LOCUS       NM_017203               4013 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus growth differentiation factor 11 (Gdf11), mRNA.
ACCESSION   NM_017203 XM_001071574 XM_343148
VERSION     NM_017203.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4013)
  AUTHORS   Wang,B., Chen,S.M., Yang,S.Q., Jiang,J.M., Zhang,P., Zou,W. and
            Tang,X.Q.
  TITLE     GDF11 mediates H2S to prevent chronic stress-induced cognitive
            impairment by reducing hippocampal NLRP3/caspase-1-dependent
            pyroptosis
  JOURNAL   J Affect Disord 344, 600-611 (2024)
   PUBMED   37827256
  REMARK    GeneRIF: GDF11 mediates H2S to prevent chronic stress-induced
            cognitive impairment by reducing hippocampal
            NLRP3/caspase-1-dependent pyroptosis.
REFERENCE   2  (bases 1 to 4013)
  AUTHORS   Zhang,Y., Bai,P., Lu,J., Lui,K.H.W., Zhao,T., Wen,D., He,B. and
            Zhu,Z.
  TITLE     Effect of growth differentiation factor 11 expression after
            peripheral nerve injury in Sprague-Dawley rats
  JOURNAL   Neurol Res 45 (9), 835-842 (2023)
   PUBMED   37220327
  REMARK    GeneRIF: Effect of growth differentiation factor 11 expression
            after peripheral nerve injury in Sprague-Dawley rats.
REFERENCE   3  (bases 1 to 4013)
  AUTHORS   Wang,H., Zhang,Y., Liu,H. and Li,S.
  TITLE     GDF11, a target of miR-32-5p, suppresses high-glucose-induced
            mitochondrial dysfunction and apoptosis in HK-2 cells through
            PI3K/AKT signaling activation
  JOURNAL   Int Urol Nephrol 55 (7), 1767-1778 (2023)
   PUBMED   36749472
  REMARK    GeneRIF: GDF11, a target of miR-32-5p, suppresses
            high-glucose-induced mitochondrial dysfunction and apoptosis in
            HK-2 cells through PI3K/AKT signaling activation.
REFERENCE   4  (bases 1 to 4013)
  AUTHORS   Wang,Z., Jiang,P., Liu,F., Du,X., Ma,L., Ye,S., Cao,H., Sun,P.,
            Su,N., Lin,F., Zhang,R. and Li,C.
  TITLE     GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt
            Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (20), 12279 (2022)
   PUBMED   36293138
  REMARK    GeneRIF: GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent
            PI3K-Akt Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4013)
  AUTHORS   Duan,F., Wang,X., Wang,H., Wang,Y., Zhang,Y., Chen,J., Zhu,X. and
            Chen,B.
  TITLE     GDF11 ameliorates severe acute pancreatitis through modulating
            macrophage M1 and M2 polarization by targeting the TGFbetaR1/SMAD-2
            pathway
  JOURNAL   Int Immunopharmacol 108, 108777 (2022)
   PUBMED   35461108
  REMARK    GeneRIF: GDF11 ameliorates severe acute pancreatitis through
            modulating macrophage M1 and M2 polarization by targeting the
            TGFbetaR1/SMAD-2 pathway.
REFERENCE   6  (bases 1 to 4013)
  AUTHORS   Kim,J., Wu,H.H., Lander,A.D., Lyons,K.M., Matzuk,M.M. and
            Calof,A.L.
  TITLE     GDF11 controls the timing of progenitor cell competence in
            developing retina
  JOURNAL   Science 308 (5730), 1927-1930 (2005)
   PUBMED   15976303
REFERENCE   7  (bases 1 to 4013)
  AUTHORS   Harmon,E.B., Apelqvist,A.A., Smart,N.G., Gu,X., Osborne,D.H. and
            Kim,S.K.
  TITLE     GDF11 modulates NGN3+ islet progenitor cell number and promotes
            beta-cell differentiation in pancreas development
  JOURNAL   Development 131 (24), 6163-6174 (2004)
   PUBMED   15548585
REFERENCE   8  (bases 1 to 4013)
  AUTHORS   Esquela,A.F. and Lee,S.J.
  TITLE     Regulation of metanephric kidney development by
            growth/differentiation factor 11
  JOURNAL   Dev Biol 257 (2), 356-370 (2003)
   PUBMED   12729564
REFERENCE   9  (bases 1 to 4013)
  AUTHORS   McPherron,A.C., Lawler,A.M. and Lee,S.J.
  TITLE     Regulation of anterior/posterior patterning of the axial skeleton
            by growth/differentiation factor 11
  JOURNAL   Nat Genet 22 (3), 260-264 (1999)
   PUBMED   10391213
REFERENCE   10 (bases 1 to 4013)
  AUTHORS   Nakashima,M., Toyono,T., Akamine,A. and Joyner,A.
  TITLE     Expression of growth/differentiation factor 11, a new member of the
            BMP/TGFbeta superfamily during mouse embryogenesis
  JOURNAL   Mech Dev 80 (2), 185-189 (1999)
   PUBMED   10072786
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XM_001071574.3, XM_343148.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.37699.1,
                                           SRR22582416.1634475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               JAXUCZ010000007.1  1904751-1905222     c
            473-870             JAXUCZ010000007.1  1899982-1900379     c
            871-4013            JAXUCZ010000007.1  1896229-1899371     c
FEATURES             Location/Qualifiers
     source          1..4013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..4013
                     /gene="Gdf11"
                     /gene_synonym="BMP-11"
                     /note="growth differentiation factor 11"
                     /db_xref="GeneID:29454"
                     /db_xref="RGD:2673"
     exon            1..472
                     /gene="Gdf11"
                     /gene_synonym="BMP-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1251
                     /gene="Gdf11"
                     /gene_synonym="BMP-11"
                     /note="GDF-11; bone morphogenetic protein 11"
                     /codon_start=1
                     /product="growth/differentiation factor 11 precursor"
                     /protein_id="NP_058899.1"
                     /db_xref="GeneID:29454"
                     /db_xref="RGD:2673"
                     /translation="MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAGVGGE
                     RSSRPAPSAAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLL
                     PKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCC
                     HFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIR
                     IRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGA
                     EGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRY
                     KANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYG
                     KIPGMVVDRCGCS"
     exon            473..870
                     /gene="Gdf11"
                     /gene_synonym="BMP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            871..4013
                     /gene="Gdf11"
                     /gene_synonym="BMP-11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccccgcccc ccagtcctcc cctcccctgc agcatggtgc tcgcggcccc gctgctgctg
       61 ggcttcctgc tcctcgccct ggagctgcgg ccccgggggg aggcggccga gggccccgcg
      121 gcggcggcgg cggcagcggc ggcggcggcc ggggtcgggg gggagcgctc cagccggccg
      181 gccccgtccg ctgcaccgga gccggacggc tgccccgtgt gcgtgtggcg gcagcacagc
      241 cgcgagctgc gcctggagag catcaagtcg cagatcctga gcaaactgcg gctcaaggag
      301 gcgcccaaca tcagccggga ggtggtgaag cagctgctgc ccaaggcgcc gccgctgcag
      361 cagatcctgg atctgcacga cttccaaggc gacgcgctgc agcccgagga cttcttggaa
      421 gaggacgagt accacgctac caccgagacg gtcataagca tggcccagga gacggaccct
      481 gcagtgcaga cagacggcag ccctctgtgt tgccatttcc acttcagccc caaggtgatg
      541 ttcacaaagg tactgaaggc ccaactgtgg gtgtacctcc ggcctgtgcc ccgcccagca
      601 acagtctacc tgcagatctt acgactgaag cccctaactg gggaagggac cgcaggggga
      661 gggggtggag gccggcgtca catccggatc cggtcactaa aaattgagct acactcacgc
      721 tccggccact ggcagagcat cgacttcaag caagtgctac acagctggtt tcgccagcca
      781 caaagcaact ggggaatcga gatcaacgcc tttgatccca gtggcacaga cctggctgtc
      841 acctccctgg ggccaggagc tgaggggctg caccctttca tggagcttcg agttctagag
      901 aacacaaaga ggtcccggcg gaacctaggc ctagactgcg atgaacactc gagtgagtcc
      961 cgctgctgcc gataccctct cacagtggac ttcgaggctt ttggctggga ctggatcatc
     1021 gcacctaagc gctacaaggc caactactgc tccggccagt gcgaatacat gttcatgcaa
     1081 aagtatccac acacccactt ggtgcaacag gccaacccac gaggctctgc tgggccctgc
     1141 tgcaccccta ccaagatgtc cccaatcaac atgctctact tcaatgacaa gcagcagatt
     1201 atctacggca agatccctgg catggtggtg gatcgatgtg gctgctccta aggtgtgggc
     1261 tacagtggat gcctccctca gaccctaccc caagaacccc agccctggtc cccattcccc
     1321 aagccctaga gcgcccctcc ccacctcttc ccacgaacgt cacaccttgt tccctgacca
     1381 agcagtgtgc aatacaacag agggaggcag gtggggatgg aggggtgagg ggttgggaga
     1441 aaagaagggc agtcagggtg gaatgtatct gagatttgca ggtgagaagg tttggcaaga
     1501 agacagatgt agggacagag aaagaagatg gaaggataga gacagagaac agacagaaca
     1561 gtgagaaagc aaaggaacag agaggcaaaa agattagaga ctaagcagat gaggagagag
     1621 actgaaatgg gagtaaaccg agagccctgt cccaagcctg tttttccaca gcaaggtgag
     1681 aggcttggta tagtttgggg tagttccctg acaactcagt aggagtaaat cagaagttca
     1741 ttcttagctt tttccctctc tccttccagt agcagccgga agtggaatga ggatggggca
     1801 aagtaaggac ctgggagggt ttttttaatt tatttattta ttatgacatt ttgttttttg
     1861 gtatttggct ttactggaat gggagggacc ttgcccactg tgccccattg gtcccttatt
     1921 ccccaaaccc tgctcttccc cggttccgac ctacttaagc acttgtatta tgcctccagg
     1981 gctggggatg gggaaagggc aagagggcta acacatggag gtttccaacc cacaatcacc
     2041 ctgaccaacc ttctcgagcc aaacgggttg aaccgagtgg tcacggaagc agttcagact
     2101 gtagagctgg gggacagggg ctgaactcaa catccatgag agcaactaaa ctacccctca
     2161 ggcctaccta tttctggtat tatttagcca gagggtatag tctgctcatc cccaaattct
     2221 cctcagccaa gagaccaaag agcctgtgga atgccctgct ctcagcctct gtcttcaggt
     2281 caataagagt tagaagtccc agagtccccc agatctggga agggtaaggg tcaagaaaat
     2341 agtaaagagg ctgaaggtta cagggcattt gaatccaaat cactgctcta ggctagggaa
     2401 tggccagcag accaaggtgg aagggattct gaaggggggg catgttagtc ccctaaccca
     2461 aagctcaggg tggaagatgg agaacaaggg agcagagtgt ctatgatttt atcttatttt
     2521 tggaatatag cagcagcacc tggcagcagg aggggacagt acagcgggga aaggcgtgtg
     2581 ccaaggccag gcacagcaga ggacgggaga ggcttgggga gcaggcaagg ggtagttgcc
     2641 actacgagtc acccactcat tcctcccaca ctcctgaccc accctcctct gcactcactg
     2701 tgcctcagtt ccttcccctt gatggaatga gcggcagcag cacccgccac agccaagaga
     2761 tgaattctga gcacttacca cgggcacttt atggacataa aatacctctc gctgtggaac
     2821 tagataacca gggcaccaca acggtggtga agagatgtga ggctaaagag tcacaggctt
     2881 cagagtacag tacacttctg cttctcagct ggacagtacc tgaagccaag gaattaaaac
     2941 ctccacacct aaccgtacct cggcagtggc ctcttggctc tagacaagag tcttaagagg
     3001 atggggtagg gagaagggag gtcacagcaa atgatcacta atagaaccag cagtgatggt
     3061 ctggcagaga ctggactgaa ccgagcctga cctggaaggt ctgcacgtcc taagagcacg
     3121 ctctctcact tgggccagac cacagagagg tcaagggatg tgtccgtcct tagcacctaa
     3181 ctcctattct catagtgagg agaggaggaa aggagtctcc gaggaatgga caggggttct
     3241 taagcctttc aactcacttc tcatgtagca gcagcagcta gtcccaagcc tctcctctct
     3301 ggccattcct aatccttttt ttcctacccc atcttaaaga gcaagacaca tttgactatc
     3361 aacaccaatc atacttcctt ggtggaggag aggtacagaa tagtaaagag gattgctttc
     3421 ctccaaagtc aaatgcctct tgatcttaga aagggtaagg gttggacaat taggtatcag
     3481 gtaaacttct ccatagttta gagagctggg gcattacact tcaattattg cctctttatt
     3541 actaccaagt acagggggaa tggggttgtc ttatgaatat aaacctgagt tgagcctcag
     3601 tttcctggtc ttttctatcc cctaagaggc ttgaggatat ggcctagcat tcagtgggag
     3661 ctggcacctc ttcccacact acctgtatgg actggccggt gctcctctga acgtattatt
     3721 agtgtaactc tttattttgt gtatttgtta catcatgtgt gtgattgcct ttgttaaggg
     3781 tgtctgagga gtatgggctg acaggggcac tggaatacca ggaaaggact tcttcaacaa
     3841 gatcaaggtt tccaggaagg aaccattgca aaaaggccat caggcagttt tcaagttatg
     3901 tgacagaggg caaagatggc caaagggtgc tctgagtttt gggacagtca catgacacaa
     3961 tccagcactt gaacctgaaa aaagaaaaat aaaagcagtc aaagagctta ata
//
