LOCUS       NM_001044240            2683 bp    mRNA    linear   ROD 18-APR-2023
DEFINITION  Rattus norvegicus growth differentiation factor 1 (Gdf1), mRNA.
ACCESSION   NM_001044240 XM_001071020 XM_224733
VERSION     NM_001044240.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2683)
  AUTHORS   Hung WC, Tang WH, Yu TH, Wu CC, Wang CP, Lu YC, Wei CT, Chung FM,
            Lee YJ and Hsu CC.
  TITLE     Low plasma growth/differentiation factor 1 levels are associated
            with liver fibrosis in patients with stable angina
  JOURNAL   J Clin Lab Anal 36 (11), e24745 (2022)
   PUBMED   36268984
REFERENCE   2  (bases 1 to 2683)
  AUTHORS   Zhang J, Wu Q, Wang L, Li X, Ma Y and Yao L.
  TITLE     Association of GDF1 rs4808863 with fetal congenital heart defects:
            a case-control study
  JOURNAL   BMJ Open 5 (12), e009352 (2015)
   PUBMED   26656983
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2683)
  AUTHORS   Bao MW, Zhang XJ, Li L, Cai Z, Liu X, Wan N, Hu G, Wan F, Zhang R,
            Zhu X, Xia H and Li H.
  TITLE     Cardioprotective role of growth/differentiation factor 1 in
            post-infarction left ventricular remodelling and dysfunction
  JOURNAL   J Pathol 236 (3), 360-372 (2015)
   PUBMED   25726944
REFERENCE   4  (bases 1 to 2683)
  AUTHORS   Zhang Y, Zhang XF, Gao L, Liu Y, Jiang DS, Chen K, Yang Q, Fan GC,
            Zhang XD and Huang C.
  TITLE     Growth/differentiation factor 1 alleviates pressure
            overload-induced cardiac hypertrophy and dysfunction
  JOURNAL   Biochim Biophys Acta 1842 (2), 232-244 (2014)
   PUBMED   24275554
REFERENCE   5  (bases 1 to 2683)
  AUTHORS   Sun X, Meng Y, You T, Li P, Wu H, Yu M and Xie X.
  TITLE     Association of growth/differentiation factor 1 gene polymorphisms
            with the risk of congenital heart disease in the Chinese Han
            population
  JOURNAL   Mol Biol Rep 40 (2), 1291-1299 (2013)
   PUBMED   23076529
REFERENCE   6  (bases 1 to 2683)
  AUTHORS   Andersson O, Bertolino P and Ibanez CF.
  TITLE     Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and
            GDF3 during early embryonic development
  JOURNAL   Dev Biol 311 (2), 500-511 (2007)
   PUBMED   17936261
REFERENCE   7  (bases 1 to 2683)
  AUTHORS   Wang B, Shi G, Fu Y and Xu X.
  TITLE     Cloning and characterization of a LASS1-GDF1 transcript in rat
            cerebral cortex: conservation of a bicistronic structure
  JOURNAL   DNA Seq 18 (2), 92-103 (2007)
   PUBMED   17364820
  REMARK    GeneRIF: Cloning and sequence analysis revealed that this
            transcript contains two nonoverlapping open reading frames (ORFs),
            LASS1 and GDF1, which are quite different to the predicted
            sequences in GenBank (accession number XM_224734 and XM_224733).
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC166409.1.
            
            On Jul 16, 2009 this sequence version replaced NM_001044240.1.
            
            Summary: This gene encodes a member of the bone morphogenetic
            protein (BMP) family and the TGF-beta superfamily. This group of
            proteins is characterized by a polybasic proteolytic processing
            site that is cleaved to produce a mature protein containing seven
            conserved cysteine residues. The members of this family are
            regulators of cell growth and differentiation in both embryonic and
            adult tissues. The mouse ortholog of this gene is involved in the
            establishment of left-right asymmetry in early embryogenesis and in
            neural development in later embryogenesis. This protein is
            transcribed from a bicistronic mRNA that also encodes the LAG1
            homolog, ceramide synthase 1 gene. Mono-cistronic transcripts for
            this gene are also found in mouse, but it is not known if they
            exist in rat. [provided by RefSeq, Jul 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166409.1, DQ479969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            bicistronic transcript :: PMID: 17364820
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2683              BC166409.1         1-2683
FEATURES             Location/Qualifiers
     source          1..2683
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2683
                     /gene="Gdf1"
                     /note="growth differentiation factor 1"
                     /db_xref="GeneID:306351"
                     /db_xref="RGD:1304678"
     exon            1..277
                     /gene="Gdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..437
                     /gene="Gdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..618
                     /gene="Gdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..780
                     /gene="Gdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..928
                     /gene="Gdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1038
                     /gene="Gdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1776
                     /gene="Gdf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1482..2555
                     /gene="Gdf1"
                     /note="embryonic growth/differentiation factor 1"
                     /codon_start=1
                     /product="embryonic growth/differentiation factor 1
                     precursor"
                     /protein_id="NP_001037705.1"
                     /db_xref="GeneID:306351"
                     /db_xref="RGD:1304678"
                     /translation="MLPVCHRFCDHLLLLLLLPSTTLAHAPASLGPAAALLQVLGLPE
                     TPRSVPTLRPVPPVMWRLFRSRNPQEARVGRPLKPCHVEELGVAGNIVRHIPDSGLSS
                     RIIQPARTSGLCPEWTVVFDLSSVEPIERPTRARLELRLEAESEDTRGWELSVALLAE
                     AEHPGPELLRVQAPPGLPLRADLLGTAVAANASVPRTLRLALALHPGAAATCGRLAEA
                     SLLLVTLDPRLCPLPRSRRHTEPRVGGGPVGTCRTRRLHVSFREVGWHRWVIAPRGFL
                     ANFCQGTCALPETLRGPGGPPALNHAVLRALMHAAAPTPGVGSPCCVPERLSPISVLF
                     FDNSDNVVLRHYEDMVVDECGCR"
     exon            1777..2657
                     /gene="Gdf1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2657
                     /gene="Gdf1"
ORIGIN      
        1 cagcggagac cgcggacgag agggtagcat ggctgctgca gcgacgacca ccgggctcga
       61 ggcgccagag cccatgccga gttatgcaga gatgttgcaa cgaagctggg cctcggcgct
      121 ggccgcagca cggggctgcg gggactgcgg ctggggactg gcgcgccgcg gcctggcgga
      181 gcacgctcat ctggctgcac ccgagctgct gctggccgtg ctctgcgctc tggggtggac
      241 agcgttgcgc tcagcagcca ccacgcgcat ctttcggccc ctggccaagc ggtgtcgcct
      301 gcagcctaga gacgcggcta ggctgcctga gagtgcctgg aagcttctgt tctacttggc
      361 ctgttggagc tactgtgcct acctgctctt gggcaccagt taccctttct tccatgaccc
      421 gccctctgtc ttctacggct ggaggtcggg catggcggtg ccctgggaca tagcggtcgc
      481 ctacctgctg caggggagtt tctactgtca ttccgtctat gccaccgtgt acatggacag
      541 ctggcgcaag gactcggtgg tcatgctggt acaccatgtg gtcaccttac tgctcatcgc
      601 ctcttcctat gcgttccgat accacaacgt gggcctcctc gtgttcttcc tgcatgacgt
      661 cagcgatgtg cagctggagt tcaccaagct caacatctac ttcaaggcca ggggtggcgc
      721 ctaccatcga ttgcacgggc tggtggccaa cctgggctgc ctcagcttct gcttctgctg
      781 gttctggttc cgcctctact ggttcccact caaggttctc tatgccacct ggcactgcag
      841 cctgcagtct gtgcctgaca ttccgtacta tttcttcttc aacactctgc tgctgctcct
      901 cctggtcatg aacatctact ggttcctgta cattgtggct tttgcagcca aggtgctgac
      961 cggtcagatg cgtgaactgg aagacttgcg ggaatacgac agtctggaag cgcagacagc
     1021 caagccctgc agagctgaga agcctctaag gaatggcctg gtgaaggaca aactcttctg
     1081 agtctcttgt cctcaactcc cgccatccag gactctgtcc cgtcctacct gggatactgg
     1141 ccccgcccct ggagactgga cccagtcccc ggaggtctgc tcccacccct ggaggcctgg
     1201 cctcgccttt ggcggcatgg ccacgcctgc aggacgatgg ccccgcccta agatgcagga
     1261 tgccaccctt ctccagggac tctggctgcc agcagctccg cctttcaggt caattctcga
     1321 ccacccacct tgggacccag cccagtcctg ccctctgggt aagtggggtc tggacacgcc
     1381 ccctccagga cctcaaagca ccctcgacct acggtcacca gcccactggt cctggacgca
     1441 gtggactctg ctgactctct tggacaccgc ctgggaggaa aatgctccct gtctgccacc
     1501 gtttttgcga ccacctcctc cttctgctct tgctgccctc aacgaccctg gcccacgcgc
     1561 cagcatcctt gggccccgct gccgccctgc tccaggttct cgggcttccc gaaacgcccc
     1621 ggagcgtccc cacactccga cctgtgcctc ctgtcatgtg gcgcctattc cgcagccgca
     1681 acccccagga ggccagagtg gggcgccctc tgaaaccatg ccacgtggag gaactggggg
     1741 ttgccggaaa cattgtgcgc cacatccccg acagcggtct gtcctccagg atcatacagc
     1801 ccgccagaac ctcagggctg tgccccgagt ggaccgtcgt ctttgacctg tcgagcgtgg
     1861 agcccataga gcgcccaaca cgcgcgcgcc tagagttgcg gctggaggct gagagcgaag
     1921 atacacgagg gtgggagcta agcgtggcgc tgttggccga ggctgagcat cctgggcctg
     1981 agctactgcg cgtgcaggcg ccacccgggc tgccactgcg cgcagaccta ctggggactg
     2041 cagtagcggc taacgcatcg gtgccgcgca ctctgcgctt ggcgctggcg ctgcaccctg
     2101 gggccgctgc aacctgtggg cgcctggctg aggcctcgtt gctgctggtg acgctggacc
     2161 cacgcctgtg tcccttgccg cggtcacggc gccacacgga gcccagggtg ggaggtggtc
     2221 cagtgggcac atgtcgcacc cgacggttgc acgtgagctt ccgtgaggtg ggctggcacc
     2281 gctgggtgat tgcgccgcgg ggctttctag ccaacttctg ccagggcacg tgtgcgctac
     2341 ctgaaacact gaggggaccc ggcgggccgc ctgcacttaa ccacgctgtg ctgcgcgcgc
     2401 tcatgcacgc agctgctccc accccgggtg taggctcgcc ctgctgcgtg ccagagcgtc
     2461 tgtcgcctat ctccgtgctc ttcttcgata atagtgacaa cgtggtgctg cgccactacg
     2521 aggacatggt ggtggatgag tgtggctgtc gctgaccacc caggacaccc tttcagggac
     2581 ggccccacgc gaaaagcagg gaccgtttgt tcatgtttta ttggtgacaa aaagcttaaa
     2641 acaaatttga ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
