccttacct gtgagagctc
     2521 ctgacatcta aagagagctc tgattcctcg ttttcctcac ggactgccat tgagtctgcc
     2581 tgcagcagcc agcttccttg aggaacgtgt cttctggcat tcagggccca gaggacctca
     2641 aaagatctga actattctca ctgggtgatg ctccaacata attttttaaa tgacctacat
     2701 tgaatgttta catggaatca gggaggaata acacaaaaca caatggagca ttggtgttta
     2761 atctgtagag ctggggaaaa ggtcaagccc taatatatgc ctggcagtgc agtgctgttc
     2821 acagatggtg gtgggtgctg atgccgtctt caggtcccag tgatgtttct gtgtgtgtga
     2881 gagagagaga gggagagttt tacttagaaa taaagtccga tgcctgga
//
