LOCUS       NM_024375               2411 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus growth differentiation factor 10 (Gdf10), mRNA.
ACCESSION   NM_024375 XM_346483
VERSION     NM_024375.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Zhao,Q., Xu,J., Han,X., Zhang,Z., Qu,J. and Cheng,Z.
  TITLE     Growth differentiation factor 10 induces angiogenesis to promote
            wound healing in rats with diabetic foot ulcers by activating
            TGF-beta1/Smad3 signaling pathway
  JOURNAL   Front Endocrinol (Lausanne) 13, 1013018 (2023)
   PUBMED   36714584
  REMARK    GeneRIF: Growth differentiation factor 10 induces angiogenesis to
            promote wound healing in rats with diabetic foot ulcers by
            activating TGF-beta1/Smad3 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Jiang,L., Tan,B., Li,S., Wang,L., Zheng,L., Liu,Y., Long,Z. and
            Wu,Y.
  TITLE     Decrease of growth and differentiation factor 10 contributes to
            neuropathic pain through N-methyl-D-aspartate receptor activation
  JOURNAL   Neuroreport 28 (8), 444-450 (2017)
   PUBMED   28394782
  REMARK    GeneRIF: Results suggest that the decreasing growth and
            differentiation factor 10 may contribute toward neuropathic pain by
            facilitating N-methyl-D-aspartate receptor activation. Findings
            shed new light on the understanding of the molecular mechanisms
            underlying neuropathic pain.
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Zhao,L., Isayama,K., Chen,H., Yamauchi,N., Shigeyoshi,Y.,
            Hashimoto,S. and Hattori,M.A.
  TITLE     The nuclear receptor REV-ERBalpha represses the transcription of
            growth/differentiation factor 10 and 15 genes in rat endometrium
            stromal cells
  JOURNAL   Physiol Rep 4 (2) (2016)
   PUBMED   26811051
  REMARK    GeneRIF: findings indicate that the attenuation of REV-ERBalpha
            leads to an upregulation of Gdf10 and Gdf15 in decidual cells
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Bubenek,S., Nastase,A., Niculescu,A.M., Baila,S., Herlea,V.,
            Lazar,V., Paslaru,L., Botezatu,A., Tomescu,D., Popescu,I. and
            Dima,S.
  TITLE     Assessment of gene expression profiles in peripheral occlusive
            arterial disease
  JOURNAL   Can J Cardiol 28 (6), 712-720 (2012)
   PUBMED   22721676
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Kaihara,S., Bessho,K., Okubo,Y., Sonobe,J., Komatsu,Y., Miura,M.,
            Miyatake,S., Nakao,K. and Iizuka,T.
  TITLE     Over expression of bone morphogenetic protein-3b (BMP-3b) using an
            adenoviral vector promote the osteoblastic differentiation in C2C12
            cells and augment the bone formation induced by bone morphogenetic
            protein-2 (BMP-2) in rats
  JOURNAL   Life Sci 72 (15), 1683-1693 (2003)
   PUBMED   12559390
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Erickson,G.F. and Shimasaki,S.
  TITLE     The spatiotemporal expression pattern of the bone morphogenetic
            protein family in rat ovary cell types during the estrous cycle
  JOURNAL   Reprod Biol Endocrinol 1, 9 (2003)
   PUBMED   12741959
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Nakamura,K., Kadotani,Y., Ushigome,H., Akioka,K., Okamoto,M.,
            Ohmori,Y., Yaoi,T., Fushiki,S., Yoshimura,R. and Yoshimura,N.
  TITLE     Antisense oligonucleotide for tissue factor inhibits hepatic
            ischemic reperfusion injury
  JOURNAL   Biochem Biophys Res Commun 297 (3), 433-441 (2002)
   PUBMED   12270110
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Hino,J., Matsuo,H. and Kangawa,K.
  TITLE     Bone morphogenetic protein-3b (BMP-3b) gene expression is
            correlated with differentiation in rat calvarial osteoblasts
  JOURNAL   Biochem Biophys Res Commun 256 (2), 419-424 (1999)
   PUBMED   10079200
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Takao,M., Hino,J., Takeshita,N., Konno,Y., Nishizawa,T., Matsuo,H.
            and Kangawa,K.
  TITLE     Identification of rat bone morphogenetic protein-3b (BMP-3b), a new
            member of BMP-3
  JOURNAL   Biochem Biophys Res Commun 219 (2), 656-662 (1996)
   PUBMED   8605043
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D49494.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346483.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2411
                     /gene="Gdf10"
                     /note="growth differentiation factor 10"
                     /db_xref="GeneID:79216"
                     /db_xref="RGD:621512"
     exon            1..546
                     /gene="Gdf10"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1670
                     /gene="Gdf10"
                     /note="bone morphogenetic protein 3b; BIP; BMP-3b; GDF-10;
                     bone-inducing protein; prepro bone inducing protein"
                     /codon_start=1
                     /product="growth/differentiation factor 10 precursor"
                     /protein_id="NP_077351.1"
                     /db_xref="GeneID:79216"
                     /db_xref="RGD:621512"
                     /translation="MAPGLARISLRSQLLPLVPLLLLLRGAGCGHRVPSWSSLPSAAD
                     SVQRDRDLQQSPGDAAAALGPGAQDIVAVHMLRLYEKYNRRGAPPGGGNTVRSFRARL
                     DVIDQKPVYFFNLTSMQDSEMILTATFHFYSEPPRWPRAREVFCKPRAKNASCRLLTP
                     GLPARLHLIFRSLSQNTATQGLLRGAMALTPPPRGLWQAKDISSIIKAARRDGELLLS
                     AQLDSGEKDLGVPRPSSHMPYILVYANDLAISEPNSVAVTLQRYDPFPAGDFEPGAAP
                     NSSADPRVRRAAQVSKPLQDNELPGLDERPAPALHAQHFHKHEFWSSPFRALKPRTGR
                     KDRKKKDQDTFTPSSSQVLDFDEKTMQKARRRQWDEPRVCSRRYLKVDFADIGWNEWI
                     ISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMNSLG
                     VLFLDENRNVVLKVYPNMSVETCACR"
     exon            547..1478
                     /gene="Gdf10"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..2411
                     /gene="Gdf10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggcgcgg gctcggctga gctccacgcg gctcaggaca gccgtgacca ctgaccgggc
       61 ggcgtggatg ctcagcaagc agctctgcca ccgcgagcca atcccgatac atcgagtcgg
      121 gtcgtcgggg ctgtccgagt ccccacagac actccagccg tggaccaggt gcacagccaa
      181 cactgagcct tccctgtctg ccctcctggg ctcagaccct tcaccactgt cactcagcca
      241 tggctccagg tcttgctcgg atcagcttga ggtctcagct gctgcccttg gtgccgctgc
      301 tcctgctact gcggggcgca ggctgcggcc acagagtccc ctcatggtcc tcactgcctt
      361 cagcagctga cagtgtgcag agggacaggg acctccagca gtcacccggg gacgctgcag
      421 ccgctctggg tccaggcgcc caggacatag tcgctgtcca catgctcagg ctctatgaga
      481 agtacaaccg gagaggcgct ccaccaggag gaggcaacac cgtccgaagc ttccgtgccc
      541 ggctggatgt gatcgaccag aagcctgtgt atttcttcaa cttgacttcc atgcaagact
      601 cagaaatgat cctcacagcc accttccact tctactcaga acctccacgg tggccccggg
      661 ctcgtgaggt attctgcaag ccccgagcta agaatgcatc ctgccggctc ctgaccccag
      721 gtctgcctgc tcgcttgcac ctaatcttcc gcagtctctc gcagaacact gccactcagg
      781 ggctgctccg cggggccatg gccctgacac ctccaccacg tggcctctgg caggccaagg
      841 acatctcctc aatcatcaag gctgcccgaa gggatggaga acttcttctc tctgctcagc
      901 tggattctgg agagaaggat ctcggagtgc cacggcccag ttcccacatg ccctatatcc
      961 ttgtctatgc aaatgacctg gccatctcgg agcccaacag tgtagcagtg acgctacaga
     1021 gatacgaccc atttccagct ggagactttg agcctggagc agcccccaac agctcagcgg
     1081 atccccgcgt gcgcagggcg gcacaggtat ccaaacccct gcaagacaat gaacttccag
     1141 ggctggacga aagaccagcg cctgccctgc acgcccagca tttccacaag cacgagttct
     1201 ggtccagtcc tttccgggca ctgaaacccc gcaccgggcg caaagaccgc aagaagaaag
     1261 accaggatac attcaccccc tcctcctcgc aggtgctgga ctttgatgag aagacgatgc
     1321 agaaagccag gaggcggcag tgggatgagc ctcgggtctg ctccaggagg tacctgaagg
     1381 tggattttgc agacatcggg tggaatgaat ggatcatctc acccaaatcc tttgatgcct
     1441 actactgtgc tggagcctgc gagttcccca tgcccaagat cgtccgcccg tccaaccatg
     1501 ccaccatcca gagcatcgtc agagctgtgg gcattgtccc tggcatcccg gagccatgct
     1561 gtgtcccaga caagatgaac tcccttggag tccttttcct ggacgagaat cggaatgtgg
     1621 ttctgaaggt gtaccccaat atgtccgtag agacctgtgc ctgtcggtaa ggtggcttca
     1681 agatggaagg cagacctcct tcacccctgc tgtgcagagt ggcattcttg gagccaggat
     1741 ttgactcgag caagtcccag gtgctagacg gagcttatag acagccaggc tgagaccaag
     1801 atctgtccac cgagccacag ttctcccgtt cttccgcgtc gtggtagctc tgtaaggact
     1861 tttttgagtt cctggaagga atctggaatt caccatggtc tgaaatttgc ccacattttt
     1921 caaggcctag aaatagcatg tgtccacaga tgtcaacccc aaggcatctg tcctctcaga
     1981 acctggaaag actatgcaaa tctcggggca ctccccgccc cccacggcag taaatgctta
     2041 tttgaaaacc ctcaagcggc atactagaaa cagggcctaa agcatggcat ggatgggtat
     2101 ttctcttaca tttcactaca catgctttta tacatgcagt acgcaacatg tactcgagac
     2161 tgatttcttc ttttaatata tgtattttga tttcaaagca aagtggacag agttgacccc
     2221 catgccccac agacgtaata ctgaaagtta ggtgtgggct gtttaaacat gcgtatgaaa
     2281 aataatacag tgatatgctg gaatactaaa aaataaccaa gattctatat ttttgtaaat
     2341 tatactttgt atactgtaga ttgtgagtgt tctgtgtttt tatggaaagc taataaatta
     2401 aaggtacagt g
//
