LOCUS       NM_019216               1387 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus growth differentiation factor 15 (Gdf15),
            transcript variant 2, mRNA.
ACCESSION   NM_019216
VERSION     NM_019216.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1387)
  AUTHORS   Klein,A.B., Ranea-Robles,P., Nicolaisen,T.S., Gil,C., Johann,K.,
            Quesada,J.P., Pistolevij,N., Hviid,K.V.R., Fich,L., Offersen,S.M.,
            Helge,J.W., Nielsen,H.S., Bakker,J., Kleinert,M. and Clemmensen,C.
  TITLE     Cross-species comparison of pregnancy-induced GDF15
  JOURNAL   Am J Physiol Endocrinol Metab 325 (4), E303-E309 (2023)
   PUBMED   37584611
  REMARK    GeneRIF: Cross-species comparison of pregnancy-induced GDF15.
REFERENCE   2  (bases 1 to 1387)
  AUTHORS   Liao,J., Gan,Y., Peng,M., Giri,M., Yang,S., Gu,L., Li,A., Xiao,R.,
            He,C., Li,Y., Bai,Y., Xu,L. and Guo,S.
  TITLE     GDF15 alleviates the progression of benign tracheobronchial
            stenosis by inhibiting epithelial-mesenchymal transition and
            inactivating fibroblasts
  JOURNAL   Exp Cell Res 421 (2), 113410 (2022)
   PUBMED   36336027
  REMARK    GeneRIF: GDF15 alleviates the progression of benign
            tracheobronchial stenosis by inhibiting epithelial-mesenchymal
            transition and inactivating fibroblasts.
REFERENCE   3  (bases 1 to 1387)
  AUTHORS   Guo,H., Zhao,X., Li,H., Liu,K., Jiang,H., Zeng,X., Chang,J., Ma,C.,
            Fu,Z., Lv,X., Wang,T., Guo,H., Liu,K., Su,H. and Li,Y.
  TITLE     GDF15 Promotes Cardiac Fibrosis and Proliferation of Cardiac
            Fibroblasts via the MAPK/ERK1/2 Pathway after Irradiation in Rats
  JOURNAL   Radiat Res 196 (2), 183-191 (2021)
   PUBMED   34019665
  REMARK    GeneRIF: GDF15 Promotes Cardiac Fibrosis and Proliferation of
            Cardiac Fibroblasts via the MAPK/ERK1/2 Pathway after Irradiation
            in Rats.
REFERENCE   4  (bases 1 to 1387)
  AUTHORS   Ren,Q., Lin,P., Wang,Q., Zhang,B. and Feng,L.
  TITLE     Chronic peripheral ghrelin injection exerts antifibrotic effects by
            increasing growth differentiation factor 15 in rat hearts with
            myocardial fibrosis induced by isoproterenol
  JOURNAL   Physiol Res 69 (3), 439-450 (2020)
   PUBMED   31852204
  REMARK    GeneRIF: Chronic peripheral ghrelin injection exerts antifibrotic
            effects by increasing growth differentiation factor 15 in rat
            hearts with myocardial fibrosis induced by isoproterenol.
REFERENCE   5  (bases 1 to 1387)
  AUTHORS   Garfield,B.E., Crosby,A., Shao,D., Yang,P., Read,C., Sawiak,S.,
            Moore,S., Parfitt,L., Harries,C., Rice,M., Paul,R., Ormiston,M.L.,
            Morrell,N.W., Polkey,M.I., Wort,S.J. and Kemp,P.R.
  TITLE     Growth/differentiation factor 15 causes TGFbeta-activated kinase
            1-dependent muscle atrophy in pulmonary arterial hypertension
  JOURNAL   Thorax 74 (2), 164-176 (2019)
   PUBMED   30554141
  REMARK    GeneRIF: Circulating GDF-15 is a biomarker of muscle loss in
            pulmonary arterial hypertension that is responsive to treatment.
REFERENCE   6  (bases 1 to 1387)
  AUTHORS   Ge,Y., Waldemer,R.J., Nalluri,R., Nuzzi,P.D. and Chen,J.
  TITLE     RNAi screen reveals potentially novel roles of cytokines in
            myoblast differentiation
  JOURNAL   PLoS One 8 (7), e68068 (2013)
   PUBMED   23844157
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1387)
  AUTHORS   Vaish,V., Piplani,H., Rana,C., Vaiphei,K. and Sanyal,S.N.
  TITLE     NSAIDs may regulate EGR-1-mediated induction of reactive oxygen
            species and non-steroidal anti-inflammatory drug-induced gene
            (NAG)-1 to initiate intrinsic pathway of apoptosis for the
            chemoprevention of colorectal cancer
  JOURNAL   Mol Cell Biochem 378 (1-2), 47-64 (2013)
   PUBMED   23435960
  REMARK    GeneRIF: Up-regulation of EGR-1 and NAG-1, along with higher
            reactive oxygen species load may positively regulate the intrinsic
            pathway of apoptosis for the NSAID mediated chemoprevention of
            colorectal cancer.
REFERENCE   8  (bases 1 to 1387)
  AUTHORS   Tsai,V.W., Macia,L., Johnen,H., Kuffner,T., Manadhar,R.,
            Jorgensen,S.B., Lee-Ng,K.K., Zhang,H.P., Wu,L., Marquis,C.P.,
            Jiang,L., Husaini,Y., Lin,S., Herzog,H., Brown,D.A., Sainsbury,A.
            and Breit,S.N.
  TITLE     TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite
            and body weight regulator
  JOURNAL   PLoS One 8 (2), e55174 (2013)
   PUBMED   23468844
REFERENCE   9  (bases 1 to 1387)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: Gdf15 expression exhibits increases >10-fold at night in
            the rat pineal gland, reaching levels that are >15-fold higher than
            the median in other tissues.
REFERENCE   10 (bases 1 to 1387)
  AUTHORS   Bottner,M., Laaff,M., Schechinger,B., Rappold,G., Unsicker,K. and
            Suter-Crazzolara,C.
  TITLE     Characterization of the rat, mouse, and human genes of
            growth/differentiation factor-15/macrophage inhibiting cytokine-1
            (GDF-15/MIC-1)
  JOURNAL   Gene 237 (1), 105-111 (1999)
   PUBMED   10524241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 29, 2022 this sequence version replaced NM_019216.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR22582419.863584.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               JAXUCZ010000016.1  18838436-18838748
            314-605             JAXUCZ010000016.1  18839279-18839570
            606-1387            JAXUCZ010000016.1  18841241-18842022
FEATURES             Location/Qualifiers
     source          1..1387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1387
                     /gene="Gdf15"
                     /note="growth differentiation factor 15"
                     /db_xref="GeneID:29455"
                     /db_xref="RGD:2674"
     exon            1..313
                     /gene="Gdf15"
                     /inference="alignment:Splign:2.1.0"
     exon            314..605
                     /gene="Gdf15"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..1237
                     /gene="Gdf15"
                     /note="GDF-15"
                     /codon_start=1
                     /product="growth/differentiation factor 15 precursor"
                     /protein_id="NP_062089.2"
                     /db_xref="GeneID:29455"
                     /db_xref="RGD:2674"
                     /translation="MALRALHAQPTGGPQLRFLLFLLLLLLLLSWPSQGDALAVPEQR
                     RSLSESQLNPDELRGRFQDLLSRLHANQSREDSNSEPTPDPAVRILSPEVRLGSHGRL
                     LLRVNRASLTQGLPEAYRVHRALLLLTPSSRPWDITRPLQRAISLQGPHARALRLRLA
                     PPPDLAVLPSGGARLELHLRSAAGRGRRSAHLHPRDSCPLGPGRCCHLETVQATLEDL
                     GWSDWVLSPRQLQLSMCVGECPHLYRSANTHAQIKARLHGLQPDRVPAPCCVPSSYTP
                     VVLMHRTDSGVSLQTYDDLVAQGCHCA"
     exon            606..1387
                     /gene="Gdf15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttggtgaca cctggtgccc tagatgctca ctctggtctc actcagaagt cccggctaca
       61 gccactaccc ttcggaggct caggctgact gtggacaggg ctcctggcga cttcgtcctc
      121 atctatcttc ctttggagcc tgagaccaac tgccctcacc ctccagccac ctaccgactc
      181 ccgactggaa ggagacccat gggcagattt cctcttgcct ctctccccaa tagagacccc
      241 tggtctgggg atactgaggc aggcacaggg caggcgtgtg tgagcaccca gtcatcctgg
      301 aaatctagtg aaggacacaa gcgacatggc cctgcgcgcg ctccatgccc agcctacagg
      361 cggtcctcag ctgaggttcc tgctgttcct gctgctcttg ctgcttctgc tgtcatggcc
      421 atctcagggg gacgccctgg cagtgcctga gcagcgacgc tccctctctg agtcccaact
      481 caacccggac gagctacggg gtcgcttcca ggacctgctg agccgactgc atgccaacca
      541 gagccgggag gactcgaact cagaaccaac ccctgaccca gctgtccgga tactcagtcc
      601 agaggtgcga ttggggtccc acggccggct gctgctccgc gtcaaccggg cgtcgctgac
      661 tcagggtctc cccgaagcct accgcgtgca ccgagcgctg ctcctgctga cgccttcgtc
      721 caggccctgg gacatcacca ggcccctgca acgtgcgatc agcctccagg gaccccacgc
      781 tcgcgcactg cgcttgcgcc tggcgccgcc tcccgaccta gccgtgctgc cctctggcgg
      841 cgcgcgcctg gaactgcact tacgatcggc cgccggcagg gggcgccgaa gcgcgcattt
      901 gcacccaaga gactcgtgcc cgctgggtcc cgggcgctgc tgtcacctgg agactgtgca
      961 ggcaactctc gaggacctag gttggagcga ctgggtactg tccccgcgtc agctgcaact
     1021 gagcatgtgc gtgggcgagt gcccccacct ctaccggtcg gccaacacgc atgcgcagat
     1081 caaagcacgc ctgcatggcc tgcagcccga cagagtgccg gccccgtgct gtgtcccctc
     1141 cagctacacc ccggtggttc ttatgcacag gacagacagc ggcgtgtcac tgcagactta
     1201 tgatgatctg gtagcccagg gctgccactg cgcttgagca ctgggccctg ctccttacct
     1261 acactcccct tccatgatgc tatttatatt tttatttaat aatattatta atttattggg
     1321 gttgggctgg gtgggtggat tgtgtattta tttaaaactc tgctaataaa ggtgagcttg
     1381 gtttcta
//
